Most cited papers in Chemical Reactions and Mechanisms
What are the most cited papers in Chemical Reactions and Mechanisms?
The most cited paper in Chemical Reactions and Mechanisms is "Carbonic anhydrases: novel therapeutic applications for inhibitors and activators" (Claudiu Trandafir Supuran, 2008), with 3,205 citations. Next come "The Reaction of no With Superoxide" (2,123) and "The Carbon Dioxide Hydration Activity of Carbonic Anhydrase" (1,915).
Showing 50 of 100 papers. Every paper with more than 344 citations is listed.
| # | Paper | ||
|---|---|---|---|
| 1 | Carbonic anhydrases: novel therapeutic applications for inhibitors and activators Claudiu Trandafir Supuran · Nature Reviews Drug Discovery | 2 Jan 2008 | 3,205 |
| 2 | The Reaction of no With Superoxide Robert E. Huie, Sarojini Padmaja · Free Radical Research Communications | 1993 | 2,123 |
| 3 | The Carbon Dioxide Hydration Activity of Carbonic Anhydrase Raja G. Khalifah · Journal of Biological Chemistry | Apr 1971 | 1,915 |
| 4 | A Medicinal Chemist’s Guide to Molecular Interactions Caterina Bissantz, Bernd Kuhn, Martin Ståhl · Journal of Medicinal Chemistry | 26 Mar 2010 | 1,760 |
| 5 | Analyzing Reaction Rates with the Distortion/Interaction‐Activation Strain Model F. Matthias Bickelhaupt, Kendall N. Houk · Angewandte Chemie International Edition | 26 Apr 2017 | 1,744 |
| 6 | IMOMM: A new integrated ab initio + molecular mechanics geometry optimization scheme of equilibrium structures and transition states Feliu Maseras, Keiji Morokuma · Journal of Computational Chemistry | Sep 1995 | 1,721 |
| 7 | “On Water”: Unique Reactivity of Organic Compounds in Aqueous Suspension Sridhar Narayan, John Muldoon, M. G. Finn et al. · Angewandte Chemie International Edition | 21 Apr 2005 | 1,686 |
| 8 | Key green chemistry research areas—a perspective from pharmaceutical manufacturers David J. C. Constable, Peter J. Dunn, John D. Hayler et al. · Green Chemistry | 2007 | 1,554 |
| 9 | Azole-Based Energetic Salts Haixiang Gao, Jean’ne M. Shreeve · Chemical Reviews | 12 Aug 2011 | 1,268 |
| 10 | Multiple Binding Modes of Inhibitors to Carbonic Anhydrases: How to Design Specific Drugs Targeting 15 Different Isoforms? Vincenzo Alterio, Anna Di Fiore, Katia D’Ambrosio et al. · Chemical Reviews | 18 May 2012 | 1,237 |
| 11 | Correlation of Biological Activity of Phenoxyacetic Acids with Hammett Substituent Constants and Partition Coefficients Corwin H. Hansch, Peyton P. Maloney, Toshio Fujita et al. · Nature | Apr 1962 | 1,070 |
| 12 | Esterase Activities of Human Carbonic Anhydrases B and C Jacob A. Verpoorte, S. N. Mehta, John T. Edsall · Journal of Biological Chemistry | Sep 1967 | 1,062 |
| 13 | A Comparison of Estimates of Michaelis-Menten Kinetic Constants from Various Linear Transformations John E. Dowd, Douglas S. Riggs · Journal of Biological Chemistry | Feb 1965 | 1,058 |
| 14 | Structure and Mechanism in Organic Chemistry Colin Eaborn · Journal of Organometallic Chemistry | May 1970 | 1,051 |
| 15 | Arene Oxides: A New Aspect of Drug Metabolism D. M. JERINA, John W. Daly · Science | 16 Aug 1974 | 1,038 |
| 16 | Structure and mechanism of carbonic anhydrase Sven F. Lindskog · Pharmacology & Therapeutics | 1997 | 1,031 |
| 17 | FLUORIDE-INDUCED 1,2-ELIMINATION OF O -TRIMETHYLSILYLPHENYL TRIFLATE TO BENZYNE UNDER MILD CONDITIONS Yoshio Himeshima, Takaaki Sonoda, Hiroshi Kobayashi · Chemistry Letters | Aug 1983 | 942 |
