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Topic · Aging

Genetics, Aging, and Longevity in Model Organisms

Genetics, Aging, and Longevity in Model Organisms is a research topic within Aging. Science Explorer counts 29k research works in it since 1950. 10.1% of them reached the world's top 10% most cited for their field and year.

This cluster of papers explores the molecular mechanisms underlying aging, longevity, and age-related diseases. It covers topics such as oxidative stress, genetic regulation of lifespan, the impact of caloric restriction, mitochondrial function, RNA interference, inflammaging, insulin signaling, and proteostasis. The research spans model organisms like C. elegans and Drosophila to mammalian studies, providing insights into the fundamental processes of aging.

  • Aging
  • Oxidative Stress
  • Longevity
  • Genetic Regulation
  • Caloric Restriction
  • Mitochondrial Function
  • RNAi
  • Inflammaging
  • Insulin Signaling
  • Proteostasis
Research works
29k
fractional, since 1950
In the world top 10%
2.9k
per year above
Top-10% rate
10.1%
share of its works in the world top 10%
Growth, 2018-21 → 2022-25
+11%
the tick is no change
Largest producer
United States
41% of the 10 largest, 2022-now
Genetics, Aging, and Longevity in Model Organisms

Which countries lead Genetics, Aging, and Longevity in Model Organisms research?

By volume, the United States and China publish the most (1.9k and 1.2k works in 2022-now).

By volume, 2022-now

  1. 1 United States 1.9k works
  2. 2 China 1.2k works
  3. 3 United Kingdom 247 works
  4. 4 Germany 233 works
  5. 5 India 231 works
  6. 6 Japan 229 works
  7. 7 Canada 173 works
  8. 8 France 168 works
  9. 9 South Korea 144 works
  10. 10 Spain 138 works

How concentrated that is

The same countries as shares of everything the list above accounts for. A node where two countries do two thirds of the work and one spread evenly across twelve read alike as a ranking and not at all alike here.

United States: 41.0%China: 25.3%United Kingdom: 5.3%Germany: 5.0%6 others listed: 23.4%41%largest
United States1,899 · 41.0%China1,171 · 25.3%United Kingdom247 · 5.3%Germany233 · 5.0%6 others listed1,082 · 23.4%

Shares of the rows listed above, not of the whole node.

Which institutions lead Genetics, Aging, and Longevity in Model Organisms research?

By volume in 2022-now, Harvard University publishes the most Genetics, Aging, and Longevity in Model Organisms research, followed by Centre National de la Recherche Scientifique and Chinese Academy of Sciences.

By volume, 2022-now

  1. 1 Harvard UniversityUnited States 67 works
  2. 2 Centre National de la Recherche ScientifiqueFrance 63 works
  3. 3 Chinese Academy of SciencesChina 62 works
  4. 4 Russian Academy of SciencesRussia 51 works
  5. 5 National Institutes of HealthUnited States 37 works
  6. 6 Max Planck SocietyGermany 34 works
  7. 7 University College LondonUnited Kingdom 29 works
  8. 8 University of California San DiegoUnited States 28 works
  9. 9 University of California, IrvineUnited States 28 works
  10. 10 University of MichiganUnited States 27 works

Who are the leading researchers in Genetics, Aging, and Longevity in Model Organisms?

The most-cited researchers publishing on Genetics, Aging, and Longevity in Model Organisms include George Davey Smith, Walter Churchill Willett and Richard M. Durbin.

  1. 1 George Davey Smith United Kingdom 435k citations
  2. 2 Walter Churchill Willett United States 411k citations
  3. 3 Richard M. Durbin United Kingdom 410k citations
  4. 4 Mark J. Daly United States 403k citations
  5. 5 Peer Bork Germany 396k citations
  6. 6 Guido Kroemer France 386k citations
  7. 7 Elaine R. Mardis United States 346k citations
  8. 8 Hermann Brenner Germany 343k citations
  9. 9 Cyrus Cooper United Kingdom 342k citations
  10. 10 Emelia J. Benjamin United States 341k citations

Ranked by citations received across their whole record, among researchers with at least three works on this topic.

What are the most cited papers in Genetics, Aging, and Longevity in Model Organisms?

The most cited paper in Genetics, Aging, and Longevity in Model Organisms is "THE GENETICS OF CAENORHABDITIS ELEGANS" (Sydney Brenner, 1974), with 15,608 citations. Next come "Potent and specific genetic interference by double-stranded RNA in Caenorhabditis elegans" (15,508) and "The Hallmarks of Aging" (15,388).

Most cited papers
#PaperReleasedCitations
1 THE GENETICS OF CAENORHABDITIS ELEGANS Sydney Brenner · Genetics May 1974 15,608
2 Potent and specific genetic interference by double-stranded RNA in Caenorhabditis elegans Andrew Z. Fire, Siqun Xu, Mary Katherine Montgomery et al. · Nature Open access Feb 1998 15,508
3 The Hallmarks of Aging Carlos López-Otı́n, Marı́a A. Blasco, Linda Partridge et al. · Cell Open access Jun 2013 15,388
4 The C. elegans heterochronic gene lin-4 encodes small RNAs with antisense complementarity to lin-14 Rosalind C. Lee, Rhonda L. Feinbaum, Victor Ambros · Cell Open access Dec 1993 13,024
5 Oxidants, oxidative stress and the biology of ageing Toren Finkel, Nikki J. Holbrook · Nature Nov 2000 9,446
All 100 most cited papers, with filters and sorting

Where is Genetics, Aging, and Longevity in Model Organisms research done?

