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Topic · Molecular Biology

Cell death mechanisms and regulation

Cell death mechanisms and regulation is a research topic within Molecular Biology. Science Explorer counts 32k research works in it since 1951. 9.9% of them reached the world's top 10% most cited for their field and year.

This cluster of papers explores the molecular mechanisms, regulation, and implications of apoptosis and other forms of cell death, with a focus on the roles of Bcl-2 family proteins, mitochondria, TNF signaling, caspases, and reactive oxygen species. It also delves into the application of these insights in cancer therapy.

  • Apoptosis
  • Cell Death
  • Bcl-2 Family
  • Mitochondria
  • TNF Signaling
  • Caspases
  • Reactive Oxygen Species
  • Necroptosis
  • Programmed Cell Death
  • Cancer Therapy
Research works
32k
fractional, since 1951
In the world top 10%
3.2k
per year above
Top-10% rate
9.9%
share of its works in the world top 10%
Growth, 2018-21 → 2022-25
-13%
the tick is no change
Largest producer
China
48% of the 10 largest, 2022-now
Cell death mechanisms and regulation

Which countries lead Cell death mechanisms and regulation research?

By volume, China and the United States publish the most (1.3k and 568 works in 2022-now).

By volume, 2022-now

  1. 1 China 1.3k works
  2. 2 United States 568 works
  3. 3 India 184 works
  4. 4 Japan 124 works
  5. 5 South Korea 119 works
  6. 6 Germany 117 works
  7. 7 Iran 98 works
  8. 8 Türkiye 84 works
  9. 9 United Kingdom 74 works
  10. 10 France 71 works

How concentrated that is

The same countries as shares of everything the list above accounts for. A node where two countries do two thirds of the work and one spread evenly across twelve read alike as a ranking and not at all alike here.

China: 48.0%United States: 20.5%India: 6.6%Japan: 4.5%6 others listed: 20.3%48%largest
China1,331 · 48.0%United States568 · 20.5%India184 · 6.6%Japan124 · 4.5%6 others listed564 · 20.3%

Shares of the rows listed above, not of the whole node.

Which institutions lead Cell death mechanisms and regulation research?

By volume in 2022-now, Chinese Academy of Sciences publishes the most Cell death mechanisms and regulation research, followed by Central South University and Sun Yat-sen University.

By volume, 2022-now

  1. 1 Chinese Academy of SciencesChina 35 works
  2. 2 Central South UniversityChina 26 works
  3. 3 Sun Yat-sen UniversityChina 26 works
  4. 4 Zhejiang UniversityChina 25 works
  5. 5 Harvard UniversityUnited States 25 works
  6. 6 Nanjing Medical UniversityChina 24 works
  7. 7 Sichuan UniversityChina 24 works
  8. 8 Shanghai Jiao Tong UniversityChina 23 works
  9. 9 Centre National de la Recherche ScientifiqueFrance 21 works
  10. 10 Soochow UniversityChina 20 works

Who are the leading researchers in Cell death mechanisms and regulation?

The most-cited researchers publishing on Cell death mechanisms and regulation include Guido Kroemer, Bert Vogelstein and Shizuo Akira.

  1. 1 Guido Kroemer France 386k citations
  2. 2 Bert Vogelstein United States 373k citations
  3. 3 Shizuo Akira Japan 342k citations
  4. 4 Jun Wang China 340k citations
  5. 5 Matthias Mann Germany 308k citations
  6. 6 Robert A. Weinberg United States 301k citations
  7. 7 Todd R. Golub United States 283k citations
  8. 8 Matthew M. Meyerson United States 280k citations
  9. 9 Michael Karin United States 276k citations
  10. 10 Hagop M. Kantarjian United States 273k citations

Ranked by citations received across their whole record, among researchers with at least three works on this topic.

What are the most cited papers in Cell death mechanisms and regulation?

The most cited paper in Cell death mechanisms and regulation is "Apoptosis: A Review of Programmed Cell Death" (Susan A. Elmore, 2007), with 13,911 citations. Next come "Mitochondria and Apoptosis" (9,050) and "The biochemistry of apoptosis" (7,357).

Most cited papers
#PaperReleasedCitations
1 Apoptosis: A Review of Programmed Cell Death Susan A. Elmore · Toxicologic Pathology Open access Jun 2007 13,911
2 Mitochondria and Apoptosis Douglas R. Green, John C. Reed · Science 28 Aug 1998 9,050
3 The biochemistry of apoptosis Michael Otmar Hengartner · Nature Oct 2000 7,357
4 Cytochrome c and dATP-Dependent Formation of Apaf-1/Caspase-9 Complex Initiates an Apoptotic Protease Cascade Peng Li, Deepak Nijhawan, I. Imawati Budihardjo et al. · Cell Open access Nov 1997 7,307
5 Cell Death: The Significance of Apoptosis A H Wyllie, John F. R. Kerr, Richard A. Currie · International review of cytology Book chapter 1980 7,243
All 100 most cited papers, with filters and sorting

Where is Cell death mechanisms and regulation research done?

