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Topic · Molecular Biology

Hedgehog Signaling Pathway Studies

Hedgehog Signaling Pathway Studies is a research topic within Molecular Biology. Science Explorer counts 20k research works in it since 1950. 10.2% of them reached the world's top 10% most cited for their field and year.

This cluster of papers focuses on the role of Hedgehog signaling in both animal development and cancer, particularly its involvement in tumorigenesis, stem cell renewal, and the progression of specific cancers such as pancreatic cancer and basal cell carcinoma. The papers also discuss the mechanisms of Hedgehog pathway inhibition and its potential as a therapeutic target for cancer treatment.

  • Hedgehog Signaling
  • Cancer
  • Development
  • Pathway Inhibition
  • Tumorigenesis
  • Stem Cells
  • Pancreatic Cancer
  • Gli Proteins
  • Smoothened
  • Basal Cell Carcinoma
Research works
20k
fractional, since 1950
In the world top 10%
2k
per year above
Top-10% rate
10.2%
share of its works in the world top 10%
Growth, 2018-21 → 2022-25
-6%
the tick is no change
Largest producer
United States
30% of the 10 largest, 2022-now
Hedgehog Signaling Pathway Studies

Which countries lead Hedgehog Signaling Pathway Studies research?

By volume, the United States and China publish the most (683 and 613 works in 2022-now).

By volume, 2022-now

  1. 1 United States 683 works
  2. 2 China 613 works
  3. 3 India 255 works
  4. 4 Japan 159 works
  5. 5 Italy 125 works
  6. 6 Germany 104 works
  7. 7 United Kingdom 101 works
  8. 8 France 89 works
  9. 9 Brazil 79 works
  10. 10 Spain 75 works

How concentrated that is

The same countries as shares of everything the list above accounts for. A node where two countries do two thirds of the work and one spread evenly across twelve read alike as a ranking and not at all alike here.

United States: 29.9%China: 26.9%India: 11.2%Japan: 7.0%6 others listed: 25.1%30%largest
United States683 · 29.9%China613 · 26.9%India255 · 11.2%Japan159 · 7.0%6 others listed572 · 25.1%

Shares of the rows listed above, not of the whole node.

Which institutions lead Hedgehog Signaling Pathway Studies research?

By volume in 2022-now, Harvard University publishes the most Hedgehog Signaling Pathway Studies research, followed by Shanghai Jiao Tong University and All India Institute of Medical Sciences.

By volume, 2022-now

  1. 1 Harvard UniversityUnited States 30 works
  2. 2 Shanghai Jiao Tong UniversityChina 19 works
  3. 3 All India Institute of Medical SciencesIndia 19 works
  4. 4 Sichuan UniversityChina 17 works
  5. 5 Mayo ClinicUnited States 16 works
  6. 6 InsermFrance 16 works
  7. 7 National Institutes of HealthUnited States 15 works
  8. 8 Capital Medical UniversityChina 14 works
  9. 9 University of TorontoCanada 14 works
  10. 10 Centre National de la Recherche ScientifiqueFrance 14 works

Who are the leading researchers in Hedgehog Signaling Pathway Studies?

The most-cited researchers publishing on Hedgehog Signaling Pathway Studies include Stacey L. Gabriel, Bert Vogelstein and Elaine R. Mardis.

  1. 1 Stacey L. Gabriel United States 402k citations
  2. 2 Bert Vogelstein United States 373k citations
  3. 3 Elaine R. Mardis United States 346k citations
  4. 4 Gregory Y.H. Lip United Kingdom 311k citations
  5. 5 Robert A. Weinberg United States 301k citations
  6. 6 Richard A. Gibbs United States 292k citations
  7. 7 John Q. Trojanowski United States 286k citations
  8. 8 Matthew M. Meyerson United States 280k citations
  9. 9 Hagop M. Kantarjian United States 273k citations
  10. 10 Martin McKee United Kingdom 270k citations

Ranked by citations received across their whole record, among researchers with at least three works on this topic.

What are the most cited papers in Hedgehog Signaling Pathway Studies?

The most cited paper in Hedgehog Signaling Pathway Studies is "Molecular mechanisms of epithelial–mesenchymal transition" (Samy Lamouille, Jian Xu, Rik Derynck, 2014), with 8,337 citations. Next come "Identification of human brain tumour initiating cells" (7,487) and "Mice deficient for p53 are developmentally normal but susceptible to spontaneous tumours" (4,702).

