Most cited papers in Hydrogen's biological and therapeutic effects
What are the most cited papers in Hydrogen's biological and therapeutic effects?
The most cited paper in Hydrogen's biological and therapeutic effects is "Oxidative stress, aging, and diseases" (Ilaria Liguori, Gennaro Russo, Francesco Curcio et al., 2018), with 4,013 citations. Next come "Hydrogen acts as a therapeutic antioxidant by selectively reducing cytotoxic oxygen radicals" (2,586) and "Oxidative Stress: An Essential Factor in the Pathogenesis of Gastrointestinal Mucosal Diseases" (2,498).
Showing 50 of 100 papers. Every paper with more than 342 citations is listed.
| # | Paper | ||
|---|---|---|---|
| 1 | Oxidative stress, aging, and diseases Ilaria Liguori, Gennaro Russo, Francesco Curcio et al. · Clinical Interventions in Aging | Apr 2018 | 4,013 |
| 2 | Hydrogen acts as a therapeutic antioxidant by selectively reducing cytotoxic oxygen radicals Ikuroh Ohsawa, Masahiro Ishikawa, Kumiko Takahashi et al. · Nature Medicine | 7 May 2007 | 2,586 |
| 3 | Oxidative Stress: An Essential Factor in the Pathogenesis of Gastrointestinal Mucosal Diseases Asima Bhattacharyya, Ranajoy Chattopadhyay, SANKAR P. MITRA et al. · Physiological Reviews | Apr 2014 | 2,498 |
| 4 | Physiological Implications of Hydrogen Sulfide: A Whiff Exploration That Blossomed Rui Ting Wang · Physiological Reviews | Apr 2012 | 1,948 |
| 5 | Defining roles of specific reactive oxygen species (ROS) in cell biology and physiology Helmut Sies, Vsevolod Vadimovich Belousov, Navdeep S. Chandel et al. · Nature Reviews Molecular Cell Biology | 21 Feb 2022 | 1,727 |
| 6 | Mitochondrial transfer from bone-marrow–derived stromal cells to pulmonary alveoli protects against acute lung injury Mohammad Naimul Islam, Shonit Das, Memet T. Emin et al. · Nature Medicine | 15 Apr 2012 | 1,631 |
| 7 | New approaches and procedures for cancer treatment: Current perspectives Dejene Tolossa Debela, Seke G. Y. Muzazu, Kidist Digamo Heraro et al. · SAGE Open Medicine | 2021 | 1,574 |
| 8 | Role of nitric oxide synthesis in macrophage antimicrobial activity Carl Nathan, John B. Hibbs · Current Opinion in Immunology | 1991 | 1,541 |
| 9 | Plasma MicroRNA Profiling Reveals Loss of Endothelial MiR-126 and Other MicroRNAs in Type 2 Diabetes Anna Zampetaki, Stefan Julia Kiechl, Ignat A. Drozdov et al. · Circulation Research | 23 Jul 2010 | 1,474 |
| 10 | Administered mesenchymal stem cells protect against ischemic acute renal failure through differentiation-independent mechanisms Florian E. Togel, Zhuma Hu, Kathleen Weiss et al. · American Journal of Physiology-Renal Physiology | 15 Feb 2005 | 1,191 |
| 11 | Perspectives series: host/pathogen interactions. Mechanisms of nitric oxide-related antimicrobial activity. Ferric C. Fang · Journal of Clinical Investigation | 15 Jun 1997 | 1,155 |
| 12 | Drinking water contamination and treatment techniques Saroj Sharma, Amit Bhattacharya · Applied Water Science | 16 Aug 2016 | 1,007 |
| 13 | Oxidative stress and redox regulation of lung inflammation in COPD Irfan Rahman, Ian Michael Adcock · European Respiratory Journal | 30 Jun 2006 | 951 |
| 14 | Measurement of Local Blood Flow with Hydrogen Gas KNUR AUKLAND, BRUCE F. BOWER, Robert W. Berliner · Circulation Research | Feb 1964 | 943 |
