Topic · Enzyme function and inhibition
Most cited papers in Enzyme function and inhibition
What are the most cited papers in Enzyme function and inhibition?
The most cited paper in Enzyme function and inhibition is "Enzymic method for quantitative determination of nanogram amounts of total and oxidized glutathione: Applications to mammalian blood and other tissues" (Frank Tietze, 1969), with 6,083 citations. Next come "Tissue fractionation studies. 6. Intracellular distribution patterns of enzymes in rat-liver tissue" (4,175) and "ACETYLORNITHINASE OF ESCHERICHIA COLI: PARTIAL PURIFICATION AND SOME PROPERTIES" (4,027).
Showing 50 of 99 papers. Every paper with more than 742 citations is listed.
| # | Paper | ||
|---|---|---|---|
| 1 | Enzymic method for quantitative determination of nanogram amounts of total and oxidized glutathione: Applications to mammalian blood and other tissues Frank Tietze · Analytical Biochemistry | Mar 1969 | 6,083 |
| 2 | Tissue fractionation studies. 6. Intracellular distribution patterns of enzymes in rat-liver tissue C. De Duve, Berton C. Pressman, R. Gianetto et al. · Biochemical Journal | Aug 1955 | 4,175 |
| 3 | ACETYLORNITHINASE OF ESCHERICHIA COLI: PARTIAL PURIFICATION AND SOME PROPERTIES Henry J. Vogel, David M. Bonner · Journal of Biological Chemistry | 1956 | 4,027 |
| 4 | Estimation of the molecular weights of proteins by Sephadex gel-filtration Patrick Andrews · Biochemical Journal | May 1964 | 3,905 |
| 5 | Statistical estimations in enzyme kinetics GN Wilkinson · Biochemical Journal | Aug 1961 | 3,569 |
| 6 | The preparation and properties of two new chromogenic substrates of trypsin Bernard F. Erlanger, Nicholas Kokowsky, William Cohen · Archives of Biochemistry and Biophysics | Nov 1961 | 3,383 |
| 7 | Carbonic anhydrases: novel therapeutic applications for inhibitors and activators Claudiu Trandafir Supuran · Nature Reviews Drug Discovery | 2 Jan 2008 | 3,205 |
| 8 | Protein Purification by Affinity Chromatography Pedro Cuatrecasas · Journal of Biological Chemistry | Jun 1970 | 2,803 |
| 9 | Atomic Structure of Acetylcholinesterase from Torpedo californica : A Prototypic Acetylcholine-Binding Protein Joel L. Sussman, Michal Harel, Felix Frolow et al. · Science | 23 Aug 1991 | 2,723 |
| 10 | Spectrophotometric assay and properties of the angiotensin-converting enzyme of rabbit lung David W. Cushman, Hong Son Cheung · Biochemical Pharmacology | Jul 1971 | 2,638 |
| 11 | Transduction of linked genetic characters of the host by bacteriophage P1 E. S. Lennox · Virology | Jul 1955 | 2,612 |
| 12 | The Role of Polyamines in the Neutralization of Bacteriophage Deoxyribonucleic Acid Bruce N. Ames, Donald T. Dubin · Journal of Biological Chemistry | Mar 1960 | 2,583 |
| 13 | Combination therapy in combating cancer Reza Bayat Mokhtari, Tina S. Homayouni, Narges Baluch et al. · Oncotarget | 30 Mar 2017 | 2,568 |
| 14 | Structure, mechanism and regulation of peroxiredoxins Zachary A. Wood, Ewald Schröder, J. Robin Harris et al. · Trends in Biochemical Sciences | 2003 | 2,553 |
| 15 | Application of a Theory of Enzyme Specificity to Protein Synthesis Daniel E. Koshland · Proceedings of the National Academy of Sciences | Feb 1958 | 2,421 |
