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Topic · Organic Chemistry

Cyclization and Aryne Chemistry

Cyclization and Aryne Chemistry is a research topic within Organic Chemistry. Science Explorer counts 3k research works in it since 1952. 10.0% of them reached the world's top 10% most cited for their field and year.

This cluster of papers explores the advances in aryne chemistry and its applications in organic synthesis, including transition-metal-free reactions, natural product total synthesis, multicomponent coupling, and the use of arynes in Diels–Alder reactions. The research also delves into the synthesis of heterocycles, regioselectivities of aryne reactions, and the role of arynes in the construction of polycyclic aromatic compounds.

  • Arynes
  • Organic Synthesis
  • Transition-Metal-Free Reactions
  • Natural Product Total Synthesis
  • Multicomponent Coupling
  • Diels–Alder Reactions
  • Benzynes
  • Heterocycles
  • Regioselectivities
  • Polycyclic Aromatic Compounds
Research works
3k
fractional, since 1952
In the world top 10%
304
per year above
Top-10% rate
10.0%
share of its works in the world top 10%
Growth, 2018-21 → 2022-25
-1%
the tick is no change
Largest producer
China
26% of the 10 largest, 2022-now
Cyclization and Aryne Chemistry

Which countries lead Cyclization and Aryne Chemistry research?

By volume, China and the United States publish the most (69 and 64 works in 2022-now).

By volume, 2022-now

  1. 1 China 69 works
  2. 2 United States 64 works
  3. 3 Japan 37 works
  4. 4 India 30 works
  5. 5 Germany 16 works
  6. 6 Russia 14 works
  7. 7 France 13 works
  8. 8 United Kingdom 8 works
  9. 9 Spain 6 works
  10. 10 Canada 5 works

How concentrated that is

The same countries as shares of everything the list above accounts for. A node where two countries do two thirds of the work and one spread evenly across twelve read alike as a ranking and not at all alike here.

China: 26.5%United States: 24.5%Japan: 14.0%India: 11.6%6 others listed: 23.4%26%largest
China69 · 26.5%United States64 · 24.5%Japan37 · 14.0%India30 · 11.6%6 others listed61 · 23.4%

Shares of the rows listed above, not of the whole node.

Which institutions lead Cyclization and Aryne Chemistry research?

By volume in 2022-now, University of Minnesota publishes the most Cyclization and Aryne Chemistry research, followed by Russian Academy of Sciences and Tokyo University of Science.

By volume, 2022-now

  1. 1 University of MinnesotaUnited States 9 works
  2. 2 Russian Academy of SciencesRussia 7 works
  3. 3 Tokyo University of ScienceJapan 7 works
  4. 4 Centre National de la Recherche ScientifiqueFrance 6 works
  5. 5 University of California, Los AngelesUnited States 6 works
  6. 6 East China University of Science and TechnologyChina 5 works
  7. 7 Council of Scientific and Industrial ResearchIndia 5 works
  8. 8 Chinese Academy of SciencesChina 4 works
  9. 9 Academy of Scientific and Innovative ResearchIndia 3 works
  10. 10 Kyoto UniversityJapan 3 works

Who are the leading researchers in Cyclization and Aryne Chemistry?

The most-cited researchers publishing on Cyclization and Aryne Chemistry include Ben Zhong Tang, John Anthony Pople and Kläus Müllen.

  1. 1 Ben Zhong Tang China 261k citations
  2. 2 John Anthony Pople United States 202k citations
  3. 3 Kläus Müllen Germany 182k citations
  4. 4 Stuart L. Schreiber United States 136k citations
  5. 5 William L. Jorgensen United States 132k citations
  6. 6 James M. Tour United States 127k citations
  7. 7 Kendall N. Houk United States 123k citations
  8. 8 Jing Li United States 120k citations
  9. 9 Jacky W. Y. Lam China 117k citations

Ranked by citations received across their whole record, among researchers with at least three works on this topic.

What are the most cited papers in Cyclization and Aryne Chemistry?

The most cited paper in Cyclization and Aryne Chemistry is "Estimation of synthetic accessibility score of drug-like molecules based on molecular complexity and fragment contributions" (Peter F. Ertl, Ansgar Schuffenhauer, 2009), with 2,053 citations. Next come "Analyzing Reaction Rates with the Distortion/Interaction‐Activation Strain Model" (1,744) and "Chemistry and Biology of the Enediyne Anticancer Antibiotics" (988).

