Most cited papers in Developmental Biology and Gene Regulation
What are the most cited papers in Developmental Biology and Gene Regulation?
The most cited paper in Developmental Biology and Gene Regulation is "Targeted gene expression as a means of altering cell fates and generating dominant phenotypes" (Andrea H. Brand, Norbert Perrimon, 1993), with 9,930 citations. Next come "Notch Signaling: Cell Fate Control and Signal Integration in Development" (5,977) and "MicroRNA targets in Drosophila" (3,822).
Showing 50 of 100 papers. Every paper with more than 1,149 citations is listed.
| # | Paper | ||
|---|---|---|---|
| 1 | Targeted gene expression as a means of altering cell fates and generating dominant phenotypes Andrea H. Brand, Norbert Perrimon · Development | Jun 1993 | 9,930 |
| 2 | Notch Signaling: Cell Fate Control and Signal Integration in Development Spyros Artavanis‐Tsakonas, Matthew D. Rand, Robert J. Lake · Science | 30 Apr 1999 | 5,977 |
| 3 | MicroRNA targets in Drosophila Anton James Enright, Bino John, Ulrike Gaul et al. · Genome biology | 12 Dec 2003 | 3,822 |
| 4 | The Canonical Notch Signaling Pathway: Unfolding the Activation Mechanism Raphael Kopan, Ma. Xenia G. Ilagan · Cell | Apr 2009 | 3,732 |
| 5 | Preservation of Duplicate Genes by Complementary, Degenerative Mutations Allan G. Force, Michael F. Lynch, F. Bryan Pickett et al. · Genetics | Apr 1999 | 3,611 |
| 6 | A theory of biological pattern formation Alfred Gierer, Hans Meinhardt · Kybernetik | Dec 1972 | 3,251 |
| 7 | Specification of Cerebral Cortical Areas PASKO T. RAKIC · Science | 8 Jul 1988 | 3,175 |
| 8 | The development of Drosophila melanogaster Philip William Ingham · Trends in Genetics | Aug 1994 | 3,165 |
| 9 | Positional information and the spatial pattern of cellular differentiation Lewis Wolpert · Journal of Theoretical Biology | Oct 1969 | 3,149 |
| 10 | Cyclopia and defective axial patterning in mice lacking Sonic hedgehog gene function Chin Chiang, Ying Litingtung, Eric Lee et al. · Nature | Oct 1996 | 3,112 |
| 11 | Hedgehog signaling in animal development: paradigms and principles Philip William Ingham, Andrew P. McMahon · Genes & Development | Dec 2001 | 3,024 |
| 12 | Developmental regulation of the growth plate Henry M. Kronenberg · Nature | May 2003 | 2,889 |
| 13 | An atlas of active enhancers across human cell types and tissues Robin Andersson et al. · Nature | Mar 2014 | 2,854 |
| 14 | Notch Signaling Augments BMP9-Induced Bone Formation by Promoting the Osteogenesis-Angiogenesis Coupling Process in Mesenchymal Stem Cells (MSCs) Junyi Liao et al. · Cellular Physiology and Biochemistry | 2017 | 2,753 |
| 15 | Homeobox genes and axial patterning William J. McGinnis, Robb K. Krumlauf · Cell | 1992 | 2,722 |
| 16 | Mosaic Analysis with a Repressible Cell Marker for Studies of Gene Function in Neuronal Morphogenesis Tzumin Lee, Liqun Luo · Neuron | Mar 1999 | 2,693 |
| 17 | Notch signalling: a simple pathway becomes complex Sarah J. Bray · Nature Reviews Molecular Cell Biology | 21 Aug 2006 | 2,644 |
| 18 | Wnt signaling: a common theme in animal development Ken M. Cadigan, Roel Nusse · Genes & Development | 15 Dec 1997 | 2,588 |
| 19 | A non-radioactive in situ hybridization method for the localization of specific RNAs in Drosophila embryos reveals translational control of the segmentation gene hunchback Diethard Tautz, Christine Pfeifle · Chromosoma | Aug 1989 | 2,562 |
| 20 | Identification of Selective Inhibitors of Cancer Stem Cells by High-Throughput Screening Piyush B. Gupta, Tamer T. Önder, Guozhi Jiang et al. · Cell | Aug 2009 | 2,395 |
| 21 | Limb proportions show developmental plasticity in response to embryo movement Andrea S. Pollard, Bethany Charlton, John R. Hutchinson et al. · Scientific Reports | 6 Feb 2017 | 2,393 |
| 22 | Sonic hedgehog mediates the polarizing activity of the ZPA Robert D. Riddle, Randy L. Johnson, Ed Laufer et al. · Cell | Dec 1993 | 2,358 |
| 23 | Sonic hedgehog, a member of a family of putative signaling molecules, is implicated in the regulation of CNS polarity Yann Echelard, Douglas J. Epstein, Benoit St‐Jacques et al. · Cell | Dec 1993 | 2,185 |
| 24 | Evo-Devo and an Expanding Evolutionary Synthesis: A Genetic Theory of Morphological Evolution Sean B. Carroll · Cell | Jul 2008 | 2,178 |
| 25 | The cell biology of neurogenesis Magdalena Götz, Wieland Β. Huttner · Nature Reviews Molecular Cell Biology | Oct 2005 | 2,157 |
| 26 | Neuronal specification in the spinal cord: inductive signals and transcriptional codes Thomas M. Jessell · Nature Reviews Genetics | Oct 2000 | 2,134 |
