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Most cited papers in Brain Metastases and Treatment

What are the most cited papers in Brain Metastases and Treatment?

The most cited paper in Brain Metastases and Treatment is "Radiotherapy Plus Concomitant and Adjuvant Temozolomide for Glioblastoma" (Roger Stupp, Warren P. Mason, Martin J. van den Bent et al., 2005), with 22,109 citations. Next come "The 2016 World Health Organization Classification of Tumors of the Central Nervous System: a summary" (16,152) and "The 2021 WHO Classification of Tumors of the Central Nervous System: a summary" (12,579).

Showing 50 of 100 papers. Every paper with more than 991 citations is listed.

Most cited papers, sortable by citations and release date
#Paper
1 Radiotherapy Plus Concomitant and Adjuvant Temozolomide for Glioblastoma Roger Stupp, Warren P. Mason, Martin J. van den Bent et al. · New England Journal of Medicine Open access 9 Mar 2005 22,109
2 The 2016 World Health Organization Classification of Tumors of the Central Nervous System: a summary David N. Louis, Arie Perry, Guido Reifenberger et al. · Acta Neuropathologica Open access 7 May 2016 16,152
3 The 2021 WHO Classification of Tumors of the Central Nervous System: a summary David N. Louis, Arie Perry, Pieter Wesseling et al. · Neuro-Oncology Open access 3 May 2021 12,579
4 Effects of radiotherapy with concomitant and adjuvant temozolomide versus radiotherapy alone on survival in glioblastoma in a randomised phase III study: 5-year analysis of the EORTC-NCIC trial Roger Stupp et al. · The Lancet Oncology 10 Mar 2009 7,889
5 MGMT Gene Silencing and Benefit from Temozolomide in Glioblastoma Monika E. Hegi, Annie‐Claire Diserens, Thierry Gorlia et al. · New England Journal of Medicine Open access 9 Mar 2005 7,397
6 Malignant Gliomas in Adults Patrick Yung Wen, Santosh Kesari · New England Journal of Medicine 30 Jul 2008 4,283
7 A Randomized Trial of Surgery in the Treatment of Single Metastases to the Brain Roy A. Patchell, Phillip A. Tibbs, JOHN W. T. WALSH et al. · New England Journal of Medicine Open access 22 Feb 1990 3,166
8 A multivariate analysis of 416 patients with glioblastoma multiforme: prognosis, extent of resection, and survival Michel Lacroix, Dima Abi-Said, Daryl R. Fourney et al. · Journal of neurosurgery Aug 2001 3,118
9 A Randomized Trial of Bevacizumab for Newly Diagnosed Glioblastoma Mark R. Gilbert et al. · New England Journal of Medicine Open access 19 Feb 2014 2,855
10 Effect of Tumor-Treating Fields Plus Maintenance Temozolomide vs Maintenance Temozolomide Alone on Survival in Patients With Glioblastoma Roger Stupp et al. · JAMA Open access 19 Dec 2017 2,699
11 CBTRUS Statistical Report: Primary Brain and Other Central Nervous System Tumors Diagnosed in the United States in 2012–2016 Quinn T. Ostrom, Gino Cioffi, Haley R Gittleman et al. · Neuro-Oncology Open access 23 Aug 2019 2,681
12 CBTRUS Statistical Report: Primary Brain and Other Central Nervous System Tumors Diagnosed in the United States in 2014–2018 Quinn T. Ostrom, Gino Cioffi, Kristin A. Waite et al. · Neuro-Oncology Oct 2021 2,612
13 Recursive partitioning analysis (RPA) of prognostic factors in three radiation therapy oncology group (RTOG) brain metastases trials Laurie E. Gaspar, Charles Scott, Marvin Rotman et al. · International Journal of Radiation Oncology*Biology*Physics Open access Mar 1997 2,570
14 Bevacizumab plus Radiotherapy–Temozolomide for Newly Diagnosed Glioblastoma Olivier Louis Chinot, Wolfgang Wick, Warren P. Mason et al. · New England Journal of Medicine Open access 19 Feb 2014 2,568
15 Neurocognition in patients with brain metastases treated with radiosurgery or radiosurgery plus whole-brain irradiation: a randomised controlled trial Eric Lin Chang, Jeffrey Scott Wefel, Kenneth R. Hess et al. · The Lancet Oncology 3 Oct 2009 2,500