Most cited papers
#PaperReleasedCitations
1 Estimation of synthetic accessibility score of drug-like molecules based on molecular complexity and fragment contributions Peter F. Ertl, Ansgar Schuffenhauer · Journal of Cheminformatics Open access 10 Jun 2009 2,053
2 Analyzing Reaction Rates with the Distortion/Interaction‐Activation Strain Model F. Matthias Bickelhaupt, Kendall N. Houk · Angewandte Chemie International Edition Open access 26 Apr 2017 1,744
3 Chemistry and Biology of the Enediyne Anticancer Antibiotics K. C. Nicolaou, Wei‐Min Dai · Angewandte Chemie International Edition in English Nov 1991 988
4 Synthesis and Properties of Allenic Natural Products and Pharmaceuticals Anja Hoffmann‐Röder, Norbert Krause · Angewandte Chemie International Edition 25 Feb 2004 967
5 FLUORIDE-INDUCED 1,2-ELIMINATION OF O -TRIMETHYLSILYLPHENYL TRIFLATE TO BENZYNE UNDER MILD CONDITIONS Yoshio Himeshima, Takaaki Sonoda, Hiroshi Kobayashi · Chemistry Letters Aug 1983 942
All 100 most cited papers, with filters and sorting

Where is Cyclization and Aryne Chemistry research done?

The largest centres of Cyclization and Aryne Chemistry research in 2022-now are Tokyo (Japan), Minneapolis (United States), Beijing (China) and Shanghai (China).

Largest cities, 2022-now

  1. 1 TokyoJapan 14 works
  2. 2 MinneapolisUnited States 11 works
  3. 3 BeijingChina 10 works
  4. 4 ShanghaiChina 9 works
  5. 5 Los AngelesUnited States 6 works
  6. 6 MoscowRussia 4 works
  7. 7 ParisFrance 4 works
  8. 8 ChongqingChina 4 works
  9. 9 NanjingChina 4 works
  10. 10 ZhengzhouChina 3 works
See Cyclization and Aryne Chemistry on the map

Where is the best place to study Cyclization and Aryne Chemistry?

Among universities, judged by research, University of Minnesota score highest, combining excellence, specialisation, size, growth and international reach. Research strength is one signal when choosing where to study; it does not measure teaching.

Excellenceshare of its work in the world top 10%, 2022-now and all time averaged
40%
Specialisationhow much of its work is in this field, counted up to 10× the world share
10%
Sizeits output in this field, on a log scale
30%
Growthoutput growth, counted from -20% to +20%
10%
Internationalshare of its work with a co-author abroad
10%
Each slider sets a weight; the share it gets of the score is beside it.
#UniversityScoreTop 10%SpecialisationWorksGrowth
1University of MinnesotaUnited States 2.214.3%46.5×9 -11.2%

Universities only. The score blends excellence (40%), size (30%), specialisation (10%), growth (10%), international reach (10%), 2022-now; growth compares 2018-21 with 2022-25 and counts up to +20%, since a jump from a small base is mostly noise.

Every institution in Cyclization and Aryne Chemistry, country by country

Is Cyclization and Aryne Chemistry research growing?

Output in 2022-2025 was 1% lower than in 2018-2021, peaking in 1996.

still counting19801990200020102020
grewheldshrank

The same series as a ribbon: one cell per year, darker for more. The line above answers how much; this answers when.

Its share of all research

Growing output can still be a shrinking share: all of science grows. This is Cyclization and Aryne Chemistry as a percentage of every work published that year, 0.00093% in 2024.

still counting0.0050%0.010%0.015%Cyclization and Aryne Chemistry0.0014% in 202519801990200020102020

Fractional works of Cyclization and Aryne Chemistry over all fractional works that year. How the balance of science has shifted.

How much of it reaches the world top 10%

Year by year.

still counting5%10%15%Cyclization and Aryne Chemistry9.6% in 2025200020102020

Of each year's works in it, the share that reached the world's 10% most cited for their field and year. A field is the world for its own topics, so there is no other line to hold it against.

Which topics inside it are moving

Growth and decline on one axis around a shared zero. Two lists side by side hide the thing that matters: whether the growth dwarfs the decline, or the other way round.

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