Most cited papers in HIV/AIDS drug development and treatment
What are the most cited papers in HIV/AIDS drug development and treatment?
The most cited paper in HIV/AIDS drug development and treatment is "AutoDock4 and AutoDockTools4: Automated docking with selective receptor flexibility" (Garrett M. Morris, Ruth Huey, William Lindstrom et al., 2009), with 25,864 citations. Next come "Declining Morbidity and Mortality among Patients with Advanced Human Immunodeficiency Virus Infection" (9,545) and "Prevention of HIV-1 Infection with Early Antiretroviral Therapy" (7,006).
Showing 50 of 101 papers. Every paper with more than 1,250 citations is listed.
| # | Paper | ||
|---|---|---|---|
| 1 | AutoDock4 and AutoDockTools4: Automated docking with selective receptor flexibility Garrett M. Morris, Ruth Huey, William Lindstrom et al. · Journal of Computational Chemistry | 27 Apr 2009 | 25,864 |
| 2 | Declining Morbidity and Mortality among Patients with Advanced Human Immunodeficiency Virus Infection Frank Joseph Palella, Kathleen M. Delaney, Anne C. Moorman et al. · New England Journal of Medicine | 26 Mar 1998 | 9,545 |
| 3 | Prevention of HIV-1 Infection with Early Antiretroviral Therapy Myron S. Cohen et al. · New England Journal of Medicine | 18 Jul 2011 | 7,006 |
| 4 | A Trial of Lopinavir–Ritonavir in Adults Hospitalized with Severe Covid-19 Bin Cao et al. · New England Journal of Medicine | 18 Mar 2020 | 5,526 |
| 5 | Preexposure Chemoprophylaxis for HIV Prevention in Men Who Have Sex with Men Robert M. Grant et al. · New England Journal of Medicine | 23 Nov 2010 | 5,186 |
| 6 | g_mmpbsa —A GROMACS Tool for High-Throughput MM-PBSA Calculations Rashmi Kumari, Rajendra Kumar, Open Source Drug Discovery Consortium et al. · Journal of Chemical Information and Modeling | 21 May 2014 | 4,935 |
| 7 | Docking and scoring in virtual screening for drug discovery: methods and applications Douglas B. Kitchen, Helene Y. Decornez, John R. Furr et al. · Nature Reviews Drug Discovery | Nov 2004 | 4,182 |
| 8 | Reduction of Maternal-Infant Transmission of Human Immunodeficiency Virus Type 1 with Zidovudine Treatment Edward M. Connor, RHODA S. SPERLING, Richard D. Gelber et al. · New England Journal of Medicine | 3 Nov 1994 | 3,755 |
| 9 | Identification of a major co-receptor for primary isolates of HIV-1 Hongkui Deng, Rong Liu, Wilfried Ellmeier et al. · Nature | Jun 1996 | 3,697 |
| 10 | Targeting multidrug resistance in cancer Gergely Szakács, Jill K. Paterson, Joseph Aloysius Ludwig et al. · Nature Reviews Drug Discovery | Mar 2006 | 3,674 |
| 11 | HIV-1 Dynamics in Vivo: Virion Clearance Rate, Infected Cell Life-Span, and Viral Generation Time Alan S. Perelson, Avidan Uriel Neumann, Martin H. Markowitz et al. · Science | 15 Mar 1996 | 3,587 |
| 12 | Membrane transporters in drug development Kathleen M. Giacomini et al. · Nature Reviews Drug Discovery | Mar 2010 | 3,373 |
| 13 | Antiretroviral Prophylaxis for HIV Prevention in Heterosexual Men and Women Jared M. Baeten et al. · New England Journal of Medicine | 11 Jul 2012 | 3,341 |
| 14 | Viral dynamics in human immunodeficiency virus type 1 infection Xiping Wei, Sajal K. Ghosh, Maria E. Taylor et al. · Nature | 1995 | 3,304 |
| 15 | Identification of a Reservoir for HIV-1 in Patients on Highly Active Antiretroviral Therapy Diana Finzi, Monika Hermankova, Theodore C. Pierson et al. · Science | 14 Nov 1997 | 3,163 |
| 16 | Homozygous Defect in HIV-1 Coreceptor Accounts for Resistance of Some Multiply-Exposed Individuals to HIV-1 Infection Rong Liu, William A. Paxton, Sunny S. Choe et al. · Cell | Aug 1996 | 3,140 |