| 15 | Oxidative Stress in Human Pathology and Aging: Molecular Mechanisms and Perspectives Younis Ahmad Hajam, Raksha Rani, Shahid Yousuf Ganie et al. · Cells | 5 Feb 2022 | 926 |
| 16 | The Biology of Nitrogen Oxides in the Airways Benjamin M Gaston, Jeffrey M. Drazen, Joseph Loscalzo et al. · American Journal of Respiratory and Critical Care Medicine | Feb 1994 | 922 |
| 17 | Oxidative stress in chronic kidney disease Kristien Daenen, Asmin Andries, Djalila Mekahli et al. · Pediatric Nephrology | 13 Aug 2018 | 891 |
| 18 | Oxidative Stress in Chronic Obstructive Pulmonary Disease John E. Repine, Aalt Bast, Ida Lankhorst · American Journal of Respiratory and Critical Care Medicine | Aug 1997 | 845 |
| 19 | Microbiological Aspects of Ozone Applications in Food: A Review M.A. Khadre, Ahmed E. Yousef, Jeongeun Kim · Journal of Food Science | Nov 2001 | 836 |
| 20 | Status of myocardial antioxidants in ischemia–reperfusion injury Naranjan S. Dhalla · Cardiovascular Research | 18 Aug 2000 | 798 |
| 21 | Organotypic vasculature: From descriptive heterogeneity to functional pathophysiology Hellmut G. Augustin, Gou Young Koh · Science | 3 Aug 2017 | 790 |
| 22 | Nitric oxide and redox mechanisms in the immune response David A. Wink, Harry B. Hines, Robert Y.S. Cheng et al. · Journal of Leukocyte Biology | 13 Jan 2011 | 774 |
| 23 | Hydrogen Sulfide Mediates Cardioprotection Through Nrf2 Signaling John W. Calvert, Saurabh Kumar Jha, Susheel Gundewar et al. · Circulation Research | 17 Jul 2009 | 724 |
| 24 | Aquaporin-3 mediates hydrogen peroxide uptake to regulate downstream intracellular signaling Evan W. Miller, Bryan C. Dickinson, Christopher J. Chang · Proceedings of the National Academy of Sciences | 19 Aug 2010 | 703 |
| 25 | Oxidative stress: animal adaptations in nature. Kenneth B. Storey · PubMed | Dec 1996 | 703 |
| 26 | Hydrogen sulfide and nitric oxide are mutually dependent in the regulation of angiogenesis and endothelium-dependent vasorelaxation Ciro Coletta, Andreas Papapetropoulos, Katalin Erdélyi et al. · Proceedings of the National Academy of Sciences | 8 May 2012 | 684 |
| 27 | Use of ozone in the food industry Zeynep B. Güzel‐Seydim, Annel K. Greene, Atıf Can Seydim · LWT | 16 Jan 2004 | 684 |
| 28 | The Role of Reactive Oxygen Species in Mesenchymal Stem Cell Adipogenic and Osteogenic Differentiation: A Review Fatemeh Atashi, Ali Modarressi, Michael Sean Pepper · Stem Cells and Development | 20 Jan 2015 | 669 |
| 29 | COPD as a Disease of Accelerated Lung Aging Kazuhiro Ito, Peter John Barnes · CHEST Journal | 2009 | 656 |
| 30 | The antioxidant, immunomodulatory, and anti-inflammatory activities of Spirulina: an overview Qinghua Wu, Lian Liu, Anca Miron et al. · Archives of Toxicology | 3 Jun 2016 | 651 |
| 31 | Scientific and Medical Aspects of Ozone Therapy. State of the Art Velio Alvaro Bocci · Archives of Medical Research | 19 Apr 2006 | 626 |
| 32 | Understanding mechanisms of antioxidant action in health and disease Barry B. Halliwell · Nature Reviews Molecular Cell Biology | 15 Sep 2023 | 623 |
| 33 | Lgr5+ Stem Cells Are Indispensable for Radiation-Induced Intestinal Regeneration Ciara Metcalfe, Noelyn M. Kljavin, Ryan Ybarra et al. · Cell stem cell | 12 Dec 2013 | 590 |
| 34 | Production and Excretion of Hydrogen Gas in Man Michael D. Levitt · New England Journal of Medicine | 17 Jul 1969 | 587 |
