Most cited papers in Cell death mechanisms and regulation
What are the most cited papers in Cell death mechanisms and regulation?
The most cited paper in Cell death mechanisms and regulation is "Apoptosis: A Review of Programmed Cell Death" (Susan A. Elmore, 2007), with 13,911 citations. Next come "Mitochondria and Apoptosis" (9,050) and "The biochemistry of apoptosis" (7,357).
Showing 50 of 100 papers. Every paper with more than 2,444 citations is listed.
| # | Paper | ||
|---|---|---|---|
| 1 | Apoptosis: A Review of Programmed Cell Death Susan A. Elmore · Toxicologic Pathology | Jun 2007 | 13,911 |
| 2 | Mitochondria and Apoptosis Douglas R. Green, John C. Reed · Science | 28 Aug 1998 | 9,050 |
| 3 | The biochemistry of apoptosis Michael Otmar Hengartner · Nature | Oct 2000 | 7,357 |
| 4 | Cytochrome c and dATP-Dependent Formation of Apaf-1/Caspase-9 Complex Initiates an Apoptotic Protease Cascade Peng Li, Deepak Nijhawan, I. Imawati Budihardjo et al. · Cell | Nov 1997 | 7,307 |
| 5 | Cell Death: The Significance of Apoptosis A H Wyllie, John F. R. Kerr, Richard A. Currie · International review of cytology | 1980 | 7,243 |
| 6 | Caspases: Enemies Within Nancy A. Thornberry, Yuri A. Lazebnik · Science | 28 Aug 1998 | 6,945 |
| 7 | Molecular mechanisms of cell death: recommendations of the Nomenclature Committee on Cell Death 2018 Lorenzo Galluzzi et al. · Cell Death and Differentiation | 23 Jan 2018 | 6,760 |
| 8 | Apoptosis in the Pathogenesis and Treatment of Disease Craig B. Thompson · Science | 10 Mar 1995 | 6,597 |
| 9 | The phosphatidylinositol 3-Kinase–AKT pathway in human cancer Igor Vivanco, Charles L. Sawyers · Nature reviews. Cancer | Jul 2002 | 6,096 |
| 10 | Bcl-2 heterodimerizes in vivo with a conserved homolog, Bax, that accelerates programed cell death Zoltán N. Oltval, Curt L. Milliman, Stanley J. Korsmeyer · Cell | Aug 1993 | 6,042 |
| 11 | Death Receptors: Signaling and Modulation Avi Ashkenazi, Vishva M. Dixit · Science | 28 Aug 1998 | 5,896 |
| 12 | Akt Phosphorylation of BAD Couples Survival Signals to the Cell-Intrinsic Death Machinery Sandeep Robert Datta, Henryk Dudek, Xu Tao et al. · Cell | Oct 1997 | 5,744 |
| 13 | A novel assay for apoptosis Flow cytometric detection of phosphatidylserine expression on early apoptotic cells using fluorescein labelled Annexin V István Vermes, C. Haanen, Helga M. Steffens-nakken et al. · Journal of Immunological Methods | Jul 1995 | 5,471 |
| 14 | The Bcl-2 Protein Family: Arbiters of Cell Survival Jerry M. Adams, Suzanne Cory · Science | 28 Aug 1998 | 5,380 |
| 15 | Opposing Effects of ERK and JNK-p38 MAP Kinases on Apoptosis Zhengui Xia, Martin Dickens, Joël Raingeaud et al. · Science | 24 Nov 1995 | 5,341 |
| 16 | Induction of Apoptotic Program in Cell-Free Extracts: Requirement for dATP and Cytochrome c Xuesong Liu, Caryn Naekyung Kim, Jie Yang et al. · Cell | Jul 1996 | 5,207 |
| 17 | Studies and Perspectives of Protein Kinase C Yasutomi Nishizuka · Science | 18 Jul 1986 | 5,143 |
| 18 | Apoptosis by Death Factor Shigekazu Nagata · Cell | Feb 1997 | 5,008 |
| 19 | Prevention of Apoptosis by Bcl-2: Release of Cytochrome c from Mitochondria Blocked Jie Yang, Xuesong Liu, Kapil N. Bhalla et al. · Science | 21 Feb 1997 | 4,964 |
| 20 | The Release of Cytochrome c from Mitochondria: A Primary Site for Bcl-2 Regulation of Apoptosis Ruth M. Kluck, Ella Bossy‐Wetzel, Douglas R. Green et al. · Science | 21 Feb 1997 | 4,758 |
| 21 | Caspases: the executioners of apoptosis Gerald M. Cohen · Biochemical Journal | 15 Aug 1997 | 4,755 |
| 22 | The BCL-2 protein family: opposing activities that mediate cell death Richard J. Youle, Andreas Strasser · Nature Reviews Molecular Cell Biology | 21 Dec 2007 | 4,708 |
| 23 | Cell Death Nika N. Danial, Stanley J. Korsmeyer · Cell | 2004 | 4,675 |
| 24 | Glucocorticoid-induced thymocyte apoptosis is associated with endogenous endonuclease activation A H Wyllie · Nature | Apr 1980 | 4,548 |
| 25 | Cleavage of BID by Caspase 8 Mediates the Mitochondrial Damage in the Fas Pathway of Apoptosis Honglin Li, Hong Zhu, Chi-jie Xu et al. · Cell | Aug 1998 | 4,466 |
| 26 | Systematic RNA interference reveals that oncogenic KRAS-driven cancers require TBK1 David Allen Barbie et al. · Nature | 21 Oct 2009 | 4,303 |
