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Topic · Pulmonary and Respiratory Medicine

Brain Metastases and Treatment

Brain Metastases and Treatment is a research topic within Pulmonary and Respiratory Medicine. Science Explorer counts 26k research works in it since 1950. 10.2% of them reached the world's top 10% most cited for their field and year.

This cluster of papers focuses on the management of brain metastases in cancer patients, including the use of radiosurgery and whole-brain radiation therapy, the impact on cognitive function, prognostic assessment, blood-brain barrier permeability, and specific considerations for HER2-positive breast cancer. It also explores the role of immunotherapy, the effects on neurocognitive function, and the challenges associated with leptomeningeal metastasis.

  • Brain Metastases
  • Radiosurgery
  • Whole-Brain Radiation Therapy
  • Cognitive Function
  • Prognostic Assessment
  • Blood-Brain Barrier
  • HER2-Positive Breast Cancer
  • Immunotherapy
  • Neurocognitive Function
  • Leptomeningeal Metastasis
Research works
26k
fractional, since 1950
In the world top 10%
2.6k
per year above
Top-10% rate
10.2%
share of its works in the world top 10%
Growth, 2018-21 → 2022-25
+15%
the tick is no change
Largest producer
United States
41% of the 10 largest, 2022-now
Brain Metastases and Treatment

This ranks research output and citation impact. It says nothing about the quality of diagnosis, treatment or care.

Which countries lead Brain Metastases and Treatment research?

By volume, the United States and China publish the most (2k and 969 works in 2022-now).

By volume, 2022-now

  1. 1 United States 2k works
  2. 2 China 969 works
  3. 3 Germany 388 works
  4. 4 Japan 355 works
  5. 5 India 255 works
  6. 6 Italy 246 works
  7. 7 United Kingdom 213 works
  8. 8 France 190 works
  9. 9 Canada 187 works
  10. 10 South Korea 141 works

How concentrated that is

The same countries as shares of everything the list above accounts for. A node where two countries do two thirds of the work and one spread evenly across twelve read alike as a ranking and not at all alike here.

United States: 40.9%China: 19.4%Germany: 7.8%Japan: 7.1%6 others listed: 24.7%41%largest
United States2,037 · 40.9%China969 · 19.4%Germany388 · 7.8%Japan355 · 7.1%6 others listed1,231 · 24.7%

Shares of the rows listed above, not of the whole node.

Which institutions lead Brain Metastases and Treatment research?

By volume in 2022-now, Harvard University publishes the most Brain Metastases and Treatment research, followed by The University of Texas MD Anderson Cancer Center and Mayo Clinic.

By volume, 2022-now

  1. 1 Harvard UniversityUnited States 93 works
  2. 2 The University of Texas MD Anderson Cancer CenterUnited States 73 works
  3. 3 Mayo ClinicUnited States 62 works
  4. 4 University of TorontoCanada 60 works
  5. 5 Memorial Sloan Kettering Cancer CenterUnited States 57 works
  6. 6 Capital Medical UniversityChina 50 works
  7. 7 Sun Yat-sen UniversityChina 49 works
  8. 8 Heidelberg UniversityGermany 49 works
  9. 9 Stanford UniversityUnited States 45 works
  10. 10 Neurological SurgeryUnited States 44 works

Who are the leading researchers in Brain Metastases and Treatment?

The most-cited researchers publishing on Brain Metastases and Treatment include Freddie Bray, Ali H. Mokdad and Julian P. T. Higgins.

  1. 1 Freddie Bray France 550k citations
  2. 2 Ali H. Mokdad United States 429k citations
  3. 3 Julian P. T. Higgins United Kingdom 390k citations
  4. 4 Gad A. Getz United States 364k citations
  5. 5 Elaine R. Mardis United States 346k citations
  6. 6 Hermann Brenner Germany 343k citations
  7. 7 Róbert Langer United States 303k citations

Ranked by citations received across their whole record, among researchers with at least three works on this topic.

What are the most cited papers in Brain Metastases and Treatment?

The most cited paper in Brain Metastases and Treatment is "Radiotherapy Plus Concomitant and Adjuvant Temozolomide for Glioblastoma" (Roger Stupp, Warren P. Mason, Martin J. van den Bent et al., 2005), with 22,109 citations. Next come "The 2016 World Health Organization Classification of Tumors of the Central Nervous System: a summary" (16,152) and "The 2021 WHO Classification of Tumors of the Central Nervous System: a summary" (12,579).

