Topic · Click Chemistry and Applications
Most cited papers in Click Chemistry and Applications
What are the most cited papers in Click Chemistry and Applications?
The most cited paper in Click Chemistry and Applications is "Click Chemistry: Diverse Chemical Function from a Few Good Reactions" (Hartmuth Christian Kolb, M. G. Finn, Karl Barry Sharpless, 2001), with 13,223 citations. Next come "A Stepwise Huisgen Cycloaddition Process: Copper(I)-Catalyzed Regioselective “Ligation” of Azides and Terminal Alkynes" (11,614) and "Automated docking using a Lamarckian genetic algorithm and an empirical binding free energy function" (10,945).
Showing 50 of 98 papers. Every paper with more than 1,290 citations is listed.
| # | Paper | ||
|---|---|---|---|
| 1 | Click Chemistry: Diverse Chemical Function from a Few Good Reactions Hartmuth Christian Kolb, M. G. Finn, Karl Barry Sharpless · Angewandte Chemie International Edition | Jun 2001 | 13,223 |
| 2 | A Stepwise Huisgen Cycloaddition Process: Copper(I)-Catalyzed Regioselective “Ligation” of Azides and Terminal Alkynes Vsevolod V. Rostovtsev, Luke G. Green, Valery V. Fokin et al. · Angewandte Chemie International Edition | 15 Jul 2002 | 11,614 |
| 3 | Automated docking using a Lamarckian genetic algorithm and an empirical binding free energy function Garrett M. Morris, David S. Goodsell, Robert S. Halliday et al. · Journal of Computational Chemistry | 15 Nov 1998 | 10,945 |
| 4 | Glide: A New Approach for Rapid, Accurate Docking and Scoring. 1. Method and Assessment of Docking Accuracy Richard A. Friesner, Jay L. Banks, Robert B. Murphy et al. · Journal of Medicinal Chemistry | 27 Feb 2004 | 10,177 |
| 5 | Peptidotriazoles on Solid Phase: [1,2,3]-Triazoles by Regiospecific Copper(I)-Catalyzed 1,3-Dipolar Cycloadditions of Terminal Alkynes to Azides Christian Wenzel Tornøe, Caspar Elo Christensen, Morten Meldal · The Journal of Organic Chemistry | 2 Apr 2002 | 8,627 |
| 6 | In situ click chemistry generation of cyclooxygenase-2 inhibitors Atul Bhardwaj, Jatinder Paul Kaur, Melinda Wuest et al. · Nature Communications | 9 Feb 2017 | 7,563 |
| 7 | Fluorine in Pharmaceuticals: Looking Beyond Intuition Klaus Müller, Christoph Faeh, François Diederich · Science | 27 Sep 2007 | 6,622 |
| 8 | pkCSM: Predicting Small-Molecule Pharmacokinetic and Toxicity Properties Using Graph-Based Signatures Douglas E. V. Pires, Tom L. Blundell, David Benjamin Ascher · Journal of Medicinal Chemistry | 10 Apr 2015 | 5,730 |
| 9 | Improved monomeric red, orange and yellow fluorescent proteins derived from Discosoma sp. red fluorescent protein Nathan C. Shaner, Robert E. Campbell, Paul A. Steinbach et al. · Nature Biotechnology | 21 Nov 2004 | 4,783 |
| 10 | Cu-Catalyzed Azide−Alkyne Cycloaddition Morten Meldal, Christian Wenzel Tornøe · Chemical Reviews | Aug 2008 | 4,612 |
| 11 | Thiol–Ene Click Chemistry Charles E. Hoyle, Christopher N. Bowman · Angewandte Chemie International Edition | 17 Feb 2010 | 4,186 |
| 12 | Synthesis of Proteins by Native Chemical Ligation Philip E. Dawson, Tom W. Muir, Ian Clark‐Lewis et al. · Science | 4 Nov 1994 | 4,169 |
| 13 | The Use of Diethyl Azodicarboxylate and Triphenylphosphine in Synthesis and Transformation of Natural Products Oyo Mitsunobu · Synthesis | 1981 | 4,109 |
| 14 | Polyvalent Interactions in Biological Systems: Implications for Design and Use of Multivalent Ligands and Inhibitors Mathai Mammen, Seok Ki Choi, George M. Whitesides · Angewandte Chemie International Edition | 2 Nov 1998 | 4,018 |