| 35 | Manipulation of dietary short chain carbohydrates alters the pattern of gas production and genesis of symptoms in irritable bowel syndrome Derrick K Ong, Shaylyn B Mitchell, Jacqueline S. Barrett et al. · Journal of Gastroenterology and Hepatology | 14 May 2010 | 583 |
| 36 | Role of Endothelial Dysfunction in Cardiovascular Diseases: The Link Between Inflammation and Hydrogen Sulfide Hai‐Jian Sun, Zhiyuan Wu, Xiao-Wei Nie et al. · Frontiers in Pharmacology | 20 Jan 2020 | 557 |
| 37 | Sonophotocatalytic degradation mechanisms of Rhodamine B dye via radicals generation by micro- and nano-particles of ZnO Carmine Lops, Andrea Ancona, Katia Di Cesare et al. · Applied Catalysis B: Environmental | 2 Nov 2018 | 556 |
| 38 | Development of a lavage solution associated with minimal water and electrolyte absorption or secretion Glenn R. Davis, Carol A. Santa Ana, Stephen G. Morawski et al. · Gastroenterology | May 1980 | 555 |
| 39 | d-Galactose-induced accelerated aging model: an overview Khairunnuur Fairuz Azman, Rahimah Zakaria · Biogerontology | 19 Sep 2019 | 544 |
| 40 | Therapeutic strategies by modulating oxygen stress in cancer and inflammation Jun Qun Fang, Takahiro Seki, Hiroshi Maeda · Advanced Drug Delivery Reviews | 27 Feb 2009 | 542 |
| 41 | HYBRIDIZATION BETWEENESCHERICHIA COLIAND SHIGELLA S. E. Luria, Jeanne W. Burrous · Journal of Bacteriology | Oct 1957 | 532 |
| 42 | Molecular hydrogen as a preventive and therapeutic medical gas: initiation, development and potential of hydrogen medicine Shigeo Ohta · Pharmacology & Therapeutics | 24 Apr 2014 | 530 |
| 43 | Oxidants and free radicals in inflammatory bowel disease Matthew B. Grisham · The Lancet | Sep 1994 | 528 |
| 44 | The Gasotransmitter Role of Hydrogen Sulfide Rui Ting Wang · Antioxidants and Redox Signaling | Aug 2003 | 518 |
| 45 | Transepithelial transport in cell culture. Dayton S. Misfeldt, S Hamamoto, Dorothy R. Pitelka · Proceedings of the National Academy of Sciences | Apr 1976 | 505 |
| 46 | Fasting, Feeding and Regulation of the Sympathetic Nervous System Lewis Landsberg, James B. Young · New England Journal of Medicine | 8 Jun 1978 | 499 |
| 47 | Long-term antibacterial efficacy of air plasma-activated water Matthew J. Traylor, Matthew J. Pavlovich, Sharmin Karim et al. · Journal of Physics D Applied Physics | 4 Nov 2011 | 492 |
| 48 | Oxidative stress and human health Taibur Rahman, Md. Ismail Hosen, Md. Monirul Islam et al. · Advances in Bioscience and Biotechnology | 2012 | 487 |
| 49 | Defining ROS in Biology and Medicine Yuanyuan Li, Michael A. Trush · Reactive Oxygen Species | 2016 | 476 |
| 50 | Differential Expression Patterns of Claudins, Tight Junction Membrane Proteins, in Mouse Nephron Segments Yumiko Kiuchi-Saishin, Shimpei Gotoh, Mikio Furuse et al. · Journal of the American Society of Nephrology | Apr 2002 | 476 |
Citations are OpenAlex's own counts, from its 2026-09-23 snapshot, so the ranking can differ from Google Scholar or Web of Science. A paper is listed for a field when OpenAlex files it under one of the field's topics; retracted papers and papers whose citation count cannot be traced to citing works are left out, and a preprint and the article it became are shown once. Release dates are OpenAlex's: where a source gave only a month or a year, that is what is shown. How the lists are chosen.