| 27 | Maintenance of pluripotency in human and mouse embryonic stem cells through activation of Wnt signaling by a pharmacological GSK-3-specific inhibitor Noboru Sato, Laurent Meijer, Leandros Alexios Skaltsounis et al. · Nature Medicine | 21 Dec 2003 | 2,125 |
| 28 | A presenilin-1-dependent γ-secretase-like protease mediates release of Notch intracellular domain Bart De Strooper, Wim G. Annaert, Philippe Cupers et al. · Nature | Apr 1999 | 2,115 |
| 29 | Hox genes in vertebrate development Robb K. Krumlauf · Cell | Jul 1994 | 2,100 |
| 30 | GSK-3: tricks of the trade for a multi-tasking kinase Bradley W. Doble, James Robert Woodgett · Journal of Cell Science | 3 Mar 2003 | 2,097 |
| 31 | Analysis of genetic mosaics in developing and adult Drosophila tissues Tian Xu, Gerald M. Rubin · Development | Apr 1993 | 2,061 |
| 32 | MECHANISMS OF WNT SIGNALING IN DEVELOPMENT Andreas Wodarz, Roel Nusse · Annual Review of Cell and Developmental Biology | Nov 1998 | 2,030 |
| 33 | Bone morphogenetic proteins: multifunctional regulators of vertebrate development. B L Hogan · Genes & Development | Jul 1996 | 1,995 |
| 34 | MEME-ChIP: motif analysis of large DNA datasets Philip Machanick, Timothy L. Bailey · Bioinformatics | 12 Apr 2011 | 1,970 |
| 35 | Kinesin superfamily motor proteins and intracellular transport Nobutaka Hirokawa, Yasuko Noda, Yosuke Tanaka et al. · Nature Reviews Molecular Cell Biology | 23 Sep 2009 | 1,942 |
| 36 | XTcf-3 Transcription Factor Mediates β-Catenin-Induced Axis Formation in Xenopus Embryos Miranda Molenaar, Marc van de Wetering, Mariëtte A. Oosterwegel et al. · Cell | Aug 1996 | 1,836 |
| 37 | Bone morphogenetic protein-4 is required for mesoderm formation and patterning in the mouse. Glenn E. Winnier, M Blessing, Patricia Ann Labosky et al. · Genes & Development | Sep 1995 | 1,807 |
| 38 | Direct binding of Smad3 and Smad4 to critical TGFβ‐inducible elements in the promoter of human plasminogen activator inhibitor‐type 1 gene Sylviane Dennler, Susumu Itoh, Denis Vivien et al. · The EMBO Journal | Jun 1998 | 1,805 |
| 39 | Dll4 signalling through Notch1 regulates formation of tip cells during angiogenesis Mats Hellström, Li‐Kun Phng, Jennifer J. Hofmann et al. · Nature | 28 Jan 2007 | 1,801 |
| 40 | Sox9 is required for cartilage formation Weimin Bi, Jian Min Deng, Zhaoping Zhang et al. · Nature Genetics | May 1999 | 1,788 |
| 41 | Zebrafish hox Clusters and Vertebrate Genome Evolution Angel Amores, Allan G. Force, Yi‐Lin Yan et al. · Science | 27 Nov 1998 | 1,778 |
| 42 | Directed Differentiation of Embryonic Stem Cells into Motor Neurons Hynek Wichterle, Ivo Lieberam, Jeffery A. Porter et al. · Cell | Aug 2002 | 1,765 |
| 43 | The snail superfamily of zinc-finger transcription factors Maria Angela Nieto · Nature Reviews Molecular Cell Biology | Mar 2002 | 1,732 |
| 44 | Altered Neural Cell Fates and Medulloblastoma in Mouse patched Mutants Lisa V. Goodrich, Ljiljana Milenković, Kay M. Higgins et al. · Science | 22 Aug 1997 | 1,723 |
| 45 | The Spemann Organizer Signal noggin Binds and Inactivates Bone Morphogenetic Protein 4 Lyle B. Zimmerman, José M De Jesús-Escobar, Richard M. Harland · Cell | Aug 1996 | 1,655 |
| 46 | The identification of genes with unique and essential functions in the development of the zebrafish, Danio rerio Pascal Haffter, Michael Granato, Michael Brand et al. · Development | Dec 1996 | 1,652 |
| 47 | Notch-1 signalling requires ligand-induced proteolytic release of intracellular domain Eric H. Schroeter, Jeffrey A. Kisslinger, Raphael Kopan · Nature | May 1998 | 1,645 |
| 48 | The many faces and functions of β‐catenin Tomáš Valenta, George Hausmann, Konrad Basler · The EMBO Journal | 22 May 2012 | 1,635 |
| 49 | Dickkopf-1 is a member of a new family of secreted proteins and functions in head induction Andrei Glinka, Wei Wu, Hajo Delius et al. · Nature | 1998 | 1,629 |
| 50 | Role of PFKFB3-Driven Glycolysis in Vessel Sprouting Katrien De Bock et al. · Cell | Aug 2013 | 1,617 |
Citations are OpenAlex's own counts, from its 2026-09-23 snapshot, so the ranking can differ from Google Scholar or Web of Science. A paper is listed for a field when OpenAlex files it under one of the field's topics; retracted papers and papers whose citation count cannot be traced to citing works are left out, and a preprint and the article it became are shown once. Release dates are OpenAlex's: where a source gave only a month or a year, that is what is shown. How the lists are chosen.