Topic · High Altitude and Hypoxia
Most cited papers in High Altitude and Hypoxia
What are the most cited papers in High Altitude and Hypoxia?
The most cited paper in High Altitude and Hypoxia is "Hypoxia-Inducible Factors in Physiology and Medicine" (Gregg L. Semenza, 2012), with 3,632 citations. Next come "Oxygen Sensing by Metazoans: The Central Role of the HIF Hydroxylase Pathway" (3,308) and "Physiological Roles of Mitochondrial Reactive Oxygen Species" (2,632).
Showing 50 of 100 papers. Every paper with more than 601 citations is listed.
| # | Paper | ||
|---|---|---|---|
| 1 | Hypoxia-Inducible Factors in Physiology and Medicine Gregg L. Semenza · Cell | Feb 2012 | 3,632 |
| 2 | Oxygen Sensing by Metazoans: The Central Role of the HIF Hydroxylase Pathway William G. Kaelin, Peter John Ratcliffe · Molecular Cell | May 2008 | 3,308 |
| 3 | Physiological Roles of Mitochondrial Reactive Oxygen Species Laura A. Sena, Navdeep S. Chandel · Molecular Cell | Oct 2012 | 2,632 |
| 4 | Hypoxia-Inducible Factors and the Response to Hypoxic Stress Amar J. Majmundar, Waihay J. Wong, M. Celeste Simon · Molecular Cell | Oct 2010 | 2,429 |
| 5 | Hypoxia and Inflammation Holger K. Eltzschig, Peter Carmeliet · New England Journal of Medicine | 16 Feb 2011 | 2,080 |
| 6 | Reactive Oxygen Species Generated at Mitochondrial Complex III Stabilize Hypoxia-inducible Factor-1α during Hypoxia Navdeep S. Chandel, David S. McClintock, Carlos E. Feliciano et al. · Journal of Biological Chemistry | Aug 2000 | 1,988 |
| 7 | Regulation of Mammalian O 2 Homeostasis by Hypoxia-Inducible Factor 1 Gregg L. Semenza · Annual Review of Cell and Developmental Biology | Nov 1999 | 1,950 |
| 8 | Mitochondrial reactive oxygen species trigger hypoxia-induced transcription Navdeep S. Chandel, Emin Maltepe, Eugene Goldwasser et al. · Proceedings of the National Academy of Sciences | 29 Sep 1998 | 1,936 |
| 9 | HIF-1: mediator of physiological and pathophysiological responses to hypoxia Gregg L. Semenza · Journal of Applied Physiology | Apr 2000 | 1,840 |
| 10 | Hypoxia Response Elements in the Aldolase A, Enolase 1, and Lactate Dehydrogenase A Gene Promoters Contain Essential Binding Sites for Hypoxia-inducible Factor 1 Gregg L. Semenza, Bing‐Hua Jiang, Sandra W. Leung et al. · Journal of Biological Chemistry | Dec 1996 | 1,785 |
| 11 | Sequencing of 50 Human Exomes Reveals Adaptation to High Altitude Xin Yi et al. · Science | Jul 2010 | 1,714 |
| 12 | Hypoxia-inducible Factor 1α (HIF-1α) Protein Is Rapidly Degraded by the Ubiquitin-Proteasome System under Normoxic Conditions Susana Alicia Salceda, J. Jaime · Journal of Biological Chemistry | Sep 1997 | 1,677 |
| 13 | Control of TH17/Treg Balance by Hypoxia-Inducible Factor 1 Eric V. Dang, Joseph Barbi, Huang‐Yu Yang et al. · Cell | 27 Aug 2011 | 1,614 |
| 14 | FIH-1 is an asparaginyl hydroxylase enzyme that regulates the transcriptional activity of hypoxia-inducible factor David Lando, Daniel J. Peet, Jeffrey John Gorman et al. · Genes & Development | 15 Jun 2002 | 1,563 |
