Most cited papers in Cyclization and Aryne Chemistry

Cyclization and Aryne Chemistry

What are the most cited papers in Cyclization and Aryne Chemistry?

The most cited paper in Cyclization and Aryne Chemistry is "Estimation of synthetic accessibility score of drug-like molecules based on molecular complexity and fragment contributions" (Peter F. Ertl, Ansgar Schuffenhauer, 2009), with 2,053 citations. Next come "Analyzing Reaction Rates with the Distortion/Interaction‐Activation Strain Model" (1,744) and "Chemistry and Biology of the Enediyne Anticancer Antibiotics" (988).

Published TypeAccessCitations

Showing 50 of 100 papers. Every paper with more than 178 citations is listed.

Most cited papers, sortable by citations and release date
#	Paper
1	Estimation of synthetic accessibility score of drug-like molecules based on molecular complexity and fragment contributions Peter F. Ertl, Ansgar Schuffenhauer · Journal of Cheminformatics Open access	10 Jun 2009	2,053
2	Analyzing Reaction Rates with the Distortion/Interaction‐Activation Strain Model F. Matthias Bickelhaupt, Kendall N. Houk · Angewandte Chemie International Edition Open access	26 Apr 2017	1,744
3	Chemistry and Biology of the Enediyne Anticancer Antibiotics K. C. Nicolaou, Wei‐Min Dai · Angewandte Chemie International Edition in English	Nov 1991	988
4	Synthesis and Properties of Allenic Natural Products and Pharmaceuticals Anja Hoffmann‐Röder, Norbert Krause · Angewandte Chemie International Edition	25 Feb 2004	967
5	FLUORIDE-INDUCED 1,2-ELIMINATION OF O -TRIMETHYLSILYLPHENYL TRIFLATE TO BENZYNE UNDER MILD CONDITIONS Yoshio Himeshima, Takaaki Sonoda, Hiroshi Kobayashi · Chemistry Letters	Aug 1983	942
6	A Comprehensive History of Arynes in Natural Product Total Synthesis Pamela M. Tadross, Brian M. Stoltz · Chemical Reviews Review	23 Mar 2012	877
7	Aromaticity as a Cornerstone of Heterocyclic Chemistry Alexandrù T. Balaban, Daniela Carmen Oniciu, ALAN ROY KATRITZKY · Chemical Reviews Review	17 Apr 2004	812
8	Transition Metal Catalyzed Cycloisomerizations of 1, n -Allenynes and -Allenenes Corinne Aubert, Louis Fensterbank, Pierre Simon Garcia et al. · Chemical Reviews Review	9 Mar 2011	649
9	Recent advances in transition-metal-free carbon–carbon and carbon–heteroatom bond-forming reactions using arynes Anup Bhunia, Santhivardhana Reddy Yetra, Akkattu T. Biju · Chemical Society Reviews Review	2012	644
10	One Century of Aryne Chemistry Hans Henning Wenk, Michael A. Winkler, Wolfram Sander · Angewandte Chemie International Edition	30 Jan 2003	630
11	Transition Structures of Hydrocarbon Pericyclic Reactions Kendall N. Houk, Yi Li, Jeffrey D. Evanseck · Angewandte Chemie International Edition in English	Jun 1992	598
12	Antitumor Antibiotics: Bleomycin, Enediynes, and Mitomycin Ute Galm, Martin H. Hager, Steven G. Van Lanen et al. · Chemical Reviews Review	21 Jan 2005	558
13	The use of arynes in organic synthesis Hélène Pellissier, Maurice Santelli · Tetrahedron	Feb 2003	543
14	DNA‐Templated Organic Synthesis: Nature's Strategy for Controlling Chemical Reactivity Applied to Synthetic Molecules Xiaoyu Li, David R. Liu · Angewandte Chemie International Edition	16 Sep 2004	537
15	The Taming of Cyclobutadiene Donald J. Cram, Martin E. Tanner, Robert G. Thomas · Angewandte Chemie International Edition in English	Aug 1991	525
