Most cited papers in Genomics, phytochemicals, and oxidative stress
What are the most cited papers in Genomics, phytochemicals, and oxidative stress?
The most cited paper in Genomics, phytochemicals, and oxidative stress is "Glutathione S-Transferases" (William H. Habig, Michael J Pabst, William B. Jakoby, 1974), with 18,239 citations. Next come "Oxidative stress, antioxidants and stress tolerance" (10,890) and "Free Radicals in the Physiological Control of Cell Function" (9,887).
Showing 50 of 100 papers. Every paper with more than 1,578 citations is listed.
| # | Paper | ||
|---|---|---|---|
| 1 | Glutathione S-Transferases William H. Habig, Michael J Pabst, William B. Jakoby · Journal of Biological Chemistry | Nov 1974 | 18,239 |
| 2 | Oxidative stress, antioxidants and stress tolerance Ron Mittler · Trends in Plant Science | Sep 2002 | 10,890 |
| 3 | Free Radicals in the Physiological Control of Cell Function Wulf Dröge · Physiological Reviews | 2002 | 9,887 |
| 4 | The determination of flavonoid contents in mulberry and their scavenging effects on superoxide radicals Jia Zhishen, Tang Mengcheng, Jianming Wu · Food Chemistry | Mar 1999 | 8,838 |
| 5 | ROS Function in Redox Signaling and Oxidative Stress Michael Schieber, Navdeep S. Chandel · Current Biology | May 2014 | 6,967 |
| 6 | Free radicals, metals and antioxidants in oxidative stress-induced cancer Marián Valko, Christopher J. Rhodes, Ján Moncóľ et al. · Chemico-Biological Interactions | 24 Jan 2006 | 6,682 |
| 7 | Oxidative stress, inflammation, and cancer: How are they linked? Simone Reuter, Subash C. Gupta, Madan Mohan Chaturvedi et al. · Free Radical Biology and Medicine | 17 Sep 2010 | 5,431 |
| 8 | Reactive oxygen species (ROS) as pleiotropic physiological signalling agents Helmut Sies, Dean P. Jones · Nature Reviews Molecular Cell Biology | 30 Mar 2020 | 5,273 |
| 9 | Oxidative Stress and Antioxidant Defense Esra Birben, Ümit Murat Şahiner, Cansın Saçkesen et al. · World Allergy Organization Journal | 2012 | 4,985 |
| 10 | Role of Nrf2 in Oxidative Stress and Toxicity Qiang Ma · The Annual Review of Pharmacology and Toxicology | 6 Jan 2013 | 4,940 |
| 11 | Reactive oxygen species (ROS) homeostasis and redox regulation in cellular signaling Paul D. Ray, Bowen Huang, Yoshiaki Tsuji · Cellular Signalling | 20 Jan 2012 | 4,423 |
| 12 | Upstream and downstream of mTOR Nissim Hay, Nahum Sonenberg · Genes & Development | 15 Aug 2004 | 4,241 |
| 13 | Levels of glutathione, glutathione reductase and glutathione S-transferase activities in rat lung and liver M MORON, Joseph William DePierre, Bengt Mannervik · Biochimica et Biophysica Acta (BBA) - General Subjects | 4 Jan 1979 | 4,221 |
| 14 | An Nrf2/Small Maf Heterodimer Mediates the Induction of Phase II Detoxifying Enzyme Genes through Antioxidant Response Elements Ken Itoh, Tomoki Chiba, Satoru Takahashi et al. · Biochemical and Biophysical Research Communications | Jul 1997 | 4,013 |
| 15 | Reactive oxygen intermediates as apparently widely used messengers in the activation of the NF‐kappa B transcription factor and HIV‐1. Ralf Schreck, PETER RIEBER, Patrick A. Baeuerle · The EMBO Journal | Aug 1991 | 3,832 |
| 16 | The CoQ oxidoreductase FSP1 acts parallel to GPX4 to inhibit ferroptosis Kirill Bersuker, Joseph M. Hendricks, Zhipeng Li et al. · Nature | 21 Oct 2019 | 3,764 |
