Most cited papers in Genetics, Aging, and Longevity in Model Organisms
What are the most cited papers in Genetics, Aging, and Longevity in Model Organisms?
The most cited paper in Genetics, Aging, and Longevity in Model Organisms is "THE GENETICS OF CAENORHABDITIS ELEGANS" (Sydney Brenner, 1974), with 15,608 citations. Next come "Potent and specific genetic interference by double-stranded RNA in Caenorhabditis elegans" (15,508) and "The Hallmarks of Aging" (15,388).
Showing 50 of 100 papers. Every paper with more than 1,800 citations is listed.
| # | Paper | ||
|---|---|---|---|
| 1 | THE GENETICS OF CAENORHABDITIS ELEGANS Sydney Brenner · Genetics | May 1974 | 15,608 |
| 2 | Potent and specific genetic interference by double-stranded RNA in Caenorhabditis elegans Andrew Z. Fire, Siqun Xu, Mary Katherine Montgomery et al. · Nature | Feb 1998 | 15,508 |
| 3 | The Hallmarks of Aging Carlos López-Otı́n, Marı́a A. Blasco, Linda Partridge et al. · Cell | Jun 2013 | 15,388 |
| 4 | The C. elegans heterochronic gene lin-4 encodes small RNAs with antisense complementarity to lin-14 Rosalind C. Lee, Rhonda L. Feinbaum, Victor Ambros · Cell | Dec 1993 | 13,024 |
| 5 | Oxidants, oxidative stress and the biology of ageing Toren Finkel, Nikki J. Holbrook · Nature | Nov 2000 | 9,446 |
| 6 | Alzheimer's Disease: The Amyloid Cascade Hypothesis John Hardy, Gerald A. Higgins · Science | 10 Apr 1992 | 7,581 |
| 7 | Green Fluorescent Protein as a Marker for Gene Expression Martin Chalfie, Yuan Tu, Ghia M. Euskirchen et al. · Science | 11 Feb 1994 | 6,824 |
| 8 | Hallmarks of aging: An expanding universe Carlos López-Otı́n, Marı́a A. Blasco, Linda Partridge et al. · Cell | 2023 | 6,477 |
| 9 | The structure of the nervous system of the nematode Caenorhabditis elegans JG White, Eileen Southgate, J. Nichol Thomson et al. · Philosophical transactions of the Royal Society of London. Series B, Biological sciences | 12 Nov 1986 | 5,884 |
| 10 | Telomeres shorten during ageing of human fibroblasts Calvin B. Harley, A. B. Futcher, Carol W. Greider · Nature | May 1990 | 5,775 |
| 11 | Inflamm‐aging: An Evolutionary Perspective on Immunosenescence Claudio Franceschi, Massimiliano Bonafè, Silvana Valensin et al. · Annals of the New York Academy of Sciences | Jun 2000 | 5,391 |
| 12 | THE HEAT-SHOCK PROTEINS S Lindquist, Elizabeth A. Craig · Annual Review of Genetics | Dec 1988 | 5,335 |
| 13 | The 21-nucleotide let-7 RNA regulates developmental timing in Caenorhabditis elegans Brenda J. Reinhart, Frank John Slack, Michael Basson et al. · Nature | Feb 2000 | 5,025 |
| 14 | Extension of Life-Span by Introduction of Telomerase into Normal Human Cells Andrea G. Bodnar, Michel M. Ouellette, Maria Frolkis et al. · Science | 16 Jan 1998 | 5,020 |
| 15 | CRISPR-Cas12a target binding unleashes indiscriminate single-stranded DNase activity Janice S. Chen, Enbo Ma, Lucas B. Harrington et al. · Science | 15 Feb 2018 | 4,623 |
| 16 | Mitochondria, Oxidants, and Aging Robert S. Balaban, Shino Nemoto, Toren Finkel · Cell | Feb 2005 | 4,416 |
| 17 | The embryonic cell lineage of the nematode Caenorhabditis elegans John Sulston, Einhard Schierenberg, John Graham White et al. · Developmental Biology | Nov 1983 | 4,376 |
| 18 | Posttranscriptional regulation of the heterochronic gene lin-14 by lin-4 mediates temporal pattern formation in C. elegans Bruce Wightman, Ilho Ha, Gary Ruvkun · Cell | Dec 1993 | 4,312 |
| 19 | Resveratrol improves health and survival of mice on a high-calorie diet Joseph A. Baur et al. · Nature | Nov 2006 | 4,279 |
| 20 | mTOR: from growth signal integration to cancer, diabetes and ageing Roberto Zoncu, Alejo Efeyan, David M. Sabatini · Nature Reviews Molecular Cell Biology | 15 Dec 2010 | 3,983 |
| 21 | Rapamycin fed late in life extends lifespan in genetically heterogeneous mice David E. Harrison, Randy Strong, Zelton Dave Sharp et al. · Nature | Jul 2009 | 3,836 |
| 22 | Small molecule activators of sirtuins extend Saccharomyces cerevisiae lifespan Konrad T. Howitz, Kevin J. Bitterman, Haim Yosef Cohen et al. · Nature | 24 Aug 2003 | 3,797 |
| 23 | Systematic functional analysis of the Caenorhabditis elegans genome using RNAi Ravi S. Kamath, Andrew G. Fraser, Dong Yan et al. · Nature | 2003 | 3,792 |
| 24 | Post-embryonic cell lineages of the nematode, Caenorhabditis elegans J.E. Sulston, H. Robert Horvitz · Developmental Biology | Mar 1977 | 3,621 |
| 25 | One-Step Generation of Mice Carrying Mutations in Multiple Genes by CRISPR/Cas-Mediated Genome Engineering Haoyi Wang, Hui Xiang Yang, Chikdu Shivalila et al. · Cell | May 2013 | 3,600 |
