Topic · Bone Metabolism and Diseases
Most cited papers in Bone Metabolism and Diseases
What are the most cited papers in Bone Metabolism and Diseases?
The most cited paper in Bone Metabolism and Diseases is "Mutation of the mouse klotho gene leads to a syndrome resembling ageing." (M Kuro-o, Y Matsumura, H Aizawa et al., 1997), with 66,570 citations. Next come "Osteoclast differentiation and activation" (6,707) and "Bone: Formation by Autoinduction" (5,578).
Showing 50 of 100 papers. Every paper with more than 1,303 citations is listed.
| # | Paper | ||
|---|---|---|---|
| 1 | Mutation of the mouse klotho gene leads to a syndrome resembling ageing. M Kuro-o, Y Matsumura, H Aizawa et al. · PubMed | 6 Nov 1997 | 66,570 |
| 2 | Osteoclast differentiation and activation William J. Boyle, W. Scott Simonet, David L. Lacey · Nature | May 2003 | 6,707 |
| 3 | Bone: Formation by Autoinduction Marshall R. Urist · Science | 12 Nov 1965 | 5,578 |
| 4 | Osteoporosis Prevention, Diagnosis, and Therapy NIH Consensus Development Panel on Osteoporosis Prevention, Diagnosis, and Thera · JAMA | 14 Feb 2001 | 5,549 |
| 5 | Osteoprotegerin Ligand Is a Cytokine that Regulates Osteoclast Differentiation and Activation David L. Lacey et al. · Cell | Apr 1998 | 5,491 |
| 6 | Smad-dependent and Smad-independent pathways in TGF-β family signalling Rik Derynck, Ying E. Zhang · Nature | 8 Oct 2003 | 5,416 |
| 7 | Osteoprotegerin: A Novel Secreted Protein Involved in the Regulation of Bone Density W. Scott Simonet et al. · Cell | Apr 1997 | 5,161 |
| 8 | Guidelines for assessment of bone microstructure in rodents using micro–computed tomography Mary Bouxsein, Steven K. Boyd, Bernd Christiansen et al. · Journal of Bone and Mineral Research | 7 Jun 2010 | 4,569 |
| 9 | Osteoclast differentiation factor is a ligand for osteoprotegerin/osteoclastogenesis-inhibitory factor and is identical to TRANCE/RANKL Hisataka Yasuda, Nobuyuki Shima, Nobuaki NAKAGAWA et al. · Proceedings of the National Academy of Sciences | 31 Mar 1998 | 4,281 |
| 10 | Osf2/Cbfa1: A Transcriptional Activator of Osteoblast Differentiation Patricia F. Ducy, Rui Zhang, Valérie A. Geoffroy et al. · Cell | May 1997 | 4,278 |
| 11 | Targeted Disruption of Results in a Complete Lack of Bone Formation owing to Maturational Arrest of Osteoblasts Toshihisa Komori, Hideshi Yagi, Shogo Nomura et al. · Cell | May 1997 | 4,270 |
| 12 | Bone Resorption by Osteoclasts Steven L. Teitelbaum · Science | Sep 2000 | 4,011 |
| 13 | Novel Regulators of Bone Formation: Molecular Clones and Activities John M. Wozney, Vicki Rosen, Anthony J. Celeste et al. · Science | 16 Dec 1988 | 3,927 |
| 14 | The diagnosis of osteoporosis John A. Professor Kanis, L. Joseph Melton, Claus Christiansen et al. · Journal of Bone and Mineral Research | Aug 1994 | 3,904 |
| 15 | The Novel Zinc Finger-Containing Transcription Factor Osterix Is Required for Osteoblast Differentiation and Bone Formation Kazuhisa Nakashima, Xin Zhou, Gary R. Kunkel et al. · Cell | 2002 | 3,643 |
| 16 | Denosumab for Prevention of Fractures in Postmenopausal Women with Osteoporosis Steven Ron Cummings, Javier San Martín, Michael R. McClung et al. · New England Journal of Medicine | 11 Aug 2009 | 3,503 |
| 17 | OPGL is a key regulator of osteoclastogenesis, lymphocyte development and lymph-node organogenesis Young‐Yun Kong, Hiroki Yoshida, Ildiko Sarosi et al. · Nature | 1999 | 3,385 |
| 18 | Reduction of Vertebral Fracture Risk in Postmenopausal Women With Osteoporosis Treated With Raloxifene Results From a 3-Year Randomized Clinical Trial Bruce B. Ettinger · JAMA | 18 Aug 1999 | 3,382 |
| 19 | Once-Yearly Zoledronic Acid for Treatment of Postmenopausal Osteoporosis Dennis M. Black et al. · New England Journal of Medicine | 3 May 2007 | 2,988 |
| 20 | European guidance for the diagnosis and management of osteoporosis in postmenopausal women John A. Kanis, E. V. McCloskey, Håkan Johansson et al. · Osteoporosis International | 18 Oct 2012 | 2,954 |
| 21 | Developmental regulation of the growth plate Henry M. Kronenberg · Nature | May 2003 | 2,889 |
| 22 | Cbfa1, a Candidate Gene for Cleidocranial Dysplasia Syndrome, Is Essential for Osteoblast Differentiation and Bone Development Florian Otto, Anders Thornell, Tessa Crompton et al. · Cell | May 1997 | 2,834 |
| 23 | Mechanisms of Bone Metastasis Garson David Roodman · New England Journal of Medicine | 14 Apr 2004 | 2,764 |
| 24 | Osteoporosis: now and the future Tilman D. Rachner, Sundeep Khosla, Lorenz Christian Hofbauer · The Lancet | 30 Mar 2011 | 2,713 |
| 25 | Induction and Activation of the Transcription Factor NFATc1 (NFAT2) Integrate RANKL Signaling in Terminal Differentiation of Osteoclasts Hiroshi Takayanagi, Sunhwa Kim, Takako Koga et al. · Developmental Cell | Dec 2002 | 2,708 |