16	Arynes and Cyclohexyne in Natural Product Synthesis Christian M. Gampe, Erick M. Carreira · Angewandte Chemie International Edition	15 Mar 2012	520
17	Molecular Rods. 1. Simple Axial Rods Peter F. H. Schwab, Michael David Levin, Josef Michl · Chemical Reviews Review	Jul 1999	511
18	Use of benzynes for the synthesis of heterocycles Anton V. Dubrovskiy, Nataliya A. Markina, Richard C. Larock · Organic & Biomolecular Chemistry	7 Nov 2012	463
19	Synthetic applications of furan Diels-Alder chemistry Christian Oliver Kappe, S. Shaun Murphree, Albert Padwa · Tetrahedron	Oct 1997	446
20	The hexadehydro-Diels–Alder reaction Thomas R. Hoye, Beeraiah Baire, Dawen Niu et al. · Nature Open access	9 Oct 2012	433
21	DNA damage and mutagenesis by radiomimetic DNA-cleaving agents: bleomycin, neocarzinostatin and other enediynes Lawrence F. Povirk · Mutation research. Fundamental and molecular mechanisms of mutagenesis	Aug 1996	431
22	o -Silylaryl Triflates: A Journey of Kobayashi Aryne Precursors Jiarong Shi, Lianggui Li, Yang Li · Chemical Reviews Review	18 Feb 2021	425
23	The chemistry of enediynes, enyne allenes and related compounds Janet Wisniewski Grissom, Gamini U. Gunawardena, Detlef Klingberg et al. · Tetrahedron	May 1996	405
24	BI 6727, A Polo-like Kinase Inhibitor with Improved Pharmacokinetic Profile and Broad Antitumor Activity Dorothea Rudolph, Martin Steegmaier, Matthias Hoffmann et al. · Clinical Cancer Research Open access	21 Apr 2009	399
25	Rhodium-Catalyzed Enantioselective Synthesis, Crystal Structures, and Photophysical Properties of Helically Chiral 1,1′-Bitriphenylenes Yayoi Sawada, Seiichi Furumi, Atsuro Takai et al. · Journal of the American Chemical Society	16 Feb 2012	397
26	The Dehydro-Diels−Alder Reaction Pablo Wessig, Gunnar Müller · Chemical Reviews Review	15 May 2008	379
27	The Enediyne Antibiotics Adrian Lloyd Smith, Kyriacos Costa Nicolaou · Journal of Medicinal Chemistry	1996	373
28	The Emergence of Allenamides in Organic Synthesis Lin‐Li Wei, Hui Xiong, Richard P. Hsung · Accounts of Chemical Research	7 Aug 2003	363
29	Toward a More Complete Understanding of Noncovalent Interactions Involving Aromatic Rings Steven E. Wheeler, Jacob W. G. Bloom · The Journal of Physical Chemistry A Open access	17 Jun 2014	351
30	The Role of Aryne Distortions, Steric Effects, and Charges in Regioselectivities of Aryne Reactions Jose M. Medina, Joel L. Mackey, Neil K. Garg et al. · Journal of the American Chemical Society Open access	10 Oct 2014	344
31	The Direct Acyl-Alkylation of Arynes Uttam K. Tambar, Brian M. Stoltz · Journal of the American Chemical Society	26 Mar 2005	338
32	Trends in the Diels–Alder reaction in polymer chemistry Benoît Briou, Bruno M. Ameduri, Bernard Boutevin · Chemical Society Reviews ReviewOpen access	2021	329
33	Designed Enediynes: A New Class of DNA-Cleaving Molecules with Potent and Selective Anticancer Activity Kyriacos Costa Nicolaou, Wei‐Min Dai, S.‐C. TSAY et al. · Science	22 May 1992	329
34	The structure of neocarzinostatin chromophore possessing a novel bicyclo-[7,3,0]dodecadiyne system Kiyoto Edo, Michinao Mizugaki, Yoshio Koide et al. · Tetrahedron Letters	1985	327
35	Ultraviolet Photoelectron Spectroscopy of the o-, m-, and p-Benzyne Negative Ions. Electron Affinities and Singlet−Triplet Splittings for o-, m-, and p-Benzyne Paul G. Wenthold, Robert R. Squires, W. C. Lineberger · Journal of the American Chemical Society	15 May 1998	321