| 26 | Transcriptional silencing and longevity protein Sir2 is an NAD-dependent histone deacetylase Shin‐ichiro Imai, Christopher M. Armstrong, Matt R. Kaeberlein et al. · Nature | Feb 2000 | 3,531 |
| 27 | A C. elegans mutant that lives twice as long as wild type Cynthia J. Kenyon, Jean Chang, Erin Gensch et al. · Nature | Dec 1993 | 3,496 |
| 28 | Germline P Granules Are Liquid Droplets That Localize by Controlled Dissolution/Condensation Clifford P. Brangwynne, Christian R. Eckmann, David S. Courson et al. · Science | 21 May 2009 | 3,471 |
| 29 | Ageing as a risk factor for neurodegenerative disease Yujun Hou, Xiuli Dan, Mansi Babbar et al. · Nature Reviews Neurology | 9 Sep 2019 | 3,412 |
| 30 | Double Nicking by RNA-Guided CRISPR Cas9 for Enhanced Genome Editing Specificity F. Ann Ran, Patrick D. Hsu, Chie-Yu Lin et al. · Cell | 29 Aug 2013 | 3,412 |
| 31 | C. elegans : des neurones et des gènes Christelle Gally, Jean‐Louis Bessereau · médecine/sciences | Jun 2003 | 3,405 |
| 32 | Forecasting the global burden of Alzheimer's disease Ron Brookmeyer, Elizabeth M. Johnson, Kathryn Ziegler‐Graham et al. · Alzheimer s & Dementia | 4 Jun 2007 | 3,398 |
| 33 | Aging, Natural Death, and the Compression of Morbidity James F. Fries · New England Journal of Medicine | 17 Jul 1980 | 3,375 |
| 34 | DNA methylation-based biomarkers and the epigenetic clock theory of ageing Steve Horvath, Kenneth Raj · Nature Reviews Genetics | 11 Apr 2018 | 3,349 |
| 35 | Cellular Senescence: Defining a Path Forward Vassilis G. Gorgoulis et al. · Cell | Oct 2019 | 3,322 |
| 36 | An Abundant Class of Tiny RNAs with Probable Regulatory Roles in Caenorhabditis elegans Nelson C. Lau, Lee P. Lim, Earl G. Weinstein et al. · Science | 26 Oct 2001 | 3,275 |
| 37 | Stress-Dependent Regulation of FOXO Transcription Factors by the SIRT1 Deacetylase Anne Sophie Brunet, Lora B. Sweeney, James Fitzhugh Sturgill et al. · Science | 23 Feb 2004 | 3,267 |
| 38 | Efficient gene transfer in C.elegans: extrachromosomal maintenance and integration of transforming sequences. C C Mello, James M. Kramer, Dan T. Stinchcomb et al. · The EMBO Journal | Dec 1991 | 3,256 |
| 39 | Apaf-1, a Human Protein Homologous to C. elegans CED-4, Participates in Cytochrome c–Dependent Activation of Caspase-3 Hua Zou, William J. Henzel, Xuesong Liu et al. · Cell | Aug 1997 | 3,170 |
| 40 | Oxidative Stress, Caloric Restriction, and Aging Rajindar S. Sohal, Richard H. Weindruch · Science | 5 Jul 1996 | 3,152 |
| 41 | Extending Healthy Life Span—From Yeast to Humans Luigi Fontana, Linda Partridge, Valter Daniel Longo · Science | 15 Apr 2010 | 3,087 |
| 42 | Accelerated telomere shortening in response to life stress Elissa S. Epel, Elizabeth Helen Blackburn, Jue Lin et al. · Proceedings of the National Academy of Sciences | Dec 2004 | 3,020 |
| 43 | Aging, Cellular Senescence, and Cancer Judith Campisi · Annual Review of Physiology | 9 Nov 2012 | 3,009 |
| 44 | Accumulation of Deficits as a Proxy Measure of Aging Arnold B. Mitnitski, Alexander J. Mogilner, Kenneth J. Rockwood · The Scientific World JOURNAL | 2001 | 2,988 |
| 45 | Maintenance of C. elegans Theresa Stiernagle · WormBook | 2006 | 2,957 |
| 46 | Evolution at Two Levels in Humans and Chimpanzees Mary‐Claire King, Allan C. Wilson · Science | 11 Apr 1975 | 2,926 |
| 47 | IRE1 couples endoplasmic reticulum load to secretory capacity by processing the XBP-1 mRNA Marcella A. Calfon, Huiqing Zeng, Fumihiko Urano et al. · Nature | 3 Jan 2002 | 2,916 |
| 48 | MAGeCK enables robust identification of essential genes from genome-scale CRISPR/Cas9 knockout screens Wei Li, Han Xu, Tengfei Xiao et al. · Genome biology | 4 Dec 2014 | 2,893 |
| 49 | An Extensive Class of Small RNAs in Caenorhabditis elegans Rosalind C. Lee, Victor Ambros · Science | 26 Oct 2001 | 2,846 |
| 50 | Geroscience: Linking Aging to Chronic Disease Brian Keith Kennedy, Shelley L. Berger, Anne Sophie Brunet et al. · Cell | Nov 2014 | 2,837 |
Citations are OpenAlex's own counts, from its 2026-09-23 snapshot, so the ranking can differ from Google Scholar or Web of Science. A paper is listed for a field when OpenAlex files it under one of the field's topics; retracted papers and papers whose citation count cannot be traced to citing works are left out, and a preprint and the article it became are shown once. Release dates are OpenAlex's: where a source gave only a month or a year, that is what is shown. How the lists are chosen.