Most cited papers in Drug Solubulity and Delivery Systems
What are the most cited papers in Drug Solubulity and Delivery Systems?
The most cited paper in Drug Solubulity and Delivery Systems is "Experimental and computational approaches to estimate solubility and permeability in drug discovery and development settings 1PII of original article: S0169-409X(96)00423-1. The article was originally published in Advanced Drug Delivery Reviews 23 (1997) 3–25. 1" (Christopher A. Lipinski, Franco Lombardo, Beryl W. Dominy et al., 2001), with 18,154 citations. Next come "Molecular Properties That Influence the Oral Bioavailability of Drug Candidates" (8,390) and "Modeling and comparison of dissolution profiles" (5,484).
Showing 50 of 99 papers. Every paper with more than 861 citations is listed.
| # | Paper | ||
|---|---|---|---|
| 1 | Experimental and computational approaches to estimate solubility and permeability in drug discovery and development settings 1PII of original article: S0169-409X(96)00423-1. The article was originally published in Advanced Drug Delivery Reviews 23 (1997) 3–25. 1 Christopher A. Lipinski, Franco Lombardo, Beryl W. Dominy et al. · Advanced Drug Delivery Reviews | Mar 2001 | 18,154 |
| 2 | Molecular Properties That Influence the Oral Bioavailability of Drug Candidates Daniel F. Veber, Stephen R. Johnson, Hung‐Yuan Cheng et al. · Journal of Medicinal Chemistry | 11 May 2002 | 8,390 |
| 3 | Modeling and comparison of dissolution profiles Paulo C. Costa, José Manuel Sousa Lobo · European Journal of Pharmaceutical Sciences | May 2001 | 5,484 |
| 4 | A Theoretical Basis for a Biopharmaceutic Drug Classification: The Correlation of in Vitro Drug Product Dissolution and in Vivo Bioavailability Gordon L. Amidon, Hans Lennernäs, Vinod P. Shah et al. · Pharmaceutical Research | Mar 1995 | 5,389 |
| 5 | Mechanism of sustained‐action medication. Theoretical analysis of rate of release of solid drugs dispersed in solid matrices Tsunehiko Higuchi · Journal of Pharmaceutical Sciences | Dec 1963 | 4,890 |
| 6 | A simple equation for description of solute release I. Fickian and non-fickian release from non-swellable devices in the form of slabs, spheres, cylinders or discs Philip L. Ritger, Nikolaos A. Peppas · Journal of Controlled Release | Jun 1987 | 3,824 |
| 7 | Biodegradable polymeric nanoparticles based drug delivery systems Avnesh Kumari, Sudesh Kumar Yadav, Subhash Chandra Yadav · Colloids and Surfaces B Biointerfaces | 9 Sep 2009 | 3,716 |
| 8 | Biodegradable polymeric nanoparticles as drug delivery devices Kumaresh S. Soppimath, Tejraj Malleshappa Aminabhavi, Anandrao R. Kulkarni et al. · Journal of Controlled Release | 2001 | 3,537 |
| 9 | Poly(ethylene glycol) in Drug Delivery: Pros and Cons as Well as Potential Alternatives Katrin Knop, Richard Hoogenboom, Dagmar Fischer et al. · Angewandte Chemie International Edition | 20 Jul 2010 | 3,525 |
| 10 | Cyclodextrins and their uses: a review Eva M. Martín del Valle · Process Biochemistry | 11 Oct 2003 | 3,359 |
| 11 | Handbook of Pharmaceutical Excipients Flynn W. Warren · American Journal of Health-System Pharmacy | Aug 1987 | 3,343 |
| 12 | Modeling of drug release from delivery systems based on hydroxypropyl methylcellulose (HPMC) Juergen Siepmann · Advanced Drug Delivery Reviews | 11 Jun 2001 | 2,608 |
| 13 | Recent advances on chitosan-based micro- and nanoparticles in drug delivery Sunil A. Agnihotri, Mallikarjuna N. Nadagouda, Tejraj Malleshappa Aminabhavi · Journal of Controlled Release | 30 Sep 2004 | 2,582 |
