Most cited papers in Hemoglobin structure and function
What are the most cited papers in Hemoglobin structure and function?
The most cited paper in Hemoglobin structure and function is "The Carbon Monoxide-binding Pigment of Liver Microsomes" (Tsuneo Omura, Ryo Sato, 1964), with 11,871 citations. Next come "A new concept for macromolecular therapeutics in cancer chemotherapy: mechanism of tumoritropic accumulation of proteins and the antitumor agent smancs." (6,800) and "Interaction Models for Water in Relation to Protein Hydration" (5,704).
Showing 50 of 99 papers. Every paper with more than 1,047 citations is listed.
| # | Paper | ||
|---|---|---|---|
| 1 | The Carbon Monoxide-binding Pigment of Liver Microsomes Tsuneo Omura, Ryo Sato · Journal of Biological Chemistry | Jul 1964 | 11,871 |
| 2 | A new concept for macromolecular therapeutics in cancer chemotherapy: mechanism of tumoritropic accumulation of proteins and the antitumor agent smancs. Yasuhiro Matsumura, Hiroshi Maeda · PubMed | Dec 1986 | 6,800 |
| 3 | Interaction Models for Water in Relation to Protein Hydration Herman J. C. Berendsen, J. Postma, W. F. van Gunsteren et al. · Jerusalem Symposia on Quantum Chemistry and Biochemistry | 1981 | 5,704 |
| 4 | Hydrodynamics of soft active matter Maria Cristina Marchetti, Jean‐François Joanny, Sriraṁ Ramaswamy et al. · Reviews of Modern Physics | 19 Jul 2013 | 4,254 |
| 5 | Atomic structure and chemistry of human serum albumin Xiao He, Daniel C. Carter · Nature | 16 Jul 1992 | 3,831 |
| 6 | The Anatomy and Taxonomy of Protein Structure Jane S. Richardson · Advances in protein chemistry | 1981 | 3,417 |
| 7 | Isolation of nitric oxide synthetase, a calmodulin-requiring enzyme. David S. Bredt, Solomon H. Snyder · Proceedings of the National Academy of Sciences | 1990 | 3,308 |
| 8 | The Energy Landscapes and Motions of Proteins Hans Frauenfelder, Stephen G. Sligar, Peter Guy Wolynes · Science | 13 Dec 1991 | 3,295 |
| 9 | Structure of Serum Albumin Daniel C. Carter, Joseph X. Ho · Advances in protein chemistry | 1994 | 3,188 |
| 10 | Structure of the protein subunits in the photosynthetic reaction centre of Rhodopseudomonas viridis at 3Å resolution J. Deisenhofer, Otto Epp, Kunio Miki et al. · Nature | Dec 1985 | 3,076 |
| 11 | Stereochemistry of Cooperative Effects in Haemoglobin: Haem–Haem Interaction and the Problem of Allostery Max Ferdinand Perutz · Nature | Nov 1970 | 2,939 |
| 12 | Biochemistry of Nitric Oxide and Its Redox-Activated Forms Jonathan S. Stamler, David J. Singel, Joseph Loscalzo · Science | 18 Dec 1992 | 2,754 |
| 13 | Exploring protein native states and large‐scale conformational changes with a modified generalized born model Alexey V. Onufriev, Donald Bashford, David Andrew Case · Proteins Structure Function and Bioinformatics | 5 Mar 2004 | 2,598 |
| 14 | THE HEME OXYGENASE SYSTEM:A Regulator of Second Messenger Gases Mahin D. Maines · The Annual Review of Pharmacology and Toxicology | Apr 1997 | 2,519 |
| 15 | Dioxygen Activation at Mononuclear Nonheme Iron Active Sites: Enzymes, Models, and Intermediates Miguel Costas, M.P. Mehn, Michael P. Jensen et al. · Chemical Reviews | 28 Jan 2004 | 2,473 |
| 16 | [38] Oxidative damage to proteins: Spectrophotometric method for carbonyl assay Abraham Zeev Reznick, Lester Packer · Methods in enzymology on CD-ROM/Methods in enzymology | 1994 | 2,462 |
| 17 | Heme-Containing Oxygenases Masanori Sono, Mark P. Roach, Eric D. Coulter et al. · Chemical Reviews | 1996 | 2,453 |
| 18 | Pathways of Oxidative Damage James A. Imlay · Annual Review of Microbiology | Oct 2003 | 2,247 |
| 19 | Why are ?natively unfolded? proteins unstructured under physiologic conditions? Vladimir Nikolaevich Uversky, Joel R. Gillespie, Anthony L. Fink · Proteins Structure Function and Bioinformatics | 2000 | 2,125 |
| 20 | Dynamics of folded proteins James Andrew McCammon, Bruce R. Gelin, Martin Karplus · Nature | Jun 1977 | 2,078 |
| 21 | Oxygen sensing by HIF hydroxylases Christopher John Schofield, Peter John Ratcliffe · Nature Reviews Molecular Cell Biology | 30 Apr 2004 | 2,068 |
| 22 | The chemical shift index: a fast and simple method for the assignment of protein secondary structure through NMR spectroscopy David Scott Wishart, Brian D. Sykes, F.M. Richards · Biochemistry | 18 Feb 1992 | 2,062 |
| 23 | Identification of a novel force-generating protein, kinesin, involved in microtubule-based motility Ronald D. Vale, Thomas S. Reese, Michael P. Sheetz · Cell | Aug 1985 | 2,017 |
| 24 | The endothelial glycocalyx: composition, functions, and visualization Sietze Reitsma, Dick W. Slaaf, Hans Vink et al. · Pflügers Archiv - European Journal of Physiology | 25 Jan 2007 | 2,006 |
