Most cited papers in FOXO transcription factor regulation
What are the most cited papers in FOXO transcription factor regulation?
The most cited paper in FOXO transcription factor regulation is "Integrated genomic analyses of ovarian carcinoma" (Debra Bell et al., 2011), with 8,268 citations. Next come "AKT/PKB Signaling: Navigating Downstream" (6,165) and "EMT: 2016" (4,612).
Showing 50 of 100 papers. Every paper with more than 869 citations is listed.
| # | Paper | ||
|---|---|---|---|
| 1 | Integrated genomic analyses of ovarian carcinoma Debra Bell et al. · Nature | 28 Jun 2011 | 8,268 |
| 2 | AKT/PKB Signaling: Navigating Downstream Brendan D. Manning, Lewis C. Cantley · Cell | Jun 2007 | 6,165 |
| 3 | EMT: 2016 Maria Angela Nieto, Ruby Yun‐Ju Huang, Rebecca Jackson et al. · Cell | Jun 2016 | 4,612 |
| 4 | Cellular survival: a play in three Akts Soma Datta, Anne Sophie Brunet, Michael E. Greenberg · Genes & Development | 15 Nov 1999 | 4,247 |
| 5 | The Role of Tumoral FOXP3 on Cell Proliferation, Migration, and Invasion in Gastric Cancer Lu Zhang, Jianghao Xu, Xuan Zhang et al. · Cellular Physiology and Biochemistry | 2017 | 4,094 |
| 6 | Mammalian Mitogen-Activated Protein Kinase Signal Transduction Pathways Activated by Stress and Inflammation John M. Kyriakis, Joseph Avruch · Physiological Reviews | Apr 2001 | 3,398 |
| 7 | A central role for JNK in obesity and insulin resistance Jiro Hirosumi, Gürol Tuncman, Lufen Chang et al. · Nature | 21 Nov 2002 | 3,377 |
| 8 | Stress-Dependent Regulation of FOXO Transcription Factors by the SIRT1 Deacetylase Anne Sophie Brunet, Lora B. Sweeney, James Fitzhugh Sturgill et al. · Science | 23 Feb 2004 | 3,267 |
| 9 | Prospective Identification of Tumorigenic Prostate Cancer Stem Cells Anne T. Collins, Paul A. Berry, Catherine Hyde et al. · Cancer Research | Dec 2005 | 2,826 |
| 10 | EMT, CSCs, and drug resistance: the mechanistic link and clinical implications Tsukasa Shibue, Robert A. Weinberg · Nature Reviews Clinical Oncology | 11 Apr 2017 | 2,616 |
| 11 | Association of reactive oxygen species levels and radioresistance in cancer stem cells Maximilian Diehn et al. · Nature | 5 Feb 2009 | 2,565 |
| 12 | Circulating Breast Tumor Cells Exhibit Dynamic Changes in Epithelial and Mesenchymal Composition Min A Yu, Aditya Bardia, Ben S. Wittner et al. · Science | 31 Jan 2013 | 2,522 |
| 13 | Mechanisms and Genes of Cellular Suicide Hermann Steller · Science | 10 Mar 1995 | 2,501 |
| 14 | Protein modules and signalling networks Tony J. Pawson · Nature | Feb 1995 | 2,452 |
| 15 | Genes that act downstream of DAF-16 to influence the lifespan of Caenorhabditis elegans Coleen Tara Murphy, Steven A. McCarroll, Cornelia I. Bargmann et al. · Nature | 29 Jun 2003 | 2,327 |
| 16 | A mammalian protein targeted by G1-arresting rapamycin–receptor complex Eric J. Brown, Mark W. Albers, Tae Bum Shin et al. · Nature | Jun 1994 | 2,082 |
| 17 | The Fork head transcription factor DAF-16 transduces insulin-like metabolic and longevity signals in C. elegans Scott Ogg, Suzanne Paradis, Shoshanna Gottlieb et al. · Nature | Oct 1997 | 1,979 |
| 18 | The Kinase LKB1 Mediates Glucose Homeostasis in Liver and Therapeutic Effects of Metformin Reuben J. Shaw, Katja A Lamia, Debbie S. Vasquez et al. · Science | 24 Nov 2005 | 1,955 |
