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Most cited papers in Esophageal and GI Pathology

What are the most cited papers in Esophageal and GI Pathology?

The most cited paper in Esophageal and GI Pathology is "A candidate genetic risk factor for vascular disease: a common mutation in methylenetetrahydrofolate reductase" (Phyllis Frosst, Henk J. Blom, Renate Milos et al., 1995), with 5,732 citations. Next come "Symptomatic Gastroesophageal Reflux as a Risk Factor for Esophageal Adenocarcinoma" (3,048) and "Endoscopic sphincterotomy complications and their management: an attempt at consensus" (2,873).

Showing 50 of 100 papers. Every paper with more than 757 citations is listed.

Most cited papers, sortable by citations and release date
#Paper
1 A candidate genetic risk factor for vascular disease: a common mutation in methylenetetrahydrofolate reductase Phyllis Frosst, Henk J. Blom, Renate Milos et al. · Nature Genetics Open access May 1995 5,732
2 Symptomatic Gastroesophageal Reflux as a Risk Factor for Esophageal Adenocarcinoma Jesper Lagergren, Reinhold Bergström, Anders Lindgren et al. · New England Journal of Medicine 18 Mar 1999 3,048
3 Endoscopic sphincterotomy complications and their management: an attempt at consensus Peter B. Cotton, Glen A. Lehman, Jack A. Vennes et al. · Gastrointestinal Endoscopy May 1991 2,873
4 Esophageal Cancer Peter C. Enzinger, Robert J. Mayer · New England Journal of Medicine 3 Dec 2003 2,525
5 A lexicon for endoscopic adverse events: report of an ASGE workshop Peter B. Cotton, Glenn M. Eisen, Lars Aabakken et al. · Gastrointestinal Endoscopy 27 Feb 2010 2,504
6 Oesophageal carcinoma Arjun Pennathur, Michael K. Gibson, Blair A. Jobe et al. · The Lancet Open access 31 Jan 2013 2,454
7 Endoscopic assessment of oesophagitis: clinical and functional correlates and further validation of the Los Angeles classification Lars R. Lundell, John Dent, J R Bennett et al. · Gut Open access Aug 1999 2,323
8 Homocysteine and Cardiovascular Disease Helga Refsum, Per Magne Ueland, Ottar Kjell Nygard et al. · Annual Review of Medicine Review Feb 1998 2,182
9 Prevalence and clinical spectrum of gastroesophageal reflux: A population-based study in Olmsted County, Minnesota G. Richard Locke, Nicholas J. Talley, Sara L. Fett et al. · Gastroenterology Open access May 1997 2,105
10 Updated Guidelines 2008 for the Diagnosis, Surveillance and Therapy of Barrett's Esophagus Kenneth K. Wang, Richard E. Sampliner · The American Journal of Gastroenterology Mar 2008 2,026
11 Chemoradiotherapy of Locally Advanced Esophageal Cancer Jay Scott Cooper, Matthew D. Guo, Arnold M. Herskovic et al. · JAMA 5 May 1999 1,982
12 The Chicago Classification of esophageal motility disorders, v3.0 Peter J. Kahrilas, Albert Jan Bredenoord, Mark R. Fox et al. · Neurogastroenterology & Motility Open access 3 Dec 2014 1,972
13 Peroral endoscopic myotomy (POEM) for esophageal achalasia Haruhiro Inoue, Hironobu Minami, Yasutoshi Kobayashi et al. · Endoscopy 30 Mar 2010 1,825
14 Minimally invasive versus open oesophagectomy for patients with oesophageal cancer: a multicentre, open-label, randomised controlled trial Surya S. A. Y. Biere, Mark I. van Berge Henegouwen, Kirsten W. Maas et al. · The Lancet May 2012 1,736
15 Survival after neoadjuvant chemotherapy or chemoradiotherapy for resectable oesophageal carcinoma: an updated meta-analysis Katrin Marie Sjoquist, Bryan Henry Burmeister, Bernard Mark Smithers et al. · The Lancet Oncology 21 Jun 2011 1,669
