Most cited papers in Digestive system and related health
What are the most cited papers in Digestive system and related health?
The most cited paper in Digestive system and related health is "The Epithelial-Mesenchymal Transition Generates Cells with Properties of Stem Cells" (Sendurai A. Mani, Wenjun Guo, Mai-Jing Liao et al., 2008), with 8,810 citations. Next come "Dietary Modulation of the Human Colonic Microbiota: Introducing the Concept of Prebiotics" (7,690) and "Identification of stem cells in small intestine and colon by marker gene Lgr5" (5,813).
Showing 50 of 99 papers. Every paper with more than 971 citations is listed.
| # | Paper | ||
|---|---|---|---|
| 1 | The Epithelial-Mesenchymal Transition Generates Cells with Properties of Stem Cells Sendurai A. Mani, Wenjun Guo, Mai-Jing Liao et al. · Cell | May 2008 | 8,810 |
| 2 | Dietary Modulation of the Human Colonic Microbiota: Introducing the Concept of Prebiotics Glenn R. Gibson, Marcel B. Roberfroid · Journal of Nutrition | Jun 1995 | 7,690 |
| 3 | Identification of stem cells in small intestine and colon by marker gene Lgr5 Nick Barker, Johan H. van Es, Jeroen Kuipers et al. · Nature | Oct 2007 | 5,813 |
| 4 | Lessons from Hereditary Colorectal Cancer Kenneth W. Kinzler, Bert Vogelstein · Cell | Oct 1996 | 4,949 |
| 5 | Induction of Intestinal Th17 Cells by Segmented Filamentous Bacteria Ivaylo I. Ivanov, Koji Atarashi, Nicolas Manel et al. · Cell | Oct 2009 | 4,598 |
| 6 | Identification and expansion of human colon-cancer-initiating cells Lucia Ricci‐Vitiani, Dario Giuseppe Lombardi, Emanuela Pilozzi et al. · Nature | 19 Nov 2006 | 4,008 |
| 7 | Mutation of the mouse klotho gene leads to a syndrome resembling ageing Makoto Kuro‐o, Yutaka Matsumura, Hiroki Aizawa et al. · Nature | 6 Nov 1997 | 3,876 |
| 8 | Short Chain Fatty Acids (SCFAs)-Mediated Gut Epithelial and Immune Regulation and Its Relevance for Inflammatory Bowel Diseases Daniela Parada Venegas, Marjorie K. De la Fuente, Glauben Landskron et al. · Frontiers in Immunology | 11 Mar 2019 | 3,862 |
| 9 | Gut flora in health and disease Francisco Guarner, Juan‐R. Malagelada · The Lancet | Feb 2003 | 3,379 |
| 10 | Short chain fatty acids in human large intestine, portal, hepatic and venous blood. John H. Cummings, Eru W. Pomare, W J Branch et al. · Gut | Oct 1987 | 3,166 |
| 11 | EMT Transition States during Tumor Progression and Metastasis Ievgenia Pastushenko, Cédric Blanpain · Trends in Cell Biology | 26 Dec 2018 | 3,125 |
| 12 | Short-Chain Fatty Acids and Human Colonic Function: Roles of Resistant Starch and Nonstarch Polysaccharides David L. Topping, Peter Marshall Clifton · Physiological Reviews | Jul 2001 | 3,102 |
| 13 | The human mutator gene homolog MSH2 and its association with hereditary nonpolyposis colon cancer Richard A. Fishel, Mary Kay Lescoe, Manchanahalli R. Satyanarayana Rao et al. · Cell | Dec 1993 | 2,908 |
| 14 | The gut flora as a forgotten organ Ann M. O’Hara, Fergus Shanahan · EMBO Reports | Jul 2006 | 2,821 |
| 15 | Colonic Health: Fermentation and Short Chain Fatty Acids Julia MW Wong, Russell J. de Souza, Cyril W.C. Kendall et al. · Journal of Clinical Gastroenterology | Mar 2006 | 2,765 |