| 19 | X-linked neonatal diabetes mellitus, enteropathy and endocrinopathy syndrome is the human equivalent of mouse scurfy Robert S. Wildin, Fred Ramsdell, Jane Peake et al. · Nature Genetics | 2001 | 1,919 |
| 20 | The tumor suppressor LKB1 kinase directly activates AMP-activated kinase and regulates apoptosis in response to energy stress Reuben J. Shaw, Monica Kosmatka, Nabeel M. Bardeesy et al. · Proceedings of the National Academy of Sciences | 25 Feb 2004 | 1,809 |
| 21 | Insulin-promoter-factor 1 is required for pancreas development in mice Jörgen Jönsson, Lena M. S. Carlsson, Helena Edlund et al. · Nature | Oct 1994 | 1,805 |
| 22 | The insulin signaling system. Morris F. White, C. Ronald Kahn · Journal of Biological Chemistry | 1994 | 1,737 |
| 23 | The p66shc adaptor protein controls oxidative stress response and life span in mammals Enrica Migliaccio, Marco Giorgio, Simonetta Mele et al. · Nature | Nov 1999 | 1,720 |
| 24 | Impaired insulin and insulin-like growth factor expression and signaling mechanisms in Alzheimer's disease – is this type 3 diabetes? Eric van Steen, Benjamin M. Terry, Enrique J. Rivera et al. · Journal of Alzheimer s Disease | 3 Mar 2005 | 1,704 |
| 25 | The SH2 and SH3 domain-containing protein GRB2 links receptor tyrosine kinases to ras signaling Eve Judith Lowenstein, Roger J. Daly, Andreas Batzer et al. · Cell | Aug 1992 | 1,663 |
| 26 | Generation of Breast Cancer Stem Cells through Epithelial-Mesenchymal Transition Anne‐Pierre Morel, Marjory Lièvre, Clémence Thomas et al. · PLoS ONE | 5 Aug 2008 | 1,662 |
| 27 | Mutations in the hepatocyte nuclear factor-1α gene in maturity-onset diabetes of the young (MODY3) Kazuya Yamagata et al. · Nature | Dec 1996 | 1,627 |
| 28 | Genetics and biology of pancreatic ductal adenocarcinoma Aram F. Hezel, Alec C. Kimmelman, Ben Z. Stanger et al. · Genes & Development | 15 May 2006 | 1,590 |
| 29 | Forkhead transcription factor FOXO3a protects quiescent cells from oxidative stress Geert J.P.L. Kops, Tobias B. Dansen, Paulien E. Polderman et al. · Nature | Sep 2002 | 1,579 |
| 30 | FoxOs Are Critical Mediators of Hematopoietic Stem Cell Resistance to Physiologic Oxidative Stress Zuzana Tóthová, Ramya Kollipara, Brian J.P. Huntly et al. · Cell | 2007 | 1,574 |
| 31 | daf-16 : An HNF-3/forkhead Family Member That Can Function to Double the Life-Span of Caenorhabditis elegans Kui Lin, Jennie B. Dorman, Aylin R. Rodan et al. · Science | 14 Nov 1997 | 1,532 |
| 32 | Mammalian MAPK Signal Transduction Pathways Activated by Stress and Inflammation: A 10-Year Update John M. Kyriakis, Joseph Avruch · Physiological Reviews | Apr 2012 | 1,499 |
| 33 | The c-Jun NH2-terminal Kinase Promotes Insulin Resistance during Association with Insulin Receptor Substrate-1 and Phosphorylation of Ser307 Vincent P. Aguirre, Tohru Uchida, Lynne Yenush et al. · Journal of Biological Chemistry | Mar 2000 | 1,488 |
| 34 | Insulin-regulated hepatic gluconeogenesis through FOXO1–PGC-1α interaction Pere Puigserver, James Rhee, Jerry Donovan et al. · Nature | 18 May 2003 | 1,488 |
| 35 | Targeted Apoptosis of Senescent Cells Restores Tissue Homeostasis in Response to Chemotoxicity and Aging Marjolein P. Baar et al. · Cell | Mar 2017 | 1,472 |