16 Extended Transthoracic Resection Compared with Limited Transhiatal Resection for Adenocarcinoma of the Esophagus Jan B.F. Hulscher, Johanna Wilhelmina van Sandick, Angela G. E. M. de Boer et al. · New England Journal of Medicine Open access 20 Nov 2002 1,647
17 A Second Common Mutation in the Methylenetetrahydrofolate Reductase Gene: An Additional Risk Factor for Neural-Tube Defects? Nathalie M. J. van der Put, Fons Gabreëls, E M Stevens et al. · The American Journal of Human Genetics Open access May 1998 1,564
18 ACG Clinical Guideline: Diagnosis and Management of Barrett’s Esophagus Nicholas J. Shaheen, Gary W. Falk, Prasad G. Iyer et al. · The American Journal of Gastroenterology Open access 3 Nov 2015 1,520
19 Risk assessment after acute upper gastrointestinal haemorrhage. Timothy Rockall, Richard F. Logan, Hugh Devlin et al. · Gut Open access Mar 1996 1,502
20 Modern diagnosis of GERD: the Lyon Consensus Chandra Prakash Gyawali, Peter J. Kahrilas, Edoardo Vincenzo Savarino et al. · Gut Open access 3 Feb 2018 1,460
21 Radiofrequency Ablation in Barrett's Esophagus with Dysplasia Nicholas J. Shaheen et al. · New England Journal of Medicine Open access 27 May 2009 1,445
22 Incidence of Adenocarcinoma among Patients with Barrett's Esophagus Frederik Hvid‐Jensen, Lars Pedersen, Asbjørn Mohr Drewes et al. · New England Journal of Medicine Open access 12 Oct 2011 1,385
23 British Society of Gastroenterology guidelines on the diagnosis and management of Barrett's oesophagus Rebecca C. Fitzgerald et al. · Gut Open access 28 Oct 2013 1,359
24 Endoscopic submucosal dissection: European Society of Gastrointestinal Endoscopy (ESGE) Guideline Pedro Pimentel‐Nunes et al. · Endoscopy Open access 28 Aug 2015 1,345
25 Larynx Preservation in Pyriform Sinus Cancer: Preliminary Results of a European Organization for Research and Treatment of Cancer Phase III Trial J.-L. Lefebvre, Dominique Chevalier, Bernard Luboinski et al. · JNCI Journal of the National Cancer Institute 3 Jul 1996 1,340
26 Chemoradiation With and Without Surgery in Patients With Locally Advanced Squamous Cell Carcinoma of the Esophagus M. Stahl, Martin Stuschke, Nils Lehmann et al. · Journal of Clinical Oncology 30 Mar 2005 1,332
27 A Second Genetic Polymorphism in Methylenetetrahydrofolate Reductase (MTHFR) Associated with Decreased Enzyme Activity Ilan S. Weisberg, Pamela Vivian Tran, Benedicte Christensen et al. · Molecular Genetics and Metabolism Jul 1998 1,290
28 Esophageal Carcinoma Anil K. Rustgi, Hashem B. El‐Serag · New England Journal of Medicine 24 Dec 2014 1,282
29 Randomized Trial of Preoperative Chemoradiation Versus Surgery Alone in Patients With Locoregional Esophageal Carcinoma Susan G. Urba, Mark B. Orringer, Andrew T. Turrisi et al. · Journal of Clinical Oncology 15 Jan 2001 1,277
30 Risk factors for post-ERCP pancreatitis: A prospective, multicenter study Martin L. Freeman, James A. DiSario, Douglas B. Nelson et al. · Gastrointestinal Endoscopy Oct 2001 1,261
31 The Global Landscape of Esophageal Squamous Cell Carcinoma and Esophageal Adenocarcinoma Incidence and Mortality in 2020 and Projections to 2040: New Estimates From GLOBOCAN 2020 Eileen Morgan, Isabelle Soerjomataram, Harriet Rumgay et al. · Gastroenterology Open access 4 Jun 2022 1,217
32 HOMOCYSTEINE METABOLISM Jacob Selhub · Annual Review of Nutrition Review Jul 1999 1,186
33 Oesophageal cancer Jesper Lagergren, Elizabeth Catherine Smyth, David Cunningham et al. · The Lancet Open access 23 Jun 2017 1,173
34 Fluoride removal from water by adsorption—A review Amit Bhatnagar, Eva Kumar, Mika E. T. Sillanpää · Chemical Engineering Journal 22 May 2011 1,165
35 International Consensus on Standardization of Data Collection for Complications Associated With Esophagectomy Donald E. Low et al. · Annals of Surgery 21 Jan 2015 1,162
