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Topic · Organic Chemistry

Chemical Reaction Mechanisms

Chemical Reaction Mechanisms is a research topic within Organic Chemistry. Science Explorer counts 27k research works in it since 1950. 9.9% of them reached the world's top 10% most cited for their field and year.

This cluster of papers explores nucleophilic reactivity in organic chemistry, covering topics such as nucleophilicity scales, acidity scales, phosphate hydrolysis mechanisms, enzymatic mechanisms, superbases for organic synthesis, electrophilicity parameters, aminolysis reactions, transition state analysis, hydride transfer reactions, and their applications in organic synthesis.

  • Nucleophilicity
  • Acidity Scales
  • Phosphate Hydrolysis
  • Enzymatic Mechanisms
  • Superbases
  • Electrophilicity
  • Aminolysis
  • Transition State Analysis
  • Hydride Transfer
  • Organic Synthesis
Research works
27k
fractional, since 1950
In the world top 10%
2.7k
per year above
Top-10% rate
9.9%
share of its works in the world top 10%
Growth, 2018-21 → 2022-25
-5%
the tick is no change
Largest producer
China
22% of the 10 largest, 2022-now
Chemical Reaction Mechanisms

Which countries lead Chemical Reaction Mechanisms research?

By volume, China and Russia publish the most (168 and 152 works in 2022-now).

By volume, 2022-now

  1. 1 China 168 works
  2. 2 Russia 152 works
  3. 3 United States 129 works
  4. 4 India 114 works
  5. 5 Germany 48 works
  6. 6 Poland 42 works
  7. 7 Japan 40 works
  8. 8 Türkiye 31 works
  9. 9 France 29 works
  10. 10 Spain 28 works

How concentrated that is

The same countries as shares of everything the list above accounts for. A node where two countries do two thirds of the work and one spread evenly across twelve read alike as a ranking and not at all alike here.

China: 21.5%Russia: 19.4%United States: 16.5%India: 14.6%6 others listed: 28.0%22%largest
China168 · 21.5%Russia152 · 19.4%United States129 · 16.5%India114 · 14.6%6 others listed218 · 28.0%

Shares of the rows listed above, not of the whole node.

Which institutions lead Chemical Reaction Mechanisms research?

By volume in 2022-now, Russian Academy of Sciences publishes the most Chemical Reaction Mechanisms research, followed by Centre National de la Recherche Scientifique and Chinese Academy of Sciences.

By volume, 2022-now

  1. 1 Russian Academy of SciencesRussia 72 works
  2. 2 Centre National de la Recherche ScientifiqueFrance 16 works
  3. 3 Chinese Academy of SciencesChina 8 works
  4. 4 Nanjing University of Science and TechnologyChina 8 works
  5. 5 Lomonosov Moscow State UniversityRussia 8 works
  6. 6 National Academy of Sciences of UkraineUkraine 8 works
  7. 7 Polish Academy of SciencesPoland 8 works
  8. 8 Beijing Institute of TechnologyChina 7 works
  9. 9 Islamic Azad University, TehranIran 7 works
  10. 10 Ludwig-Maximilians-Universität MünchenGermany 6 works

Who are the leading researchers in Chemical Reaction Mechanisms?

The most-cited researchers publishing on Chemical Reaction Mechanisms include Christopher J L Murray, Jeremy Grimshaw and George M. Whitesides.

  1. 1 Christopher J L Murray United States 583k citations
  2. 2 Jeremy Grimshaw Canada 281k citations
  3. 3 George M. Whitesides United States 267k citations
  4. 4 John C. Morris United States 241k citations
  5. 5 Donald G. Truhlar United States 230k citations
  6. 6 Stefan Grimme Germany 224k citations
  7. 7 Axel D. Becke Canada 222k citations
  8. 8 George M. Sheldrick Germany 220k citations
  9. 9 Ronald Klein United States 214k citations
  10. 10 John Anthony Pople United States 202k citations

Ranked by citations received across their whole record, among researchers with at least three works on this topic.

What are the most cited papers in Chemical Reaction Mechanisms?

The most cited paper in Chemical Reaction Mechanisms is "Conceptual Density Functional Theory" (Paul Geerlings, Frank De Proft, Wilfried Langenaeker, 2003), with 5,304 citations. Next come "PROPKA3: Consistent Treatment of Internal and Surface Residues in Empirical p K a Predictions" (4,654) and "Interactions with Aromatic Rings in Chemical and Biological Recognition" (3,543).

Most cited papers
#PaperReleasedCitations
1 Conceptual Density Functional Theory Paul Geerlings, Frank De Proft, Wilfried Langenaeker · Chemical Reviews Review 17 Apr 2003 5,304
2 PROPKA3: Consistent Treatment of Internal and Surface Residues in Empirical p K a Predictions Mats H. M. Olsson, Chresten R. Søndergaard, Michał Rostkowski et al. · Journal of Chemical Theory and Computation 6 Jan 2011 4,654
3 Interactions with Aromatic Rings in Chemical and Biological Recognition Emmanuel A. Meyer, Ronald K. Castellano, François Diederich · Angewandte Chemie International Edition 13 Mar 2003 3,543
4 Using redundant internal coordinates to optimize equilibrium geometries and transition states Chunyang Peng, Philippe Y. Ayala, H. Bernhard Schlegel et al. · Journal of Computational Chemistry 15 Jan 1996 2,751
5 Protective groups in organic synthesis Philip Hodge · Polymer 1992 2,222
All 100 most cited papers, with filters and sorting

Where is Chemical Reaction Mechanisms research done?

The largest centres of Chemical Reaction Mechanisms research in 2022-now are Moscow (Russia), Beijing (China), Nanjing (China) and Yekaterinburg (Russia). Among places with at least 20 works in it, it is an unusually large share of all research in Moscow.

Largest cities, 2022-now

  1. 1 MoscowRussia 44 works
  2. 2 BeijingChina 33 works
  3. 3 NanjingChina 16 works
  4. 4 YekaterinburgRussia 15 works
  5. 5 KyivUkraine 14 works
  6. 6 Saint PetersburgRussia 14 works
  7. 7 WarsawPoland 13 works
  8. 8 TokyoJapan 11 works
  9. 9 NovosibirskRussia 11 works
  10. 10 TehranIran 11 works

Where it is the local speciality

  1. MoscowRU · 44.4 works3.9×
← less than its size predicts1×more →

Location quotient: how much more of its research is in Chemical Reaction Mechanisms than the world average.

See Chemical Reaction Mechanisms on the map

Is Chemical Reaction Mechanisms research growing?

Output in 2022-2025 was 5% lower than in 2018-2021, peaking in 1987.

still counting19801990200020102020
grewheldshrank

The same series as a ribbon: one cell per year, darker for more. The line above answers how much; this answers when.

Its share of all research

Growing output can still be a shrinking share: all of science grows. This is Chemical Reaction Mechanisms as a percentage of every work published that year, 0.0050% in 2024.

still counting0.050%0.10%0.15%Chemical Reaction Mechanisms0.0048% in 202519801990200020102020

Fractional works of Chemical Reaction Mechanisms over all fractional works that year. How the balance of science has shifted.

How much of it reaches the world top 10%

Year by year.

still counting5%10%15%Chemical Reaction Mechanisms10.4% in 2025200020102020

Of each year's works in it, the share that reached the world's 10% most cited for their field and year. A field is the world for its own topics, so there is no other line to hold it against.

Which topics inside it are moving

Growth and decline on one axis around a shared zero. Two lists side by side hide the thing that matters: whether the growth dwarfs the decline, or the other way round.

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