Most cited papers
#PaperReleasedCitations
1 Molecular mechanisms of epithelial–mesenchymal transition Samy Lamouille, Jian Xu, Rik Derynck · Nature Reviews Molecular Cell Biology ReviewOpen access 21 Feb 2014 8,337
2 Identification of human brain tumour initiating cells Sheila Kumari Singh, Cynthia E Hawkins, Ian D. Clarke et al. · Nature Nov 2004 7,487
3 Mice deficient for p53 are developmentally normal but susceptible to spontaneous tumours Lawrence A. Donehower, Michele Harvey, Betty L. Slagle et al. · Nature Mar 1992 4,702
4 TGFβ in Cancer Joan Massagué · Cell Open access Jul 2008 3,950
5 Germ Line p53 Mutations in a Familial Syndrome of Breast Cancer, Sarcomas, and Other Neoplasms David M. Malkin, Frederick P. Li, Louise C. Strong et al. · Science 30 Nov 1990 3,809
All 100 most cited papers, with filters and sorting

Where is Hedgehog Signaling Pathway Studies research done?

The largest centres of Hedgehog Signaling Pathway Studies research in 2022-now are Beijing (China), Shanghai (China), Tokyo (Japan) and Paris (France). Among places with at least 20 works in it, it is an unusually large share of all research in Houston.

Largest cities, 2022-now

  1. 1 BeijingChina 73 works
  2. 2 ShanghaiChina 54 works
  3. 3 TokyoJapan 41 works
  4. 4 ParisFrance 37 works
  5. 5 GuangzhouChina 34 works
  6. 6 LondonUnited Kingdom 32 works
  7. 7 SeoulSouth Korea 29 works
  8. 8 RomeItaly 28 works
  9. 9 New YorkUnited States 28 works
  10. 10 HangzhouChina 26 works

Where it is the local speciality

  1. HoustonUS · 24.9 works3.3×
← less than its size predicts1×more →

Location quotient: how much more of its research is in Hedgehog Signaling Pathway Studies than the world average.

See Hedgehog Signaling Pathway Studies on the map

Where is the best place to study Hedgehog Signaling Pathway Studies?

Among universities, judged by research, Harvard University, Sichuan University and Zhejiang University score highest, combining excellence, specialisation, size, growth and international reach. Research strength is one signal when choosing where to study; it does not measure teaching.

0%10%20%30%mean 17.37%fractional works in this field (log) →share of work in the world top 10% →Zhejiang UniversityHarvard UniversitySichuan UniversityUniversity of Califo…
above the meannear itbelow it

One dot per university in the first ten of the table below, at the default weights. The upper left is the interesting corner: small places doing unusually strong work.

Excellenceshare of its work in the world top 10%, 2022-now and all time averaged
40%
Specialisationhow much of its work is in this field, counted up to 10× the world share
10%
Sizeits output in this field, on a log scale
30%
Growthoutput growth, counted from -20% to +20%
10%
Internationalshare of its work with a co-author abroad
10%
Each slider sets a weight; the share it gets of the score is beside it.
#UniversityScoreTop 10%SpecialisationWorksGrowth
1Harvard UniversityUnited States 86.223.7%3.5×30 -0.2%
2Sichuan UniversityChina 59.221.1%2.9×17 +19.0%
3Zhejiang UniversityChina 55.227.5%1.8×13 +34.9%
4University of California, San FranciscoUnited States 48.915.7%5.6×11 -27.7%
5Yale UniversityUnited States 47.610.6%3.7×11 +35.3%
6Stanford UniversityUnited States 47.515.4%2.9×12 -40.1%
7University of TorontoCanada 46.413.5%2.6×14 -20.1%
8Chongqing Medical UniversityChina 44.511.3%8.0×12 +82.4%
9Chinese Academy of Medical Sciences & Peking Union Medical CollegeChina 44.014.4%4.2×12 +29.8%
10Heidelberg UniversityGermany 42.420.5%4.2×9 -24.5%

Universities only. The score blends excellence (40%), size (30%), specialisation (10%), growth (10%), international reach (10%), 2022-now; growth compares 2018-21 with 2022-25 and counts up to +20%, since a jump from a small base is mostly noise.

Every institution in Hedgehog Signaling Pathway Studies, country by country

Is Hedgehog Signaling Pathway Studies research growing?

Output in 2022-2025 was 6% lower than in 2018-2021, peaking in 2015.

still counting19801990200020102020
grewheldshrank

The same series as a ribbon: one cell per year, darker for more. The line above answers how much; this answers when.

Its share of all research

Growing output can still be a shrinking share: all of science grows. This is Hedgehog Signaling Pathway Studies as a percentage of every work published that year, 0.012% in 2024.

still counting0.010%0.020%0.030%Hedgehog Signaling Pathway Studies0.012% in 202519801990200020102020

Fractional works of Hedgehog Signaling Pathway Studies over all fractional works that year. How the balance of science has shifted.

How much of it reaches the world top 10%

Year by year.

still counting5%10%15%Hedgehog Signaling Pathway Studies10.1% in 2025200020102020

Of each year's works in it, the share that reached the world's 10% most cited for their field and year. A field is the world for its own topics, so there is no other line to hold it against.

Which topics inside it are moving

Growth and decline on one axis around a shared zero. Two lists side by side hide the thing that matters: whether the growth dwarfs the decline, or the other way round.

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