| 26 | A multigenic program mediating breast cancer metastasis to bone Yibin Kang, Peter M. Siegel, Weiping Shu et al. · Cancer Cell | Jun 2003 | 2,627 |
| 27 | Assessment of fracture risk and its application to screening for postmenopausal osteoporosis: Synopsis of a WHO report John А. Kanis, John А. Kanis · Osteoporosis International | Nov 1994 | 2,553 |
| 28 | osteoprotegerin-deficient mice develop early onset osteoporosis and arterial calcification Nathan Bucay, Ildiko Sarosi, Colin Robert Dunstan et al. · Genes & Development | May 1998 | 2,498 |
| 29 | FRAX™ and the assessment of fracture probability in men and women from the UK John А. Kanis, Olof Johnell, A. Oden et al. · Osteoporosis International | 21 Feb 2008 | 2,471 |
| 30 | Osteoporosis Juliet Elizabeth Compston, Michael R. McClung, William Donald Leslie · The Lancet | 2019 | 2,398 |
| 31 | An overview and management of osteoporosis Tümay Sözen, Lale Özışık, Nursel Çalık Başaran · European Journal of Rheumatology | 7 Dec 2016 | 2,298 |
| 32 | The amazing osteocyte Lynda Faye Bonewald · Journal of Bone and Mineral Research | 16 Dec 2010 | 2,285 |
| 33 | Modulation of Osteoclast Differentiation and Function by the New Members of the Tumor Necrosis Factor Receptor and Ligand Families Tatsuo Suda, Naoyuki Takahashi, Nobuyuki Udagawa et al. · Endocrine Reviews | Jun 1999 | 2,275 |
| 34 | Birth and Death of Bone Cells: Basic Regulatory Mechanisms and Implications for the Pathogenesis and Treatment of Osteoporosis* Stavros C. Manolagas · Endocrine Reviews | Apr 2000 | 2,238 |
| 35 | Normal Bone Anatomy and Physiology Bart Lyman Clarke · Clinical Journal of the American Society of Nephrology | Nov 2008 | 2,167 |
| 36 | Bone “mass” and the “mechanostat”: A proposal Harold M. Frost · The Anatomical Record | Sep 1987 | 2,125 |
| 37 | Bone Quality — The Material and Structural Basis of Bone Strength and Fragility Ego Seeman, Pierre Dominique Delmas · New England Journal of Medicine | 24 May 2006 | 2,086 |
| 38 | Blastocyst implantation depends on maternal expression of leukaemia inhibitory factor Colin L. Stewart, Petr Kašpar, Lisa J. Brunet et al. · Nature | Sep 1992 | 2,050 |
| 39 | Biology of Bone Tissue: Structure, Function, and Factors That Influence Bone Cells Rinaldo Florencio‐Silva, Gisela Rodrigues da Silva Sasso, Estela Sasso‐Cerri et al. · BioMed Research International | 2015 | 2,040 |
| 40 | Targeted disruption of the c-src proto-oncogene leads to osteopetrosis in mice Philippe M. Soriano, Charles A. Montgomery, Robert S. Geske et al. · Cell | Feb 1991 | 2,036 |
| 41 | Bone morphogenetic proteins: multifunctional regulators of vertebrate development. B L Hogan · Genes & Development | Jul 1996 | 1,995 |
| 42 | The TGF-beta superfamily: new members, new receptors, and new genetic tests of function in different organisms. David M. Kingsley · Genes & Development | 1994 | 1,941 |
| 43 | European guidance for the diagnosis and management of osteoporosis in postmenopausal women John А. Kanis, Cyrus Cooper, René Rizzoli et al. · Osteoporosis International | 15 Oct 2018 | 1,898 |
| 44 | SPECIFICITY AND VERSATILITY IN TGF-β SIGNALING THROUGH SMADS Xin‐Hua Feng, Rik Derynck · Annual Review of Cell and Developmental Biology | Jul 2005 | 1,881 |
| 45 | Osteoimmunology: shared mechanisms and crosstalk between the immune and bone systems Hiroshi Takayanagi · Nature reviews. Immunology | 23 Mar 2007 | 1,880 |
| 46 | Activated T cells regulate bone loss and joint destruction in adjuvant arthritis through osteoprotegerin ligand Young‐Yun Kong et al. · Nature | Nov 1999 | 1,873 |
| 47 | Functions of RANKL/RANK/OPG in bone modeling and remodeling Brendan F. Boyce, Lianping Xing · Archives of Biochemistry and Biophysics | 26 Mar 2008 | 1,847 |
| 48 | The biology of fracture healing Richard Marsell, Thomas A. Einhorn · Injury | 18 Apr 2011 | 1,818 |
| 49 | The murine mutation osteopetrosis is in the coding region of the macrophage colony stimulating factor gene Hisahiro Yoshida, Shinichi Hayashi, Takahiro Kunisada et al. · Nature | May 1990 | 1,803 |
| 50 | A syndrome of altered cardiovascular, craniofacial, neurocognitive and skeletal development caused by mutations in TGFBR1 or TGFBR2 Bart Loeys et al. · Nature Genetics | 30 Jan 2005 | 1,798 |
Citations are OpenAlex's own counts, from its 2026-09-23 snapshot, so the ranking can differ from Google Scholar or Web of Science. A paper is listed for a field when OpenAlex files it under one of the field's topics; retracted papers and papers whose citation count cannot be traced to citing works are left out, and a preprint and the article it became are shown once. Release dates are OpenAlex's: where a source gave only a month or a year, that is what is shown. How the lists are chosen.