The largest centres of Cell death mechanisms and regulation research in 2022-now are Beijing (China), Shanghai (China), Guangzhou (China) and Nanjing (China). Among places with at least 20 works in it, it is an unusually large share of all research in Wenzhou.

Largest cities, 2022-now

  1. 1 BeijingChina 118 works
  2. 2 ShanghaiChina 96 works
  3. 3 GuangzhouChina 81 works
  4. 4 NanjingChina 59 works
  5. 5 HangzhouChina 55 works
  6. 6 SeoulSouth Korea 50 works
  7. 7 ChangshaChina 47 works
  8. 8 ChengduChina 44 works
  9. 9 WuhanChina 43 works
  10. 10 JinanChina 38 works

Where it is the local speciality

  1. WenzhouCN · 20.9 works6.7×
← less than its size predicts1×more →

Location quotient: how much more of its research is in Cell death mechanisms and regulation than the world average.

See Cell death mechanisms and regulation on the map

Where is the best place to study Cell death mechanisms and regulation?

Among universities, judged by research, Harvard University, Central South University and Wenzhou Medical University score highest, combining excellence, specialisation, size, growth and international reach. Research strength is one signal when choosing where to study; it does not measure teaching.

0%10%20%mean 15.03%fractional works in this field (log) →share of work in the world top 10% →The University of Me…Harvard UniversityCentral South Univer…Wenzhou Medical Univ…
above the meannear itbelow it

One dot per university in the first ten of the table below, at the default weights. The upper left is the interesting corner: small places doing unusually strong work.

Excellenceshare of its work in the world top 10%, 2022-now and all time averaged
40%
Specialisationhow much of its work is in this field, counted up to 10× the world share
10%
Sizeits output in this field, on a log scale
30%
Growthoutput growth, counted from -20% to +20%
10%
Internationalshare of its work with a co-author abroad
10%
Each slider sets a weight; the share it gets of the score is beside it.
#UniversityScoreTop 10%SpecialisationWorksGrowth
1Harvard UniversityUnited States 71.918.8%2.5×25 -26.6%
2Central South UniversityChina 65.317.9%4.4×26 +11.9%
3Wenzhou Medical UniversityChina 57.712.2%12.4×19 +32.6%
4The University of MelbourneAustralia 57.621.8%3.1×11 -19.7%
5Nanjing Medical UniversityChina 57.513.4%8.6×24 +7.0%
6Sun Yat-sen UniversityChina 54.613.0%4.1×26 -11.2%
7Soochow UniversityChina 54.611.1%6.7×20 +4.9%
8Fujian Medical UniversityChina 53.013.6%10.0×17 +9.9%
9Lanzhou UniversityChina 52.416.6%6.7×14 +137.0%
10Southern Medical UniversityChina 52.011.9%9.3×18 +10.5%

Universities only. The score blends excellence (40%), size (30%), specialisation (10%), growth (10%), international reach (10%), 2022-now; growth compares 2018-21 with 2022-25 and counts up to +20%, since a jump from a small base is mostly noise.

Every institution in Cell death mechanisms and regulation, country by country

Is Cell death mechanisms and regulation research growing?

Output in 2022-2025 was 13% lower than in 2018-2021, peaking in 2003.

still counting19801990200020102020
grewheldshrank

The same series as a ribbon: one cell per year, darker for more. The line above answers how much; this answers when.

Its share of all research

Growing output can still be a shrinking share: all of science grows. This is Cell death mechanisms and regulation as a percentage of every work published that year, 0.012% in 2024.

still counting0.050%0.10%Cell death mechanisms and regulation0.014% in 202519801990200020102020

Fractional works of Cell death mechanisms and regulation over all fractional works that year. How the balance of science has shifted.

How much of it reaches the world top 10%

Year by year.

still counting5%10%15%Cell death mechanisms and regulation10.1% in 2025200020102020

Of each year's works in it, the share that reached the world's 10% most cited for their field and year. A field is the world for its own topics, so there is no other line to hold it against.

Which topics inside it are moving

Growth and decline on one axis around a shared zero. Two lists side by side hide the thing that matters: whether the growth dwarfs the decline, or the other way round.

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