16 Whole brain radiation therapy with or without stereotactic radiosurgery boost for patients with one to three brain metastases: phase III results of the RTOG 9508 randomised trial David William Andrews, Charles Scott, Paul W. Sperduto et al. · The Lancet May 2004 2,435
17 Glioblastoma and Other Malignant Gliomas Antonio M. P. Omuro · JAMA 5 Nov 2013 2,348
18 CBTRUS Statistical Report: Primary Brain and Other Central Nervous System Tumors Diagnosed in the United States in 2011–2015 Quinn T. Ostrom, Haley R Gittleman, Gabrielle Truitt et al. · Neuro-Oncology Open access 10 Sep 2018 2,249
19 Chemoradiotherapy versus radiotherapy in patients with advanced nasopharyngeal cancer: phase III randomized Intergroup study 0099. Muhyi Al‐Sarraf, Michael Leo LeBlanc, Padmini Giri et al. · Journal of Clinical Oncology Apr 1998 2,245
20 Stereotactic Radiosurgery Plus Whole-Brain Radiation Therapy vs Stereotactic Radiosurgery Alone for Treatment of Brain Metastases Hidefumi Aoyama, Hiroki Shirato, Masao Tago et al. · JAMA 6 Jun 2006 2,226
21 A Perivascular Niche for Brain Tumor Stem Cells Christopher R. Calabrese, Helen Poppleton, Mehmet Koçak et al. · Cancer Cell Open access 2007 2,214
22 Management of glioblastoma: State of the art and future directions Aaron C. Tan, David M. Ashley, Giselle Yvette Lopez et al. · CA A Cancer Journal for Clinicians Open access Jun 2020 2,080
23 EANO guidelines on the diagnosis and treatment of diffuse gliomas of adulthood Michael Weller et al. · Nature Reviews Clinical Oncology ReviewOpen access 8 Dec 2020 2,063
24 Adjuvant Whole-Brain Radiotherapy Versus Observation After Radiosurgery or Surgical Resection of One to Three Cerebral Metastases: Results of the EORTC 22952-26001 Study Martin Köcher, Riccardo Soffietti, Ufuk Abacıoğlu et al. · Journal of Clinical Oncology Open access 2 Nov 2010 2,017
25 CBTRUS Statistical Report: Primary Brain and Other Central Nervous System Tumors Diagnosed in the United States in 2013–2017 Quinn T. Ostrom, Nirav T. Patil, Gino Cioffi et al. · Neuro-Oncology Open access 17 Aug 2020 2,016
26 Glioma Groups Based on 1p/19q, IDH , and TERT Promoter Mutations in Tumors Jeanette E. Eckel‐Passow et al. · New England Journal of Medicine Open access 11 Jun 2015 2,009
27 The Microenvironmental Landscape of Brain Tumors Daniela F. Quail, Johanna A. Joyce · Cancer Cell Open access Mar 2017 1,956
28 Postoperative radiotherapy in the treatment of single metastases to the brain: a randomized trial. Roy A. Patchell, Phillip A. Tibbs, William F. Regine et al. · PubMed 4 Nov 1998 1,926
29 Genes that mediate breast cancer metastasis to the brain Paula D. Bos, Xiang H.-F. Zhang, Cristina Nadal et al. · Nature Open access 6 May 2009 1,915
30 Incidence Proportions of Brain Metastases in Patients Diagnosed (1973 to 2001) in the Metropolitan Detroit Cancer Surveillance System Jill S. Barnholtz‐Sloan, Andrew Edward Sloan, Faith G. Davis et al. · Journal of Clinical Oncology 14 Jul 2004 1,872
31 Prophylactic Cranial Irradiation for Patients with Small-Cell Lung Cancer in Complete Remission Anne Aupérin, Rodrigo Arriagada, Jean‐Pierre Pignon et al. · New England Journal of Medicine Open access 12 Aug 1999 1,725
32 Effect of Radiosurgery Alone vs Radiosurgery With Whole Brain Radiation Therapy on Cognitive Function in Patients With 1 to 3 Brain Metastases Paul David Brown, Kurt A. Jaeckle, Karla V. Ballman et al. · JAMA Open access 26 Jul 2016 1,689
33 An extent of resection threshold for newly diagnosed glioblastomas Nader Sanai, Mei‐Yin C. Polley, Michael W. McDermott et al. · Journal of neurosurgery 18 Mar 2011 1,678