| 15 | HIF prolyl‐hydroxylase 2 is the key oxygen sensor setting low steady‐state levels of HIF‐1α in normoxia Edurne Berra, Emmanuel Benizri, Amandine Ginouvès et al. · The EMBO Journal | 11 Aug 2003 | 1,361 |
| 16 | Altitude adaptation in Tibetans caused by introgression of Denisovan-like DNA Emilia Huerta‐Sánchez et al. · Nature | Jul 2014 | 1,346 |
| 17 | The Expression and Distribution of the Hypoxia-Inducible Factors HIF-1α and HIF-2α in Normal Human Tissues, Cancers, and Tumor-Associated Macrophages Katherine Louise Talks, Helen Turley, Kevin C. Gatter et al. · American Journal Of Pathology | Aug 2000 | 1,311 |
| 18 | HIF-1 and mechanisms of hypoxia sensing Gregg L. Semenza · Current Opinion in Cell Biology | Apr 2001 | 1,304 |
| 19 | High-Altitude Illness Peter H. Hackett, Robert C. Roach · New England Journal of Medicine | 12 Jul 2001 | 1,302 |
| 20 | Genetic Evidence for High-Altitude Adaptation in Tibet Tatum S. Simonson, Yingzhong Yang, Chad Daniel Huff et al. · Science | 13 May 2010 | 1,261 |
| 21 | Hypoxia of the Renal Medulla — Its Implications for Disease Mayer Brezis, Seymour Rosen · New England Journal of Medicine | 9 Mar 1995 | 1,240 |
| 22 | HIF-1 Regulates Cytochrome Oxidase Subunits to Optimize Efficiency of Respiration in Hypoxic Cells Ryo Fukuda, Huafeng Zhang, Jung‐whan Kim et al. · Cell | Apr 2007 | 1,236 |
| 23 | Hypoxia-inducible factor 1 levels vary exponentially over a physiologically relevant range of O2 tension Bing‐Hua Jiang, Gregg L. Semenza, Christian J. E. Bauer et al. · American Journal of Physiology-Cell Physiology | Oct 1996 | 1,222 |
| 24 | HIF Transcription Factors, Inflammation, and Immunity Asís Palazón, Ananda W. Goldrath, Victor Nizet et al. · Immunity | Oct 2014 | 1,220 |
| 25 | Oxygen Sensing, Hypoxia-Inducible Factors, and Disease Pathophysiology Gregg L. Semenza · Annual Review of Pathology Mechanisms of Disease | 12 Aug 2013 | 1,208 |
| 26 | Alcohol dependence: provisional description of a clinical syndrome. Griffith Edwards, Milton M. Gross · BMJ | May 1976 | 1,178 |
| 27 | Transcriptional regulation of vascular endothelial cell responses to hypoxia by HIF-1 Dominador J. Manalo, Ashley Rowan, Tera L. Lavoie et al. · Blood | 17 Sep 2004 | 1,172 |
| 28 | Parachute use to prevent death and major trauma related to gravitational challenge: systematic review of randomised controlled trials Gordon C. S. Smith, Jill P Pell · BMJ | 18 Dec 2003 | 1,163 |
| 29 | The NASA Twins Study: A multidimensional analysis of a year-long human spaceflight Francine E. Garrett-Bakelman et al. · Science | 12 Apr 2019 | 1,157 |
| 30 | Heme Oxygenase-1: Function, Regulation, and Implication of a Novel Stress-Inducible Protein in Oxidant-Induced Lung Injury Augustine M.K. Choi, Jubayer Alam · American Journal of Respiratory Cell and Molecular Biology | Jul 1996 | 1,142 |
| 31 | Inhaled nitric oxide. A selective pulmonary vasodilator reversing hypoxic pulmonary vasoconstriction. CLAES G. FROSTELL, M D Fratacci, John C. Wain et al. · Circulation | Jun 1991 | 1,139 |
| 32 | Differential Function of the Prolyl Hydroxylases PHD1, PHD2, and PHD3 in the Regulation of Hypoxia-inducible Factor Rebecca J. Appelhoff, Ya‐Min Tian, Raju R. Raval et al. · Journal of Biological Chemistry | 7 Jul 2004 | 1,124 |
