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Topic · Molecular Biology

Congenital heart defects research

Congenital heart defects research is a research topic within Molecular Biology. Science Explorer counts 29k research works in it since 1950. 9.9% of them reached the world's top 10% most cited for their field and year.

This cluster of papers explores the molecular mechanisms underlying cardiac development, regeneration, and congenital heart defects. It covers topics such as cardiomyocyte renewal, cardiac progenitor populations, endothelial cell-lineage analysis, neural crest contributions, epicardial progenitors, Wnt signaling, T-box genes, and the potential of microRNA therapy for cardiac regeneration.

  • Cardiomyocyte Renewal
  • Heart Regeneration
  • Cardiac Progenitor Population
  • Congenital Heart Defects
  • Endothelial Cell-Lineage Analysis
  • Neural Crest
  • Epicardial Progenitors
  • Wnt Signaling
  • T-Box Genes
  • MicroRNA Therapy
Research works
29k
fractional, since 1950
In the world top 10%
2.9k
per year above
Top-10% rate
9.9%
share of its works in the world top 10%
Growth, 2018-21 → 2022-25
+6%
the tick is no change
Largest producer
United States
37% of the 10 largest, 2022-now
Congenital heart defects research

Which countries lead Congenital heart defects research research?

By volume, the United States and China publish the most (1.5k and 1k works in 2022-now).

By volume, 2022-now

  1. 1 United States 1.5k works
  2. 2 China 1k works
  3. 3 United Kingdom 250 works
  4. 4 Germany 245 works
  5. 5 Japan 236 works
  6. 6 Italy 188 works
  7. 7 India 179 works
  8. 8 France 148 works
  9. 9 Canada 147 works
  10. 10 Spain 124 works

How concentrated that is

The same countries as shares of everything the list above accounts for. A node where two countries do two thirds of the work and one spread evenly across twelve read alike as a ranking and not at all alike here.

United States: 37.4%China: 25.1%United Kingdom: 6.2%Germany: 6.1%6 others listed: 25.3%37%largest
United States1,512 · 37.4%China1,014 · 25.1%United Kingdom250 · 6.2%Germany245 · 6.1%6 others listed1,022 · 25.3%

Shares of the rows listed above, not of the whole node.

Which institutions lead Congenital heart defects research research?

By volume in 2022-now, Harvard University publishes the most Congenital heart defects research research, followed by Shanghai Jiao Tong University and University of Toronto.

By volume, 2022-now

  1. 1 Harvard UniversityUnited States 78 works
  2. 2 Shanghai Jiao Tong UniversityChina 42 works
  3. 3 University of TorontoCanada 39 works
  4. 4 InsermFrance 35 works
  5. 5 Chinese Academy of Medical Sciences & Peking Union Medical CollegeChina 34 works
  6. 6 Centre National de la Recherche ScientifiqueFrance 33 works
  7. 7 University of North Carolina at Chapel HillUnited States 32 works
  8. 8 Stanford UniversityUnited States 31 works
  9. 9 The Ohio State UniversityUnited States 30 works
  10. 10 Baylor College of MedicineUnited States 30 works

Who are the leading researchers in Congenital heart defects research?

The most-cited researchers publishing on Congenital heart defects research include Eric S. Lander, George Davey Smith and Richard M. Durbin.

  1. 1 Eric S. Lander United States 524k citations
  2. 2 George Davey Smith United Kingdom 435k citations
  3. 3 Richard M. Durbin United Kingdom 410k citations
  4. 4 Mark J. Daly United States 403k citations
  5. 5 Stacey L. Gabriel United States 402k citations
  6. 6 Robert John Tibshirani United States 396k citations
  7. 7 John J.V. McMurray United Kingdom 349k citations
  8. 8 Elaine R. Mardis United States 346k citations
  9. 9 Emelia J. Benjamin United States 341k citations
  10. 10 Jun Wang China 340k citations

Ranked by citations received across their whole record, among researchers with at least three works on this topic.

What are the most cited papers in Congenital heart defects research?

The most cited paper in Congenital heart defects research is "Stages of embryonic development of the zebrafish" (Charles B. Kimmel, William Whitney Ballard, Seth R. Kimmel et al., 1995), with 12,479 citations. Next come "Epithelial-Mesenchymal Transitions in Development and Disease" (10,099) and "Culture of Human Endothelial Cells Derived from Umbilical Veins. IDENTIFICATION BY MORPHOLOGIC AND IMMUNOLOGIC CRITERIA" (6,923).