| 15 | Platinum Compounds: a New Class of Potent Antitumour Agents Barnett Rosenberg, Loretta Vancamp, James Edward Trosko et al. · Nature | Apr 1969 | 3,961 |
| 16 | Applications of Fluorine in Medicinal Chemistry Eric P. Gillis, Kyle J. Eastman, Matthew Davenport Hill et al. · Journal of Medicinal Chemistry | 22 Jul 2015 | 3,653 |
| 17 | How many drug targets are there? John P. Overington, Bissan Al‐Lazikani, Andrew L. Hopkins · Nature Reviews Drug Discovery | Dec 2006 | 3,554 |
| 18 | The dawning era of polymer therapeutics Ruth Duncan · Nature Reviews Drug Discovery | May 2003 | 3,264 |
| 19 | Bioorthogonal Chemistry: Fishing for Selectivity in a Sea of Functionality Ellen M. Sletten, Carolyn Ruth Bertozzi · Angewandte Chemie International Edition | 27 Aug 2009 | 3,183 |
| 20 | The growing impact of click chemistry on drug discovery Hartmuth Christian Kolb, Karl Barry Sharpless · Drug Discovery Today | Dec 2003 | 3,149 |
| 21 | A Strain-Promoted [3 + 2] Azide−Alkyne Cycloaddition for Covalent Modification of Biomolecules in Living Systems Nicholas J. Agard, Jennifer A. Prescher, Carolyn Ruth Bertozzi · Journal of the American Chemical Society | Nov 2004 | 3,025 |
| 22 | The Combinatorial Synthesis of Bicyclic Privileged Structures or Privileged Substructures Douglas A. Horton, Gregory T. Bourne, Mark L. Smythe · Chemical Reviews | 22 Feb 2003 | 3,010 |
| 23 | Synopsis of Some Recent Tactical Application of Bioisosteres in Drug Design Nicholas A. Meanwell · Journal of Medicinal Chemistry | 17 Mar 2011 | 2,856 |
| 24 | A Fast Flexible Docking Method using an Incremental Construction Algorithm Matthias Rarey, BERND J. KRÄMER, Thomas Lengauer et al. · Journal of Molecular Biology | Aug 1996 | 2,848 |
| 25 | Next Generation of Fluorine-Containing Pharmaceuticals, Compounds Currently in Phase II–III Clinical Trials of Major Pharmaceutical Companies: New Structural Trends and Therapeutic Areas Yu Chang Zhou, Jiang Wang, Zhanni Gu et al. · Chemical Reviews | 12 Jan 2016 | 2,807 |
| 26 | The Medicinal Chemist’s Toolbox: An Analysis of Reactions Used in the Pursuit of Drug Candidates Stephen D. Roughley, Allan Michael Jordan · Journal of Medicinal Chemistry | 19 Apr 2011 | 2,771 |
| 27 | FLUORESCENCE OF CATECHOL AMINES AND RELATED COMPOUNDS CONDENSED WITH FORMALDEHYDE BENGT FALCK, N.‐Å. Hillarp, Georg Thieme et al. · Journal of Histochemistry & Cytochemistry | May 1962 | 2,708 |
| 28 | HaloTag: A Novel Protein Labeling Technology for Cell Imaging and Protein Analysis Georgyi V. Los, Lance P. Encell, Mark G. McDougall et al. · ACS Chemical Biology | Jun 2008 | 2,688 |
| 29 | Fluorine and Fluorinated Motifs in the Design and Application of Bioisosteres for Drug Design Nicholas A. Meanwell · Journal of Medicinal Chemistry | 5 Feb 2018 | 2,663 |
| 30 | Fluorescamine: A Reagent for Assay of Amino Acids, Peptides, Proteins, and Primary Amines in the Picomole Range Sidney Udenfriend, Stanley J. Stein, Peter Böhlen et al. · Science | 24 Nov 1972 | 2,660 |
| 31 | Target-Oriented and Diversity-Oriented Organic Synthesis in Drug Discovery Stuart L. Schreiber · Science | 17 Mar 2000 | 2,579 |
| 32 | Molecular Docking and Structure-Based Drug Design Strategies Leonardo L. G. Ferreira, Ricardo Nascimento dos Santos, Glaucius Oliva et al. · Molecules | 22 Jul 2015 | 2,578 |