34 Sacituzumab Govitecan in Metastatic Triple-Negative Breast Cancer Aditya Bardia et al. · New England Journal of Medicine Open access 21 Apr 2021 1,671
35 Brain Tumors Lisa Marie DeAngelis · New England Journal of Medicine 11 Jan 2001 1,664
36 Randomized Comparisons of Radiotherapy and Nitrosoureas for the Treatment of Malignant Glioma after Surgery MICHAEL D. WALKER, Sylvan B. Green, David P. Byar et al. · New England Journal of Medicine 4 Dec 1980 1,629
37 Specific Genetic Predictors of Chemotherapeutic Response and Survival in Patients With Anaplastic Oligodendrogliomas John Gregory Cairncross, Keisuke Ueki, Magdelena C. Zlatescu et al. · JNCI Journal of the National Cancer Institute 7 Oct 1998 1,622
38 Single dose radiosurgical treatment of recurrent previously irradiated primary brain tumors and brain metastases: final report of RTOG protocol 90-05 EDWARD A. SHAW, Charles Scott, Luís Souhami et al. · International Journal of Radiation Oncology*Biology*Physics May 2000 1,616
39 Incidence of brain metastases in a cohort of patients with carcinoma of the breast, colon, kidney, and lung and melanoma Leo J. Schouten, Joost Rutten, Hans A. M. Huveneers et al. · Cancer Open access 14 May 2002 1,604
40 CBTRUS Statistical Report: Primary Brain and Other Central Nervous System Tumors Diagnosed in the United States in 2015–2019 Quinn T. Ostrom, Mackenzie Price, Corey Neff et al. · Neuro-Oncology Open access 5 Oct 2022 1,598
41 Phase II Trial of Single-Agent Bevacizumab Followed by Bevacizumab Plus Irinotecan at Tumor Progression in Recurrent Glioblastoma Teri Nguyen Kreisl, Lyndon Kim, Kraig Moore et al. · Journal of Clinical Oncology Open access 29 Dec 2008 1,583
42 Effect of Nivolumab vs Bevacizumab in Patients With Recurrent Glioblastoma David A. Reardon, Alba Ariela Brandes, Antonio M. P. Omuro et al. · JAMA Oncology Open access 21 May 2020 1,528
43 Stereotactic radiosurgery for patients with multiple brain metastases (JLGK0901): a multi-institutional prospective observational study Masaaki Yamamoto et al. · The Lancet Oncology 10 Mar 2014 1,463
44 Summary Report on the Graded Prognostic Assessment: An Accurate and Facile Diagnosis-Specific Tool to Estimate Survival for Patients With Brain Metastases Paul W. Sperduto et al. · Journal of Clinical Oncology Open access 27 Dec 2011 1,444
45 Primary brain tumours in adults Sarah Lapointe, Arie Perry, Nicholas Arthur Butowski · The Lancet 27 Jul 2018 1,432
46 Placebo-controlled trial of safety and efficacy of intraoperative controlled delivery by biodegradable polymers of chemotherapy for recurrent gliomas Henry Brem, Steven Piantadosi, P. C. Burger et al. · The Lancet Open access Apr 1995 1,399
47 Bevacizumab Plus Irinotecan in Recurrent Glioblastoma Multiforme James J. Vredenburgh, Annick Desjardins, James E. Herndon et al. · Journal of Clinical Oncology 18 Oct 2007 1,396
48 Epidemiology of Brain Metastases Lakshmi Nayak, Eudocia Q. Lee, Patrick Yung Wen · Current Oncology Reports 19 Oct 2011 1,392
49 Selection of Successive Tumour Lines for Metastasis Isaiah J. Fidler · Nature New Biology Apr 1973 1,368
50 Combined Nivolumab and Ipilimumab in Melanoma Metastatic to the Brain Hussein A. Tawbi et al. · New England Journal of Medicine Open access 22 Aug 2018 1,344

Citations are OpenAlex's own counts, from its 2026-09-23 snapshot, so the ranking can differ from Google Scholar or Web of Science. A paper is listed for a field when OpenAlex files it under one of the field's topics; retracted papers and papers whose citation count cannot be traced to citing works are left out, and a preprint and the article it became are shown once. Release dates are OpenAlex's: where a source gave only a month or a year, that is what is shown. How the lists are chosen.