Most cited papers in Hedgehog Signaling Pathway Studies
What are the most cited papers in Hedgehog Signaling Pathway Studies?
The most cited paper in Hedgehog Signaling Pathway Studies is "Molecular mechanisms of epithelial–mesenchymal transition" (Samy Lamouille, Jian Xu, Rik Derynck, 2014), with 8,337 citations. Next come "Identification of human brain tumour initiating cells" (7,487) and "Mice deficient for p53 are developmentally normal but susceptible to spontaneous tumours" (4,702).
Showing 50 of 100 papers. Every paper with more than 1,056 citations is listed.
| # | Paper | ||
|---|---|---|---|
| 1 | Molecular mechanisms of epithelial–mesenchymal transition Samy Lamouille, Jian Xu, Rik Derynck · Nature Reviews Molecular Cell Biology | 21 Feb 2014 | 8,337 |
| 2 | Identification of human brain tumour initiating cells Sheila Kumari Singh, Cynthia E Hawkins, Ian D. Clarke et al. · Nature | Nov 2004 | 7,487 |
| 3 | Mice deficient for p53 are developmentally normal but susceptible to spontaneous tumours Lawrence A. Donehower, Michele Harvey, Betty L. Slagle et al. · Nature | Mar 1992 | 4,702 |
| 4 | TGFβ in Cancer Joan Massagué · Cell | Jul 2008 | 3,950 |
| 5 | Germ Line p53 Mutations in a Familial Syndrome of Breast Cancer, Sarcomas, and Other Neoplasms David M. Malkin, Frederick P. Li, Louise C. Strong et al. · Science | 30 Nov 1990 | 3,809 |
| 6 | Tumour stem cells and drug resistance Michael C. Dean, Tito Fojo, Susan E. Bates · Nature reviews. Cancer | Apr 2005 | 3,695 |
| 7 | Cancer stem cells in solid tumours: accumulating evidence and unresolved questions Jane E. Visvader, Geoffrey J. Lindeman · Nature reviews. Cancer | 11 Sep 2008 | 3,485 |
| 8 | Identification of Pancreatic Cancer Stem Cells Chenwei Li, David G. Heidt, Piero D. Dalerba et al. · Cancer Research | Feb 2007 | 3,385 |
| 9 | Inhibition of Hedgehog Signaling Enhances Delivery of Chemotherapy in a Mouse Model of Pancreatic Cancer Kenneth P. Olive et al. · Science | 21 May 2009 | 3,195 |
| 10 | Cyclopia and defective axial patterning in mice lacking Sonic hedgehog gene function Chin Chiang, Ying Litingtung, Eric Lee et al. · Nature | Oct 1996 | 3,112 |
| 11 | Hedgehog signaling in animal development: paradigms and principles Philip William Ingham, Andrew P. McMahon · Genes & Development | Dec 2001 | 3,024 |
| 12 | TGF-β-induced epithelial to mesenchymal transition Jian Xu, Samy Lamouille, Rik Derynck · Cell Research | 20 Jan 2009 | 2,868 |
| 13 | Prediction of central nervous system embryonal tumour outcome based on gene expression Scott L. Pomeroy et al. · Nature | 2002 | 2,395 |
| 14 | p63 is essential for regenerative proliferation in limb, craniofacial and epithelial development Annie Yang, Ronen Schweitzer, Deqin Sun et al. · Nature | Apr 1999 | 2,264 |
| 15 | Sonic hedgehog, a member of a family of putative signaling molecules, is implicated in the regulation of CNS polarity Yann Echelard, Douglas J. Epstein, Benoit St‐Jacques et al. · Cell | Dec 1993 | 2,185 |
| 16 | Pericytes are required for blood–brain barrier integrity during embryogenesis Richard Daneman, Lu Zhou, Amanuel A. Kebede et al. · Nature | 13 Oct 2010 | 2,183 |
