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Most cited papers in Free Radicals and Antioxidants

What are the most cited papers in Free Radicals and Antioxidants?

The most cited paper in Free Radicals and Antioxidants is "Antioxidant activity applying an improved ABTS radical cation decolorization assay" (Roberta Re, Nicoletta Pellegrini, Anna R. Proteggente et al., 1999), with 26,207 citations. Next come "Use of a free radical method to evaluate antioxidant activity" (25,846) and "Universal Solvation Model Based on Solute Electron Density and on a Continuum Model of the Solvent Defined by the Bulk Dielectric Constant and Atomic Surface Tensions" (18,056).

Showing 50 of 100 papers. Every paper with more than 1,991 citations is listed.

Most cited papers, sortable by citations and release date
#Paper
1 Antioxidant activity applying an improved ABTS radical cation decolorization assay Roberta Re, Nicoletta Pellegrini, Anna R. Proteggente et al. · Free Radical Biology and Medicine May 1999 26,207
2 Use of a free radical method to evaluate antioxidant activity Wendy Brand-Williams, Marie‐Elisabeth Cuvelier, Claudette Berset · LWT Open access 1995 25,846
3 Universal Solvation Model Based on Solute Electron Density and on a Continuum Model of the Solvent Defined by the Bulk Dielectric Constant and Atomic Surface Tensions Aleksandr V. Marenich, Christopher J. Cramer, Donald G. Truhlar · The Journal of Physical Chemistry B Open access 14 Apr 2009 18,056
4 Free radicals and antioxidants in normal physiological functions and human disease Marián Valko, Dieter Leibfritz, Ján Moncóľ et al. · The International Journal of Biochemistry & Cell Biology 7 Aug 2006 14,300
5 Superoxide Dismutase Joe M. McCord, Irwin Fridovich · Journal of Biological Chemistry Open access Nov 1969 12,906
6 Critical Review of rate constants for reactions of hydrated electrons, hydrogen atoms and hydroxyl radicals (⋅OH/⋅O− in Aqueous Solution George V. Buxton, Clive L. Greenstock, W. Phillips Helman et al. · Journal of Physical and Chemical Reference Data Apr 1988 12,349
7 Involvement of the Superoxide Anion Radical in the Autoxidation of Pyrogallol and a Convenient Assay for Superoxide Dismutase Stefan L. Marklund, Gudrun MARKLUND · European Journal of Biochemistry Open access Sep 1974 10,396
8 Quantum Calculation of Molecular Energies and Energy Gradients in Solution by a Conductor Solvent Model Vincenzo Barone, Maurizio Cossi · The Journal of Physical Chemistry A 20 Feb 1998 10,212
9 Structure-antioxidant activity relationships of flavonoids and phenolic acids Catherine A Rice-Evans, Nicholas J. Miller, George Paganga · Free Radical Biology and Medicine 1996 9,068
10 ROS Function in Redox Signaling and Oxidative Stress Michael Schieber, Navdeep S. Chandel · Current Biology Open access May 2014 6,967
11 Chemistry and biochemistry of 4-hydroxynonenal, malonaldehyde and related aldehydes Hermann Esterbauer, Rudolf Jörg Schaur, Helmward Zöllner · Free Radical Biology and Medicine 1991 6,700
12 Free radicals, metals and antioxidants in oxidative stress-induced cancer Marián Valko, Christopher J. Rhodes, Ján Moncóľ et al. · Chemico-Biological Interactions 24 Jan 2006 6,682
13 Lipid Peroxidation: Production, Metabolism, and Signaling Mechanisms of Malondialdehyde and 4-Hydroxy-2-Nonenal Antonio Ayala, Mario Muñoz, Sandro Argüelles · Oxidative Medicine and Cellular Longevity Open access 2014 6,379
14 Lead- and drug-like compounds: the rule-of-five revolution Christopher A. Lipinski · Drug Discovery Today Technologies Dec 2004 6,290
15 An improved algorithm for reaction path following Carlos A. Gonzalez, H. Bernhard Schlegel · The Journal of Chemical Physics 15 Feb 1989 6,170
