Topic · Cholesterol and Lipid Metabolism
Most cited papers in Cholesterol and Lipid Metabolism
What are the most cited papers in Cholesterol and Lipid Metabolism?
The most cited paper in Cholesterol and Lipid Metabolism is "A Receptor-Mediated Pathway for Cholesterol Homeostasis" (Michael Scott Brown, Joseph L. Goldstein, 1986), with 5,742 citations. Next come "Inflammation and Alzheimer's disease" (4,553) and "Ezetimibe Added to Statin Therapy after Acute Coronary Syndromes" (4,523).
Showing 50 of 98 papers. Every paper with more than 1,179 citations is listed.
| # | Paper | ||
|---|---|---|---|
| 1 | A Receptor-Mediated Pathway for Cholesterol Homeostasis Michael Scott Brown, Joseph L. Goldstein · Science | 4 Apr 1986 | 5,742 |
| 2 | Inflammation and Alzheimer's disease Haruhiko Akiyama · Neurobiology of Aging | Jun 2000 | 4,553 |
| 3 | Ezetimibe Added to Statin Therapy after Acute Coronary Syndromes Christopher P. Cannon et al. · New England Journal of Medicine | 4 Jun 2015 | 4,523 |
| 4 | SREBPs: activators of the complete program of cholesterol and fatty acid synthesis in the liver Jay D. Horton, Joseph L. Goldstein, Michael Scott Brown · Journal of Clinical Investigation | May 2002 | 4,328 |
| 5 | NLRP3 inflammasomes are required for atherogenesis and activated by cholesterol crystals Peter Duewell, Hajime Kono, Katey J. Rayner et al. · Nature | Apr 2010 | 4,042 |
| 6 | The SREBP Pathway: Regulation of Cholesterol Metabolism by Proteolysis of a Membrane-Bound Transcription Factor Michael S. Brown, Joseph L. Goldstein · Cell | May 1997 | 3,866 |
| 7 | Biological, clinical and population relevance of 95 loci for blood lipids Tanya M. Teslovich et al. · Nature | Aug 2010 | 3,706 |
| 8 | A SIMPLIFIED METHOD FOR THE ESTIMATION OF TOTAL CHOLESTEROL IN SERUM AND DEMONSTRATION OF ITS SPECIFICITY Liese L. Abell, Betty B. Levy, Bernard B. Brodie et al. · Journal of Biological Chemistry | Mar 1952 | 3,109 |
| 9 | Atherosclerosis Christopher K. Glass, Joseph Lee Witztum · Cell | Feb 2001 | 3,066 |
| 10 | Mutations in PCSK9 cause autosomal dominant hypercholesterolemia Marianne Abifadel et al. · Nature Genetics | 5 May 2003 | 3,051 |
| 11 | Resolving inflammation: dual anti-inflammatory and pro-resolution lipid mediators Charles Nicholas Serhan, Nan Chiang, Thomas E. Van Dyke · Nature reviews. Immunology | 25 Apr 2008 | 2,945 |
| 12 | Familial hypercholesterolaemia is underdiagnosed and undertreated in the general population: guidance for clinicians to prevent coronary heart disease: Consensus Statement of the European Atherosclerosis Society Børge Grønne Nordestgaard et al. · European Heart Journal | 15 Aug 2013 | 2,797 |
| 13 | Seven-transmembrane receptors Kristen L. Pierce, Richard T. Premont, Robert J. Lefkowitz · Nature Reviews Molecular Cell Biology | Sep 2002 | 2,739 |
| 14 | Identification of a Nuclear Receptor for Bile Acids Makoto Makishima, Arthur Y. Okamoto, Joyce J. Repa et al. · Science | 21 May 1999 | 2,723 |
| 15 | n−3 Polyunsaturated fatty acids, inflammation, and inflammatory diseases Philip C. Calder · American Journal of Clinical Nutrition | Jun 2006 | 2,526 |