| 14 | Improving drug solubility for oral delivery using solid dispersions C Leuner · European Journal of Pharmaceutics and Biopharmaceutics | 3 Jul 2000 | 2,576 |
| 15 | The Stability of Cyclodextrin Complexes in Solution Kenneth A. Connors · Chemical Reviews | Aug 1997 | 2,175 |
| 16 | Pharmaceutical Applications of Cyclodextrins. 1. Drug Solubilization and Stabilization Þorsteinn Loftsson, Marcus Eli Brewster · Journal of Pharmaceutical Sciences | Oct 1996 | 2,168 |
| 17 | Cyclodextrin Drug Carrier Systems Kaneto Uekama, Fumitoshi Hirayama, Tetsumi Irie · Chemical Reviews | 9 Jun 1998 | 2,137 |
| 18 | Drug Solubility: Importance and Enhancement Techniques Ketan T. Savjani, Anuradha Ketan Gajjar, Jignasa Savjani · ISRN Pharmaceutics | 5 Jul 2012 | 2,013 |
| 19 | Polyionic hydrocolloids for the intestinal delivery of protein drugs: Alginate and chitosan — a review Meera George, T. Emilia Abraham · Journal of Controlled Release | 23 May 2006 | 2,003 |
| 20 | Cyclodextrin-based pharmaceutics: past, present and future Mark E. Davis, Marcus Eli Brewster · Nature Reviews Drug Discovery | Dec 2004 | 1,994 |
| 21 | Characteristics and Significance of the Amorphous State in Pharmaceutical Systems Bruno C. Hancock, George Zografi · Journal of Pharmaceutical Sciences | 1997 | 1,922 |
| 22 | Review: A History of Cyclodextrins Grégorio Crini · Chemical Reviews | 23 Sep 2014 | 1,903 |
| 23 | A physiological approach to hepatic drug clearance Grant R. Wilkinson, David G. Shand · Clinical Pharmacology & Therapeutics | Oct 1975 | 1,889 |
| 24 | Cyclodextrins as pharmaceutical solubilizers Marcus Eli Brewster, Þorsteinn Loftsson · Advanced Drug Delivery Reviews | 30 May 2007 | 1,879 |
| 25 | On the importance and mechanisms of burst release in matrix-controlled drug delivery systems Xiao Bing Huang, Christopher S. Brazel · Journal of Controlled Release | Jun 2001 | 1,806 |
| 26 | Lipids and lipid-based formulations: optimizing the oral delivery of lipophilic drugs Christopher J. H. Porter, Natalie L. Trevaskis, William N. Charman · Nature Reviews Drug Discovery | Mar 2007 | 1,806 |
| 27 | Pharmaceutical Applications of Solid Dispersion Systems Win Loung Chiou, Sidney Riegelman · Journal of Pharmaceutical Sciences | Sep 1971 | 1,795 |
| 28 | Cyclodextrins and their pharmaceutical applications Þorsteinn Loftsson, Dominique Duchêne · International Journal of Pharmaceutics | 10 Nov 2006 | 1,734 |
| 29 | Pharmaceutical Particle Engineering via Spray Drying Reinhard Vehring · Pharmaceutical Research | 26 Nov 2007 | 1,690 |
| 30 | Drug delivery systems: An updated review Gaurav Tiwari, Ruchı Tıwarı, S. Bannerjee et al. · International Journal of Pharmaceutical Investigation | 2012 | 1,672 |
| 31 | DDSolver: An Add-In Program for Modeling and Comparison of Drug Dissolution Profiles Yong Zhang, Meirong Huo, Jianping Zhou et al. · The AAPS Journal | 5 Apr 2010 | 1,653 |
| 32 | Solid dispersion of poorly water‐soluble drugs: Early promises, subsequent problems, and recent breakthroughs Abu T.M. Serajuddin · Journal of Pharmaceutical Sciences | Oct 1999 | 1,650 |
| 33 | Oral drug delivery with polymeric nanoparticles: The gastrointestinal mucus barriers Laura M. Ensign, Richard A. Cone, Justin S. Hanes · Advanced Drug Delivery Reviews | 24 Dec 2011 | 1,613 |