| 17 | The Prevalence of Hepatitis C Virus Infection in the United States, 1988 through 1994 Miriam J. Alter, Deanna Kruszon-Moran, Omana V. Nainan et al. · New England Journal of Medicine | 19 Aug 1999 | 3,028 |
| 18 | Structure of an HIV gp120 envelope glycoprotein in complex with the CD4 receptor and a neutralizing human antibody Peter D. Kwong, Richard T. Wyatt, James E. Robinson et al. · Nature | Jun 1998 | 3,015 |
| 19 | Full-Length Human Immunodeficiency Virus Type 1 Genomes from Subtype C-Infected Seroconverters in India, with Evidence of Intersubtype Recombination Kavita Satish Lole, Robert C. Bollinger, Ramesh Paranjape et al. · Journal of Virology | 1999 | 2,771 |
| 20 | A Controlled Trial of Two Nucleoside Analogues plus Indinavir in Persons with Human Immunodeficiency Virus Infection and CD4 Cell Counts of 200 per Cubic Millimeter or Less Scott M. Hammer, Kathleen Squires, Michael D. Hughes et al. · New England Journal of Medicine | 11 Sep 1997 | 2,687 |
| 21 | Boceprevir for Untreated Chronic HCV Genotype 1 Infection Fred F Poordad, Jonathan McCone, Bruce R. Bacon et al. · New England Journal of Medicine | 30 Mar 2011 | 2,519 |
| 22 | Antiretroviral Treatment of Adult HIV Infection Melanie Ann Thompson, Judith A. Aberg, Jennifer F. Hoy et al. · JAMA | 25 Jul 2012 | 2,478 |
| 23 | Starch gel electrophoresis of enzymes?A compilation of recipes Charles R. Shaw, Rupi Prasad · Biochemical Genetics | Apr 1970 | 2,441 |
| 24 | Telaprevir for Previously Untreated Chronic Hepatitis C Virus Infection Ira M. Jacobson et al. · New England Journal of Medicine | 22 Jun 2011 | 2,394 |
| 25 | The β-Chemokine Receptors CCR3 and CCR5 Facilitate Infection by Primary HIV-1 Isolates Hyeryun Choe, Michael Reynolds Farzan, Ying Sun et al. · Cell | Jun 1996 | 2,323 |
| 26 | Lamivudine for Patients with Chronic Hepatitis B and Advanced Liver Disease Yun‐Fan Liaw, Joseph J.�Y. Sung, Wan Cheng Chow et al. · New England Journal of Medicine | 6 Oct 2004 | 2,281 |
| 27 | Recovery of Replication-Competent HIV Despite Prolonged Suppression of Plasma Viremia Joseph K. Wong, Marjan Hezareh, Huldrych Fritz Günthard et al. · Science | 14 Nov 1997 | 2,250 |
| 28 | CD4+ Count–Guided Interruption of Antiretroviral Treatment The Strategies for Management of Antiretroviral Therapy (SMART) Study Group · New England Journal of Medicine | 29 Nov 2006 | 2,248 |
| 29 | Quantification of latent tissue reservoirs and total body viral load in HIV-1 infection Tae‐Wook Chun, Lucy M. Carruth, Diana Finzi et al. · Nature | May 1997 | 2,089 |
| 30 | The results of direct and indirect treatment comparisons in meta-analysis of randomized controlled trials Heiner C. Bucher, Gordon Henry Guyatt, Lauren E. Griffith et al. · Journal of Clinical Epidemiology | Jun 1997 | 2,085 |
| 31 | BIOCHEMICAL, CELLULAR, AND PHARMACOLOGICAL ASPECTS OF THE MULTIDRUG TRANSPORTER Suresh V. Ambudkar, Saibal Dey, Christine A. Hrycyna et al. · The Annual Review of Pharmacology and Toxicology | Apr 1999 | 2,073 |
| 32 | Antiretroviral Preexposure Prophylaxis for Heterosexual HIV Transmission in Botswana Michael C. Thigpen et al. · New England Journal of Medicine | 11 Jul 2012 | 2,041 |
| 33 | Universal voluntary HIV testing with immediate antiretroviral therapy as a strategy for elimination of HIV transmission: a mathematical model Reuben Granich, Charles F. Gilks, Christopher Dye et al. · The Lancet | 28 Nov 2008 | 2,021 |
| 34 | HIV Population Dynamics in Vivo: Implications for Genetic Variation, Pathogenesis, and Therapy John M. Coffin · Science | 27 Jan 1995 | 2,003 |