36 Development of International Terminology and Definitions for Texture-Modified Foods and Thickened Fluids Used in Dysphagia Management: The IDDSI Framework Julie A. Y. Cichero, Peter Lam, Catriona Margaret Steele et al. · Dysphagia Open access 2 Dec 2016 1,131
37 Oesophageal cancer: ESMO Clinical Practice Guidelines for diagnosis, treatment and follow-up Florian Lordick, C. Mariette, Karin M. Haustermans et al. · Annals of Oncology Open access Sep 2016 1,128
38 Oesophageal cancer Elizabeth Catherine Smyth, Jesper Lagergren, Rebecca C. Fitzgerald et al. · Nature Reviews Disease Primers ReviewOpen access 27 Jul 2017 1,105
39 Eosinophilic esophagitis attributed to gastroesophageal reflux: Improvement with an amino acid-based formula Kevin J. Kelly, Audrey J. Lazenby, Peter C. Rowe et al. · Gastroenterology Open access Nov 1995 1,095
40 Guidelines on eosinophilic esophagitis: evidence‐based statements and recommendations for diagnosis and management in children and adults Alfredo José Lucendo et al. · United European Gastroenterology Journal Open access 24 Jan 2017 1,086
41 Esophageal motility disorders on high‐resolution manometry: Chicago classification version 4.0 © Rena H. Yadlapati et al. · Neurogastroenterology & Motility Open access 29 Dec 2020 1,079
42 The Validity and Reliability of the Reflux Finding Score (RFS) Peter Charles Belafsky, Gregory N. Postma, James A. Koufman · The Laryngoscope Open access Aug 2001 1,076
43 American Gastroenterological Association Technical Review on the Management of Barrett's Esophagus Stuart Jon Spechler, Prateek Sharma, Rhonda Frances Souza et al. · Gastroenterology Open access Mar 2011 1,063
44 Homocysteine and vascular disease Graeme J. Hankey, John W. Eikelboom · The Lancet Jul 1999 1,059
45 Esophageal cancer: Risk factors, screening and endoscopic treatment in Western and Eastern countries María José Domper-Arnal · World Journal of Gastroenterology Open access 2015 1,056
46 The Development and Validation of an Endoscopic Grading System for Barrett’s Esophagus: The Prague C & M Criteria Prateek Sharma, John Dent, David G. Armstrong et al. · Gastroenterology Open access 17 Aug 2006 1,055
47 5, 10-Methylenetetrahydrofolate Reductase Gene Variants and Congenital Anomalies: A HuGE Review Lorenzo D. Botto, Quanhe Yang · American Journal of Epidemiology May 2000 1,053
48 D2 Lymphadenectomy Alone or with Para-aortic Nodal Dissection for Gastric Cancer Mitsuru Sasako, Takeshi Sano, Seiichiro Yamamoto et al. · New England Journal of Medicine Open access 30 Jul 2008 1,029
49 ACG Clinical Guideline for the Diagnosis and Management of Gastroesophageal Reflux Disease Philip O. Katz, Kerry B. Dunbar, Felice H. Schnoll‐Sussman et al. · The American Journal of Gastroenterology Open access 22 Nov 2021 1,019
50 Neoadjuvant Chemoradiotherapy Followed by Surgery Versus Surgery Alone for Locally Advanced Squamous Cell Carcinoma of the Esophagus (NEOCRTEC5010): A Phase III Multicenter, Randomized, Open-Label Clinical Trial Hong Qiong Yang et al. · Journal of Clinical Oncology Open access 8 Aug 2018 1,016

Citations are OpenAlex's own counts, from its 2026-09-23 snapshot, so the ranking can differ from Google Scholar or Web of Science. A paper is listed for a field when OpenAlex files it under one of the field's topics; retracted papers and papers whose citation count cannot be traced to citing works are left out, and a preprint and the article it became are shown once. Release dates are OpenAlex's: where a source gave only a month or a year, that is what is shown. How the lists are chosen.