The largest centres of Genetics, Aging, and Longevity in Model Organisms research in 2022-now are Beijing (China), Shanghai (China), New York (United States) and London (United Kingdom). Among places with at least 20 works in it, it is an unusually large share of all research in Chevy Chase, Worcester and Irvine.

Largest cities, 2022-now

  1. 1 BeijingChina 195 works
  2. 2 ShanghaiChina 93 works
  3. 3 New YorkUnited States 91 works
  4. 4 LondonUnited Kingdom 85 works
  5. 5 ParisFrance 83 works
  6. 6 TokyoJapan 71 works
  7. 7 MoscowRussia 68 works
  8. 8 NanjingChina 65 works
  9. 9 GuangzhouChina 63 works
  10. 10 CambridgeUnited States 54 works

Where it is the local speciality

  1. Chevy ChaseUS · 22.1 works42×
  2. WorcesterUS · 27.1 works12×
  3. IrvineUS · 28.4 works7.7×
← less than its size predicts1×more →

Location quotient: how much more of its research is in Genetics, Aging, and Longevity in Model Organisms than the world average.

See Genetics, Aging, and Longevity in Model Organisms on the map

Where is the best place to study Genetics, Aging, and Longevity in Model Organisms?

Among universities, judged by research, Zunyi Medical University, Harvard University and Southeast University score highest, combining excellence, specialisation, size, growth and international reach. Research strength is one signal when choosing where to study; it does not measure teaching.

0%20%40%mean 20.54%fractional works in this field (log) →share of work in the world top 10% →Southeast UniversityZunyi Medical Univer…Rockefeller UniversityHarvard University
above the meannear itbelow it

One dot per university in the first ten of the table below, at the default weights. The upper left is the interesting corner: small places doing unusually strong work.

Excellenceshare of its work in the world top 10%, 2022-now and all time averaged
40%
Specialisationhow much of its work is in this field, counted up to 10× the world share
10%
Sizeits output in this field, on a log scale
30%
Growthoutput growth, counted from -20% to +20%
10%
Internationalshare of its work with a co-author abroad
10%
Each slider sets a weight; the share it gets of the score is beside it.
#UniversityScoreTop 10%SpecialisationWorksGrowth
1Zunyi Medical UniversityChina 62.741.7%11.2×10 +489.5%
2Harvard UniversityUnited States 61.012.7%4.1×66 -7.1%
3Southeast UniversityChina 54.343.5%3.2×24 -10.2%
4Rockefeller UniversityUnited States 53.416.8%65.5×21 +309.1%
5University College LondonUnited Kingdom 52.310.1%3.5×29 +26.5%
6Massachusetts Institute of TechnologyUnited States 51.920.2%3.6×13 +19.4%
7McGill UniversityCanada 48.811.3%4.8×24 +13.6%
8University of Alabama at BirminghamUnited States 47.617.8%8.4×21 +36.1%
9University of CologneGermany 47.315.9%8.3×19 +29.2%
10University of Massachusetts Chan Medical SchoolUnited States 47.115.4%24.1×21 +0.3%

Universities only. The score blends excellence (40%), size (30%), specialisation (10%), growth (10%), international reach (10%), 2022-now; growth compares 2018-21 with 2022-25 and counts up to +20%, since a jump from a small base is mostly noise.

Every institution in Genetics, Aging, and Longevity in Model Organisms, country by country

Is Genetics, Aging, and Longevity in Model Organisms research growing?

Output in 2022-2025 was 11% higher than in 2018-2021, peaking in 2025. The fastest-growing topics are Genetics, Aging, and Longevity in Model Organisms.

still counting19801990200020102020
grewheldshrank

The same series as a ribbon: one cell per year, darker for more. The line above answers how much; this answers when.

Its share of all research

Growing output can still be a shrinking share: all of science grows. This is Genetics, Aging, and Longevity in Model Organisms as a percentage of every work published that year, 0.024% in 2024.

still counting0.020%0.040%Genetics, Aging, and Longevity in Model Organisms0.025% in 202519801990200020102020

Fractional works of Genetics, Aging, and Longevity in Model Organisms over all fractional works that year. How the balance of science has shifted.

How much of it reaches the world top 10%

Year by year.

still counting5%10%15%Genetics, Aging, and Longevity in Model Organisms10.5% in 2025200020102020

Of each year's works in it, the share that reached the world's 10% most cited for their field and year. A field is the world for its own topics, so there is no other line to hold it against.

Which topics inside it are moving

Growth and decline on one axis around a shared zero. Two lists side by side hide the thing that matters: whether the growth dwarfs the decline, or the other way round.

Questions people ask

Who leads longevity research?

By volume in 2022-now, Harvard University publishes the most Genetics, Aging, and Longevity in Model Organisms research, followed by Centre National de la Recherche Scientifique and Chinese Academy of Sciences. By volume, the United States and China publish the most (1.9k and 1.2k works in 2022-now).

All 1,273 questions in the Question Catalogue

Discussion

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