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Cholesterol and Lipid Metabolism

Cholesterol and Lipid Metabolism is a research topic within Surgery. Science Explorer counts 24k research works in it since 1950. 9.9% of them reached the world's top 10% most cited for their field and year.

This cluster of papers focuses on the intricate mechanisms of cholesterol metabolism, including the roles of key regulators such as LXR and SREBP, the impact on atherosclerosis, and the involvement of specific proteins like ABCA1 in processes such as cholesterol efflux from cells. It also delves into the effects of phytosterols on lipid levels and the interplay between cholesterol homeostasis and inflammation in conditions like atherosclerosis.

  • Cholesterol
  • Metabolism
  • Atherosclerosis
  • LXR
  • SREBP
  • ABCA1
  • Phytosterols
  • HDL
  • LDL
  • Macrophage
Research works
24k
fractional, since 1950
In the world top 10%
2.3k
per year above
Top-10% rate
9.9%
share of its works in the world top 10%
Growth, 2018-21 → 2022-25
+2%
the tick is no change
Largest producer
China
44% of the 10 largest, 2022-now
Cholesterol and Lipid Metabolism

This ranks research output and citation impact. It says nothing about the quality of diagnosis, treatment or care.

Which countries lead Cholesterol and Lipid Metabolism research?

By volume, China and the United States publish the most (997 and 486 works in 2022-now).

By volume, 2022-now

  1. 1 China 997 works
  2. 2 United States 486 works
  3. 3 India 164 works
  4. 4 Japan 127 works
  5. 5 Italy 107 works
  6. 6 Spain 87 works
  7. 7 Germany 84 works
  8. 8 South Korea 75 works
  9. 9 France 70 works
  10. 10 United Kingdom 62 works

How concentrated that is

The same countries as shares of everything the list above accounts for. A node where two countries do two thirds of the work and one spread evenly across twelve read alike as a ranking and not at all alike here.

China: 44.1%United States: 21.5%India: 7.2%Japan: 5.6%6 others listed: 21.5%44%largest
China997 · 44.1%United States486 · 21.5%India164 · 7.2%Japan127 · 5.6%6 others listed487 · 21.5%

Shares of the rows listed above, not of the whole node.

Which institutions lead Cholesterol and Lipid Metabolism research?

By volume in 2022-now, Sun Yat-sen University publishes the most Cholesterol and Lipid Metabolism research, followed by Chinese Academy of Medical Sciences & Peking Union Medical College and Shanghai Jiao Tong University.

By volume, 2022-now

  1. 1 Sun Yat-sen UniversityChina 23 works
  2. 2 Chinese Academy of Medical Sciences & Peking Union Medical CollegeChina 20 works
  3. 3 Shanghai Jiao Tong UniversityChina 18 works
  4. 4 Centre National de la Recherche ScientifiqueFrance 18 works
  5. 5 Harvard UniversityUnited States 16 works
  6. 6 Sichuan UniversityChina 15 works
  7. 7 Chinese Academy of SciencesChina 15 works
  8. 8 Capital Medical UniversityChina 15 works
  9. 9 Zhejiang UniversityChina 15 works
  10. 10 InsermFrance 14 works

Who are the leading researchers in Cholesterol and Lipid Metabolism?

The most-cited researchers publishing on Cholesterol and Lipid Metabolism include George Davey Smith, Walter Churchill Willett and Mark J. Daly.

  1. 1 George Davey Smith United Kingdom 435k citations
  2. 2 Walter Churchill Willett United States 411k citations
  3. 3 Mark J. Daly United States 403k citations
  4. 4 Stacey L. Gabriel United States 402k citations
  5. 5 Jost Bruno Jonas Germany 350k citations
  6. 6 Hermann Brenner Germany 343k citations
  7. 7 Jun Wang China 340k citations
  8. 8 Giuseppe Remuzzi Italy 328k citations
  9. 9 Mika Kivimäki United Kingdom 318k citations
  10. 10 Gregory Y.H. Lip United Kingdom 311k citations

Ranked by citations received across their whole record, among researchers with at least three works on this topic.

What are the most cited papers in Cholesterol and Lipid Metabolism?

The most cited paper in Cholesterol and Lipid Metabolism is "A Receptor-Mediated Pathway for Cholesterol Homeostasis" (Michael Scott Brown, Joseph L. Goldstein, 1986), with 5,742 citations. Next come "Inflammation and Alzheimer's disease" (4,553) and "Ezetimibe Added to Statin Therapy after Acute Coronary Syndromes" (4,523).

