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Topic · Genetics

High Altitude and Hypoxia

High Altitude and Hypoxia is a research topic within Genetics. Science Explorer counts 21k research works in it since 1950. 10.1% of them reached the world's top 10% most cited for their field and year.

This cluster of papers explores the genetic and physiological adaptations of humans and other vertebrates to high-altitude environments, focusing on topics such as hypoxia, acute mountain sickness, erythropoietin response, oxidative stress, pulmonary edema, and the effects of endurance training. The research covers a wide range of aspects including molecular, systemic, and cellular responses to high-altitude conditions.

  • High Altitude
  • Adaptation
  • Hypoxia
  • Genetic
  • Physiological
  • Acute Mountain Sickness
  • Erythropoietin
  • Oxidative Stress
  • Pulmonary Edema
  • Endurance Training
Research works
21k
fractional, since 1950
In the world top 10%
2.1k
per year above
Top-10% rate
10.1%
share of its works in the world top 10%
Growth, 2018-21 → 2022-25
+10%
the tick is no change
Largest producer
China
35% of the 10 largest, 2022-now
High Altitude and Hypoxia

Which countries lead High Altitude and Hypoxia research?

By volume, China and the United States publish the most (846 and 672 works in 2022-now).

By volume, 2022-now

  1. 1 China 846 works
  2. 2 United States 672 works
  3. 3 India 150 works
  4. 4 Russia 131 works
  5. 5 France 128 works
  6. 6 Germany 118 works
  7. 7 United Kingdom 104 works
  8. 8 Canada 101 works
  9. 9 Japan 92 works
  10. 10 Italy 89 works

How concentrated that is

The same countries as shares of everything the list above accounts for. A node where two countries do two thirds of the work and one spread evenly across twelve read alike as a ranking and not at all alike here.

China: 34.8%United States: 27.6%India: 6.2%Russia: 5.4%6 others listed: 26.0%35%largest
China846 · 34.8%United States672 · 27.6%India150 · 6.2%Russia131 · 5.4%6 others listed633 · 26.0%

Shares of the rows listed above, not of the whole node.

Which institutions lead High Altitude and Hypoxia research?

By volume in 2022-now, Russian Academy of Sciences publishes the most High Altitude and Hypoxia research, followed by Sichuan University and Qinghai University.

By volume, 2022-now

  1. 1 Russian Academy of SciencesRussia 47 works
  2. 2 Sichuan UniversityChina 31 works
  3. 3 Qinghai UniversityChina 26 works
  4. 4 Defence Research and Development OrganisationIndia 22 works
  5. 5 Harvard UniversityUnited States 22 works
  6. 6 University of ZurichSwitzerland 21 works
  7. 7 United States Department of DefenseUnited States 21 works
  8. 8 University of LausanneSwitzerland 19 works
  9. 9 Chinese Academy of SciencesChina 19 works
  10. 10 Capital Medical UniversityChina 19 works

Who are the leading researchers in High Altitude and Hypoxia?

The most-cited researchers publishing on High Altitude and Hypoxia include Jun Wang, Gregory Y.H. Lip and Luigi Ferrucci.

  1. 1 Jun Wang China 340k citations
  2. 2 Gregory Y.H. Lip United Kingdom 311k citations
  3. 3 Luigi Ferrucci United States 281k citations
  4. 4 Jean‐Louis Vincent Belgium 262k citations
  5. 5 Piotr P. Ponikowski Poland 253k citations
  6. 6 Tommi Juhani Vasankari Finland 248k citations
  7. 7 Huanming Yang China 246k citations
  8. 8 Erkin Mirsaidovich Mirrakhimov Kyrgyzstan 238k citations
  9. 9 Didier Raoult France 232k citations

Ranked by citations received across their whole record, among researchers with at least three works on this topic.

What are the most cited papers in High Altitude and Hypoxia?

The most cited paper in High Altitude and Hypoxia is "Hypoxia-Inducible Factors in Physiology and Medicine" (Gregg L. Semenza, 2012), with 3,632 citations. Next come "Oxygen Sensing by Metazoans: The Central Role of the HIF Hydroxylase Pathway" (3,308) and "Physiological Roles of Mitochondrial Reactive Oxygen Species" (2,632).

Most cited papers
#PaperReleasedCitations
1 Hypoxia-Inducible Factors in Physiology and Medicine Gregg L. Semenza · Cell Open access Feb 2012 3,632
2 Oxygen Sensing by Metazoans: The Central Role of the HIF Hydroxylase Pathway William G. Kaelin, Peter John Ratcliffe · Molecular Cell Open access May 2008 3,308
3 Physiological Roles of Mitochondrial Reactive Oxygen Species Laura A. Sena, Navdeep S. Chandel · Molecular Cell Open access Oct 2012 2,632
4 Hypoxia-Inducible Factors and the Response to Hypoxic Stress Amar J. Majmundar, Waihay J. Wong, M. Celeste Simon · Molecular Cell Open access Oct 2010 2,429
5 Hypoxia and Inflammation Holger K. Eltzschig, Peter Carmeliet · New England Journal of Medicine Open access 16 Feb 2011 2,080
All 100 most cited papers, with filters and sorting

Where is High Altitude and Hypoxia research done?