| 16 | Binding site on macrophages that mediates uptake and degradation of acetylated low density lipoprotein, producing massive cholesterol deposition Joseph L. Goldstein, Yiu Kee Ho, Sandip Kumar Basu et al. · Proceedings of the National Academy of Sciences | 1979 | 2,469 |
| 17 | The plasma lecithin:cholesterol acyltransferase reaction John A. Glomset · Journal of Lipid Research | Mar 1968 | 2,420 |
| 18 | Characterization of Mammalian Selenoproteomes Gregory V. Kryukov, Sergi Castellano, Sergey V. Novoselov et al. · Science | 29 May 2003 | 2,385 |
| 19 | Identification of Scavenger Receptor SR-BI as a High Density Lipoprotein Receptor Susan L. Acton, Attilio Rigotti, Katherine T. Landschulz et al. · Science | 26 Jan 1996 | 2,354 |
| 20 | Peroxidation of polyunsaturated fatty acids by lipoxygenases drives ferroptosis Wan Seok Yang, Katherine J. Kim, Michael M. Gaschler et al. · Proceedings of the National Academy of Sciences | 9 Aug 2016 | 2,348 |
| 21 | Bile Acids: Natural Ligands for an Orphan Nuclear Receptor Derek J. Parks, Steven G. Blanchard, Randy K. Bledsoe et al. · Science | 21 May 1999 | 2,273 |
| 22 | Spontaneous Hypercholesterolemia and Arterial Lesions in Mice Lacking Apolipoprotein E Sunny H. Zhang, Robert Lee Reddick, Jorge A. Piedrahita et al. · Science | 16 Oct 1992 | 2,248 |
| 23 | Bile acids induce energy expenditure by promoting intracellular thyroid hormone activation Mitsuhiro Watanabe, Sander M. Houten, Chikage Mataki et al. · Nature | 2006 | 2,230 |
| 24 | Atherosclerosis: current pathogenesis and therapeutic options Christian Weber, Heidi Noels · Nature Medicine | Nov 2011 | 2,220 |
| 25 | Omega-3 fatty acids in health and disease and in growth and development AP Simopoulos · American Journal of Clinical Nutrition | Sep 1991 | 2,172 |
| 26 | Common variants at ABCA7, MS4A6A/MS4A4E, EPHA1, CD33 and CD2AP are associated with Alzheimer's disease the Alzheimer's Disease Neuroimaging Initiative et al. · Nature Genetics | 3 Apr 2011 | 2,100 |
| 27 | Nuclear Receptors and Lipid Physiology: Opening the X-Files Ajay Chawla, Joyce J. Repa, Ronald M. Evans et al. · Science | 30 Nov 2001 | 2,096 |
| 28 | Dependency of a therapy-resistant state of cancer cells on a lipid peroxidase pathway Vasanthi S. Viswanathan et al. · Nature | Jul 2017 | 2,090 |
| 29 | The Enzymes, Regulation, and Genetics of Bile Acid Synthesis David W. Russell · Annual Review of Biochemistry | Jun 2003 | 2,075 |
| 30 | Mechanisms and regulation of cholesterol homeostasis Jie Luo, Hongyuan Yang, Bao‐Liang Song · Nature Reviews Molecular Cell Biology | 17 Dec 2019 | 2,064 |
| 31 | Omega-3 Fatty Acids in Inflammation and Autoimmune Diseases Artemis P. Simopoulos · Journal of the American College of Nutrition | Dec 2002 | 2,016 |
| 32 | Cholesterol Efflux Capacity, High-Density Lipoprotein Function, and Atherosclerosis Amit Khera, Marina Cuchel, Margarita de la Llera-Moya et al. · New England Journal of Medicine | 12 Jan 2011 | 1,968 |
| 33 | Lipid peroxidation and ferroptosis: The role of GSH and GPx4 Fulvio Ursini, Matilde Maiorino · Free Radical Biology and Medicine | 9 Mar 2020 | 1,955 |
| 34 | A Regulatory Cascade of the Nuclear Receptors FXR, SHP-1, and LRH-1 Represses Bile Acid Biosynthesis Bryan J. Goodwin, Stacey A. Jones, Roger R. Price et al. · Molecular Cell | Sep 2000 | 1,931 |