Most cited papers
#PaperReleasedCitations
1 A Receptor-Mediated Pathway for Cholesterol Homeostasis Michael Scott Brown, Joseph L. Goldstein · Science 4 Apr 1986 5,742
2 Inflammation and Alzheimer's disease Haruhiko Akiyama · Neurobiology of Aging Open access Jun 2000 4,553
3 Ezetimibe Added to Statin Therapy after Acute Coronary Syndromes Christopher P. Cannon et al. · New England Journal of Medicine Open access 4 Jun 2015 4,523
4 SREBPs: activators of the complete program of cholesterol and fatty acid synthesis in the liver Jay D. Horton, Joseph L. Goldstein, Michael Scott Brown · Journal of Clinical Investigation Open access May 2002 4,328
5 NLRP3 inflammasomes are required for atherogenesis and activated by cholesterol crystals Peter Duewell, Hajime Kono, Katey J. Rayner et al. · Nature Open access Apr 2010 4,042
All 98 most cited papers, with filters and sorting

Where is Cholesterol and Lipid Metabolism research done?

The largest centres of Cholesterol and Lipid Metabolism research in 2022-now are Beijing (China), Guangzhou (China), Shanghai (China) and Nanjing (China).

Largest cities, 2022-now

  1. 1 BeijingChina 120 works
  2. 2 GuangzhouChina 72 works
  3. 3 ShanghaiChina 69 works
  4. 4 NanjingChina 47 works
  5. 5 WuhanChina 44 works
  6. 6 HangzhouChina 38 works
  7. 7 ParisFrance 31 works
  8. 8 TokyoJapan 29 works
  9. 9 SeoulSouth Korea 29 works
  10. 10 ChengduChina 28 works
See Cholesterol and Lipid Metabolism on the map

Where is the best place to study Cholesterol and Lipid Metabolism?

Among universities, judged by research, Wuhan University, Sun Yat-sen University and Shanghai Jiao Tong University score highest, combining excellence, specialisation, size, growth and international reach. Research strength is one signal when choosing where to study; it does not measure teaching.

0%20%40%mean 20.69%fractional works in this field (log) →share of work in the world top 10% →Wuhan UniversityShanghai Jiao Tong U…Chinese Academy of M…Sun Yat-sen University
above the meannear itbelow it

One dot per university in the first ten of the table below, at the default weights. The upper left is the interesting corner: small places doing unusually strong work.

Excellenceshare of its work in the world top 10%, 2022-now and all time averaged
40%
Specialisationhow much of its work is in this field, counted up to 10× the world share
10%
Sizeits output in this field, on a log scale
30%
Growthoutput growth, counted from -20% to +20%
10%
Internationalshare of its work with a co-author abroad
10%
Each slider sets a weight; the share it gets of the score is beside it.
#UniversityScoreTop 10%SpecialisationWorksGrowth
1Wuhan UniversityChina 70.532.1%3.4×13 +32.7%
2Sun Yat-sen UniversityChina 63.516.6%4.1×23 +93.7%
3Shanghai Jiao Tong UniversityChina 60.922.8%2.3×18 +31.3%
4Chinese Academy of Medical Sciences & Peking Union Medical CollegeChina 60.217.1%6.8×20 +26.8%
5Shanghai University of Traditional Chinese MedicineChina 59.424.5%15.6×12 +92.7%
6Harvard UniversityUnited States 58.916.4%1.8×16 +0.3%
7Saveetha UniversityIndia 56.623.7%3.1×8 +174.8%
8Zhejiang UniversityChina 50.218.3%2.0×15 +35.8%
9Peking UniversityChina 48.814.8%2.5×14 +66.5%
10Guangzhou University of Chinese MedicineChina 47.720.6%14.7×10 +96.8%

Universities only. The score blends excellence (40%), size (30%), specialisation (10%), growth (10%), international reach (10%), 2022-now; growth compares 2018-21 with 2022-25 and counts up to +20%, since a jump from a small base is mostly noise.

Every institution in Cholesterol and Lipid Metabolism, country by country

Is Cholesterol and Lipid Metabolism research growing?

Output in 2022-2025 was 2% higher than in 2018-2021, peaking in 2025. The fastest-growing topics are Cholesterol and Lipid Metabolism.

still counting19801990200020102020
grewheldshrank

The same series as a ribbon: one cell per year, darker for more. The line above answers how much; this answers when.

Its share of all research

Growing output can still be a shrinking share: all of science grows. This is Cholesterol and Lipid Metabolism as a percentage of every work published that year, 0.012% in 2024.

still counting0.020%0.040%0.060%Cholesterol and Lipid Metabolism0.013% in 202519801990200020102020

Fractional works of Cholesterol and Lipid Metabolism over all fractional works that year. How the balance of science has shifted.

How much of it reaches the world top 10%

Year by year.

still counting5%10%15%Cholesterol and Lipid Metabolism10.1% in 2025200020102020

Of each year's works in it, the share that reached the world's 10% most cited for their field and year. A field is the world for its own topics, so there is no other line to hold it against.

Which topics inside it are moving

Growth and decline on one axis around a shared zero. Two lists side by side hide the thing that matters: whether the growth dwarfs the decline, or the other way round.

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