16 The Chemistry behind Antioxidant Capacity Assays Dejian Huang, Boxin Ou, Ronald L. Prior · Journal of Agricultural and Food Chemistry 25 Feb 2005 6,143
17 Standardized Methods for the Determination of Antioxidant Capacity and Phenolics in Foods and Dietary Supplements Ronald L. Prior, Xianli Wu, Karen M. Schaich · Journal of Agricultural and Food Chemistry 26 Apr 2005 5,638
18 Targeting cancer cells by ROS-mediated mechanisms: a radical therapeutic approach? Dunyaporn Trachootham, Jérôme Alexandre, Peng Huang · Nature Reviews Drug Discovery Review 29 May 2009 5,449
19 Theoretical Basis, Experimental Design, and Computerized Simulation of Synergism and Antagonism in Drug Combination Studies Ting‐Chao Chou · Pharmacological Reviews Sep 2006 5,252
20 Molecular excitation energies to high-lying bound states from time-dependent density-functional response theory: Characterization and correction of the time-dependent local density approximation ionization threshold Mark E. Casida, Christine Jödicke Jamorski, Kim C. Casida et al. · The Journal of Chemical Physics 15 Mar 1998 5,027
21 Flavonoids as Antioxidants Piergiorgio Pietta · Journal of Natural Products 27 May 2000 4,873
22 PROPKA3: Consistent Treatment of Internal and Surface Residues in Empirical p K a Predictions Mats H. M. Olsson, Chresten R. Søndergaard, Michał Rostkowski et al. · Journal of Chemical Theory and Computation 6 Jan 2011 4,654
23 Oxidative stress: oxidants and antioxidants Helmut Sies · Experimental Physiology Mar 1997 4,576
24 Plant Phenolics: Extraction, Analysis and Their Antioxidant and Anticancer Properties Jin Dai, Russell J. Mumper · Molecules Open access 21 Oct 2010 4,484
25 Antioxidant properties of phenolic compounds Catherine A Rice-Evans, Nicholas J. Miller, George Paganga · Trends in Plant Science Review Apr 1997 4,381
26 Flavonoid antioxidants: chemistry, metabolism and structure-activity relationships Kelly E Heim, Anthony R. Tagliaferro, Dennis J. Bobilya · The Journal of Nutritional Biochemistry Oct 2002 4,216
27 Systematic optimization of long-range corrected hybrid density functionals Jeng‐Da Chai, Martin Head‐Gordon · The Journal of Chemical Physics 27 Feb 2008 4,196
28 First line defence antioxidants-superoxide dismutase (SOD), catalase (CAT) and glutathione peroxidase (GPX): Their fundamental role in the entire antioxidant defence grid Osasenaga Macdonald. Ighodaro, Oluseyi Adeboye Akinloye · Alexandria Journal of Medicine Open access 13 Nov 2017 3,970
29 Kinetics of Fluorescence Quenching by Electron and H‐Atom Transfer Dieter Rehm, Albert Weller · Israel Journal of Chemistry 1970 3,961
30 [2] Ferric reducing/antioxidant power assay: Direct measure of total antioxidant activity of biological fluids and modified version for simultaneous measurement of total antioxidant power and ascorbic acid concentration Iris F. F. Benzie, JJ Strain · Methods in enzymology on CD-ROM/Methods in enzymology Book chapter 1999 3,940
31 Antioxidant Activity and Total Phenolics in Selected Fruits, Vegetables, and Grain Products Y. Sedat Velioğlu, Giuseppe Antonio Mazza, Ling Gao et al. · Journal of Agricultural and Food Chemistry 29 Aug 1998 3,861
32 Design of Density Functionals by Combining the Method of Constraint Satisfaction with Parametrization for Thermochemistry, Thermochemical Kinetics, and Noncovalent Interactions Yan Zhao, Nathan E. Schultz, Donald G. Truhlar · Journal of Chemical Theory and Computation 4 Feb 2006 3,781
33 Rate Constants for Reactions of Inorganic Radicals in Aqueous Solution Pedatsur Neta, Robert E. Huie, Alberta B. Ross · Journal of Physical and Chemical Reference Data Jul 1988 3,649
