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Topic · Molecular Biology

Bone Metabolism and Diseases

Bone Metabolism and Diseases is a research topic within Molecular Biology. Science Explorer counts 29k research works in it since 1950. 9.9% of them reached the world's top 10% most cited for their field and year.

This cluster of papers explores the molecular mechanisms underlying osteoclast differentiation, bone resorption, and the regulation of bone homeostasis. It delves into the signaling pathways, transcription factors, and cytokines involved in osteoclast and osteoblast differentiation, as well as the interplay between the immune system and bone metabolism. Additionally, it investigates the impact of oxidative stress and inflammatory cytokines on bone remodeling.

  • Osteoclast Differentiation
  • Bone Resorption
  • RANKL Signaling
  • Osteoblast Differentiation
  • Bone Formation
  • Regulation of Bone Homeostasis
  • Osteoprotegerin
  • Tumor Necrosis Factor-a
  • Oxidative Stress
  • Immune System Interactions
Research works
29k
fractional, since 1950
In the world top 10%
2.8k
per year above
Top-10% rate
9.9%
share of its works in the world top 10%
Growth, 2018-21 → 2022-25
0%
the tick is no change
Largest producer
China
59% of the 10 largest, 2022-now
Bone Metabolism and Diseases

Which countries lead Bone Metabolism and Diseases research?

By volume, China and the United States publish the most (2.3k and 516 works in 2022-now).

By volume, 2022-now

  1. 1 China 2.3k works
  2. 2 United States 516 works
  3. 3 Japan 259 works
  4. 4 India 203 works
  5. 5 South Korea 191 works
  6. 6 Germany 133 works
  7. 7 United Kingdom 105 works
  8. 8 Italy 102 works
  9. 9 Brazil 79 works
  10. 10 Iran 67 works

How concentrated that is

The same countries as shares of everything the list above accounts for. A node where two countries do two thirds of the work and one spread evenly across twelve read alike as a ranking and not at all alike here.

China: 58.7%United States: 12.9%Japan: 6.5%India: 5.1%6 others listed: 16.9%59%largest
China2,350 · 58.7%United States516 · 12.9%Japan259 · 6.5%India203 · 5.1%6 others listed676 · 16.9%

Shares of the rows listed above, not of the whole node.

Which institutions lead Bone Metabolism and Diseases research?

By volume in 2022-now, Shanghai Jiao Tong University publishes the most Bone Metabolism and Diseases research, followed by Sichuan University and Guangzhou University of Chinese Medicine.

By volume, 2022-now

  1. 1 Shanghai Jiao Tong UniversityChina 70 works
  2. 2 Sichuan UniversityChina 54 works
  3. 3 Guangzhou University of Chinese MedicineChina 43 works
  4. 4 Zhejiang UniversityChina 43 works
  5. 5 Soochow UniversityChina 39 works
  6. 6 Stomatology HospitalChina 37 works
  7. 7 Southern Medical UniversityChina 37 works
  8. 8 Sun Yat-sen UniversityChina 36 works
  9. 9 Nanjing Medical UniversityChina 36 works
  10. 10 Central South UniversityChina 34 works

Who are the leading researchers in Bone Metabolism and Diseases?

The most-cited researchers publishing on Bone Metabolism and Diseases include George Davey Smith, Shizuo Akira and Cyrus Cooper.

  1. 1 George Davey Smith United Kingdom 435k citations
  2. 2 Shizuo Akira Japan 342k citations
  3. 3 Cyrus Cooper United Kingdom 342k citations
  4. 4 Emelia J. Benjamin United States 341k citations
  5. 5 Jun Wang China 340k citations
  6. 6 John P. A. Ioannidis United States 317k citations
  7. 7 Gordon Henry Guyatt Canada 315k citations
  8. 8 Luigi Ferrucci United States 281k citations
  9. 9 Michael Karin United States 276k citations
  10. 10 Yousef Saleh Khader Jordan 274k citations

Ranked by citations received across their whole record, among researchers with at least three works on this topic.

What are the most cited papers in Bone Metabolism and Diseases?

The most cited paper in Bone Metabolism and Diseases is "Mutation of the mouse klotho gene leads to a syndrome resembling ageing." (M Kuro-o, Y Matsumura, H Aizawa et al., 1997), with 66,570 citations. Next come "Osteoclast differentiation and activation" (6,707) and "Bone: Formation by Autoinduction" (5,578).

