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Topic · Cell Biology

Calpain Protease Function and Regulation

Calpain Protease Function and Regulation is a research topic within Cell Biology. Science Explorer counts 7.3k research works in it since 1950. 10.0% of them reached the world's top 10% most cited for their field and year.

This cluster of papers explores the role of calpain, a calcium-dependent protease, in regulating various cellular processes such as cell migration, neurodegeneration, apoptosis, and its involvement in diseases including diabetes, cancer, and cardiovascular remodeling. The papers also discuss the structure, activation, and inhibition of calpain as a potential therapeutic target.

  • Calpain
  • Cell Migration
  • Neurodegeneration
  • Proteolytic System
  • Apoptosis
  • Diabetes
  • Cancer
  • Mitochondria
  • Inhibitors
  • Cardiovascular Remodeling
Research works
7.3k
fractional, since 1950
In the world top 10%
732
per year above
Top-10% rate
10.0%
share of its works in the world top 10%
Growth, 2018-21 → 2022-25
-16%
the tick is no change
Largest producer
China
43% of the 10 largest, 2022-now
Calpain Protease Function and Regulation

Which countries lead Calpain Protease Function and Regulation research?

By volume, China and the United States publish the most (215 and 114 works in 2022-now).

By volume, 2022-now

  1. 1 China 215 works
  2. 2 United States 114 works
  3. 3 India 44 works
  4. 4 Japan 26 works
  5. 5 Brazil 24 works
  6. 6 Germany 18 works
  7. 7 Türkiye 15 works
  8. 8 France 15 works
  9. 9 Canada 15 works
  10. 10 United Kingdom 14 works

How concentrated that is

The same countries as shares of everything the list above accounts for. A node where two countries do two thirds of the work and one spread evenly across twelve read alike as a ranking and not at all alike here.

China: 42.9%United States: 22.9%India: 8.8%Japan: 5.2%6 others listed: 20.2%43%largest
China215 · 42.9%United States114 · 22.9%India44 · 8.8%Japan26 · 5.2%6 others listed101 · 20.2%

Shares of the rows listed above, not of the whole node.

Which institutions lead Calpain Protease Function and Regulation research?

By volume in 2022-now, Russian Academy of Sciences publishes the most Calpain Protease Function and Regulation research, followed by Chinese Academy of Sciences and Centre National de la Recherche Scientifique.

By volume, 2022-now

  1. 1 Russian Academy of SciencesRussia 5 works
  2. 2 Chinese Academy of SciencesChina 5 works
  3. 3 Centre National de la Recherche ScientifiqueFrance 5 works
  4. 4 McGill UniversityCanada 4 works
  5. 5 Chongqing Medical UniversityChina 4 works
  6. 6 Chinese Academy of Agricultural SciencesChina 4 works
  7. 7 Fudan UniversityChina 4 works
  8. 8 University of CalcuttaIndia 4 works
  9. 9 National Institute of Biomedical GenomicsIndia 4 works
  10. 10 Soochow UniversityChina 4 works

Who are the leading researchers in Calpain Protease Function and Regulation?

The most-cited researchers publishing on Calpain Protease Function and Regulation include Guido Kroemer, John Q. Trojanowski and Frank B. Hu.

  1. 1 Guido Kroemer France 386k citations
  2. 2 John Q. Trojanowski United States 286k citations
  3. 3 Frank B. Hu United States 281k citations
  4. 4 Mark I. McCarthy United Kingdom 267k citations
  5. 5 Amirhossein Sahebkar Iran 258k citations
  6. 6 Kaj Blennow Sweden 247k citations
  7. 7 Dennis W. Dickson United States 237k citations

Ranked by citations received across their whole record, among researchers with at least three works on this topic.

What are the most cited papers in Calpain Protease Function and Regulation?

The most cited paper in Calpain Protease Function and Regulation is "Artemisinin Resistance in Plasmodium falciparum Malaria" (Arjen M. Dondorp et al., 2009), with 3,505 citations. Next come "Apoptosis, oncosis, and necrosis. An overview of cell death." (3,335) and "Ischemic Cell Death in Brain Neurons" (3,056).

Most cited papers
#PaperReleasedCitations
1 Artemisinin Resistance in Plasmodium falciparum Malaria Arjen M. Dondorp et al. · New England Journal of Medicine Open access 29 Jul 2009 3,505
2 Apoptosis, oncosis, and necrosis. An overview of cell death. Guido Majno, I Joris · PubMed Open access 1995 3,335
3 Ischemic Cell Death in Brain Neurons Peter Lipton · Physiological Reviews Review 10 Jan 1999 3,056
4 Regulation of cell death: the calcium–apoptosis link Sten Orrenius, Boris Zhivotovsky, Pierluigi Nicotera · Nature Reviews Molecular Cell Biology Review Jul 2003 3,018
5 The Calpain System Darrel E. Goll, Valery F. Thompson, Hongqi Li et al. · Physiological Reviews Review Jul 2003 2,837
All 100 most cited papers, with filters and sorting

Where is Calpain Protease Function and Regulation research done?

The largest centres of Calpain Protease Function and Regulation research in 2022-now are Beijing (China), Guangzhou (China), Shanghai (China) and Tokyo (Japan).

Largest cities, 2022-now

  1. 1 BeijingChina 20 works
  2. 2 GuangzhouChina 14 works
  3. 3 ShanghaiChina 13 works
  4. 4 TokyoJapan 9 works
  5. 5 NanjingChina 7 works
  6. 6 WuhanChina 7 works
  7. 7 Xi'anChina 7 works
  8. 8 HangzhouChina 6 works
  9. 9 ChongqingChina 6 works
  10. 10 ParisFrance 6 works
See Calpain Protease Function and Regulation on the map

Is Calpain Protease Function and Regulation research growing?

Output in 2022-2025 was 16% lower than in 2018-2021, peaking in 2012.

still counting19801990200020102020
grewheldshrank

The same series as a ribbon: one cell per year, darker for more. The line above answers how much; this answers when.

Its share of all research

Growing output can still be a shrinking share: all of science grows. This is Calpain Protease Function and Regulation as a percentage of every work published that year, 0.0029% in 2024.

still counting0.0050%0.010%0.015%Calpain Protease Function and Regulation0.0028% in 202519801990200020102020

Fractional works of Calpain Protease Function and Regulation over all fractional works that year. How the balance of science has shifted.

How much of it reaches the world top 10%

Year by year.

still counting5%10%15%Calpain Protease Function and Regulation11.0% in 2025200020102020

Of each year's works in it, the share that reached the world's 10% most cited for their field and year. A field is the world for its own topics, so there is no other line to hold it against.

Which topics inside it are moving

Growth and decline on one axis around a shared zero. Two lists side by side hide the thing that matters: whether the growth dwarfs the decline, or the other way round.

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