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Topic · Organic Chemistry

Catalytic C–H Functionalization Methods

Catalytic C–H Functionalization Methods is a research topic within Organic Chemistry. Science Explorer counts 50k research works in it since 1957. 9.7% of them reached the world's top 10% most cited for their field and year.

This cluster of papers focuses on the transition-metal-catalyzed functionalization of carbon-hydrogen (C–H) bonds, enabling the formation of carbon-carbon bonds, arylation, and synthesis of heterocycles. The research also explores applications in drug synthesis and oxidative coupling reactions.

  • Transition Metal Catalysis
  • C–H Activation
  • Carbon–Carbon Bond Formation
  • Arylation
  • Heterocycles
  • Drug Synthesis
  • Oxidative Coupling
  • Directed C–H Functionalization
  • Metal-Catalyzed Reactions
  • Biaryl Molecules
Research works
50k
fractional, since 1957
In the world top 10%
4.8k
per year above
Top-10% rate
9.7%
share of its works in the world top 10%
Growth, 2018-21 → 2022-25
+2%
the tick is no change
Largest producer
China
55% of the 10 largest, 2022-now
Catalytic C–H Functionalization Methods

Which countries lead Catalytic C–H Functionalization Methods research?

By volume, China and India publish the most (5.4k and 1.4k works in 2022-now).

By volume, 2022-now

  1. 1 China 5.4k works
  2. 2 India 1.4k works
  3. 3 United States 933 works
  4. 4 Japan 513 works
  5. 5 Germany 423 works
  6. 6 France 269 works
  7. 7 Russia 203 works
  8. 8 Spain 199 works
  9. 9 United Kingdom 189 works
  10. 10 South Korea 180 works

How concentrated that is

The same countries as shares of everything the list above accounts for. A node where two countries do two thirds of the work and one spread evenly across twelve read alike as a ranking and not at all alike here.

China: 55.3%India: 14.8%United States: 9.6%Japan: 5.3%6 others listed: 15.0%55%largest
China5,383 · 55.3%India1,436 · 14.8%United States933 · 9.6%Japan513 · 5.3%6 others listed1,462 · 15.0%

Shares of the rows listed above, not of the whole node.

Which institutions lead Catalytic C–H Functionalization Methods research?

By volume in 2022-now, Chinese Academy of Sciences publishes the most Catalytic C–H Functionalization Methods research, followed by Centre National de la Recherche Scientifique and Henan Normal University.

By volume, 2022-now

  1. 1 Chinese Academy of SciencesChina 417 works
  2. 2 Centre National de la Recherche ScientifiqueFrance 146 works
  3. 3 Henan Normal UniversityChina 129 works
  4. 4 Sichuan UniversityChina 116 works
  5. 5 Nankai UniversityChina 113 works
  6. 6 Council of Scientific and Industrial ResearchIndia 106 works
  7. 7 University of Chinese Academy of SciencesChina 98 works
  8. 8 Russian Academy of SciencesRussia 96 works
  9. 9 Academy of Scientific and Innovative ResearchIndia 86 works
  10. 10 Zhengzhou UniversityChina 85 works

Who are the leading researchers in Catalytic C–H Functionalization Methods?

The most-cited researchers publishing on Catalytic C–H Functionalization Methods include Michaël Grätzel, Matthias Ernzerhof and Wei Huang.

  1. 1 Michaël Grätzel Switzerland 458k citations
  2. 2 Matthias Ernzerhof Canada 276k citations
  3. 3 Wei Huang China 267k citations
  4. 4 Ben Zhong Tang China 261k citations
  5. 5 Stefan Grimme Germany 224k citations
  6. 6 Kai You Wang China 224k citations
  7. 7 George M. Sheldrick Germany 220k citations
  8. 8 Markus Antonietti Germany 185k citations
  9. 9 Qiang Zhang China 184k citations
  10. 10 William A. Goddard United States 182k citations

Ranked by citations received across their whole record, among researchers with at least three works on this topic.

What are the most cited papers in Catalytic C–H Functionalization Methods?

The most cited paper in Catalytic C–H Functionalization Methods is "Visible Light Photoredox Catalysis with Transition Metal Complexes: Applications in Organic Synthesis" (Christopher K. Prier, Danica A. Rankic, David W. C. MacMillan, 2013), with 9,625 citations. Next come "Palladium-Catalyzed Ligand-Directed C−H Functionalization Reactions" (6,127) and "Palladium(II)‐Catalyzed CH Activation/CC Cross‐Coupling Reactions: Versatility and Practicality" (4,122).

Most cited papers
#PaperReleasedCitations
1 Visible Light Photoredox Catalysis with Transition Metal Complexes: Applications in Organic Synthesis Christopher K. Prier, Danica A. Rankic, David W. C. MacMillan · Chemical Reviews ReviewOpen access 19 Mar 2013 9,625
2 Palladium-Catalyzed Ligand-Directed C−H Functionalization Reactions Thomas W. Lyons, Melanie Sarah Sanford · Chemical Reviews ReviewOpen access 15 Jan 2010 6,127
3 Palladium(II)‐Catalyzed CH Activation/CC Cross‐Coupling Reactions: Versatility and Practicality Xiao Chen, Keary M. Engle, Dong‐Hui Wang et al. · Angewandte Chemie International Edition Open access 25 Jun 2009 4,122
4 The Heck Reaction as a Sharpening Stone of Palladium Catalysis I. P. Beletskaya, Andrei V. Cheprakov · Chemical Reviews Review 21 Jul 2000 3,914
5 Catalytic Dehydrogenative Cross-Coupling: Forming Carbon−Carbon Bonds by Oxidizing Two Carbon−Hydrogen Bonds Charles See Yeung, Vy M. Dong · Chemical Reviews Review 9 Mar 2011 3,866
All 99 most cited papers, with filters and sorting

Where is Catalytic C–H Functionalization Methods research done?