| 36 | AFX-like Forkhead transcription factors mediate cell-cycle regulation by Ras and PKB through p27kip1 René H. Medema, Geert J.P.L. Kops, Johannes L. Bos et al. · Nature | Apr 2000 | 1,457 |
| 37 | Pancreatic β Cell Dedifferentiation as a Mechanism of Diabetic β Cell Failure Chutima Talchai, Shouhong Xuan, Hua V. Lin et al. · Cell | Sep 2012 | 1,428 |
| 38 | Chromosome-Wide Mapping of Estrogen Receptor Binding Reveals Long-Range Regulation Requiring the Forkhead Protein FoxA1 Jason S. Carroll, X. Shirley Liu, Alexander S. Brodsky et al. · Cell | Jul 2005 | 1,415 |
| 39 | LKB1 is a master kinase that activates 13 kinases of the AMPK subfamily, including MARK/PAR‐1 José Miguel Lizcano, Olga Göransson, Rachel Toth et al. · The EMBO Journal | 19 Feb 2004 | 1,398 |
| 40 | FoxOs at the Crossroads of Cellular Metabolism, Differentiation, and Transformation Domenico Accili, Karen C. Arden · Cell | May 2004 | 1,366 |
| 41 | Mammalian SIRT1 Represses Forkhead Transcription Factors Maria Carla Motta, Nullin Divecha, Madeleine E. Lemieux et al. · Cell | Feb 2004 | 1,361 |
| 42 | The Myc/Max/Mad Network and the Transcriptional Control of Cell Behavior Carla Grandori, Shaun M. Cowley, Leonard Philip James et al. · Annual Review of Cell and Developmental Biology | Nov 2000 | 1,358 |
| 43 | Control of Pancreas and Liver Gene Expression by HNF Transcription Factors Duncan T. Odom, Nora Zizlsperger, David Benjamin Gordon et al. · Science | 26 Feb 2004 | 1,344 |
| 44 | FOXO transcription factors at the interface between longevity and tumor suppression Eric Lieberman Greer, Anne Sophie Brunet · Oncogene | 14 Nov 2005 | 1,319 |
| 45 | Novel Role of FBXW7 Circular RNA in Repressing Glioma Tumorigenesis Yibing Yang, Xinya Gao, Maolei Zhang et al. · JNCI Journal of the National Cancer Institute | 26 Jul 2017 | 1,224 |
| 46 | Downregulation of miRNA-200c Links Breast Cancer Stem Cells with Normal Stem Cells Yohei Shimono, Maider Zabala, Robert W. Cho et al. · Cell | Aug 2009 | 1,217 |
| 47 | Transcription factors as targets for cancer therapy James E. Darnell Jr. · Nature reviews. Cancer | Oct 2002 | 1,217 |
| 48 | From Estrogen-Centric to Aging and Oxidative Stress: A Revised Perspective of the Pathogenesis of Osteoporosis Stavros C. Manolagas · Endocrine Reviews | Jun 2010 | 1,212 |
| 49 | Identification and Characterization of Tumorigenic Liver Cancer Stem/Progenitor Cells Stephanie Ma, Kwok‐Wah Chan, Liang Hu et al. · Gastroenterology | 16 Apr 2007 | 1,211 |
| 50 | Transcription-dependent and -independent control of neuronal survival by the PI3K–Akt signaling pathway Anne Sophie Brunet, Sandeep Robert Datta, Michael E. Greenberg · Current Opinion in Neurobiology | Jun 2001 | 1,200 |
Citations are OpenAlex's own counts, from its 2026-09-23 snapshot, so the ranking can differ from Google Scholar or Web of Science. A paper is listed for a field when OpenAlex files it under one of the field's topics; retracted papers and papers whose citation count cannot be traced to citing works are left out, and a preprint and the article it became are shown once. Release dates are OpenAlex's: where a source gave only a month or a year, that is what is shown. How the lists are chosen.