| 17 | Cell Survival Responses to Environmental Stresses Via the Keap1-Nrf2-ARE Pathway Thomas W. Kensler, Nobunao Wakabayashi, Shyam S. Biswal · The Annual Review of Pharmacology and Toxicology | 29 Aug 2006 | 3,654 |
| 18 | ROS as signalling molecules: mechanisms that generate specificity in ROS homeostasis Benoît D’Autréaux, Michel B. Tolédano · Nature Reviews Molecular Cell Biology | 12 Sep 2007 | 3,648 |
| 19 | Keap1 represses nuclear activation of antioxidant responsive elements by Nrf2 through binding to the amino-terminal Neh2 domain Ken Itoh, Nobunao Wakabayashi, Yasutake Katoh et al. · Genes & Development | 1999 | 3,637 |
| 20 | Modulation of oxidative stress as an anticancer strategy Chiara Gorrini, Isaac S. Harris, Tak W. Mak · Nature Reviews Drug Discovery | 29 Nov 2013 | 3,620 |
| 21 | GLUTATHIONE TRANSFERASES John David Hayes, Jack U. Flanagan, Ian R. Jowsey · The Annual Review of Pharmacology and Toxicology | 2 Nov 2004 | 3,565 |
| 22 | Transcriptional silencing and longevity protein Sir2 is an NAD-dependent histone deacetylase Shin‐ichiro Imai, Christopher M. Armstrong, Matt R. Kaeberlein et al. · Nature | Feb 2000 | 3,531 |
| 23 | Oxidative Stress Helmut Sies, Carsten Berndt, Dean P. Jones · Annual Review of Biochemistry | 25 Apr 2017 | 3,524 |
| 24 | The Glut athione S-Transferase Supergene Family: Regulation of GST and the Contribution of the lsoenzymes to Cancer Chemoprotection and Drug Resistance Part I John David Hayes, David J. Pulford · Critical Reviews in Biochemistry and Molecular Biology | 1995 | 3,487 |
| 25 | Targeting the KEAP1-NRF2 System to Prevent Kidney Disease Progression Masahiro Nezu, Norio Suzuki, Masayuki P. Yamamoto · American Journal of Nephrology | 2017 | 3,459 |
| 26 | Investigation of the Alamar Blue (resazurin) fluorescent dye for the assessment of mammalian cell cytotoxicity John O’Brien, Ian D. Wilson, Terry C. Orton et al. · European Journal of Biochemistry | Sep 2000 | 3,452 |
| 27 | Reactive oxygen species in cancer Geou‐Yarh Liou, Peter Störz · Free Radical Research | 2010 | 3,440 |
| 28 | Oxidative stress: a concept in redox biology and medicine Helmut Sies · Redox Biology | 2 Jan 2015 | 3,026 |
| 29 | The chemical diversity and distribution of glucosinolates and isothiocyanates among plants Jed W. Fahey, Amy T. Zalcmann, Paul Talalay · Phytochemistry | 2001 | 2,987 |
| 30 | Redox Homeostasis and Antioxidant Signaling: A Metabolic Interface between Stress Perception and Physiological Responses Christine Helen Foyer, Graham Noctor · The Plant Cell | 29 Jun 2005 | 2,964 |
| 31 | Cancer chemoprevention with dietary phytochemicals Young‐Joon Surh · Nature reviews. Cancer | 24 Nov 2003 | 2,962 |
| 32 | Targeting oxidative stress in disease: promise and limitations of antioxidant therapy Henry Jay Forman, Hongqiao Zhang · Nature Reviews Drug Discovery | 30 Jun 2021 | 2,901 |
| 33 | The role of antioxidants in the chemistry of oxidative stress: A review Aurelia Magdalena Pisoschi, Aneta Pop · European Journal of Medicinal Chemistry | 21 Apr 2015 | 2,890 |
| 34 | Primary carcinoma of the liver.A study of 100 cases among 48,900 necropsies Hugh A. Edmondson, Paul E. Steiner · Cancer | May 1954 | 2,816 |
| 35 | Modulation of NF‐κB‐dependent transcription and cell survival by the SIRT1 deacetylase Fan Yeung, Jamie E. Hoberg, C S Ramsey et al. · The EMBO Journal | 20 May 2004 | 2,747 |