| 17 | Identification of a subpopulation of cells with cancer stem cell properties in head and neck squamous cell carcinoma Mark E. Prince, Ranjiv Sivanandan, Adam Kaczorowski et al. · Proceedings of the National Academy of Sciences | 8 Jan 2007 | 2,182 |
| 18 | Positional Cloning of the Gene for Multiple Endocrine Neoplasia-Type 1 Settara C. Chandrasekharappa et al. · Science | 18 Apr 1997 | 2,099 |
| 19 | Stromal Elements Act to Restrain, Rather Than Support, Pancreatic Ductal Adenocarcinoma Andrew D. Rhim, Paul E. Oberstein, Dafydd Thomas et al. · Cancer Cell | 22 May 2014 | 2,087 |
| 20 | Mutations of the Human Homolog of Drosophila patched in the Nevoid Basal Cell Carcinoma Syndrome Heidi Hahn et al. · Cell | Jun 1996 | 2,038 |
| 21 | Regulation of Rate of Cartilage Differentiation by Indian Hedgehog and PTH-Related Protein Andrea Vortkamp, Kaechoong Lee, Beate Lanske et al. · Science | 2 Aug 1996 | 2,009 |
| 22 | p63 is a p53 homologue required for limb and epidermal morphogenesis Alea A. Mills, Binhai Zheng, Xiao‐Jing Wang et al. · Nature | Apr 1999 | 2,008 |
| 23 | pl5INK4B is a potentia| effector of TGF-β-induced cell cycle arrest Gregory James Hannon, David Beach · Nature | Sep 1994 | 1,946 |
| 24 | The primary cilium: a signalling centre during vertebrate development Sarah C. Goetz, Kathryn V. Anderson · Nature Reviews Genetics | 16 Apr 2010 | 1,905 |
| 25 | Isolation and characterization of a zinc finger polypeptide gene at the human chromosome 11 Wilms' tumor locus Katherine M. Call, Tom M. Glaser, Caryn Y. Ito et al. · Cell | Feb 1990 | 1,895 |
| 26 | The epigenetic progenitor origin of human cancer Andrew P. Feinberg, Rolf I. OHLSSON, Steven Henikoff · Nature Reviews Genetics | 21 Dec 2005 | 1,870 |
| 27 | Human Homolog of patched , a Candidate Gene for the Basal Cell Nevus Syndrome Ronald L. Johnson, Alana Rothman, Jingwu Xie et al. · Science | 14 Jun 1996 | 1,868 |
| 28 | Molecular requirements for epithelial–mesenchymal transition during tumor progression Margit Anna Huber, Norbert Kraut, Hartmut Beug · Current Opinion in Cell Biology | 12 Aug 2005 | 1,830 |
| 29 | The mechanisms of Hedgehog signalling and its roles in development and disease James Briscoe, Pascal P. Thérond · Nature Reviews Molecular Cell Biology | 30 May 2013 | 1,828 |
| 30 | Effects of an Rb mutation in the mouse Tyler Jacks, Amin Fazeli, Earlene M. Schmitt et al. · Nature | Sep 1992 | 1,779 |
| 31 | WNT and β-catenin signalling: diseases and therapies Randall T. Moon, Aimee D. Kohn, Giancarlo V De Ferrari et al. · Nature Reviews Genetics | Sep 2004 | 1,777 |
| 32 | Indian hedgehog signaling regulates proliferation and differentiation of chondrocytes and is essential for bone formation Benoit St‐Jacques, Matthias Hammerschmidt, Andrew P. McMahon · Genes & Development | 15 Aug 1999 | 1,769 |
| 33 | Regulation of the Hedgehog and Wingless signalling pathways by the F-box/WD40-repeat protein Slimb Jin Jiang, Gary Struhl · Nature | 1998 | 1,745 |
| 34 | Altered Neural Cell Fates and Medulloblastoma in Mouse patched Mutants Lisa V. Goodrich, Ljiljana Milenković, Kay M. Higgins et al. · Science | 22 Aug 1997 | 1,723 |
