Most cited papers in Congenital heart defects research
What are the most cited papers in Congenital heart defects research?
The most cited paper in Congenital heart defects research is "Stages of embryonic development of the zebrafish" (Charles B. Kimmel, William Whitney Ballard, Seth R. Kimmel et al., 1995), with 12,479 citations. Next come "Epithelial-Mesenchymal Transitions in Development and Disease" (10,099) and "Culture of Human Endothelial Cells Derived from Umbilical Veins. IDENTIFICATION BY MORPHOLOGIC AND IMMUNOLOGIC CRITERIA" (6,923).
Showing 50 of 100 papers. Every paper with more than 1,259 citations is listed.
| # | Paper | ||
|---|---|---|---|
| 1 | Stages of embryonic development of the zebrafish Charles B. Kimmel, William Whitney Ballard, Seth R. Kimmel et al. · Developmental Dynamics | Jul 1995 | 12,479 |
| 2 | Epithelial-Mesenchymal Transitions in Development and Disease Jean Paul Thiery, Hervé Acloque, Ruby Yun‐Ju Huang et al. · Cell | Nov 2009 | 10,099 |
| 3 | Culture of Human Endothelial Cells Derived from Umbilical Veins. IDENTIFICATION BY MORPHOLOGIC AND IMMUNOLOGIC CRITERIA ERIC A. JAFFE, Ralph L. Nachman, Carl G. Becker et al. · Journal of Clinical Investigation | Nov 1973 | 6,923 |
| 4 | Abnormal blood vessel development and lethality in embryos lacking a single VEGF allele Peter Carmeliet, Valérie Ferreira, Georg Breier et al. · Nature | Apr 1996 | 4,163 |
| 5 | Failure of blood-island formation and vasculogenesis in Flk-1-deficient mice Fouad Shalaby, Janet Rossant, Terry P. Yamaguchi et al. · Nature | Jul 1995 | 3,971 |
| 6 | Twist, a Master Regulator of Morphogenesis, Plays an Essential Role in Tumor Metastasis Jing Lan Yang, Sendurai A. Mani, Joana Liu Donaher et al. · Cell | Jun 2004 | 3,886 |
| 7 | Vascular-specific growth factors and blood vessel formation George D. Yancopoulos, Samuel H. Davis, Nicholas W. Gale et al. · Nature | Sep 2000 | 3,706 |
| 8 | Heterozygous embryonic lethality induced by targeted inactivation of the VEGF gene Napoleone Ferrara, Karen Carver-Moore, Helen Chen et al. · Nature | Apr 1996 | 3,673 |
| 9 | Adult Cardiac Stem Cells Are Multipotent and Support Myocardial Regeneration Antonio Paolo Beltrami, Laura Barlucchi, Daniele Torella et al. · Cell | Sep 2003 | 3,553 |
| 10 | Molecular Regulation of Vascular Smooth Muscle Cell Differentiation in Development and Disease Gary K. Owens, Meena Suresh Kumar, Brian R. Wamhoff · Physiological Reviews | Jul 2004 | 3,526 |
| 11 | Bone Marrow Origin of Endothelial Progenitor Cells Responsible for Postnatal Vasculogenesis in Physiological and Pathological Neovascularization Takayuki Asahara, Haruchika Masuda, Tomono Takahashi et al. · Circulation Research | 6 Aug 1999 | 3,271 |
| 12 | Evidence for Cardiomyocyte Renewal in Humans Olaf Bergmann, Ratan D. Bhardwaj, Samuel Bernard et al. · Science | 2 Apr 2009 | 3,183 |
| 13 | Consensus Statement: Chromosomal Microarray Is a First-Tier Clinical Diagnostic Test for Individuals with Developmental Disabilities or Congenital Anomalies David T. Miller et al. · The American Journal of Human Genetics | May 2010 | 2,934 |
| 14 | Perfusion-decellularized matrix: using nature's platform to engineer a bioartificial heart Harald C. Ott, Thomas S. Matthiesen, Saik-Kia Goh et al. · Nature Medicine | 13 Jan 2008 | 2,656 |
| 15 | Transient Regenerative Potential of the Neonatal Mouse Heart Enzo R. Porrello, Ahmed I. Mahmoud, Emma Simpson et al. · Science | 24 Feb 2011 | 2,649 |
| 16 | The human endothelin family: three structurally and pharmacologically distinct isopeptides predicted by three separate genes. Akiko Inoue, Masashi Yanagisawa, Sadao Kimura et al. · Proceedings of the National Academy of Sciences | Apr 1989 | 2,536 |