| 35 | Oxidized LDL Regulates Macrophage Gene Expression through Ligand Activation of PPARγ Laszlo Tibor Nagy, Peter Tontonoz, Jacqueline G. A. Alvarez et al. · Cell | Apr 1998 | 1,874 |
| 36 | A comprehensive classification system for lipids Eoin Fahy, Shankar Subramaniam, H. Alex Brown et al. · Journal of Lipid Research | 16 Feb 2005 | 1,865 |
| 37 | Targeted Disruption of the Nuclear Receptor FXR/BAR Impairs Bile Acid and Lipid Homeostasis Christopher J. Sinal, Masahiro Tohkin, Masaaki Miyata et al. · Cell | Sep 2000 | 1,820 |
| 38 | PPARγ Promotes Monocyte/Macrophage Differentiation and Uptake of Oxidized LDL Peter Tontonoz, Laszlo Tibor Nagy, Jacqueline G. A. Alvarez et al. · Cell | Apr 1998 | 1,819 |
| 39 | The PPARs: From Orphan Receptors to Drug Discovery Timothy Mark Willson, Peter J. Brown, Daniel D. Sternbach et al. · Journal of Medicinal Chemistry | Feb 2000 | 1,816 |
| 40 | Lipids and lipid-based formulations: optimizing the oral delivery of lipophilic drugs Christopher J. H. Porter, Natalie L. Trevaskis, William N. Charman · Nature Reviews Drug Discovery | Mar 2007 | 1,806 |
| 41 | Review of the biology of quercetin and related bioflavonoids Joseph V. Formica, William Regelson · Food and Chemical Toxicology | Dec 1995 | 1,772 |
| 42 | The Human ATP-Binding Cassette (ABC) Transporter Superfamily Michael C. Dean, Andrey Rzhetsky, Rando L. Allikmets · Genome Research | 18 Jan 2001 | 1,761 |
| 43 | An oxysterol signalling pathway mediated by the nuclear receptor LXRα Bethany A. Janowski, Patricia J. Willy, Thota Rama Devi et al. · Nature | Oct 1996 | 1,758 |
| 44 | CNS Synaptogenesis Promoted by Glia-Derived Cholesterol Daniela H. Mauch, Karl Nägler, Stefan Schumacher et al. · Science | 9 Nov 2001 | 1,727 |
| 45 | Mutations in ABC1 in Tangier disease and familial high-density lipoprotein deficiency Angela R Brooks-Wilson et al. · Nature Genetics | Aug 1999 | 1,720 |
| 46 | Protein Sensors for Membrane Sterols Joseph L. Goldstein, Russell A. DeBose‐Boyd, Michael Scott Brown · Cell | 2006 | 1,717 |
| 47 | Marine omega-3 fatty acids and inflammatory processes: Effects, mechanisms and clinical relevance Philip C. Calder · Biochimica et Biophysica Acta (BBA) - Molecular and Cell Biology of Lipids | 20 Aug 2014 | 1,713 |
| 48 | Regulation of mouse sterol regulatory element-binding protein-1c gene (SREBP-1c) by oxysterol receptors, LXRα and LXRβ Joyce J. Repa, Guosheng Liang, Jiafu Ou et al. · Genes & Development | 15 Nov 2000 | 1,712 |
| 49 | Essential fatty acids in health and chronic disease Artemis P. Simopoulos · American Journal of Clinical Nutrition | Sep 1999 | 1,707 |
| 50 | Role of LXRs in control of lipogenesis Joshua R. Schultz, Hua Tu, Alvin Y. Luk et al. · Genes & Development | 15 Nov 2000 | 1,688 |
Citations are OpenAlex's own counts, from its 2026-09-23 snapshot, so the ranking can differ from Google Scholar or Web of Science. A paper is listed for a field when OpenAlex files it under one of the field's topics; retracted papers and papers whose citation count cannot be traced to citing works are left out, and a preprint and the article it became are shown once. Release dates are OpenAlex's: where a source gave only a month or a year, that is what is shown. How the lists are chosen.