| 33 | Hypoxia-inducible factor 1: master regulator of O2 homeostasis Gregg L. Semenza · Current Opinion in Genetics & Development | Oct 1998 | 1,100 |
| 34 | Hyperglycemic Pseudohypoxia and Diabetic Complications Joseph R. Williamson, Katherine C. Chang, Myrto Frangos et al. · Diabetes | Jun 1993 | 1,057 |
| 35 | The yak genome and adaptation to life at high altitude Qiang Qiu et al. · Nature Genetics | Jul 2012 | 1,046 |
| 36 | Integration of Oxygen Signaling at the Consensus HRE Roland H. Wenger, Daniel P. Stiehl, Gieri Camenisch · Science s STKE | 18 Oct 2005 | 1,043 |
| 37 | Heme oxygenase-1 mediates the anti-inflammatory effect of interleukin-10 in mice Tzong‐Shyuan Lee, Lee‐Young Chau · Nature Medicine | Mar 2002 | 1,019 |
| 38 | Carotid body chemoreceptors: from natural stimuli to sensory discharges. Christian E. Gonzalez, Laura Almaraz, Ana Obeso et al. · Physiological Reviews | Oct 1994 | 1,000 |
| 39 | Oxygen Sensing, Homeostasis, and Disease Gregg L. Semenza · New England Journal of Medicine | 10 Aug 2011 | 998 |
| 40 | Hyperbaric Oxygen for Acute Carbon Monoxide Poisoning Lindell K. Weaver, Ramona O. Hopkins, Karen J. Chan et al. · New England Journal of Medicine | 3 Oct 2002 | 980 |
| 41 | Hypoxia promotes fibrogenesis in vivo via HIF-1 stimulation of epithelial-to-mesenchymal transition Debra F. Higgins, Kuniko Kimura, Wanja M. Bernhardt et al. · Journal of Clinical Investigation | 21 Nov 2007 | 980 |
| 42 | Meteorin-like Is a Hormone that Regulates Immune-Adipose Interactions to Increase Beige Fat Thermogenesis Rajesh R. Rao, Jonathan Z. Long, James P. White et al. · Cell | Jun 2014 | 975 |
| 43 | Factors Affecting Running Economy in Trained Distance Runners Philo U. Saunders, David B. Pyne, Richard D. Telford et al. · Sports Medicine | 2004 | 974 |
| 44 | Locomotion: Energy Cost of Swimming, Flying, and Running Knut Schmidt‐Nielsen · Science | 21 Jul 1972 | 960 |
| 45 | Hypoxia-Inducible Factor 1 (HIF-1) Pathway Gregg L. Semenza · Science s STKE | 9 Oct 2007 | 956 |
| 46 | HIF-1, O2, and the 3 PHDs Gregg L. Semenza · Cell | Oct 2001 | 952 |
| 47 | Biology of HIF-1α Alexander Weidemann, Randall S. Johnson · Cell Death and Differentiation | 8 Feb 2008 | 946 |
| 48 | Regulation of Oxygen Homeostasis by Hypoxia-Inducible Factor 1 Gregg L. Semenza · Physiology | Apr 2009 | 934 |
| 49 | Hypoxia-inducible factor 1: oxygen homeostasis and disease pathophysiology Gregg L. Semenza · Trends in Molecular Medicine | Aug 2001 | 933 |
| 50 | Advances in Hypoxia-Inducible Factor Biology Hani Choudhry, Adrian L. Harris · Cell Metabolism | 9 Nov 2017 | 930 |
Citations are OpenAlex's own counts, from its 2026-09-23 snapshot, so the ranking can differ from Google Scholar or Web of Science. A paper is listed for a field when OpenAlex files it under one of the field's topics; retracted papers and papers whose citation count cannot be traced to citing works are left out, and a preprint and the article it became are shown once. Release dates are OpenAlex's: where a source gave only a month or a year, that is what is shown. How the lists are chosen.