| 18 | Structure and function of carbonic anhydrases Claudiu Trandafir Supuran · Biochemical Journal | 12 Jul 2016 | 931 |
| 19 | Best‐Practice DFT Protocols for Basic Molecular Computational Chemistry** Markus Bursch, Jan‐Michael Mewes, Andreas Hansen et al. · Angewandte Chemie International Edition | 14 Sep 2022 | 892 |
| 20 | Preparation of Esters of Carboxylic and Phosphoric Acid via Quaternary Phosphonium Salts Oyo Mitsunobu, Masaaki Yamada · Bulletin of the Chemical Society of Japan | Oct 1967 | 855 |
| 21 | THE MECHANISM OF ACTION OF FOSFOMYCIN (PHOSPHONOMYCIN) Frederick M. Kahan, Jean S. Kahan, Patrick J. Cassidy et al. · Annals of the New York Academy of Sciences | May 1974 | 790 |
| 22 | Energetic Nitrogen‐Rich Salts and Ionic Liquids Rajendra Prasad Singh, R. D. VERMA, Dayal T. Meshri et al. · Angewandte Chemie International Edition | 18 May 2006 | 786 |
| 23 | Addition of p -Azido- l -phenylalanine to the Genetic Code of Escherichia c oli Jason W. Chin, Stephen W. Santoro, Andrew B. Martin et al. · Journal of the American Chemical Society | 11 Jul 2002 | 743 |
| 24 | How many carbonic anhydrase inhibition mechanisms exist? Claudiu Trandafir Supuran · Journal of Enzyme Inhibition and Medicinal Chemistry | 30 Nov 2015 | 742 |
| 25 | Excited-state proton transfer reactions II. Intramolecular reactions Sebastião J. Formosinho, Luı́s G. Arnaut · Journal of Photochemistry and Photobiology A Chemistry | Oct 1993 | 709 |
| 26 | Methanolysis of Dimethyl (1-Diazo-2-oxopropyl) Phosphonate: Generation of Dimethyl (Diazomethyl) Phosphonate and Reaction with Carbonyl Compounds Susumu Ohira · Synthetic Communications | Feb 1989 | 706 |
| 27 | Active Oxygen Species Generated from Photoexcited Fullerene (C60) as Potential Medicines: O2-•versus1O2 Yoko Nakajima Yamakoshi, Naoki Umezawa, Akemi Ryu et al. · Journal of the American Chemical Society | 24 Sep 2003 | 699 |
| 28 | Review Article Silvia Pastoreková, Seppo Parkkila, Jaromı́r Pastorek et al. · Journal of Enzyme Inhibition and Medicinal Chemistry | 2004 | 665 |
| 29 | THE ISOLATION AND CRYSTALLIZATION OF RABBIT SKELETAL MUSCLE PHOSPHORYLASE b Edmond H. Fischer, Edwin G. Krebs · Journal of Biological Chemistry | Mar 1958 | 661 |
| 30 | A New Intermolecular Interaction: UnconventionalHydrogen Bonds with Element−Hydride Bonds as ProtonAcceptor Robert H. Crabtree, Per E. M. Siegbahn, Odile Eisenstein et al. · Accounts of Chemical Research | 11 Jan 1996 | 654 |
| 31 | Recent advances in transition-metal-free carbon–carbon and carbon–heteroatom bond-forming reactions using arynes Anup Bhunia, Santhivardhana Reddy Yetra, Akkattu T. Biju · Chemical Society Reviews | 2012 | 644 |
| 32 | A simplified radiometric assay for plasma norepinephrine and epinephrine Philip G. Passon, Jacob D. Peuler · Analytical Biochemistry | Feb 1973 | 640 |
| 33 | One Century of Aryne Chemistry Hans Henning Wenk, Michael A. Winkler, Wolfram Sander · Angewandte Chemie International Edition | 30 Jan 2003 | 630 |
| 34 | Formation and Properties of Peroxynitrite as Studied by Laser Flash Photolysis, High-Pressure Stopped-Flow Technique, and Pulse Radiolysis Reinhard Kissner, Thomas Nauser, Pascal Bugnon et al. · Chemical Research in Toxicology | Nov 1997 | 627 |