Most cited papers
#PaperReleasedCitations
1 Mutation of the mouse klotho gene leads to a syndrome resembling ageing. M Kuro-o, Y Matsumura, H Aizawa et al. · PubMed 6 Nov 1997 66,570
2 Osteoclast differentiation and activation William J. Boyle, W. Scott Simonet, David L. Lacey · Nature May 2003 6,707
3 Bone: Formation by Autoinduction Marshall R. Urist · Science 12 Nov 1965 5,578
4 Osteoporosis Prevention, Diagnosis, and Therapy NIH Consensus Development Panel on Osteoporosis Prevention, Diagnosis, and Thera · JAMA 14 Feb 2001 5,549
5 Osteoprotegerin Ligand Is a Cytokine that Regulates Osteoclast Differentiation and Activation David L. Lacey et al. · Cell Open access Apr 1998 5,491
All 100 most cited papers, with filters and sorting

Where is Bone Metabolism and Diseases research done?

The largest centres of Bone Metabolism and Diseases research in 2022-now are Shanghai (China), Beijing (China), Guangzhou (China) and Xi'an (China). Among places with at least 20 works in it, it is an unusually large share of all research in Luzhou and Wenzhou.

Largest cities, 2022-now

  1. 1 ShanghaiChina 201 works
  2. 2 BeijingChina 190 works
  3. 3 GuangzhouChina 178 works
  4. 4 Xi'anChina 111 works
  5. 5 HangzhouChina 101 works
  6. 6 WuhanChina 85 works
  7. 7 NanjingChina 82 works
  8. 8 JinanChina 76 works
  9. 9 ChengduChina 71 works
  10. 10 SeoulSouth Korea 68 works

Where it is the local speciality

  1. LuzhouCN · 20.2 works16×
  2. WenzhouCN · 36.4 works8.4×
← less than its size predicts1×more →

Location quotient: how much more of its research is in Bone Metabolism and Diseases than the world average.

See Bone Metabolism and Diseases on the map

Where is the best place to study Bone Metabolism and Diseases?

Among universities, judged by research, Shanghai Jiao Tong University, Sichuan University and Wenzhou Medical University score highest, combining excellence, specialisation, size, growth and international reach. Research strength is one signal when choosing where to study; it does not measure teaching.

0%10%20%mean 16.94%fractional works in this field (log) →share of work in the world top 10% →Wenzhou Medical Univ…Sichuan UniversityShanghai Jiao Tong U…Zhejiang University
above the meannear itbelow it

One dot per university in the first ten of the table below, at the default weights. The upper left is the interesting corner: small places doing unusually strong work.

Excellenceshare of its work in the world top 10%, 2022-now and all time averaged
40%
Specialisationhow much of its work is in this field, counted up to 10× the world share
10%
Sizeits output in this field, on a log scale
30%
Growthoutput growth, counted from -20% to +20%
10%
Internationalshare of its work with a co-author abroad
10%
Each slider sets a weight; the share it gets of the score is beside it.
#UniversityScoreTop 10%SpecialisationWorksGrowth
1Shanghai Jiao Tong UniversityChina 72.017.3%5.6×70 -6.5%
2Sichuan UniversityChina 71.217.5%5.5×54 +10.9%
3Wenzhou Medical UniversityChina 69.517.7%14.6×32 +55.5%
4Zhejiang UniversityChina 68.215.4%3.7×43 +21.4%
5Huazhong University of Science and TechnologyChina 67.623.5%3.5×28 +22.0%
6Central South UniversityChina 65.920.2%4.1×34 -0.1%
7Guangzhou University of Chinese MedicineChina 65.812.4%41.4×43 +34.5%
8Soochow UniversityChina 64.815.5%9.2×39 +4.2%
9Wuhan UniversityChina 64.216.6%4.7×29 +41.8%
10Southern Medical UniversityChina 61.713.3%13.8×37 +9.9%

Universities only. The score blends excellence (40%), size (30%), specialisation (10%), growth (10%), international reach (10%), 2022-now; growth compares 2018-21 with 2022-25 and counts up to +20%, since a jump from a small base is mostly noise.

Every institution in Bone Metabolism and Diseases, country by country

Is Bone Metabolism and Diseases research growing?

Output in 2022-2025 was 0% lower than in 2018-2021, peaking in 2025.

still counting19801990200020102020
grewheldshrank

The same series as a ribbon: one cell per year, darker for more. The line above answers how much; this answers when.

Its share of all research

Growing output can still be a shrinking share: all of science grows. This is Bone Metabolism and Diseases as a percentage of every work published that year, 0.018% in 2024.

still counting0.020%0.040%Bone Metabolism and Diseases0.021% in 202519801990200020102020

Fractional works of Bone Metabolism and Diseases over all fractional works that year. How the balance of science has shifted.

How much of it reaches the world top 10%

Year by year.

still counting5%10%15%Bone Metabolism and Diseases9.8% in 2025200020102020

Of each year's works in it, the share that reached the world's 10% most cited for their field and year. A field is the world for its own topics, so there is no other line to hold it against.

Which topics inside it are moving

Growth and decline on one axis around a shared zero. Two lists side by side hide the thing that matters: whether the growth dwarfs the decline, or the other way round.

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