The largest centres of High Altitude and Hypoxia research in 2022-now are Beijing (China), Chengdu (China), Moscow (Russia) and Xining (China). Among places with at least 20 works in it, it is an unusually large share of all research in Lhasa, Xining and Innsbruck.

Largest cities, 2022-now

  1. 1 BeijingChina 167 works
  2. 2 ChengduChina 69 works
  3. 3 MoscowRussia 58 works
  4. 4 XiningChina 54 works
  5. 5 ShanghaiChina 42 works
  6. 6 ParisFrance 40 works
  7. 7 LanzhouChina 36 works
  8. 8 ChongqingChina 36 works
  9. 9 Xi'anChina 35 works
  10. 10 LhasaChina 31 works

Where it is the local speciality

  1. LhasaCN · 30.8 works96×
  2. XiningCN · 54.1 works53×
  3. InnsbruckAT · 27.1 works18×
  4. DelhiIN · 22.0 works11×
← less than its size predicts1×more →

Location quotient: how much more of its research is in High Altitude and Hypoxia than the world average.

See High Altitude and Hypoxia on the map

Where is the best place to study High Altitude and Hypoxia?

Among universities, judged by research, Chengdu University of Traditional Chinese Medicine, University of Lausanne and University of Zurich score highest, combining excellence, specialisation, size, growth and international reach. Research strength is one signal when choosing where to study; it does not measure teaching.

0%20%40%mean 18.62%fractional works in this field (log) →share of work in the world top 10% →Chengdu University o…Harvard UniversityUniversity of LausanneUniversity of Zurich
above the meannear itbelow it

One dot per university in the first ten of the table below, at the default weights. The upper left is the interesting corner: small places doing unusually strong work.

Excellenceshare of its work in the world top 10%, 2022-now and all time averaged
40%
Specialisationhow much of its work is in this field, counted up to 10× the world share
10%
Sizeits output in this field, on a log scale
30%
Growthoutput growth, counted from -20% to +20%
10%
Internationalshare of its work with a co-author abroad
10%
Each slider sets a weight; the share it gets of the score is beside it.
#UniversityScoreTop 10%SpecialisationWorksGrowth
1Chengdu University of Traditional Chinese MedicineChina 62.945.8%12.2×9 +226.8%
2University of LausanneSwitzerland 61.815.3%14.2×19 +52.0%
3University of ZurichSwitzerland 58.312.4%10.1×21 -3.9%
4Harvard UniversityUnited States 57.918.8%2.3×22 +9.0%
5Sichuan UniversityChina 54.911.7%4.6×31 +132.2%
6Lanzhou UniversityChina 54.328.2%7.3×15 +56.1%
7Universität InnsbruckAustria 52.59.6%20.7×17 +72.5%
8Qinghai UniversityChina 51.712.4%52.9×26 +88.7%
9Capital Medical UniversityChina 46.516.5%5.8×19 +80.2%
10Chinese Academy of Medical Sciences & Peking Union Medical CollegeChina 42.615.5%5.0×16 +58.9%

Universities only. The score blends excellence (40%), size (30%), specialisation (10%), growth (10%), international reach (10%), 2022-now; growth compares 2018-21 with 2022-25 and counts up to +20%, since a jump from a small base is mostly noise.

Every institution in High Altitude and Hypoxia, country by country

Is High Altitude and Hypoxia research growing?

Output in 2022-2025 was 10% higher than in 2018-2021, peaking in 2025. The fastest-growing topics are High Altitude and Hypoxia.

still counting19801990200020102020
grewheldshrank

The same series as a ribbon: one cell per year, darker for more. The line above answers how much; this answers when.

Its share of all research

Growing output can still be a shrinking share: all of science grows. This is High Altitude and Hypoxia as a percentage of every work published that year, 0.015% in 2024.

still counting0.010%0.020%0.030%High Altitude and Hypoxia0.015% in 202519801990200020102020

Fractional works of High Altitude and Hypoxia over all fractional works that year. How the balance of science has shifted.

How much of it reaches the world top 10%

Year by year.

still counting5%10%15%High Altitude and Hypoxia10.2% in 2025200020102020

Of each year's works in it, the share that reached the world's 10% most cited for their field and year. A field is the world for its own topics, so there is no other line to hold it against.

Which topics inside it are moving

Growth and decline on one axis around a shared zero. Two lists side by side hide the thing that matters: whether the growth dwarfs the decline, or the other way round.

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