| 17 | Large-Scale Exome Sequencing Study Implicates Both Developmental and Functional Changes in the Neurobiology of Autism F. Kyle Satterstrom et al. · Cell | 23 Jan 2020 | 2,534 |
| 18 | Direct Reprogramming of Fibroblasts into Functional Cardiomyocytes by Defined Factors Masaki Ieda, Ji‐Dong Fu, Paul Delgado-Olguı́n et al. · Cell | Aug 2010 | 2,491 |
| 19 | Limb proportions show developmental plasticity in response to embryo movement Andrea S. Pollard, Bethany Charlton, John R. Hutchinson et al. · Scientific Reports | 6 Feb 2017 | 2,393 |
| 20 | Number and Migratory Activity of Circulating Endothelial Progenitor Cells Inversely Correlate With Risk Factors for Coronary Artery Disease Mariuca Vasa, Stephan Fichtlscherer, Alexandra Aicher et al. · Circulation Research | 6 Jul 2001 | 2,333 |
| 21 | Expression of VEGFR-2 and AC133 by circulating human CD34+ cells identifies a population of functional endothelial precursors Mario Peichev, Afzal Jamal Naiyer, Daniel Peixoto Pereira et al. · Blood | Feb 2000 | 2,280 |
| 22 | 22q11.2 deletion syndrome Donna M. McDonald‐McGinn, Kathleen E. Sullivan, Bruno Marino et al. · Nature Reviews Disease Primers | 18 Nov 2015 | 2,278 |
| 23 | Human Mesenchymal Stem Cells Differentiate to a Cardiomyocyte Phenotype in the Adult Murine Heart Catalin Toma, Mark F. Pittenger, Kevin S. Cahill et al. · Circulation | 2002 | 2,250 |
| 24 | Endothelial-to-mesenchymal transition contributes to cardiac fibrosis Elisabeth Maria Zeisberg, Oleg Tarnavski, Michael Zeisberg et al. · Nature Medicine | 29 Jul 2007 | 2,242 |
| 25 | Cardiomyocytes derived from human embryonic stem cells in pro-survival factors enhance function of infarcted rat hearts Michael A. Laflamme, Kent Y Chen, Anna V. Naumova et al. · Nature Biotechnology | 26 Aug 2007 | 2,229 |
| 26 | Transplantation of Progenitor Cells and Regeneration Enhancement in Acute Myocardial Infarction (TOPCARE-AMI) Birgit Aßmus, Volker Schächinger, Claudius Teupe et al. · Circulation | 10 Dec 2002 | 2,210 |
| 27 | Haematopoietic stem cells do not transdifferentiate into cardiac myocytes in myocardial infarcts Charles E. Murry, Mark H. Soonpaa, Hans Reinecke et al. · Nature | 21 Mar 2004 | 2,159 |
| 28 | DECIPHER: Database of Chromosomal Imbalance and Phenotype in Humans Using Ensembl Resources Helen V. Firth, Shola M. Richards, A. Paul Bevan et al. · The American Journal of Human Genetics | Apr 2009 | 2,115 |
| 29 | Functional impact of global rare copy number variation in autism spectrum disorders Dalila Pinto et al. · Nature | 8 Jun 2010 | 2,073 |
| 30 | Double muscling in cattle due to mutations in the myostatin gene Alexandra C. McPherron, Se‐Jin Lee · Proceedings of the National Academy of Sciences | 11 Nov 1997 | 2,065 |
| 31 | New approach for understanding genome variations in KEGG Minoru I. Kanehisa, Yoko Sato, Miho Furumichi et al. · Nucleic Acids Research | 5 Oct 2018 | 2,061 |
| 32 | Heart Regeneration in Zebrafish Kenneth D. Poss, Lindsay G. Wilson, Mark T. Keating · Science | 12 Dec 2002 | 1,984 |
| 33 | Regeneration of ischemic cardiac muscle and vascular endothelium by adult stem cells Kathyjo A. Jackson, Susan M. Majka, Hongyu Wang et al. · Journal of Clinical Investigation | Jun 2001 | 1,972 |
| 34 | 22q11.21 Deletion Syndromes: A Review of Proximal, Central, and Distal Deletions and Their Associated Features Rachel D. Burnside · Cytogenetic and Genome Research | 2015 | 1,968 |