| 16 | EMT, cancer stem cells and drug resistance: an emerging axis of evil in the war on cancer Anurag Singh, Jeff Settleman · Oncogene | 7 Jun 2010 | 2,591 |
| 17 | Paneth cells constitute the niche for Lgr5 stem cells in intestinal crypts Toshiro Sato, Johan H. van Es, Hugo J.G. Snippert et al. · Nature | 28 Nov 2010 | 2,547 |
| 18 | Dietary modulation of the human colonic microbiota: updating the concept of prebiotics Glenn R. Gibson, Hollie M. Probert, Jan Van Loo et al. · Nutrition Research Reviews | Dec 2004 | 2,541 |
| 19 | The Role of Short-Chain Fatty Acids in Health and Disease Jian Tan, Craig I. McKenzie, Maria Potamitis et al. · Advances in immunology | 2014 | 2,449 |
| 20 | Epithelial-mesenchymal transition and its implications for fibrosis Raghu K. Kalluri, Eric G. Neilson · Journal of Clinical Investigation | 15 Dec 2003 | 2,297 |
| 21 | Prebiotic effects: metabolic and health benefits Marcel B. Roberfroid et al. · British Journal Of Nutrition | Aug 2010 | 2,083 |
| 22 | Method for assay of intestinal disaccharidases Arne Dahlqvist · Analytical Biochemistry | 1964 | 2,059 |
| 23 | The epithelial–mesenchymal transition: new insights in signaling, development, and disease Jonathan M. Lee, Shoukat Dedhar, Raghu K. Kalluri et al. · The Journal of Cell Biology | 27 Mar 2006 | 2,046 |
| 24 | EMT in cancer Thomas Brabletz, Raghu K. Kalluri, Maria Angela Nieto et al. · Nature reviews. Cancer | 12 Jan 2018 | 2,033 |
| 25 | Transforming growth factor beta 1 null mutation in mice causes excessive inflammatory response and early death. A B Kulkarni, C G Huh, Daniel M. Becker et al. · Proceedings of the National Academy of Sciences | 15 Jan 1993 | 1,971 |
| 26 | Stem Cells, Self-Renewal, and Differentiation in the Intestinal Epithelium Laurens G. van der Flier, Hans C. Clevers · Annual Review of Physiology | 22 Sep 2008 | 1,889 |
| 27 | Vitamin D and Human Health: Lessons from Vitamin D Receptor Null Mice Roger Bouillon, Geert Carmeliet, Lieve Verlinden et al. · Endocrine Reviews | Oct 2008 | 1,794 |
| 28 | Intestinal barrier function: Molecular regulation and disease pathogenesis Katherine R. Groschwitz, Simon Patrick Hogan · Journal of Allergy and Clinical Immunology | 27 Jun 2009 | 1,778 |
| 29 | Signaling mechanisms of the epithelial-mesenchymal transition David M. Gonzalez, Damian Medici · Science Signaling | 23 Sep 2014 | 1,775 |
| 30 | The abundance and variety of carbohydrate-active enzymes in the human gut microbiota Abdessamad El Kaoutari, Fabrice Armougom, Jeffrey I. Gordon et al. · Nature Reviews Microbiology | 10 Jun 2013 | 1,756 |
| 31 | Origin, differentiation and renewal of the four main epithelial cell types in the mouse small intestine V. Unitarian theory of the origin of the four epithelial cell types Hazel Cheng, Charles Philippe Leblond · American Journal of Anatomy | Dec 1974 | 1,740 |
| 32 | Convergent adaptation of human lactase persistence in Africa and Europe Sarah A. Tishkoff, Floyd A. Reed, Alessia Ranciaro et al. · Nature Genetics | 10 Dec 2006 | 1,671 |
| 33 | A serine/threonine kinase gene defective in Peutz–Jeghers syndrome Akseli Hemminki et al. · Nature | 1998 | 1,664 |
| 34 | Celiac Disease Peter H.R. Green, Christophe Cellier · New England Journal of Medicine | 24 Oct 2007 | 1,637 |
