Most cited papers in HIV Research and Treatment

HIV Research and Treatment

What are the most cited papers in HIV Research and Treatment?

The most cited paper in HIV Research and Treatment is "AutoDock4 and AutoDockTools4: Automated docking with selective receptor flexibility" (Garrett M. Morris, Ruth Huey, William Lindstrom et al., 2009), with 25,864 citations. Next come "Prevention of HIV-1 Infection with Early Antiretroviral Therapy" (7,006) and "1993 Revised Classification System for HIV Infection and Expanded Surveillance Case Definition for AIDS Among Adolescents and Adults" (4,364).

Published TypeAccessAuthorsCitations

Showing 50 of 100 papers. Every paper with more than 1,560 citations is listed.

Most cited papers, sortable by citations and release date
#	Paper
1	AutoDock4 and AutoDockTools4: Automated docking with selective receptor flexibility Garrett M. Morris, Ruth Huey, William Lindstrom et al. · Journal of Computational Chemistry Open access	27 Apr 2009	25,864
2	Prevention of HIV-1 Infection with Early Antiretroviral Therapy Myron S. Cohen et al. · New England Journal of Medicine Open access	18 Jul 2011	7,006
3	1993 Revised Classification System for HIV Infection and Expanded Surveillance Case Definition for AIDS Among Adolescents and Adults Kenneth G. Castro, Jill Ward, Laurence Slutsker et al. · Clinical Infectious Diseases	Oct 1993	4,364
4	Rapid turnover of plasma virions and CD4 lymphocytes in HIV-1 infection David D. Ho, Avidan Uriel Neumann, Alan S. Perelson et al. · Nature	1995	4,310
5	Reduction of Maternal-Infant Transmission of Human Immunodeficiency Virus Type 1 with Zidovudine Treatment Edward M. Connor, RHODA S. SPERLING, Richard D. Gelber et al. · New England Journal of Medicine Open access	3 Nov 1994	3,755
6	Identification of a major co-receptor for primary isolates of HIV-1 Hongkui Deng, Rong Liu, Wilfried Ellmeier et al. · Nature	Jun 1996	3,697
7	Microbial translocation is a cause of systemic immune activation in chronic HIV infection Jason M. Brenchley, David Anthony Price, Timothy W. Schacker et al. · Nature Medicine	19 Nov 2006	3,596
8	HIV-1 Dynamics in Vivo: Virion Clearance Rate, Infected Cell Life-Span, and Viral Generation Time Alan S. Perelson, Avidan Uriel Neumann, Martin H. Markowitz et al. · Science	15 Mar 1996	3,587
9	A Third-Generation Lentivirus Vector with a Conditional Packaging System Tom Dull, Romain Zufferey, Michael T. Kelly et al. · Journal of Virology Open access	Nov 1998	3,409
10	Antiretroviral Prophylaxis for HIV Prevention in Heterosexual Men and Women Jared M. Baeten et al. · New England Journal of Medicine Open access	11 Jul 2012	3,341
11	Viral dynamics in human immunodeficiency virus type 1 infection Xiping Wei, Sajal K. Ghosh, Maria E. Taylor et al. · Nature	1995	3,304
12	HIV-1 entry into CD4+ cells is mediated by the chemokine receptor CC-CKR-5 Tatjana Dragic, Virginia Litwin, Graham P. Allaway et al. · Nature	20 Jun 1996	3,221
13	Identification of a Reservoir for HIV-1 in Patients on Highly Active Antiretroviral Therapy Diana Finzi, Monika Hermankova, Theodore C. Pierson et al. · Science	14 Nov 1997	3,163
14	Homozygous Defect in HIV-1 Coreceptor Accounts for Resistance of Some Multiply-Exposed Individuals to HIV-1 Infection Rong Liu, William A. Paxton, Sunny S. Choe et al. · Cell Open access	Aug 1996	3,140
15	Viral Load and Heterosexual Transmission of Human Immunodeficiency Virus Type 1 Thomas C. Quinn, Maria Joan Wawer, Nelson Kaulukusi Sewankambo et al. · New England Journal of Medicine Open access	30 Mar 2000	3,081