| 33 | Chemistry and Biology Of Multicomponent Reactions Alexander S. S. Dömling, Wei Wang, Kan Wang · Chemical Reviews | 22 Mar 2012 | 2,557 |
| 34 | Cell Sensitivity Assays: The MTT Assay Johan van Meerloo, Gertjan J.L. Kaspers, Jacqueline J Cloos · Methods in molecular biology | 2011 | 2,549 |
| 35 | Rings in Drugs Richard D. Taylor, Malcolm MacCoss, Alastair D. G. Lawson · Journal of Medicinal Chemistry | 28 Jan 2014 | 2,540 |
| 36 | Cell Surface Engineering by a Modified Staudinger Reaction Eliana Saxon, Carolyn Ruth Bertozzi · Science | 17 Mar 2000 | 2,469 |
| 37 | Molecular Docking: Shifting Paradigms in Drug Discovery Luca Pinzi, Giulio Rastelli · International Journal of Molecular Sciences | 4 Sep 2019 | 2,376 |
| 38 | The growing applications of click chemistry John E. Moses, Adam D. Moorhouse · Chemical Society Reviews | 2007 | 2,376 |
| 39 | Efficient proximity labeling in living cells and organisms with TurboID Tess Caroline Branon, Justin A. Bosch, Ariana D. Sanchez et al. · Nature Biotechnology | 20 Aug 2018 | 2,338 |
| 40 | Rules for ring closure Jack Edward Baldwin · Journal of the Chemical Society Chemical Communications | 1976 | 2,256 |
| 41 | Computational Methods in Drug Discovery Gregory R. Sliwoski, Sandeepkumar Kothiwale, Jens Meiler et al. · Pharmacological Reviews | 31 Dec 2013 | 2,236 |
| 42 | Organic Azides: An Exploding Diversity of a Unique Class of Compounds Stefan Bräse, Carmen Gil, Kerstin Knepper et al. · Angewandte Chemie International Edition | 15 Aug 2005 | 2,226 |
| 43 | Copper-catalyzed azide–alkyne cycloaddition (CuAAC) and beyond: new reactivity of copper(i) acetylides Jason E. Hein, Valery V. Fokin · Chemical Society Reviews | 2010 | 2,195 |
| 44 | Novel Procedure for Modeling Ligand/Receptor Induced Fit Effects Woody Sherman, Tyler Day, Matthew P. Jacobson et al. · Journal of Medicinal Chemistry | 23 Dec 2005 | 2,083 |
| 45 | A general method for the covalent labeling of fusion proteins with small molecules in vivo Antje Keppler, Susanne Gendreizig, Thomas Gronemeyer et al. · Nature Biotechnology | 9 Dec 2002 | 2,042 |
| 46 | The Future of Peptide‐based Drugs David J. Craik, David P. Fairlie, Spiros Liras et al. · Chemical Biology & Drug Design | 17 Dec 2012 | 2,015 |
| 47 | Creating new fluorescent probes for cell biology Jin Zhang, Robert E. Campbell, Alice Y. Ting et al. · Nature Reviews Molecular Cell Biology | Dec 2002 | 1,988 |
| 48 | Subdiffraction‐Resolution Fluorescence Imaging with Conventional Fluorescent Probes Mike Heilemann, Sebastian van de Linde, Mark Schüttpelz et al. · Angewandte Chemie International Edition | 22 Jul 2008 | 1,967 |
| 49 | A chemical method for fast and sensitive detection of DNA synthesis in vivo Adrian N. Salic, Timothy John Mitchison · Proceedings of the National Academy of Sciences | 12 Feb 2008 | 1,914 |
| 50 | Click Chemistry for Drug Development and Diverse Chemical–Biology Applications Thirumurugan Prakasam, Dariusz Matosiuk, Krzysztof Jóźwiak · Chemical Reviews | 27 Mar 2013 | 1,898 |
Citations are OpenAlex's own counts, from its 2026-09-23 snapshot, so the ranking can differ from Google Scholar or Web of Science. A paper is listed for a field when OpenAlex files it under one of the field's topics; retracted papers and papers whose citation count cannot be traced to citing works are left out, and a preprint and the article it became are shown once. Release dates are OpenAlex's: where a source gave only a month or a year, that is what is shown. How the lists are chosen.