| 35 | Cancer Stem Cells Craig T. Jordan, Mónica L. Guzmán, Mark Noble · New England Journal of Medicine | 21 Sep 2006 | 1,713 |
| 36 | Exome Sequencing of Head and Neck Squamous Cell Carcinoma Reveals Inactivating Mutations in NOTCH1 Nishant Agrawal et al. · Science | 28 Jul 2011 | 1,711 |
| 37 | The Spemann Organizer Signal noggin Binds and Inactivates Bone Morphogenetic Protein 4 Lyle B. Zimmerman, José M De Jesús-Escobar, Richard M. Harland · Cell | Aug 1996 | 1,655 |
| 38 | Applying the principles of stem-cell biology to cancer Ricardo Pardal, Michael F. Clarke, Sean J. Morrison · Nature reviews. Cancer | Dec 2003 | 1,629 |
| 39 | Wound healing - A literature review Ana Cristina Gonzalez, Tila Fortuna Costa, Zilton de Araújo Andrade et al. · Anais Brasileiros de Dermatologia | Oct 2016 | 1,608 |
| 40 | Notch/γ-secretase inhibition turns proliferative cells in intestinal crypts and adenomas into goblet cells Johan H. van Es, Marielle E van Gijn, Orbicia Riccio et al. · Nature | Jun 2005 | 1,551 |
| 41 | Vertebrate Smoothened functions at the primary cilium Kevin C. Corbit, Pia Aanstad, Veena Singla et al. · Nature | 31 Aug 2005 | 1,522 |
| 42 | Inhibition of Hedgehog signaling by direct binding of cyclopamine to Smoothened James Chen, Jussi Taipale, Michael K. Cooper et al. · Genes & Development | Nov 2002 | 1,490 |
| 43 | Patched1 Regulates Hedgehog Signaling at the Primary Cilium Rajat Rohatgi, Ljiljana Milenković, Matthew P. Scott · Science | 19 Jul 2007 | 1,483 |
| 44 | Niemann-Pick C1 Disease Gene: Homology to Mediators of Cholesterol Homeostasis Eugene D. Carstea et al. · Science | 11 Jul 1997 | 1,482 |
| 45 | Hedgehog is an early and late mediator of pancreatic cancer tumorigenesis Sarah P. Thayer, Marina Pasca di Magliano, Patrick W. Heiser et al. · Nature | 14 Sep 2003 | 1,482 |
| 46 | Fate of the mammalian cranial neural crest during tooth and mandibular morphogenesis Yang Chai, Xiaobing Jiang, Yoshihiro Ito et al. · Development | 15 Apr 2000 | 1,480 |
| 47 | Targeting the Wnt/β-catenin signaling pathway in cancer Ya Zhang, Xin Wang · Journal of Hematology & Oncology | Dec 2020 | 1,465 |
| 48 | Efficacy and Safety of Vismodegib in Advanced Basal-Cell Carcinoma Aleksandar Sekulić, Michael Robert Migden, Anthony E. Oro et al. · New England Journal of Medicine | 7 Jun 2012 | 1,464 |
| 49 | Hedgehog signalling in the mouse requires intraflagellar transport proteins Danwei Huangfu, Aimin Liu, Andrew S. Rakeman et al. · Nature | Nov 2003 | 1,462 |
| 50 | Rescue of early embryonic lethality in mdm2-deficient mice by deletion of p53 Roberto Montes de Oca Luna, Daniel S. Wagner, Guillermina Lozano · Nature | Nov 1995 | 1,428 |
Citations are OpenAlex's own counts, from its 2026-09-23 snapshot, so the ranking can differ from Google Scholar or Web of Science. A paper is listed for a field when OpenAlex files it under one of the field's topics; retracted papers and papers whose citation count cannot be traced to citing works are left out, and a preprint and the article it became are shown once. Release dates are OpenAlex's: where a source gave only a month or a year, that is what is shown. How the lists are chosen.