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Enzyme function and inhibition

Enzyme function and inhibition is a research topic within Molecular Biology. Science Explorer counts 17k research works in it since 1950. 9.9% of them reached the world's top 10% most cited for their field and year.

This cluster of papers explores the role of carbonic anhydrases in medicine and biotechnology, focusing on their inhibitors, activators, and their potential therapeutic applications in cancer therapy and CO2 capture. The papers cover a wide range of topics including tumor hypoxia, drug discovery, enzyme structure and function, and the use of carbonic anhydrases as targets for medicinal chemistry.

  • Carbonic Anhydrases
  • Inhibitors
  • Activators
  • Tumor Hypoxia
  • Cancer Therapy
  • Enzyme
  • Biomedical Applications
  • Drug Discovery
  • CO2 Capture
  • Anticancer Agents
Research works
17k
fractional, since 1950
In the world top 10%
1.7k
per year above
Top-10% rate
9.9%
share of its works in the world top 10%
Growth, 2018-21 → 2022-25
+12%
the tick is no change
Largest producer
India
20% of the 10 largest, 2022-now

Which countries lead Enzyme function and inhibition research?

By volume, India and China publish the most (229 and 229 works in 2022-now).

By volume, 2022-now

  1. 1 India 229 works
  2. 2 China 229 works
  3. 3 Türkiye 196 works
  4. 4 United States 144 works
  5. 5 Italy 116 works
  6. 6 Egypt 61 works
  7. 7 Pakistan 57 works
  8. 8 Saudi Arabia 56 works
  9. 9 Russia 44 works
  10. 10 Germany 37 works

How concentrated that is

The same countries as shares of everything the list above accounts for. A node where two countries do two thirds of the work and one spread evenly across twelve read alike as a ranking and not at all alike here.

India: 19.6%China: 19.6%Türkiye: 16.8%United States: 12.3%6 others listed: 31.7%20%largest
India229 · 19.6%China229 · 19.6%Türkiye196 · 16.8%United States144 · 12.3%6 others listed371 · 31.7%

Shares of the rows listed above, not of the whole node.

Which institutions lead Enzyme function and inhibition research?

By volume in 2022-now, University of Florence publishes the most Enzyme function and inhibition research, followed by Russian Academy of Sciences and Atatürk University.

Who are the leading researchers in Enzyme function and inhibition?

The most-cited researchers publishing on Enzyme function and inhibition include George M. Whitesides, Amirhossein Sahebkar and Bruce S. McEwen.

  1. 1 George M. Whitesides United States 267k citations
  2. 2 Amirhossein Sahebkar Iran 258k citations
  3. 3 Bruce S. McEwen United States 216k citations

Ranked by citations received across their whole record, among researchers with at least three works on this topic.

What are the most cited papers in Enzyme function and inhibition?

The most cited paper in Enzyme function and inhibition is "Enzymic method for quantitative determination of nanogram amounts of total and oxidized glutathione: Applications to mammalian blood and other tissues" (Frank Tietze, 1969), with 6,083 citations. Next come "Tissue fractionation studies. 6. Intracellular distribution patterns of enzymes in rat-liver tissue" (4,175) and "ACETYLORNITHINASE OF ESCHERICHIA COLI: PARTIAL PURIFICATION AND SOME PROPERTIES" (4,027).

Most cited papers
#PaperReleasedCitations
1 Enzymic method for quantitative determination of nanogram amounts of total and oxidized glutathione: Applications to mammalian blood and other tissues Frank Tietze · Analytical Biochemistry Mar 1969 6,083
2 Tissue fractionation studies. 6. Intracellular distribution patterns of enzymes in rat-liver tissue C. De Duve, Berton C. Pressman, R. Gianetto et al. · Biochemical Journal Open access Aug 1955 4,175
3 ACETYLORNITHINASE OF ESCHERICHIA COLI: PARTIAL PURIFICATION AND SOME PROPERTIES Henry J. Vogel, David M. Bonner · Journal of Biological Chemistry Open access 1956 4,027
4 Estimation of the molecular weights of proteins by Sephadex gel-filtration Patrick Andrews · Biochemical Journal Open access May 1964 3,905
5 Statistical estimations in enzyme kinetics GN Wilkinson · Biochemical Journal Open access Aug 1961 3,569
All 99 most cited papers, with filters and sorting

Where is Enzyme function and inhibition research done?

The largest centres of Enzyme function and inhibition research in 2022-now are Florence (Italy), Beijing (China), Riyadh (Saudi Arabia) and Cairo (Egypt). Among places with at least 20 works in it, it is an unusually large share of all research in Florence.

Largest cities, 2022-now

  1. 1 FlorenceItaly 54 works
  2. 2 BeijingChina 24 works
  3. 3 RiyadhSaudi Arabia 22 works
  4. 4 CairoEgypt 19 works
  5. 5 ErzurumTürkiye 19 works
  6. 6 IstanbulTürkiye 18 works
  7. 7 ChennaiIndia 17 works
  8. 8 ShanghaiChina 17 works
  9. 9 GizaEgypt 16 works
  10. 10 MoscowRussia 15 works

Where it is the local speciality

  1. FlorenceIT · 54.4 works40×
← less than its size predicts1×more →

Location quotient: how much more of its research is in Enzyme function and inhibition than the world average.

See Enzyme function and inhibition on the map

Where is the best place to study Enzyme function and inhibition?

Among universities, judged by research, Atatürk University, King Saud University and University of Florence score highest, combining excellence, specialisation, size, growth and international reach. Research strength is one signal when choosing where to study; it does not measure teaching.

Excellenceshare of its work in the world top 10%, 2022-now and all time averaged
40%
Specialisationhow much of its work is in this field, counted up to 10× the world share
10%
Sizeits output in this field, on a log scale
30%
Growthoutput growth, counted from -20% to +20%
10%
Internationalshare of its work with a co-author abroad
10%
Each slider sets a weight; the share it gets of the score is beside it.
#UniversityScoreTop 10%SpecialisationWorksGrowth
1Atatürk UniversityTürkiye 58.515.9%34.4×18 -22.4%
2King Saud UniversitySaudi Arabia 54.121.1%7.8×11 +25.7%
3University of FlorenceItaly 43.513.9%67.3×58 -26.8%

Universities only. The score blends excellence (40%), size (30%), specialisation (10%), growth (10%), international reach (10%), 2022-now; growth compares 2018-21 with 2022-25 and counts up to +20%, since a jump from a small base is mostly noise.

Every institution in Enzyme function and inhibition, country by country

Is Enzyme function and inhibition research growing?

Output in 2022-2025 was 12% higher than in 2018-2021, peaking in 2025. The fastest-growing topics are Enzyme function and inhibition.

still counting19801990200020102020
grewheldshrank

The same series as a ribbon: one cell per year, darker for more. The line above answers how much; this answers when.

Its share of all research

Growing output can still be a shrinking share: all of science grows. This is Enzyme function and inhibition as a percentage of every work published that year, 0.0063% in 2024.

still counting0.10%0.20%Enzyme function and inhibition0.0069% in 202519801990200020102020

Fractional works of Enzyme function and inhibition over all fractional works that year. How the balance of science has shifted.

How much of it reaches the world top 10%

Year by year.

still counting5%10%15%Enzyme function and inhibition10.1% in 2025200020102020

Of each year's works in it, the share that reached the world's 10% most cited for their field and year. A field is the world for its own topics, so there is no other line to hold it against.

Which topics inside it are moving

Growth and decline on one axis around a shared zero. Two lists side by side hide the thing that matters: whether the growth dwarfs the decline, or the other way round.

Discussion

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