| 35 | High affinity VEGF binding and developmental expression suggest Flk-1 as a major regulator of vasculogenesis and angiogenesis Birgit Millauer, Susanne Wizigmann-Voos, Harald Schnürch et al. · Cell | Mar 1993 | 1,957 |
| 36 | Intravenous hMSCs Improve Myocardial Infarction in Mice because Cells Embolized in Lung Are Activated to Secrete the Anti-inflammatory Protein TSG-6 Ryang Hwa Lee, Andrey A. Pulin, Min Jeong Seo et al. · Cell stem cell | Jul 2009 | 1,955 |
| 37 | Production of pancreatic hormone–expressing endocrine cells from human embryonic stem cells Kevin A. D’Amour, Anne G. Bang, Susan Eliazer et al. · Nature Biotechnology | 19 Oct 2006 | 1,932 |
| 38 | Cardiomyocytes can be generated from marrow stromal cells in vitro Shinji Makino, Keiichi Fukuda, Shunichirou Miyoshi et al. · Journal of Clinical Investigation | Mar 1999 | 1,889 |
| 39 | Advances in autism genetics: on the threshold of a new neurobiology Brett S. Abrahams, Daniel H. Geschwind · Nature Reviews Genetics | 15 Apr 2008 | 1,878 |
| 40 | Directed cardiomyocyte differentiation from human pluripotent stem cells by modulating Wnt/β-catenin signaling under fully defined conditions Xiaojun Lance Lian, Jianhua Zhang, Samira Michelle Azarin et al. · Nature Protocols | 20 Dec 2012 | 1,866 |
| 41 | Transplantation of ex vivo expanded endothelial progenitor cells for therapeutic neovascularization Christoph Kalka, Haruchika Masuda, Tomono Takahashi et al. · Proceedings of the National Academy of Sciences | 21 Mar 2000 | 1,865 |
| 42 | Mutations of the X-linked genes encoding neuroligins NLGN3 and NLGN4 are associated with autism Stéphane Jamain, Hélène Quach, Catalina Betancur et al. · Nature Genetics | 31 Mar 2003 | 1,864 |
| 43 | VEGF contributes to postnatal neovascularization by mobilizing bone marrow‐derived endothelial progenitor cells Takayuki Asahara, Tomono Takahashi, Haruchika Masuda et al. · The EMBO Journal | 15 Jul 1999 | 1,856 |
| 44 | Cells of the adult human heart Monika Litviňuková et al. · Nature | 24 Sep 2020 | 1,845 |
| 45 | Bone morphogenetic protein-4 is required for mesoderm formation and patterning in the mouse. Glenn E. Winnier, M Blessing, Patricia Ann Labosky et al. · Genes & Development | Sep 1995 | 1,807 |
| 46 | Losartan, an AT1 Antagonist, Prevents Aortic Aneurysm in a Mouse Model of Marfan Syndrome Jennifer Pardo Habashi, Daniel Philip Judge, Tammy M. Holm et al. · Science | 6 Apr 2006 | 1,806 |
| 47 | Large recurrent microdeletions associated with schizophrenia GROUP et al. · Nature | 30 Jul 2008 | 1,787 |
| 48 | Efficient differentiation of human embryonic stem cells to definitive endoderm Kevin A. D’Amour, Alan D. Agulnick, Susan Eliazer et al. · Nature Biotechnology | 28 Oct 2005 | 1,771 |
| 49 | Cardiac progenitor cells from adult myocardium: Homing, differentiation, and fusion after infarction Hidemasa Oh, Steven B. Bradfute, Teresa D. Gallardo et al. · Proceedings of the National Academy of Sciences | 6 Oct 2003 | 1,759 |
| 50 | Differentiation of Embryonic Stem Cells to Clinically Relevant Populations: Lessons from Embryonic Development Charles E. Murry, Gordon M. Keller · Cell | Feb 2008 | 1,750 |
Citations are OpenAlex's own counts, from its 2026-09-23 snapshot, so the ranking can differ from Google Scholar or Web of Science. A paper is listed for a field when OpenAlex files it under one of the field's topics; retracted papers and papers whose citation count cannot be traced to citing works are left out, and a preprint and the article it became are shown once. Release dates are OpenAlex's: where a source gave only a month or a year, that is what is shown. How the lists are chosen.