36	Inside Cover: [16]Cloverphene: a Clover‐Shaped cata‐Condensed Nanographene with Sixteen Fused Benzene Rings (Angew. Chem. Int. Ed. 1/2012) Jose Miguel Alonso, Alba E. Díaz‐Álvarez, Alejandro Criado et al. · Angewandte Chemie International Edition	15 Nov 2011	318
37	RECENT APPLICATIONS OF ARYNE CHEMISTRY TO ORGANIC SYNTHESIS. A REVIEW Roberto Sanz · Organic Preparations and Procedures International	Jun 2008	315
38	Cascade Radical Cyclizations via Biradicals Generated from Enediynes, Enyne-Allenes, and Enyne-Ketenes Kung K. Wang · Chemical Reviews Review	1996	313
39	Palladium‐Catalyzed Annulation of Acyloximes with Arynes (or Alkynes): Synthesis of Phenanthridines and Isoquinolines Thibaud Gerfaud, Luc Neuville, Jieping Zhu · Angewandte Chemie International Edition Open access	9 Dec 2008	308
40	Indeno[1,2‐b]fluorenes: Fully Conjugated Antiaromatic Analogues of Acenes Daniel T. Chase, Bradley D. Rose, Sean P. McClintock et al. · Angewandte Chemie International Edition	22 Dec 2010	307
41	Employing Arynes in Diels–Alder Reactions and Transition-Metal-Free Multicomponent Coupling and Arylation Reactions Sachin Suresh Bhojgude, Anup Bhunia, Akkattu T. Biju · Accounts of Chemical Research	25 Aug 2016	304
42	All-Carbon Molecules: Evidence for the Generation of Cyclo[18]carbon from a Stable Organic Precursor François Diederich, Yves F. Rubin, Carolyn B. Knobler et al. · Science	8 Sep 1989	302
43	Efficient Palladium-Catalyzed Cyclotrimerization of Arynes: Synthesis of Triphenylenes Diego Peña, Sonia Escudero, Dolores Pérez et al. · Angewandte Chemie International Edition	16 Oct 1998	298
44	Aryne-based strategy in the total synthesis of naturally occurring polycyclic compounds Hiroshi Takikawa, Arata Nishii, Takahiro Sakai et al. · Chemical Society Reviews Review	2018	297
45	Synthesis of biaryls using aryne intermediates José-Antonio Garcı́a-López, Michael F. Greaney · Chemical Society Reviews Review	2016	297
46	Uncovering the Neglected Similarities of Arynes and Donor–Acceptor Cyclopropanes Daniel Bodo Werz, Akkattu T. Biju · Angewandte Chemie International Edition Open access	17 Sep 2019	296
47	Aryne Cycloaddition Reactions in the Synthesis of Large Polycyclic Aromatic Compounds Dolores Pérez, Diego Peña, Enrique Guitián · European Journal of Organic Chemistry	4 Jul 2013	284
48	PtIV-Catalyzed Cyclization of Arene−Alkyne Substrates via Intramolecular Electrophilic Hydroarylation Stefan J. Pastine, So Won Youn, Dalibor Sameš · Organic Letters	11 Mar 2003	275
49	Benzyne Click Chemistry: Synthesis of Benzotriazoles from Benzynes and Azides Feng Shi, Jesse P. Waldo, Yu April Chen et al. · Organic Letters Open access	14 May 2008	272
50	Aryne cycloaddition: highly efficient chemical modification of graphene Xing Zhong, Jun Eon Jin, Shuwen Li et al. · Chemical Communications Open access	2010	263

Citations are OpenAlex's own counts, from its 2026-09-23 snapshot, so the ranking can differ from Google Scholar or Web of Science. A paper is listed for a field when OpenAlex files it under one of the field's topics; retracted papers and papers whose citation count cannot be traced to citing works are left out, and a preprint and the article it became are shown once. Release dates are OpenAlex's: where a source gave only a month or a year, that is what is shown. How the lists are chosen.