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Topic · Molecular Biology

FOXO transcription factor regulation

FOXO transcription factor regulation is a research topic within Molecular Biology. Science Explorer counts 7.5k research works in it since 1970. 10.3% of them reached the world's top 10% most cited for their field and year.

This cluster of papers focuses on the regulation and diverse functions of FoxO transcription factors, including their roles in cell cycle regulation, response to oxidative stress, metabolism, apoptosis, cancer development and therapy, aging, DNA repair, and insulin signaling.

  • FoxO transcription factors
  • cell cycle regulation
  • oxidative stress
  • metabolism
  • apoptosis
  • cancer
  • aging
  • regulation
  • DNA repair
  • insulin signaling
Research works
7.5k
fractional, since 1970
In the world top 10%
767
per year above
Top-10% rate
10.3%
share of its works in the world top 10%
Growth, 2018-21 → 2022-25
-6%
the tick is no change
Largest producer
China
57% of the 10 largest, 2022-now
FOXO transcription factor regulation

Which countries lead FOXO transcription factor regulation research?

By volume, China and the United States publish the most (875 and 335 works in 2022-now).

By volume, 2022-now

  1. 1 China 875 works
  2. 2 United States 335 works
  3. 3 India 69 works
  4. 4 Japan 59 works
  5. 5 South Korea 55 works
  6. 6 Germany 41 works
  7. 7 Iran 35 works
  8. 8 Italy 27 works
  9. 9 United Kingdom 26 works
  10. 10 Türkiye 25 works

How concentrated that is

The same countries as shares of everything the list above accounts for. A node where two countries do two thirds of the work and one spread evenly across twelve read alike as a ranking and not at all alike here.

China: 56.5%United States: 21.7%India: 4.5%Japan: 3.8%6 others listed: 13.5%57%largest
China875 · 56.5%United States335 · 21.7%India69 · 4.5%Japan59 · 3.8%6 others listed209 · 13.5%

Shares of the rows listed above, not of the whole node.

Which institutions lead FOXO transcription factor regulation research?

By volume in 2022-now, Nanjing Medical University publishes the most FOXO transcription factor regulation research, followed by Shanghai Jiao Tong University and Sun Yat-sen University.

By volume, 2022-now

  1. 1 Nanjing Medical UniversityChina 20 works
  2. 2 Shanghai Jiao Tong UniversityChina 20 works
  3. 3 Sun Yat-sen UniversityChina 20 works
  4. 4 Zhejiang UniversityChina 16 works
  5. 5 Zhengzhou UniversityChina 14 works
  6. 6 Huazhong University of Science and TechnologyChina 13 works
  7. 7 Fudan UniversityChina 13 works
  8. 8 China Medical UniversityChina 12 works
  9. 9 Harvard UniversityUnited States 12 works
  10. 10 Sichuan UniversityChina 12 works

Who are the leading researchers in FOXO transcription factor regulation?

The most-cited researchers publishing on FOXO transcription factor regulation include Eric S. Lander, Guido Kroemer and Bert Vogelstein.

  1. 1 Eric S. Lander United States 524k citations
  2. 2 Guido Kroemer France 386k citations
  3. 3 Bert Vogelstein United States 373k citations
  4. 4 Gad A. Getz United States 364k citations
  5. 5 Shizuo Akira Japan 342k citations
  6. 6 Jun Wang China 340k citations
  7. 7 Matthias Mann Germany 308k citations
  8. 8 Robert A. Weinberg United States 301k citations
  9. 9 Richard A. Gibbs United States 292k citations
  10. 10 Luigi Ferrucci United States 281k citations

Ranked by citations received across their whole record, among researchers with at least three works on this topic.

What are the most cited papers in FOXO transcription factor regulation?

The most cited paper in FOXO transcription factor regulation is "Integrated genomic analyses of ovarian carcinoma" (Debra Bell et al., 2011), with 8,268 citations. Next come "AKT/PKB Signaling: Navigating Downstream" (6,165) and "EMT: 2016" (4,612).

Most cited papers
#PaperReleasedCitations
1 Integrated genomic analyses of ovarian carcinoma Debra Bell et al. · Nature Open access255 authors 28 Jun 2011 8,268
2 AKT/PKB Signaling: Navigating Downstream Brendan D. Manning, Lewis C. Cantley · Cell Open access Jun 2007 6,165
3 EMT: 2016 Maria Angela Nieto, Ruby Yun‐Ju Huang, Rebecca Jackson et al. · Cell Open access Jun 2016 4,612
4 Cellular survival: a play in three Akts Soma Datta, Anne Sophie Brunet, Michael E. Greenberg · Genes & Development Open access 15 Nov 1999 4,247
5 The Role of Tumoral FOXP3 on Cell Proliferation, Migration, and Invasion in Gastric Cancer Lu Zhang, Jianghao Xu, Xuan Zhang et al. · Cellular Physiology and Biochemistry Open access 2017 4,094
All 100 most cited papers, with filters and sorting

Where is FOXO transcription factor regulation research done?