Most cited papers
#PaperReleasedCitations
1 Radiotherapy Plus Concomitant and Adjuvant Temozolomide for Glioblastoma Roger Stupp, Warren P. Mason, Martin J. van den Bent et al. · New England Journal of Medicine Open access 9 Mar 2005 22,109
2 The 2016 World Health Organization Classification of Tumors of the Central Nervous System: a summary David N. Louis, Arie Perry, Guido Reifenberger et al. · Acta Neuropathologica Open access 7 May 2016 16,152
3 The 2021 WHO Classification of Tumors of the Central Nervous System: a summary David N. Louis, Arie Perry, Pieter Wesseling et al. · Neuro-Oncology Open access 3 May 2021 12,579
4 Effects of radiotherapy with concomitant and adjuvant temozolomide versus radiotherapy alone on survival in glioblastoma in a randomised phase III study: 5-year analysis of the EORTC-NCIC trial Roger Stupp et al. · The Lancet Oncology 10 Mar 2009 7,889
5 MGMT Gene Silencing and Benefit from Temozolomide in Glioblastoma Monika E. Hegi, Annie‐Claire Diserens, Thierry Gorlia et al. · New England Journal of Medicine Open access 9 Mar 2005 7,397
All 100 most cited papers, with filters and sorting

Where is Brain Metastases and Treatment research done?

The largest centres of Brain Metastases and Treatment research in 2022-now are Beijing (China), New York (United States), Houston (United States) and Guangzhou (China). Among places with at least 20 works in it, it is an unusually large share of all research in Rockville Centre, Miami and Heidelberg.

Largest cities, 2022-now

  1. 1 BeijingChina 142 works
  2. 2 New YorkUnited States 126 works
  3. 3 HoustonUnited States 106 works
  4. 4 GuangzhouChina 102 works
  5. 5 BostonUnited States 90 works
  6. 6 ShanghaiChina 86 works
  7. 7 TorontoCanada 81 works
  8. 8 TokyoJapan 80 works
  9. 9 SeoulSouth Korea 79 works
  10. 10 HeidelbergGermany 73 works

Where it is the local speciality

  1. Rockville CentreUS · 43.7 works49×
  2. MiamiUS · 54.4 works14×
  3. HeidelbergDE · 73.2 works11×
  4. TampaUS · 43.8 works10×
← less than its size predicts1×more →

Location quotient: how much more of its research is in Brain Metastases and Treatment than the world average.

See Brain Metastases and Treatment on the map

Where is the best place to study Brain Metastases and Treatment?

Among universities, judged by research, Heidelberg University, Harvard University and University of Toronto score highest, combining excellence, specialisation, size, growth and international reach. Research strength is one signal when choosing where to study; it does not measure teaching.

0%10%20%30%mean 17.78%fractional works in this field (log) →share of work in the world top 10% →Heidelberg UniversityStanford UniversityHarvard UniversityUniversity of Toronto
above the meannear itbelow it

One dot per university in the first ten of the table below, at the default weights. The upper left is the interesting corner: small places doing unusually strong work.

Excellenceshare of its work in the world top 10%, 2022-now and all time averaged
40%
Specialisationhow much of its work is in this field, counted up to 10× the world share
10%
Sizeits output in this field, on a log scale
30%
Growthoutput growth, counted from -20% to +20%
10%
Internationalshare of its work with a co-author abroad
10%
Each slider sets a weight; the share it gets of the score is beside it.
#UniversityScoreTop 10%SpecialisationWorksGrowth
1Heidelberg UniversityGermany 77.017.6%11.3×49 +29.0%
2Harvard UniversityUnited States 72.015.9%5.2×93 -24.2%
3University of TorontoCanada 72.013.9%5.2×60 +24.1%
4Stanford UniversityUnited States 70.116.2%5.4×45 +58.4%
5University of California, San FranciscoUnited States 66.114.1%8.0×32 +14.9%
6Duke UniversityUnited States 65.815.0%6.3×29 +46.6%
7University of LausanneSwitzerland 65.322.9%3.8×10 +79.0%
8University of ZurichSwitzerland 62.617.6%6.0×24 +5.0%
9University of RegensburgGermany 61.020.2%7.2×10 +84.5%
10Central South UniversityChina 59.424.4%1.5×16 +67.1%

Universities only. The score blends excellence (40%), size (30%), specialisation (10%), growth (10%), international reach (10%), 2022-now; growth compares 2018-21 with 2022-25 and counts up to +20%, since a jump from a small base is mostly noise.

Every institution in Brain Metastases and Treatment, country by country

Is Brain Metastases and Treatment research growing?

Output in 2022-2025 was 15% higher than in 2018-2021, peaking in 2025. The fastest-growing topics are Brain Metastases and Treatment.

still counting19801990200020102020
grewheldshrank

The same series as a ribbon: one cell per year, darker for more. The line above answers how much; this answers when.

Its share of all research

Growing output can still be a shrinking share: all of science grows. This is Brain Metastases and Treatment as a percentage of every work published that year, 0.025% in 2024.

still counting0.010%0.020%0.030%Brain Metastases and Treatment0.028% in 202519801990200020102020

Fractional works of Brain Metastases and Treatment over all fractional works that year. How the balance of science has shifted.

How much of it reaches the world top 10%

Year by year.

still counting5%10%15%Brain Metastases and Treatment10.0% in 2025200020102020

Of each year's works in it, the share that reached the world's 10% most cited for their field and year. A field is the world for its own topics, so there is no other line to hold it against.

Which topics inside it are moving

Growth and decline on one axis around a shared zero. Two lists side by side hide the thing that matters: whether the growth dwarfs the decline, or the other way round.

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