16	Vaccination with ALVAC and AIDSVAX to Prevent HIV-1 Infection in Thailand Supachai Rerks‐Ngarm et al. · New England Journal of Medicine Open access	20 Oct 2009	3,067
17	Structure of an HIV gp120 envelope glycoprotein in complex with the CD4 receptor and a neutralizing human antibody Peter D. Kwong, Richard T. Wyatt, James E. Robinson et al. · Nature Open access	Jun 1998	3,015
18	Resistance to HIV-1 infection in Caucasian individuals bearing mutant alleles of the CCR-5 chemokine receptor gene Michel Samson et al. · Nature	Aug 1996	2,920
19	Production of acquired immunodeficiency syndrome-associated retrovirus in human and nonhuman cells transfected with an infectious molecular clone Akio Adachi, Howard Eliot Gendelman, Scott Koenig et al. · Journal of Virology Open access	Aug 1986	2,910
20	Identification of RANTES, MIP-1α, and MIP-1β as the Major HIV-Suppressive Factors Produced by CD8 + T Cells Fiorenza Cocchi, Anthony L. DeVico, Alfredo Garzino Demo et al. · Science	15 Dec 1995	2,893
21	Cellular uptake of the tat protein from human immunodeficiency virus Alan D. Frankel, Carl O. Pabo · Cell	Dec 1988	2,798
22	Full-Length Human Immunodeficiency Virus Type 1 Genomes from Subtype C-Infected Seroconverters in India, with Evidence of Intersubtype Recombination Kavita Satish Lole, Robert C. Bollinger, Ramesh Paranjape et al. · Journal of Virology Open access	1999	2,771
23	CC CKR5: A RANTES, MIP-1α, MIP-1β Receptor as a Fusion Cofactor for Macrophage-Tropic HIV-1 Ghalib Alkhatib, Christophe Combadière, Christopher C. Broder et al. · Science	28 Jun 1996	2,736
24	Prognosis in HIV-1 Infection Predicted by the Quantity of Virus in Plasma John W. Mellors, Charles R. Rinaldo, Phalguni Gupta et al. · Science	24 May 1996	2,716
25	PD-1 expression on HIV-specific T cells is associated with T-cell exhaustion and disease progression Cheryl L. Day et al. · Nature	20 Aug 2006	2,694
26	A Controlled Trial of Two Nucleoside Analogues plus Indinavir in Persons with Human Immunodeficiency Virus Infection and CD4 Cell Counts of 200 per Cubic Millimeter or Less Scott M. Hammer, Kathleen Squires, Michael D. Hughes et al. · New England Journal of Medicine Open access	11 Sep 1997	2,687
27	Updated research nosology for HIV-associated neurocognitive disorders Andrea Antinori et al. · Neurology Open access	4 Oct 2007	2,637
28	Function of the chemokine receptor CXCR4 in haematopoiesis and in cerebellar development Yong-Rui Zou, Andreas H. Kottmann, Masahiko Kuroda et al. · Nature	Jun 1998	2,543
29	Temporal association of cellular immune responses with the initial control of viremia in primary human immunodeficiency virus type 1 syndrome Richard A. Koup, Jeffrey T. Safrit, Yaming Cao et al. · Journal of Virology Open access	Jul 1994	2,515
30	Genetic Restriction of HIV-1 Infection and Progression to AIDS by a Deletion Allele of the CKR5 Structural Gene Michael C. Dean, Mary N Carrington, Cheryl Ann Winkler et al. · Science	27 Sep 1996	2,512
31	Not So Different After All: A Comparison of Methods for Detecting Amino Acid Sites Under Selection Sergei L. Kosakovsky Pond, Simon D. W. Frost · Molecular Biology and Evolution	9 Feb 2005	2,510
32	Antibody neutralization and escape by HIV-1 Xiping Wei, Julie M. Decker, Shuyi Wang et al. · Nature	19 Mar 2003	2,480
33	Antiretroviral Treatment of Adult HIV Infection Melanie Ann Thompson, Judith A. Aberg, Jennifer F. Hoy et al. · JAMA	25 Jul 2012	2,478
34	DC-SIGN, a Dendritic Cell–Specific HIV-1-Binding Protein that Enhances trans-Infection of T Cells Teunis B. H. Geijtenbeek, Douglas S. Kwon, Ruurd Torensma et al. · Cell Open access	Mar 2000	2,440
