Most cited papers in Blood Coagulation and Thrombosis Mechanisms
What are the most cited papers in Blood Coagulation and Thrombosis Mechanisms?
The most cited paper in Blood Coagulation and Thrombosis Mechanisms is "Tissue Plasminogen Activator for Acute Ischemic Stroke" (The National Institute of Neurological Disorders and Stroke rt-PA Stroke Study G, 1995), with 11,752 citations. Next come "Acute Kidney Injury Network: report of an initiative to improve outcomes in acute kidney injury" (7,137) and "Efficacy and Safety of Recombinant Human Activated Protein C for Severe Sepsis" (6,170).
Showing 50 of 100 papers. Every paper with more than 1,141 citations is listed.
| # | Paper | ||
|---|---|---|---|
| 1 | Tissue Plasminogen Activator for Acute Ischemic Stroke The National Institute of Neurological Disorders and Stroke rt-PA Stroke Study G · New England Journal of Medicine | 14 Dec 1995 | 11,752 |
| 2 | Acute Kidney Injury Network: report of an initiative to improve outcomes in acute kidney injury Ravindra L. Mehta, John A. Kellum, Sudhir V. Shah et al. · Critical Care | Mar 2007 | 7,137 |
| 3 | Efficacy and Safety of Recombinant Human Activated Protein C for Severe Sepsis Gordon R. Bernard, Jean‐Louis Vincent, Pierre‐François Laterre et al. · New England Journal of Medicine | 8 Mar 2001 | 6,170 |
| 4 | Matrix Metalloproteinases: Regulators of the Tumor Microenvironment Kai Kessenbrock, Vicki Plaks, Zena Werb · Cell | Apr 2010 | 5,146 |
| 5 | How Matrix Metalloproteinases Regulate Cell Behavior Mark D. Sternlicht, Zena Werb · Annual Review of Cell and Developmental Biology | Nov 2001 | 3,957 |
| 6 | Matrix Metalloproteinases Hideaki Nagase, J. Frederick Woessner · Journal of Biological Chemistry | Jul 1999 | 3,917 |
| 7 | Mutation in blood coagulation factor V associated with resistance to activated protein C Rogier M. Bertina, Bobby P. C. Koeleman, Ted Koster et al. · Nature | May 1994 | 3,854 |
| 8 | Prevention of Venous Thromboembolism William H Geerts, David Bergqvist, Graham F. Pineo et al. · CHEST Journal | Jun 2008 | 3,836 |
| 9 | A common genetic variation in the 3'-untranslated region of the prothrombin gene is associated with elevated plasma prothrombin levels and an increase in venous thrombosis SR Poort, FR Rosendaal, PH Reitsma et al. · Blood | 15 Nov 1996 | 3,128 |
| 10 | Intra-arterial Prourokinase for Acute Ischemic Stroke Anthony J. Furlan, Randall T. Higashida, Lawrence R. Wechsler et al. · JAMA | Dec 1999 | 3,083 |
| 11 | Matrix metalloproteinases and the regulation of tissue remodelling Andrea Page-McCaw, Andrew J. Ewald, Zena Werb · Nature Reviews Molecular Cell Biology | 23 Feb 2007 | 3,033 |
| 12 | Trends in the Incidence of Deep Vein Thrombosis and Pulmonary Embolism Marc D. Silverstein, John A. Heit, David N. Mohr et al. · Archives of Internal Medicine | 23 Mar 1998 | 2,678 |
| 13 | Dabigatran versus Warfarin in the Treatment of Acute Venous Thromboembolism Sam Schulman, Clive Kearon, Ajay K. Kakkar et al. · New England Journal of Medicine | 6 Dec 2009 | 2,584 |
| 14 | Increased expression of matrix metalloproteinases and matrix degrading activity in vulnerable regions of human atherosclerotic plaques. Zorina S. Galis, Galina K. Sukhova, Michael W. Lark et al. · Journal of Clinical Investigation | Dec 1994 | 2,547 |