| 36 | Role of Nrf2/HO-1 system in development, oxidative stress response and diseases: an evolutionarily conserved mechanism Agnieszka Łoboda, Milena Damulewicz, Elżbieta Pyza et al. · Cellular and Molecular Life Sciences | 21 Apr 2016 | 2,707 |
| 37 | The Nrf2-Antioxidant Response Element Signaling Pathway and Its Activation by Oxidative Stress Truyen Nguyen, Paul Nioi, Cecil B. Pickett · Journal of Biological Chemistry | Feb 2009 | 2,697 |
| 38 | Glutathione: Overview of its protective roles, measurement, and biosynthesis Henry Jay Forman, Hongqiao Zhang, Alessandra Rinna · Molecular Aspects of Medicine | 31 Aug 2008 | 2,644 |
| 39 | Reactive oxygen species, toxicity, oxidative stress, and antioxidants: chronic diseases and aging Klaudia Jomová, Renáta Raptová, Suliman Yousef Alomar et al. · Archives of Toxicology | 19 Aug 2023 | 2,548 |
| 40 | Prooxidant States and Tumor Promotion P Cerutti · Science | 25 Jan 1985 | 2,515 |
| 41 | Oxidative Stress: An Essential Factor in the Pathogenesis of Gastrointestinal Mucosal Diseases Asima Bhattacharyya, Ranajoy Chattopadhyay, SANKAR P. MITRA et al. · Physiological Reviews | Apr 2014 | 2,498 |
| 42 | NRF2 plays a critical role in mitigating lipid peroxidation and ferroptosis Matthew B. Dodson, Raúl Castro-Portuguez, Donna D. Zhang · Redox Biology | 11 Jan 2019 | 2,486 |
| 43 | The selective autophagy substrate p62 activates the stress responsive transcription factor Nrf2 through inactivation of Keap1 Masaaki Komatsu, Hirofumi Kurokawa, Satoshi Waguri et al. · Nature Cell Biology | 21 Feb 2010 | 2,454 |
| 44 | Mammalian thioredoxin is a direct inhibitor of apoptosis signal‐regulating kinase (ASK) 1 Masao Saitoh, Hideki Nishitoh, Makiko Fujii et al. · The EMBO Journal | May 1998 | 2,396 |
| 45 | Cellular defenses against damage from reactive oxygen species Bo Yu · Physiological Reviews | 1994 | 2,383 |
| 46 | Damage to DNA by reactive oxygen and nitrogen species: role in inflammatory disease and progression to cancer Helen Wiseman, Barry B. Halliwell · Biochemical Journal | 1996 | 2,349 |
| 47 | Cellular response to oxidative stress: Signaling for suicide and survival* Jennifer L. Martindale, Nikki J. Holbrook · Journal of Cellular Physiology | 24 May 2002 | 2,327 |
| 48 | BIOLOGY AND BIOCHEMISTRY OF GLUCOSINOLATES Barbara Ann Halkier, Jonathan Gershenzon · Annual Review of Plant Biology | 31 Jan 2006 | 2,324 |
| 49 | Oncogene-induced Nrf2 transcription promotes ROS detoxification and tumorigenesis Gina M. DeNicola, Florian A. Karreth, Timothy J. Humpton et al. · Nature | Jul 2011 | 2,302 |
| 50 | Transcriptional Regulation by Nrf2 Claudia Tonelli, Iok In Christine Chio, David Arthur Tuveson · Antioxidants and Redox Signaling | 20 Oct 2017 | 2,248 |
Citations are OpenAlex's own counts, from its 2026-09-23 snapshot, so the ranking can differ from Google Scholar or Web of Science. A paper is listed for a field when OpenAlex files it under one of the field's topics; retracted papers and papers whose citation count cannot be traced to citing works are left out, and a preprint and the article it became are shown once. Release dates are OpenAlex's: where a source gave only a month or a year, that is what is shown. How the lists are chosen.