| 27 | Cellular survival: a play in three Akts Soma Datta, Anne Sophie Brunet, Michael E. Greenberg · Genes & Development | 15 Nov 1999 | 4,247 |
| 28 | Molecular characterization of mitochondrial apoptosis-inducing factor Santos A. Susín, Hans Kristian Lorenzo, Naoufal Zamzami et al. · Nature | Feb 1999 | 4,082 |
| 29 | Tumor suppressor p53 is a direct transcriptional activator of the human bax gene Toshiyuki Miyashita, John C. Reed · Cell | 1995 | 4,079 |
| 30 | The Bcl2 family: regulators of the cellular life-or-death switch Suzanne Cory, Jerry M. Adams · Nature reviews. Cancer | Sep 2002 | 4,029 |
| 31 | The Fas Death Factor Shigekazu Nagata, Pierre Golstein · Science | 10 Mar 1995 | 4,028 |
| 32 | Identification and inhibition of the ICE/CED-3 protease necessary for mammalian apoptosis Donald W. Nicholson, Ambereen Ali, Nancy A. Thornberry et al. · Nature | Jul 1995 | 4,026 |
| 33 | Proapoptotic BAX and BAK: A Requisite Gateway to Mitochondrial Dysfunction and Death Michael C. Wei, Wei‐Xing Zong, Emily H. Cheng et al. · Science | 27 Apr 2001 | 3,999 |
| 34 | Emerging roles of caspase-3 in apoptosis Alan George Porter, Reiner U. Jänicke · Cell Death and Differentiation | 28 Jan 1999 | 3,932 |
| 35 | Bcl-2 is an inner mitochondrial membrane protein that blocks programmed cell death David M. Hockenbery, Gabriel Núñez, Curt L. Milliman et al. · Nature | Nov 1990 | 3,802 |
| 36 | Activation of apoptosis signalling pathways by reactive oxygen species Maureen Redza-Dutordoir, Diana A. Averill‐Bates · Biochimica et Biophysica Acta (BBA) - Molecular Cell Research | 17 Sep 2016 | 3,794 |
| 37 | BCL-2 family members and the mitochondria in apoptosis Atan Gross, James M. McDonnell, S J Korsmeyer · Genes & Development | Aug 1999 | 3,664 |
| 38 | Bid, a Bcl2 Interacting Protein, Mediates Cytochrome c Release from Mitochondria in Response to Activation of Cell Surface Death Receptors Xu Luo, I. Imawati Budihardjo, Hua Zou et al. · Cell | Aug 1998 | 3,659 |
| 39 | Missing Pieces in the NF-κB Puzzle Sankar Ghosh, Michael Karin · Cell | Apr 2002 | 3,643 |
| 40 | Mitochondrial Membrane Permeabilization in Cell Death Guido Kroemer, Lorenzo Galluzzi, Catherine Brenner · Physiological Reviews | 2007 | 3,622 |
| 41 | Bcl-2 Antiapoptotic Proteins Inhibit Beclin 1-Dependent Autophagy Sophie Pattingre, Amina Tassa, Xueping Qu et al. · Cell | Sep 2005 | 3,541 |
| 42 | Smac, a Mitochondrial Protein that Promotes Cytochrome c–Dependent Caspase Activation by Eliminating IAP Inhibition Chunying Du, Min Hui Fang, Yucheng Li et al. · Cell | Jul 2000 | 3,499 |
| 43 | Bcl-2 functions in an antioxidant pathway to prevent apoptosis David M. Hockenbery, Zoltán N. Oltvai, Xiao-Ming Yin et al. · Cell | Oct 1993 | 3,450 |
| 44 | An inhibitor of Bcl-2 family proteins induces regression of solid tumours Tilman Oltersdorf et al. · Nature | 15 May 2005 | 3,430 |
| 45 | Proliferation, cell cycle and apoptosis in cancer Gérard I. Evan, Karen H. Vousden · Nature | May 2001 | 3,427 |
| 46 | The Pathophysiology of Mitochondrial Cell Death Douglas R. Green, Guido Kroemer · Science | 30 Jul 2004 | 3,411 |
| 47 | Classification of cell death: recommendations of the Nomenclature Committee on Cell Death 2009 Guido Kroemer et al. · Cell Death and Differentiation | 10 Oct 2008 | 3,386 |
| 48 | Apoptosis, oncosis, and necrosis. An overview of cell death. Guido Majno, I Joris · PubMed | 1995 | 3,335 |
| 49 | Disruption of epithelial cell-matrix interactions induces apoptosis SM Frisch, H. Francis · The Journal of Cell Biology | 15 Feb 1994 | 3,286 |
| 50 | Caspase-12 mediates endoplasmic-reticulum-specific apoptosis and cytotoxicity by amyloid-β Toshiyuki Nakagawa, Hong Zhu, Nobuhiro Morishima et al. · Nature | 2000 | 3,278 |
Citations are OpenAlex's own counts, from its 2026-09-23 snapshot, so the ranking can differ from Google Scholar or Web of Science. A paper is listed for a field when OpenAlex files it under one of the field's topics; retracted papers and papers whose citation count cannot be traced to citing works are left out, and a preprint and the article it became are shown once. Release dates are OpenAlex's: where a source gave only a month or a year, that is what is shown. How the lists are chosen.