| 15 | Low-Molecular-Weight Heparin versus a Coumarin for the Prevention of Recurrent Venous Thromboembolism in Patients with Cancer Agnes Y. Y. Lee, Mark N. Levine, Ross Ian Baker et al. · New England Journal of Medicine | 9 Jul 2003 | 2,541 |
| 16 | Thrombin signalling and protease-activated receptors Shaun R. Coughlin · Nature | Sep 2000 | 2,497 |
| 17 | Guidelines for the Early Management of Adults With Ischemic Stroke Harold P. Adams, Gregory del Zoppo, Mark J. Alberts et al. · Stroke | 12 Apr 2007 | 2,479 |
| 18 | Oral Apixaban for the Treatment of Acute Venous Thromboembolism Giancarlo Agnelli, Harry Roger Buller, Alexander T. Cohen et al. · New England Journal of Medicine | Jul 2013 | 2,328 |
| 19 | Endothelial cells in physiology and in the pathophysiology of vascular disorders. Douglas B. Cines, Eleanor S. Pollak, Clayton A. Buck et al. · PubMed | 15 May 1998 | 2,267 |
| 20 | Development and validation of a predictive model for chemotherapy-associated thrombosis Alok A. Khorana, Nicole M. Kuderer, Eva Culakova et al. · Blood | 23 Jan 2008 | 2,245 |
| 21 | Guidelines on the Use of Therapeutic Apheresis in Clinical Practice – Evidence‐Based Approach from the Writing Committee of the American Society for Apheresis: The Eighth Special Issue Anand Padmanabhan, Laura S. Connelly‐Smith, Nicole A. Aqui et al. · Journal of Clinical Apheresis | Jun 2019 | 2,235 |
| 22 | The Long-Term Clinical Course of Acute Deep Venous Thrombosis Paolo Prandoni, Anthonie W.A. Lensing, Alberto Cogo et al. · Annals of Internal Medicine | Jul 1996 | 2,119 |
| 23 | Vascular Permeability Factor, an Endothelial Cell Mitogen Related to PDGF Pamela J. Keck, Scott D. Hauser, Gwen G. Krivi et al. · Science | 8 Dec 1989 | 2,077 |
| 24 | Annexins: From Structure to Function Volker Gerke, Stephen E. Moss · Physiological Reviews | Apr 2002 | 2,056 |
| 25 | Antithrombotic Therapy for Venous Thromboembolic Disease Thomas M. Hyers, Giancarlo Agnelli, Russell Douglas Hull et al. · CHEST Journal | 2001 | 2,051 |
| 26 | WFH Guidelines for the Management of Hemophilia, 3rd edition Alok Srivastava, Elena Santagostino, Alison Dougall et al. · Haemophilia | Aug 2020 | 2,029 |
| 27 | Disseminated Intravascular Coagulation Marcel M Levi, Hugo Ten Cate · New England Journal of Medicine | 19 Aug 1999 | 2,005 |
| 28 | Familial thrombophilia due to a previously unrecognized mechanism characterized by poor anticoagulant response to activated protein C: prediction of a cofactor to activated protein C. Björn Dahlbäck, Martin Carlsson, Peter J. Svensson · Proceedings of the National Academy of Sciences | Feb 1993 | 1,990 |
| 29 | Thrombosis as an intravascular effector of innate immunity Bernd Engelmann, Steffen Maßberg · Nature reviews. Immunology | 7 Dec 2012 | 1,969 |
| 30 | Malignancies, Prothrombotic Mutations, and the Risk of Venous Thrombosis Jeanet W. Blom · JAMA | 8 Feb 2005 | 1,966 |
| 31 | Mechanisms of Thrombus Formation Bruce Furie, Barbara C. Furie · New England Journal of Medicine | 27 Aug 2008 | 1,925 |
| 32 | Tissue inhibitors of metalloproteinases: evolution, structure and function Keith Brew, Deendayal Dinakarpandian, Hideaki Nagase · Biochimica et Biophysica Acta (BBA) - Protein Structure and Molecular Enzymology | Mar 2000 | 1,910 |
| 33 | Rivaroxaban in Patients with a Recent Acute Coronary Syndrome Jessica L. Mega, Eugene Braunwald, Stephen D. Wiviott et al. · New England Journal of Medicine | 13 Nov 2011 | 1,902 |