| 34 | Strategies to Address Low Drug Solubility in Discovery and Development Hywel D. Williams, Natalie L. Trevaskis, Susan A. Charman et al. · Pharmacological Reviews | 2013 | 1,574 |
| 35 | Pharmacokinetics and Biodistribution of Nanoparticles Shyh‐Dar Li, Leaf Huang · Molecular Pharmaceutics | 9 Jul 2008 | 1,566 |
| 36 | Solid dispersions as strategy to improve oral bioavailability of poor water soluble drugs Teófilo Vasconcelos, Bruno Filipe Carmelino Cardoso Sarmento, Paulo C. Costa · Drug Discovery Today | Dec 2007 | 1,565 |
| 37 | Caco-2 monolayers in experimental and theoretical predictions of drug transport1PII of original article: S0169-409X(96)00415-2. The article was originally published in Advanced Drug Delivery Reviews 22 (1996) 67–84.1 Per Artursson, Katrin Palm, Kristina Luthman · Advanced Drug Delivery Reviews | Mar 2001 | 1,550 |
| 38 | Nanosuspensions in drug delivery Barrett E. Rabinow · Nature Reviews Drug Discovery | Sep 2004 | 1,528 |
| 39 | Alginate in Drug Delivery Systems Hanne Hjorth Tønnesen, Jan Reinert Karlsen · Drug Development and Industrial Pharmacy | 2002 | 1,515 |
| 40 | Determination of drug permeability and prediction of drug absorption in Caco-2 monolayers Ina Hubatsch, Eva Ragnarsson, Per Artursson · Nature Protocols | 23 Aug 2007 | 1,512 |
| 41 | Effects of particle size and surface coating on cellular uptake of polymeric nanoparticles for oral delivery of anticancer drugs Khin Yin Win, Si‐Shen Feng · Biomaterials | 14 Sep 2004 | 1,458 |
| 42 | Understanding Pharmaceutical Quality by Design Lawrence X. Yu, Gregory E. Amidon, Mansoor A. Khan et al. · The AAPS Journal | 22 May 2014 | 1,458 |
| 43 | Crystal engineering of active pharmaceutical ingredients to improve solubility and dissolution rates N. Blagden, Marcel de Matas, Pauline T. Gavan et al. · Advanced Drug Delivery Reviews | 30 May 2007 | 1,450 |
| 44 | Insoluble drug delivery strategies: review of recent advances and business prospects Sandeep Kalepu, Vijaykumar Nekkanti · Acta Pharmaceutica Sinica B | 25 Aug 2015 | 1,406 |
| 45 | Solubilizing Excipients in Oral and Injectable Formulations Robert G. Strickley · Pharmaceutical Research | Feb 2004 | 1,404 |
| 46 | Amorphous pharmaceutical solids: preparation, characterization and stabilization Lian Yu · Advanced Drug Delivery Reviews | May 2001 | 1,397 |
| 47 | An Overview of Chitosan Nanoparticles and Its Application in Non-Parenteral Drug Delivery Munawar Mohammed, Jaweria Syeda, Kishor M. Wasan et al. · Pharmaceutics | 20 Nov 2017 | 1,374 |
| 48 | Mathematical modeling of drug delivery Juergen Siepmann, Florence Siepmann · International Journal of Pharmaceutics | 12 Sep 2008 | 1,366 |
| 49 | Nanosuspensions as particulate drug formulations in therapy Rainer Helmut Müller, Claudia Jacobs, Oliver Kayser · Advanced Drug Delivery Reviews | Mar 2001 | 1,366 |
| 50 | Self-emulsifying drug delivery systems (SEDDS) for improved oral delivery of lipophilic drugs R. Neslihan Gürsoy, Simon Benita · Biomedicine & Pharmacotherapy | 14 Mar 2004 | 1,353 |
Citations are OpenAlex's own counts, from its 2026-09-23 snapshot, so the ranking can differ from Google Scholar or Web of Science. A paper is listed for a field when OpenAlex files it under one of the field's topics; retracted papers and papers whose citation count cannot be traced to citing works are left out, and a preprint and the article it became are shown once. Release dates are OpenAlex's: where a source gave only a month or a year, that is what is shown. How the lists are chosen.