| 25 | Human serum albumin: From bench to bedside Gabriella Fanali, Alessandra di Masi, Viviana Trezza et al. · Molecular Aspects of Medicine | 30 Dec 2011 | 1,959 |
| 26 | X-ray structure analysis of a membrane protein complex J. Deisenhofer, Otto Epp, Kunio Miki et al. · Journal of Molecular Biology | Dec 1984 | 1,928 |
| 27 | Size and charge isomer separation and estimation of molecular weights of proteins by disc gel electrophoresis Jerry L. Hedrick, Alan Jay Smith · Archives of Biochemistry and Biophysics | Jul 1968 | 1,902 |
| 28 | Hydrogen bonding in globular proteins Edward N. Baker, Roderick E. Hubbard · Progress in Biophysics and Molecular Biology | 1984 | 1,875 |
| 29 | Nitrite reduction to nitric oxide by deoxyhemoglobin vasodilates the human circulation Kenyatta Cosby, Kristine S Partovi, Jack H. Crawford et al. · Nature Medicine | 2 Nov 2003 | 1,816 |
| 30 | Nitric oxide. A macrophage product responsible for cytostasis and respiratory inhibition in tumor target cells. Dennis J. Stuehr, Carl Nathan · The Journal of Experimental Medicine | May 1989 | 1,761 |
| 31 | BAR Domains as Sensors of Membrane Curvature: The Amphiphysin BAR Structure Brian J. Peter, Helen M. Kent, Ian Geoffrey Mills et al. · Science | Dec 2003 | 1,747 |
| 32 | Identification of the haemoglobin scavenger receptor Mette Kristiansen, Jonas Heilskov Graversen, Christian Borch Jacobsen et al. · Nature | 2001 | 1,728 |
| 33 | Geometric and Electronic Structure/Function Correlations in Non-Heme Iron Enzymes Edward I. Solomon, Thomas C. Brunold, Mindy I. Davis et al. · Chemical Reviews | 18 Dec 1999 | 1,720 |
| 34 | Heme oxygenase: function, multiplicity, regulatory mechanisms, and clinical applications Mahin D. Maines · The FASEB Journal | Jul 1988 | 1,718 |
| 35 | The lipocalin protein family: structure and function Darren R. Flower · Biochemical Journal | 15 Aug 1996 | 1,696 |
| 36 | Regulation of biosynthesis of nitric oxide. Carl Nathan, Q.W. Xie · Journal of Biological Chemistry | May 1994 | 1,687 |
| 37 | A Three-Dimensional Model of the Myoglobin Molecule Obtained by X-Ray Analysis John Cowdery Kendrew, G. Bodo, Howard M. Dintzis et al. · Nature | Mar 1958 | 1,672 |
| 38 | Principles of structure, bonding, and reactivity for metal nitrosyl complexes John H. Enemark, Robert D. Feltham · Coordination Chemistry Reviews | Sep 1974 | 1,652 |
| 39 | Dynamics of ligand binding to myoglobin Robert H. Austin, K. W. Beeson, L. Eisenstein et al. · Biochemistry | Dec 1975 | 1,634 |
| 40 | S-nitrosohaemoglobin: a dynamic activity of blood involved in vascular control Lee Jia, Celia Bonaventura, Joseph Bonaventura et al. · Nature | Mar 1996 | 1,614 |
| 41 | Preparation and Properties of a Cholesterol Oxidase from Nocardia sp. and Its Application to the Enzymatic Assay of Total Cholesterol in Serum W. Richmond · Clinical Chemistry | Dec 1973 | 1,596 |
| 42 | Cellular Defenses against Superoxide and Hydrogen Peroxide James A. Imlay · Annual Review of Biochemistry | 3 Jan 2008 | 1,580 |
| 43 | The Clinical Sequelae of Intravascular Hemolysis and Extracellular Plasma Hemoglobin Russell P. Rother, Leonard B. Bell, Peter Hillmen et al. · JAMA | 6 Apr 2005 | 1,555 |
| 44 | Preservation of Membranes in Anhydrobiotic Organisms: The Role of Trehalose John H. Crowe, Lois M. Crowe, Dennis Chapman · Science | 17 Feb 1984 | 1,512 |
| 45 | The interaction of a naphthalene dye with apomyoglobin and apohemoglobin Lubert Stryer · Journal of Molecular Biology | Sep 1965 | 1,504 |
| 46 | Abnormal human haemoglobins J. B. Clegg, Michael A. Naughton, David John Weatherall · Journal of Molecular Biology | Aug 1966 | 1,496 |
| 47 | THE ULTRASTRUCTURAL BASIS OF CAPILLARY PERMEABILITY STUDIED WITH PEROXIDASE AS A TRACER Morris J. Karnovsky · The Journal of Cell Biology | Oct 1967 | 1,494 |
| 48 | The Influence of Macromolecular Crowding and Macromolecular Confinement on Biochemical Reactions in Physiological Media Allen P. Minton · Journal of Biological Chemistry | Apr 2001 | 1,489 |
| 49 | Chemical and biological evolution of a nucleotide-binding protein Michael George Rossmann, Dino Moras, Kenneth W. Olsen · Nature | Jul 1974 | 1,483 |
| 50 | RESPIRATORY ENZYMES IN OXIDATIVE PHOSPHORYLATION Britton Chance, Gene R. Williams · Journal of Biological Chemistry | Nov 1955 | 1,480 |
Citations are OpenAlex's own counts, from its 2026-09-23 snapshot, so the ranking can differ from Google Scholar or Web of Science. A paper is listed for a field when OpenAlex files it under one of the field's topics; retracted papers and papers whose citation count cannot be traced to citing works are left out, and a preprint and the article it became are shown once. Release dates are OpenAlex's: where a source gave only a month or a year, that is what is shown. How the lists are chosen.