The largest centres of Catalytic C–H Functionalization Methods research in 2022-now are Beijing (China), Shanghai (China), Nanjing (China) and Hangzhou (China). Among places with at least 20 works in it, it is an unusually large share of all research in Xinxiang, Mülheim and Huaibei.

Largest cities, 2022-now

  1. 1 BeijingChina 550 works
  2. 2 ShanghaiChina 431 works
  3. 3 NanjingChina 277 works
  4. 4 HangzhouChina 272 works
  5. 5 GuangzhouChina 248 works
  6. 6 ChengduChina 197 works
  7. 7 TianjinChina 186 works
  8. 8 WuhanChina 182 works
  9. 9 HefeiChina 145 works
  10. 10 XinxiangChina 140 works

Where it is the local speciality

  1. XinxiangCN · 140.3 works47×
  2. MülheimDE · 23.8 works44×
  3. HuaibeiCN · 20.5 works32×
  4. JiangmenCN · 20.0 works30×
  5. SantiniketanIN · 22.4 works26×
  6. TaizhouCN · 32.6 works22×
  7. GhaziabadIN · 86.9 works17×
  8. QufuCN · 31.1 works15×
← less than its size predicts1×more →

Location quotient: how much more of its research is in Catalytic C–H Functionalization Methods than the world average.

See Catalytic C–H Functionalization Methods on the map

Where is the best place to study Catalytic C–H Functionalization Methods?

Among universities, judged by research, Henan Normal University, Southern University of Science and Technology and Princeton University score highest, combining citation excellence, specialisation, size, growth and international reach. Research strength is one signal when choosing where to study; it does not measure teaching.

0%20%40%mean 26.46%fractional works in this field (log) →share of work in the world top 10% →Princeton UniversitySouthern University …Nankai UniversityHenan Normal Univers…
above the meannear itbelow it

One dot per university in the first ten of the table below, at the default weights. The upper left is the interesting corner: small places doing unusually strong work.

Citation excellenceshare of its work in the world top 10%, 2022-now and all time averaged
40%
Specialisationhow much of its work is in this field, counted up to 10× the world share
10%
Sizeits output in this field, on a log scale
30%
Growthoutput growth, counted from -20% to +20%
10%
Internationalshare of its work with a co-author abroad
10%
Each slider sets a weight; the share it gets of the score is beside it.
#UniversityScoreTop 10%SpecialisationWorksGrowth
1Henan Normal UniversityChina 65.418.9%70.2×129 +164.2%
2Southern University of Science and TechnologyChina 65.223.3%11.7×57 +22.6%
3Princeton UniversityUnited States 62.140.2%6.0×25 -6.7%
4Nankai UniversityChina 61.519.2%17.9×113 +7.5%
5The University of Texas at DallasUnited States 61.142.8%5.0×9 +75.5%
6Westlake UniversityChina 57.827.5%17.8×21 +581.9%
7University of MünsterGermany 57.631.4%10.0×40 -30.9%
8Central China Normal UniversityChina 57.226.1%14.4×34 +19.0%
9Sichuan UniversityChina 56.210.6%5.5×116 +24.9%
10Wuhan UniversityChina 55.924.6%4.6×60 +4.8%

Universities only. The score blends citation excellence (40%), size (30%), specialisation (10%), growth (10%), international reach (10%), 2022-now; growth compares 2018-21 with 2022-25 and counts up to +20%, since a jump from a small base is mostly noise.

Every institution in Catalytic C–H Functionalization Methods, country by country

Is Catalytic C–H Functionalization Methods research growing?

Output in 2022-2025 was 2% higher than in 2018-2021, peaking in 2015. The fastest-growing topics are Catalytic C–H Functionalization Methods.

still counting19801990200020102020
grewheldshrank

The same series as a ribbon: one cell per year, darker for more. The line above answers how much; this answers when.

Its share of all research

Growing output can still be a shrinking share: all of science grows. This is Catalytic C–H Functionalization Methods as a percentage of every work published that year, 0.042% in 2024.

still counting0.050%0.10%Catalytic C–H Functionalization Methods0.039% in 202519801990200020102020

Fractional works of Catalytic C–H Functionalization Methods over all fractional works that year. How the balance of science has shifted.

How much of it reaches the world top 10%

Year by year.

still counting5%10%15%Catalytic C–H Functionalization Methods9.6% in 2025200020102020

Of each year's works in it, the share that reached the world's 10% most cited for their field and year. A field is the world for its own topics, so there is no other line to hold it against.

Which topics inside it are moving

Growth and decline on one axis around a shared zero. Two lists side by side hide the thing that matters: whether the growth dwarfs the decline, or the other way round.

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