| 16 | Extraction, Purification and Properties of Aequorin, a Bioluminescent Protein from the Luminous Hydromedusan, Aequorea Osamu Shimomura, Frank H. Johnson, Yo Saiga · Journal of Cellular and Comparative Physiology | Jun 1962 | 2,360 |
| 17 | Dysregulated pH: a perfect storm for cancer progression Bradley A. Webb, Michael S. Chimenti, Matthew P. Jacobson et al. · Nature reviews. Cancer | 11 Aug 2011 | 2,277 |
| 18 | Allosteric proteins and cellular control systems Jacques Monod, Jean‐Pierre Changeux, François Jacob · Journal of Molecular Biology | Apr 1963 | 2,253 |
| 19 | Chemical Coupling of Peptides and Proteins to Polysaccharides by Means of Cyanogen Halides Rolf Axén, Jerker O. Porath, Sverker Ernback · Nature | Jun 1967 | 2,162 |
| 20 | Hyperthermophilic Enzymes: Sources, Uses, and Molecular Mechanisms for Thermostability Claire Vieille, G. Zeikus · Microbiology and Molecular Biology Reviews | Mar 2001 | 2,140 |
| 21 | The kinetics of enzyme-catalyzed reactions with two or more substrates or products☆I. Nomenclature and rate equations William W. Cleland · Biochimica et Biophysica Acta | 1963 | 2,100 |
| 22 | Epac is a Rap1 guanine-nucleotide-exchange factor directly activated by cyclic AMP Johan de Rooij, Fried J. T. Zwartkruis, Mark H. G. Verheijen et al. · Nature | Dec 1998 | 1,992 |
| 23 | The Carbon Dioxide Hydration Activity of Carbonic Anhydrase Raja G. Khalifah · Journal of Biological Chemistry | Apr 1971 | 1,915 |
| 24 | The kinetics of enzyme-catalyzed reactions with two or more substrates or products William W. Cleland · Biochimica et Biophysica Acta (BBA) - Specialized Section on Enzymological Subjects | 1963 | 1,911 |
| 25 | Methods for the quantitative estimation of N-acetylneuraminic acid and their application to hydrolysates of sialomucoids David Aminoff · Biochemical Journal | Nov 1961 | 1,899 |
| 26 | Design of Specific Inhibitors of Angiotensin-Converting Enzyme: New Class of Orally Active Antihypertensive Agents Miguel A. Ondetti, Bernard Rubin, David W. Cushman · Science | 22 Apr 1977 | 1,867 |
| 27 | TRANSFORMATION OF BIOCHEMICALLY DEFICIENT STRAINS OF BACILLUS SUBTILIS BY DEOXYRIBONUCLEATE John Spizizen · Proceedings of the National Academy of Sciences | 15 Oct 1958 | 1,823 |
| 28 | Inhibitory effect of a marine-sponge toxin, okadaic acid, on protein phosphatases. Specificity and kinetics Corinna Bialojan, Akira Takai · Biochemical Journal | 15 Nov 1988 | 1,699 |
| 29 | Acid pH in tumors and its potential for therapeutic exploitation. Ian F. Tannock, Daniela Rotin · PubMed | 15 Aug 1989 | 1,643 |
| 30 | Polypeptide with Broad Biological Activity: Isolation from Small Intestine Sami I. Said, Viktor Mutt · Science | 18 Sep 1970 | 1,603 |
| 31 | The direct linear plot. A new graphical procedure for estimating enzyme kinetic parameters Robert Eisenthal, Athel J. Cornish-Bowden · Biochemical Journal | Jun 1974 | 1,565 |
| 32 | Interfering with pH regulation in tumours as a therapeutic strategy Dario Neri, Claudiu Trandafir Supuran · Nature Reviews Drug Discovery | 16 Sep 2011 | 1,554 |
| 33 | A spectrophotometric determination of trypsin and chymotrypsin George W. Schwert, Yasuo Takenaka · Biochimica et Biophysica Acta | 1955 | 1,551 |
| 34 | An Improved Bacterial Test System for the Detection and Classification of Mutagens and Carcinogens Bruce N. Ames, Frank D. Lee, William E. Durston · Proceedings of the National Academy of Sciences | Mar 1973 | 1,547 |