| 34 | Preeclampsia: An endothelial cell disorder James M. Roberts, Robert N. Taylor, Thomas J. Musci et al. · American Journal of Obstetrics and Gynecology | Nov 1989 | 1,873 |
| 35 | Bivalirudin during Primary PCI in Acute Myocardial Infarction Gregg W. Stone, Bernhard Witzenbichler, Giulio Guagliumi et al. · New England Journal of Medicine | 21 May 2008 | 1,869 |
| 36 | Preeclampsia: An excessive maternal inflammatory response to pregnancy Christopher W.G. Redman, Gavin P. Sacks, Ian L. Sargent · American Journal of Obstetrics and Gynecology | Feb 1999 | 1,858 |
| 37 | Serine Protease Mechanism and Specificity Lizbeth Hedstrom · Chemical Reviews | 23 Nov 2002 | 1,841 |
| 38 | Monocytes, neutrophils, and platelets cooperate to initiate and propagate venous thrombosis in mice in vivo Marie-Luise von Brühl et al. · The Journal of Experimental Medicine | 26 Mar 2012 | 1,840 |
| 39 | The coagulation cascade: initiation, maintenance, and regulation Earl W. Davie, Kazuo Fujikawa, Walter Kisiel · Biochemistry | Oct 1991 | 1,823 |
| 40 | Endovascular Therapy after Intravenous t-PA versus t-PA Alone for Stroke Joseph P. Broderick et al. · New England Journal of Medicine | 7 Feb 2013 | 1,819 |
| 41 | Matrix metalloproteinases in vascular remodeling and atherogenesis: the good, the bad, and the ugly. Zorina S. Galis, Jaikirshan J. Khatri · PubMed | 22 Feb 2002 | 1,792 |
| 42 | Platelets and the immune continuum John W. Semple, Joseph E. Italiano, John J Freedman · Nature reviews. Immunology | 25 Mar 2011 | 1,710 |
| 43 | Risk Factors for Venous Thromboembolism Frederick A. Anderson, Frederick Alan Spencer · Circulation | 17 Jun 2003 | 1,665 |
| 44 | Anti-phospholipid antibodies are directed against a complex antigen that includes a lipid-binding inhibitor of coagulation: beta 2-glycoprotein I (apolipoprotein H). H. Patrick McNeil, Richard J. Simpson, C.N. Chesterman et al. · Proceedings of the National Academy of Sciences | Jun 1990 | 1,617 |
| 45 | Mechanism Of Cell Surface Activation Of 72-kDa Type IV Collagenase Alex Y. Strongin, Ivan E. Collier, Gregory A. Bannikov et al. · Journal of Biological Chemistry | Mar 1995 | 1,597 |
| 46 | Thrombosis of the Cerebral Veins and Sinuses Jan Stam · New England Journal of Medicine | 27 Apr 2005 | 1,593 |
| 47 | Platelets in atherothrombosis Zaverio M. Ruggeri · Nature Medicine | Nov 2002 | 1,593 |
| 48 | Venous thrombosis: a multicausal disease FR Rosendaal · The Lancet | Apr 1999 | 1,583 |
| 49 | Evaluation of D-Dimer in the Diagnosis of Suspected Deep-Vein Thrombosis Philip Stephen Wells, David R. Anderson, Marc Alan Rodger et al. · New England Journal of Medicine | 24 Sep 2003 | 1,572 |
| 50 | The urokinase-type plasminogen activator system in cancer metastasis: A review Peter A. Andreasen, Lars Kjøller, Lise Christensen et al. · International Journal of Cancer | 3 Jul 1997 | 1,560 |
Citations are OpenAlex's own counts, from its 2026-09-23 snapshot, so the ranking can differ from Google Scholar or Web of Science. A paper is listed for a field when OpenAlex files it under one of the field's topics; retracted papers and papers whose citation count cannot be traced to citing works are left out, and a preprint and the article it became are shown once. Release dates are OpenAlex's: where a source gave only a month or a year, that is what is shown. How the lists are chosen.