34 Oxidative Stress and Neurodegenerative Diseases: A Review of Upstream and Downstream Antioxidant Therapeutic Options Bayani Uttara, Ajay Singh, Paolo Zamboni et al. · Current Neuropharmacology Open access Mar 2009 3,398
35 The Biology of Oxygen Radicals Irwin Fridovich · Science 8 Sep 1978 3,349
36 Phenolic compounds in plants and agri-industrial by-products: Antioxidant activity, occurrence, and potential uses Nagendran Balasundram, Kalyana Sundram, Samir Samman · Food Chemistry 6 Oct 2005 3,109
37 Phenolics and polyphenolics in foods, beverages and spices: Antioxidant activity and health effects – A review Fereidoon Shahidi, Priyatharini Ambigaipalan · Journal of Functional Foods Open access 21 Jul 2015 3,051
38 Oxidative stress: a concept in redox biology and medicine Helmut Sies · Redox Biology Open access 2 Jan 2015 3,026
39 Cancer chemoprevention with dietary phytochemicals Young‐Joon Surh · Nature reviews. Cancer Review 24 Nov 2003 2,962
40 Free radicals, antioxidants, and human disease: curiosity, cause, or consequence? Barry B. Halliwell · The Lancet Sep 1994 2,956
41 Development and Validation of an Improved Oxygen Radical Absorbance Capacity Assay Using Fluorescein as the Fluorescent Probe Boxin Ou, Maureen Hampsch‐Woodill, Ronald L. Prior · Journal of Agricultural and Food Chemistry 18 Sep 2001 2,938
42 Assaying for superoxide dismutase activity: Some large consequences of minor changes in conditions Wayne F. Beyer, Irwin Fridovich · Analytical Biochemistry Mar 1987 2,937
43 Free radicals in biology and medicine Barry B. Halliwell, John M.C. Gutteridge · Journal of Free Radicals in Biology & Medicine 1985 2,932
44 Free Radicals: Properties, Sources, Targets, and Their Implication in Various Diseases Phaniendra Alugoju, Dinesh Babu Jestadi, Latha Periyasamy · Indian Journal of Clinical Biochemistry Open access 14 Jul 2014 2,908
45 Targeting oxidative stress in disease: promise and limitations of antioxidant therapy Henry Jay Forman, Hongqiao Zhang · Nature Reviews Drug Discovery ReviewOpen access 30 Jun 2021 2,901
46 Comparative assessment of a new nonempirical density functional: Molecules and hydrogen-bonded complexes Viktor N. Staroverov, Gustavo E. Scuseria, Jianmin Tao et al. · The Journal of Chemical Physics 4 Dec 2003 2,895
47 The role of antioxidants in the chemistry of oxidative stress: A review Aurelia Magdalena Pisoschi, Aneta Pop · European Journal of Medicinal Chemistry 21 Apr 2015 2,890
48 Antioxidant Activity and Phenolic Compounds in Selected Herbs Wei Zheng, Shiow Y. Wang · Journal of Agricultural and Food Chemistry 28 Sep 2001 2,885
49 Antioxidant activity and phenolic compounds of 112 traditional Chinese medicinal plants associated with anticancer Yi‐Zhong Cai, Qiong Luo, Mei Sun et al. · Life Sciences Open access 12 Jan 2004 2,833
50 Novel Total Antioxidant Capacity Index for Dietary Polyphenols and Vitamins C and E, Using Their Cupric Ion Reducing Capability in the Presence of Neocuproine: CUPRAC Method Reşat Apak, Kubilay Güçlü, Mustafa Özyürek et al. · Journal of Agricultural and Food Chemistry 25 Nov 2004 2,812

Citations are OpenAlex's own counts, from its 2026-09-23 snapshot, so the ranking can differ from Google Scholar or Web of Science. A paper is listed for a field when OpenAlex files it under one of the field's topics; retracted papers and papers whose citation count cannot be traced to citing works are left out, and a preprint and the article it became are shown once. Release dates are OpenAlex's: where a source gave only a month or a year, that is what is shown. How the lists are chosen.