| 35 | RESPIRATORY ENZYMES IN OXIDATIVE PHOSPHORYLATION Britton Chance, Gene R. Williams · Journal of Biological Chemistry | Nov 1955 | 1,480 |
| 36 | The Original Michaelis Constant: Translation of the 1913 Michaelis–Menten Paper Kenneth Allen Johnson, Roger Sidney Goody · Biochemistry | 2 Sep 2011 | 1,462 |
| 37 | Carbonic anhydrase inhibitors Claudiu Trandafir Supuran, Andrea Scozzafava, Angela Casini · Medicinal Research Reviews | 13 Dec 2002 | 1,450 |
| 38 | The Electrophoretic α; 1 -Globulin Pattern of Serum in α; 1 -Antitrypsin Deficiency C.‐B. Laurell, Sten Eriksson · Scandinavian Journal of Clinical and Laboratory Investigation | 1963 | 1,410 |
| 39 | Acetylcholinesterase — new roles for an old actor Hermona Soreq, Shlomo Seidman · Nature reviews. Neuroscience | Apr 2001 | 1,404 |
| 40 | Structures of Human Acetylcholinesterase in Complex with Pharmacologically Important Ligands Jonah Cheung, Michael J. Rudolph, Fiana Burshteyn et al. · Journal of Medicinal Chemistry | 4 Oct 2012 | 1,365 |
| 41 | Further studies on the properties and assay of glucose 6-phosphate dehydrogenase and 6-phosphogluconate dehydrogenase of rat liver Gertrude Evelyn Glock, Patricia McLean · Biochemical Journal | Oct 1953 | 1,333 |
| 42 | Partial Resolution of the Enzymes Catalyzing Oxidative Phosphorylation Maynard E. Pullman, Harvey S. Penefsky, Anima Datta et al. · Journal of Biological Chemistry | Nov 1960 | 1,318 |
| 43 | Hypoxia-inducible expression of tumor-associated carbonic anhydrases. Charles C. Wykoff, Nigel J P Beasley, Peter Hamilton Watson et al. · PubMed | 15 Dec 2000 | 1,286 |
| 44 | Nitrate reductase assay in intact plant tissues Ernest G. Jaworski · Biochemical and Biophysical Research Communications | Jun 1971 | 1,239 |
| 45 | Multiple Binding Modes of Inhibitors to Carbonic Anhydrases: How to Design Specific Drugs Targeting 15 Different Isoforms? Vincenzo Alterio, Anna Di Fiore, Katia D’Ambrosio et al. · Chemical Reviews | 18 May 2012 | 1,237 |
| 46 | Molecular and cellular biology of cholinesterases Jean Massoulié, Leo Pezzementi, Suzanne Bon et al. · Progress in Neurobiology | Jul 1993 | 1,224 |
| 47 | The Reduction of Cytochrome c by Milk Xanthine Oxidase Joe M. McCord, Irwin Fridovich · Journal of Biological Chemistry | Nov 1968 | 1,203 |
| 48 | Protein–inorganic hybrid nanoflowers Jun Yan Ge, Jiandu Lei, Richard N. Zare · Nature Nanotechnology | 3 Jun 2012 | 1,202 |
| 49 | Enzymatic iodination of polypeptides with 125I to high specific activity Jan I. Thorell, Bengt G. A. Johansson · Biochimica et Biophysica Acta (BBA) - Protein Structure | Dec 1971 | 1,163 |
| 50 | Function and Mechanism of Zinc Metalloenzymes Keith A. McCall, Chih-chin Huang, Carol A. Fierke · Journal of Nutrition | May 2000 | 1,148 |
Citations are OpenAlex's own counts, from its 2026-09-23 snapshot, so the ranking can differ from Google Scholar or Web of Science. A paper is listed for a field when OpenAlex files it under one of the field's topics; retracted papers and papers whose citation count cannot be traced to citing works are left out, and a preprint and the article it became are shown once. Release dates are OpenAlex's: where a source gave only a month or a year, that is what is shown. How the lists are chosen.