| 35 | Deoxynucleoside phosphoramidites—A new class of key intermediates for deoxypolynucleotide synthesis Serge L. Beaucage, Marvin H. Caruthers · Tetrahedron Letters | 1981 | 2,002 |
| 36 | Identification and characterization of transmitted and early founder virus envelopes in primary HIV-1 infection Brandon F. Keele et al. · Proceedings of the National Academy of Sciences | 19 May 2008 | 1,967 |
| 37 | Structure of P-Glycoprotein Reveals a Molecular Basis for Poly-Specific Drug Binding Stephen G. Aller, Jodie Yu, Andrew B. Ward et al. · Science | 26 Mar 2009 | 1,935 |
| 38 | Treatment with Indinavir, Zidovudine, and Lamivudine in Adults with Human Immunodeficiency Virus Infection and Prior Antiretroviral Therapy Roy M. Gulick, John W. Mellors, Diane V. Havlir et al. · New England Journal of Medicine | 11 Sep 1997 | 1,922 |
| 39 | Crystal Structure at 3.5 Å Resolution of HIV-1 Reverse Transcriptase Complexed with an Inhibitor Lori A. Kohlstaedt, Jimin Wang, Jonathan M. Friedman et al. · Science | 26 Jun 1992 | 1,912 |
| 40 | Revisiting the role of ABC transporters in multidrug-resistant cancer Robert W. Robey, Kristen M. Pluchino, Matthew D. Hall et al. · Nature reviews. Cancer | 11 Apr 2018 | 1,890 |
| 41 | A Dual-Tropic Primary HIV-1 Isolate That Uses Fusin and the β-Chemokine Receptors CKR-5, CKR-3, and CKR-2b as Fusion Cofactors Benjamin J. Doranz, Joseph B. Rucker, Yanjie Yi et al. · Cell | Jun 1996 | 1,854 |
| 42 | Reduction of Maternal-Infant Transmission of Human Immunodeficiency Virus 1 with Zidovudine Treatment Edward M. Connor, RHODA S. SPERLING, Richard D. Gelber et al. · Obstetrical & Gynecological Survey | Apr 1995 | 1,824 |
| 43 | Regression of cirrhosis during treatment with tenofovir disoproxil fumarate for chronic hepatitis B: a 5-year open-label follow-up study Patrick Marcellin, Edward John Gane, Marı́a Buti et al. · The Lancet | 9 Dec 2012 | 1,802 |
| 44 | Broad and Potent Neutralizing Antibodies from an African Donor Reveal a New HIV-1 Vaccine Target Laura M. Walker et al. · Science | 3 Sep 2009 | 1,775 |
| 45 | A Family of Drug Transporters: the Multidrug Resistance-Associated Proteins Piet Borst, Raymond Evers, Marcel Kool et al. · JNCI Journal of the National Cancer Institute | 16 Aug 2000 | 1,766 |
| 46 | The Human ATP-Binding Cassette (ABC) Transporter Superfamily Michael C. Dean, Andrey Rzhetsky, Rando L. Allikmets · Genome Research | 18 Jan 2001 | 1,761 |
| 47 | Extensively drug-resistant tuberculosis as a cause of death in patients co-infected with tuberculosis and HIV in a rural area of South Africa Neel R. Gandhi, Anthony P. Moll, A. Willem Sturm et al. · The Lancet | 28 Oct 2006 | 1,748 |
| 48 | Ledipasvir and Sofosbuvir for Untreated HCV Genotype 1 Infection Nezam H. Afdhal et al. · New England Journal of Medicine | 12 Apr 2014 | 1,718 |
| 49 | Life expectancy of individuals on combination antiretroviral therapy in high-income countries: a collaborative analysis of 14 cohort studies ‡ · The Lancet | Jul 2008 | 1,683 |
| 50 | The AIDS dementia complex: I. Clinical features BRADFORD A. NAVIA, Barry D. Jordan, Richard W. Price · Annals of Neurology | Jun 1986 | 1,674 |
Citations are OpenAlex's own counts, from its 2026-09-23 snapshot, so the ranking can differ from Google Scholar or Web of Science. A paper is listed for a field when OpenAlex files it under one of the field's topics; retracted papers and papers whose citation count cannot be traced to citing works are left out, and a preprint and the article it became are shown once. Release dates are OpenAlex's: where a source gave only a month or a year, that is what is shown. How the lists are chosen.