| 35 | The Genetic Structure and History of Africans and African Americans Sarah A. Tishkoff et al. · Science | 30 Apr 2009 | 1,617 |
| 36 | Depletion of epithelial stem-cell compartments in the small intestine of mice lacking Tcf-4 Vladimír Kořínek, Nick Barker, Petra Moerer et al. · Nature Genetics | Aug 1998 | 1,588 |
| 37 | Lgr5+ve Stem Cells Drive Self-Renewal in the Stomach and Build Long-Lived Gastric Units In Vitro Nick Barker, Meritxell Huch, Pekka Kujala et al. · Cell stem cell | 2010 | 1,571 |
| 38 | Genetics and biology of vitamin D receptor polymorphisms André Gerardus Uitterlinden, Yue Fang, Joyce B. J. van Meurs et al. · Gene | 23 Jul 2004 | 1,558 |
| 39 | Linking Colorectal Cancer to Wnt Signaling Mariann Bienz, Hans C. Clevers · Cell | Oct 2000 | 1,522 |
| 40 | SCFA: mechanisms and functional importance in the gut Camille Martin‐Gallausiaux, Ludovica Marinelli, Hervé M. Blottière et al. · Proceedings of The Nutrition Society | 2 Apr 2020 | 1,510 |
| 41 | Prebiotics: The Concept Revisited1, Marcel Roberfroid · Journal of Nutrition | Mar 2007 | 1,500 |
| 42 | The Caco-2 cell line as a model of the intestinal barrier: influence of cell and culture-related factors on Caco-2 cell functional characteristics Yula Sambuy, Isabella De Angelis, Giulia Ranaldi et al. · Cell Biology and Toxicology | 2005 | 1,498 |
| 43 | Caught up in a Wnt storm: Wnt signaling in cancer Rachel H. Giles, Johan H. van Es, Hans C. Clevers · Biochimica et Biophysica Acta (BBA) - Reviews on Cancer | 28 Feb 2003 | 1,481 |
| 44 | Probiotics and their fermented food products are beneficial for health Shoukat Parvez, Khairuddin Malik, ⋅Sang-Mo Kang et al. · Journal of Applied Microbiology | 5 Apr 2006 | 1,437 |
| 45 | Cell population kinetics in the intestinal epithelium of the mouse Henry Quastler, Frederick G. Sherman · Experimental Cell Research | Jun 1959 | 1,437 |
| 46 | W/kit gene required for interstitial cells of Cajal and for intestinal pacemaker activity Jan D. Hulzinga, Lars Thuneberg, Michael Klüppel et al. · Nature | 1995 | 1,417 |
| 47 | Functional food science and gastrointestinal physiology and function Seppo Salminen, C. Bouley, M C Boutron et al. · British Journal Of Nutrition | Aug 1998 | 1,411 |
| 48 | Converting Nitrogen into Protein—Beyond 6.25 and Jones' Factors François Mariotti, Daniel Tomé, Philippe Patureau Mirand · Critical Reviews in Food Science and Nutrition | 31 Jan 2008 | 1,408 |
| 49 | Microbes in Gastrointestinal Health and Disease Andrew Scott Neish · Gastroenterology | 20 Nov 2008 | 1,396 |
| 50 | Adult intestinal stem cells: critical drivers of epithelial homeostasis and regeneration Nick Barker · Nature Reviews Molecular Cell Biology | 11 Dec 2013 | 1,376 |
Citations are OpenAlex's own counts, from its 2026-09-23 snapshot, so the ranking can differ from Google Scholar or Web of Science. A paper is listed for a field when OpenAlex files it under one of the field's topics; retracted papers and papers whose citation count cannot be traced to citing works are left out, and a preprint and the article it became are shown once. Release dates are OpenAlex's: where a source gave only a month or a year, that is what is shown. How the lists are chosen.