| 35 | Sidewall Functionalization of Carbon Nanotubes This work was supported by the European Union under the 5th Framework Research Training Network 1999, HPRNT 1999-00011 FUNCARS. Michael Holzinger, Otto Vostrowsky, Andreas Hirsch et al. · Angewandte Chemie International Edition | 5 Nov 2001 | 616 |
| 36 | The α‐Addition of Immonium Ions and Anions to Isonitriles Accompanied by Secondary Reactions Ivar Ugi · Angewandte Chemie International Edition in English | 27 Jan 1962 | 599 |
| 37 | Enzyme dynamics and hydrogen tunnelling in a thermophilic alcohol dehydrogenase Amnon Kohen, Raffaele Cannio, Simonetta Bartolucci et al. · Nature | Jun 1999 | 582 |
| 38 | Carbonic anhydrases as targets for medicinal chemistry Claudiu Trandafir Supuran, Andrea Scozzafava · Bioorganic & Medicinal Chemistry | 20 Apr 2007 | 581 |
| 39 | Carbonic Anhydrase: New Insights for an Ancient Enzyme Brian C. Tripp, Kerry S. Smith, James Gregory Ferry · Journal of Biological Chemistry | Dec 2001 | 569 |
| 40 | ENZYMATIC CARBOXYL ACTIVATION OF AMINO ACIDS Mahlon B. Hoagland, Elizabeth B. Keller, Paul C. Zamecnik · Journal of Biological Chemistry | 1956 | 567 |
| 41 | The Pharmacology, Metabolism, Analysis, and Applications of Coumarin and Coumarin-Related Compounds Denise A. Egan, Richard J O’Kennedy, Elizabeth E. Moran et al. · Drug Metabolism Reviews | 1990 | 558 |
| 42 | Effects of Lipolytic and Antilipolytic Substances on Adenosine 3′,5′-Monophosphate Levels in Isolated Fat Cells Reginald W. Butcher, CHRISTINE E. BAIRD, Earl W. Sutherland · Journal of Biological Chemistry | Apr 1968 | 556 |
| 43 | The use of arynes in organic synthesis Hélène Pellissier, Maurice Santelli · Tetrahedron | Feb 2003 | 543 |
| 44 | Carbonic Anhydrases An Overview Claudiu Trandafir Supuran · Current Pharmaceutical Design | Mar 2008 | 533 |
| 45 | The Taming of Cyclobutadiene Donald J. Cram, Martin E. Tanner, Robert G. Thomas · Angewandte Chemie International Edition in English | Aug 1991 | 525 |
| 46 | Mechanistic Aspects of the Reactions of Nitric Oxide with Transition-Metal Complexes Peter C. Ford, Ivan M. Lorković · Chemical Reviews | 4 Mar 2002 | 523 |
| 47 | Hybrid Quantum and Molecular Mechanical Simulations: An Alternative Avenue to Solvent Effects in Organic Chemistry Jiali Gao · Accounts of Chemical Research | 13 Jun 1996 | 518 |
| 48 | Non-Zinc Mediated Inhibition of Carbonic Anhydrases: Coumarins Are a New Class of Suicide Inhibitors Alfonso Maresca, Claudia Temperini, Hoan Thi Vu et al. · Journal of the American Chemical Society | 10 Feb 2009 | 518 |
| 49 | Synthesis of polyazapolycyclic caged polynitramines Arnold T. Nielsen, Andrew P. Chafin, Stephen L. Christian et al. · Tetrahedron | Sep 1998 | 513 |
| 50 | Structure of native and apo carbonic anhydrase II and structure of some of its anion-ligand complexes Kjell Erik Julius Håkansson, Maurits Carlsson, L. Anders Svensson et al. · Journal of Molecular Biology | Oct 1992 | 512 |
Citations are OpenAlex's own counts, from its 2026-09-23 snapshot, so the ranking can differ from Google Scholar or Web of Science. A paper is listed for a field when OpenAlex files it under one of the field's topics; retracted papers and papers whose citation count cannot be traced to citing works are left out, and a preprint and the article it became are shown once. Release dates are OpenAlex's: where a source gave only a month or a year, that is what is shown. How the lists are chosen.