Most cited papers
#PaperReleasedCitations
1 Stages of embryonic development of the zebrafish Charles B. Kimmel, William Whitney Ballard, Seth R. Kimmel et al. · Developmental Dynamics Jul 1995 12,479
2 Epithelial-Mesenchymal Transitions in Development and Disease Jean Paul Thiery, Hervé Acloque, Ruby Yun‐Ju Huang et al. · Cell Open access Nov 2009 10,099
3 Culture of Human Endothelial Cells Derived from Umbilical Veins. IDENTIFICATION BY MORPHOLOGIC AND IMMUNOLOGIC CRITERIA ERIC A. JAFFE, Ralph L. Nachman, Carl G. Becker et al. · Journal of Clinical Investigation Open access Nov 1973 6,923
4 Abnormal blood vessel development and lethality in embryos lacking a single VEGF allele Peter Carmeliet, Valérie Ferreira, Georg Breier et al. · Nature Apr 1996 4,163
5 Failure of blood-island formation and vasculogenesis in Flk-1-deficient mice Fouad Shalaby, Janet Rossant, Terry P. Yamaguchi et al. · Nature Jul 1995 3,971
All 100 most cited papers, with filters and sorting

Where is Congenital heart defects research research done?

The largest centres of Congenital heart defects research research in 2022-now are Beijing (China), Shanghai (China), London (United Kingdom) and Guangzhou (China). Among places with at least 20 works in it, it is an unusually large share of all research in Cincinnati and Philadelphia.

Largest cities, 2022-now

  1. 1 BeijingChina 149 works
  2. 2 ShanghaiChina 124 works
  3. 3 LondonUnited Kingdom 95 works
  4. 4 GuangzhouChina 75 works
  5. 5 ParisFrance 71 works
  6. 6 PhiladelphiaUnited States 66 works
  7. 7 BostonUnited States 64 works
  8. 8 TokyoJapan 63 works
  9. 9 New YorkUnited States 62 works
  10. 10 HoustonUnited States 55 works

Where it is the local speciality

  1. CincinnatiUS · 29.1 works7.2×
  2. PhiladelphiaUS · 66.2 works4.9×
← less than its size predicts1×more →

Location quotient: how much more of its research is in Congenital heart defects research than the world average.

See Congenital heart defects research on the map

Where is the best place to study Congenital heart defects research?

Among universities, judged by research, Harvard University, Karolinska Institutet and Stanford University score highest, combining excellence, specialisation, size, growth and international reach. Research strength is one signal when choosing where to study; it does not measure teaching.

0%10%20%mean 16.72%fractional works in this field (log) →share of work in the world top 10% →Maastricht UniversityKarolinska InstitutetHarvard UniversityStanford University
above the meannear itbelow it

One dot per university in the first ten of the table below, at the default weights. The upper left is the interesting corner: small places doing unusually strong work.

Excellenceshare of its work in the world top 10%, 2022-now and all time averaged
40%
Specialisationhow much of its work is in this field, counted up to 10× the world share
10%
Sizeits output in this field, on a log scale
30%
Growthoutput growth, counted from -20% to +20%
10%
Internationalshare of its work with a co-author abroad
10%
Each slider sets a weight; the share it gets of the score is beside it.
#UniversityScoreTop 10%SpecialisationWorksGrowth
1Harvard UniversityUnited States 86.518.1%5.4×78 -3.9%
2Karolinska InstitutetSweden 69.623.0%5.4×14 +3.4%
3Stanford UniversityUnited States 64.415.5%4.5×31 -1.7%
4Maastricht UniversityNetherlands 63.923.8%5.9×11 +18.6%
5University of TorontoCanada 63.411.3%4.2×39 -3.3%
6Chinese Academy of Medical Sciences & Peking Union Medical CollegeChina 62.814.9%7.1×34 +61.8%
7Peking UniversityChina 60.117.2%2.4×23 +107.8%
8University of CincinnatiUnited States 60.014.0%10.3×28 -8.2%
9University of California San DiegoUnited States 58.914.8%3.8×17 +23.5%
10University of PennsylvaniaUnited States 58.414.6%5.1×25 -6.7%

Universities only. The score blends excellence (40%), size (30%), specialisation (10%), growth (10%), international reach (10%), 2022-now; growth compares 2018-21 with 2022-25 and counts up to +20%, since a jump from a small base is mostly noise.

Every institution in Congenital heart defects research, country by country

Is Congenital heart defects research research growing?

Output in 2022-2025 was 6% higher than in 2018-2021, peaking in 2025. The fastest-growing topics are Congenital heart defects research.

still counting19801990200020102020
grewheldshrank

The same series as a ribbon: one cell per year, darker for more. The line above answers how much; this answers when.

Its share of all research

Growing output can still be a shrinking share: all of science grows. This is Congenital heart defects research as a percentage of every work published that year, 0.020% in 2024.

still counting0.020%0.040%0.060%Congenital heart defects research0.022% in 202519801990200020102020

Fractional works of Congenital heart defects research over all fractional works that year. How the balance of science has shifted.

How much of it reaches the world top 10%

Year by year.

still counting5%10%15%Congenital heart defects research10.0% in 2025200020102020

Of each year's works in it, the share that reached the world's 10% most cited for their field and year. A field is the world for its own topics, so there is no other line to hold it against.

Which topics inside it are moving

Growth and decline on one axis around a shared zero. Two lists side by side hide the thing that matters: whether the growth dwarfs the decline, or the other way round.

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