The largest centres of FOXO transcription factor regulation research in 2022-now are Shanghai (China), Beijing (China), Guangzhou (China) and Nanjing (China). Among places with at least 20 works in it, it is an unusually large share of all research in Guangzhou.

Largest cities, 2022-now

  1. 1 ShanghaiChina 71 works
  2. 2 BeijingChina 66 works
  3. 3 GuangzhouChina 60 works
  4. 4 NanjingChina 36 works
  5. 5 HangzhouChina 36 works
  6. 6 WuhanChina 32 works
  7. 7 ChongqingChina 25 works
  8. 8 SeoulSouth Korea 24 works
  9. 9 ChangshaChina 23 works
  10. 10 ChengduChina 21 works

Where it is the local speciality

  1. GuangzhouCN · 60.3 works3.9×
← less than its size predicts1×more →

Location quotient: how much more of its research is in FOXO transcription factor regulation than the world average.

See FOXO transcription factor regulation on the map

Where is the best place to study FOXO transcription factor regulation?

Among universities, judged by research, Harvard University, Sun Yat-sen University and Wenzhou Medical University score highest, combining excellence, specialisation, size, growth and international reach. Research strength is one signal when choosing where to study; it does not measure teaching.

0%10%20%mean 13.55%fractional works in this field (log) →share of work in the world top 10% →Harvard UniversityWenzhou Medical Univ…Sun Yat-sen UniversityZhejiang University
above the meannear itbelow it

One dot per university in the first ten of the table below, at the default weights. The upper left is the interesting corner: small places doing unusually strong work.

Excellenceshare of its work in the world top 10%, 2022-now and all time averaged
40%
Specialisationhow much of its work is in this field, counted up to 10× the world share
10%
Sizeits output in this field, on a log scale
30%
Growthoutput growth, counted from -20% to +20%
10%
Internationalshare of its work with a co-author abroad
10%
Each slider sets a weight; the share it gets of the score is beside it.
#UniversityScoreTop 10%SpecialisationWorksGrowth
1Harvard UniversityUnited States 64.318.0%2.5×12 -27.7%
2Sun Yat-sen UniversityChina 56.611.5%6.1×20 -29.3%
3Wenzhou Medical UniversityChina 54.617.7%12.6×10 +14.2%
4Zhejiang UniversityChina 52.27.9%3.8×16 +32.2%
5Nanjing Medical UniversityChina 51.18.2%14.3×20 -19.9%
6Shanghai Jiao Tong UniversityChina 50.910.4%4.4×20 -26.2%
7Chongqing Medical UniversityChina 50.515.8%12.7×11 +17.5%
8Chinese Academy of Medical Sciences & Peking Union Medical CollegeChina 49.617.5%6.5×11 -1.5%
9Southern Medical UniversityChina 47.916.8%11.2×11 -10.0%
10Huazhong University of Science and TechnologyChina 45.611.7%4.7×13 -8.3%

Universities only. The score blends excellence (40%), size (30%), specialisation (10%), growth (10%), international reach (10%), 2022-now; growth compares 2018-21 with 2022-25 and counts up to +20%, since a jump from a small base is mostly noise.

Every institution in FOXO transcription factor regulation, country by country

Is FOXO transcription factor regulation research growing?

Output in 2022-2025 was 6% lower than in 2018-2021, peaking in 2025.

still counting19801990200020102020
grewheldshrank

The same series as a ribbon: one cell per year, darker for more. The line above answers how much; this answers when.

Its share of all research

Growing output can still be a shrinking share: all of science grows. This is FOXO transcription factor regulation as a percentage of every work published that year, 0.0065% in 2024.

still counting0.0050%0.010%FOXO transcription factor regulation0.0072% in 202519801990200020102020

Fractional works of FOXO transcription factor regulation over all fractional works that year. How the balance of science has shifted.

How much of it reaches the world top 10%

Year by year.

still counting5%10%15%FOXO transcription factor regulation10.7% in 2025200020102020

Of each year's works in it, the share that reached the world's 10% most cited for their field and year. A field is the world for its own topics, so there is no other line to hold it against.

Which topics inside it are moving

Growth and decline on one axis around a shared zero. Two lists side by side hide the thing that matters: whether the growth dwarfs the decline, or the other way round.

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