35	A Truncated HIV-1 Tat Protein Basic Domain Rapidly Translocates through the Plasma Membrane and Accumulates in the Cell Nucleus Éric Vivès, Priscille M Brodin, Bernard Lebleu · Journal of Biological Chemistry Open access	Jun 1997	2,384
36	Incidence of cancers in people with HIV/AIDS compared with immunosuppressed transplant recipients: a meta-analysis Andrew E. Grulich, Marina T. van Leeuwen, Michael O. Falster et al. · The Lancet Review	Jul 2007	2,359
37	Isolation of a human gene that inhibits HIV-1 infection and is suppressed by the viral Vif protein Ann M. Sheehy, Nathan Gaddis, Jonathan D. Choi et al. · Nature	14 Jul 2002	2,352
38	HIV-associated neurocognitive disorders persist in the era of potent antiretroviral therapy Robert K. Heaton et al. · Neurology Open access	6 Dec 2010	2,346
39	The β-Chemokine Receptors CCR3 and CCR5 Facilitate Infection by Primary HIV-1 Isolates Hyeryun Choe, Michael Reynolds Farzan, Ying Sun et al. · Cell Open access	Jun 1996	2,323
40	Recovery of Replication-Competent HIV Despite Prolonged Suppression of Plasma Viremia Joseph K. Wong, Marjan Hezareh, Huldrych Fritz Günthard et al. · Science	14 Nov 1997	2,250
41	CD4+ Count–Guided Interruption of Antiretroviral Treatment The Strategies for Management of Antiretroviral Therapy (SMART) Study Group · New England Journal of Medicine Open access	29 Nov 2006	2,248
42	Control of Viremia in Simian Immunodeficiency Virus Infection by CD8 + Lymphocytes Jörn E. Schmitz, Marcelo J. Kuroda, Sampa Santra et al. · Science	5 Feb 1999	2,203
43	CHEMOKINE RECEPTORS AS HIV-1 CORECEPTORS: Roles in Viral Entry, Tropism, and Disease Edward A. Berger, Philip M. Murphy, Joshua M. Farber · Annual Review of Immunology Review	Apr 1999	2,198
44	Selective rejection of H–2-deficient lymphoma variants suggests alternative immune defence strategy Klas Kärre, Hans Gustaf Ljunggren, Gerald E. Piontek et al. · Nature	20 Feb 1986	2,169
45	Latent infection of CD4+ T cells provides a mechanism for lifelong persistence of HIV-1, even in patients on effective combination therapy Diana Finzi, Joel N. Blankson, Janet D'Angelo Siliciano et al. · Nature Medicine	May 1999	2,168
46	Hepatitis C Viral Dynamics in Vivo and the Antiviral Efficacy of Interferon-α Therapy Avidan Uriel Neumann, Nancy P. Lam, Harel Dahari et al. · Science	2 Oct 1998	2,127
47	Quantification of latent tissue reservoirs and total body viral load in HIV-1 infection Tae‐Wook Chun, Lucy M. Carruth, Diana Finzi et al. · Nature	May 1997	2,089
48	An inducible transcription factor activates expression of human immunodeficiency virus in T cells Gary J. Nabel, David Baltimore · Nature	22 Apr 1987	2,086
49	Presence of an inducible HIV-1 latent reservoir during highly active antiretroviral therapy Tae‐Wook Chun, Lieven J. Stuyver, Stephanie B. Mizell et al. · Proceedings of the National Academy of Sciences Open access	25 Nov 1997	2,027
50	Universal voluntary HIV testing with immediate antiretroviral therapy as a strategy for elimination of HIV transmission: a mathematical model Reuben Granich, Charles F. Gilks, Christopher Dye et al. · The Lancet	28 Nov 2008	2,021

Citations are OpenAlex's own counts, from its 2026-09-23 snapshot, so the ranking can differ from Google Scholar or Web of Science. A paper is listed for a field when OpenAlex files it under one of the field's topics; retracted papers and papers whose citation count cannot be traced to citing works are left out, and a preprint and the article it became are shown once. Release dates are OpenAlex's: where a source gave only a month or a year, that is what is shown. How the lists are chosen.