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Hydrogen's biological and therapeutic effects

Hydrogen's biological and therapeutic effects is a research topic within Surgery. Science Explorer counts 9.6k research works in it since 1950. 10.1% of them reached the world's top 10% most cited for their field and year.

This cluster of papers explores the therapeutic applications of molecular hydrogen therapy, focusing on its potential as an antioxidant and anti-inflammatory agent. The research covers a wide range of medical conditions, including neurodegenerative diseases, diabetes, cardiovascular disorders, and ischemia-reperfusion injuries. Molecular hydrogen is investigated for its ability to reduce oxidative stress, alleviate inflammation, and provide neuroprotection in various disease models.

  • Molecular Hydrogen
  • Therapeutic Gas
  • Oxidative Stress
  • Antioxidant
  • Inflammation
  • Neuroprotection
  • Ischemia-Reperfusion Injury
  • Metabolic Syndrome
  • Diabetes
  • Cardiovascular Disorders
Research works
9.6k
fractional, since 1950
In the world top 10%
967
per year above
Top-10% rate
10.1%
share of its works in the world top 10%
Growth, 2018-21 → 2022-25
+17%
the tick is no change
Largest producer
China
46% of the 10 largest, 2022-now
Hydrogen's biological and therapeutic effects

This ranks research output and citation impact. It says nothing about the quality of diagnosis, treatment or care.

Which countries lead Hydrogen's biological and therapeutic effects research?

By volume, China and the United States publish the most (732 and 221 works in 2022-now).

By volume, 2022-now

  1. 1 China 732 works
  2. 2 United States 221 works
  3. 3 Japan 119 works
  4. 4 Russia 112 works
  5. 5 Türkiye 95 works
  6. 6 India 88 works
  7. 7 Iran 65 works
  8. 8 Indonesia 53 works
  9. 9 Italy 48 works
  10. 10 South Korea 44 works

How concentrated that is

The same countries as shares of everything the list above accounts for. A node where two countries do two thirds of the work and one spread evenly across twelve read alike as a ranking and not at all alike here.

China: 46.4%United States: 14.0%Japan: 7.6%Russia: 7.1%6 others listed: 24.9%46%largest
China732 · 46.4%United States221 · 14.0%Japan119 · 7.6%Russia112 · 7.1%6 others listed393 · 24.9%

Shares of the rows listed above, not of the whole node.

Which institutions lead Hydrogen's biological and therapeutic effects research?

By volume in 2022-now, Russian Academy of Sciences publishes the most Hydrogen's biological and therapeutic effects research, followed by Shanghai Jiao Tong University and Chinese Academy of Sciences.

By volume, 2022-now

  1. 1 Russian Academy of SciencesRussia 21 works
  2. 2 Shanghai Jiao Tong UniversityChina 20 works
  3. 3 Chinese Academy of SciencesChina 18 works
  4. 4 Harbin Medical UniversityChina 15 works
  5. 5 Sichuan UniversityChina 12 works
  6. 6 Tianjin Medical UniversityChina 11 works
  7. 7 Fudan UniversityChina 11 works
  8. 8 Soochow UniversityChina 10 works
  9. 9 Capital Medical UniversityChina 10 works
  10. 10 Sun Yat-sen UniversityChina 10 works

Who are the leading researchers in Hydrogen's biological and therapeutic effects?

The most-cited researchers publishing on Hydrogen's biological and therapeutic effects include Jun Wang, Amirhossein Sahebkar and Peter John Barnes.

  1. 1 Jun Wang China 340k citations
  2. 2 Amirhossein Sahebkar Iran 258k citations
  3. 3 Peter John Barnes United Kingdom 225k citations
  4. 4 Kai You Wang China 224k citations

Ranked by citations received across their whole record, among researchers with at least three works on this topic.

What are the most cited papers in Hydrogen's biological and therapeutic effects?

The most cited paper in Hydrogen's biological and therapeutic effects is "Oxidative stress, aging, and diseases" (Ilaria Liguori, Gennaro Russo, Francesco Curcio et al., 2018), with 4,013 citations. Next come "Hydrogen acts as a therapeutic antioxidant by selectively reducing cytotoxic oxygen radicals" (2,586) and "Oxidative Stress: An Essential Factor in the Pathogenesis of Gastrointestinal Mucosal Diseases" (2,498).

Most cited papers
#PaperReleasedCitations
1 Oxidative stress, aging, and diseases Ilaria Liguori, Gennaro Russo, Francesco Curcio et al. · Clinical Interventions in Aging Open access Apr 2018 4,013
2 Hydrogen acts as a therapeutic antioxidant by selectively reducing cytotoxic oxygen radicals Ikuroh Ohsawa, Masahiro Ishikawa, Kumiko Takahashi et al. · Nature Medicine 7 May 2007 2,586
3 Oxidative Stress: An Essential Factor in the Pathogenesis of Gastrointestinal Mucosal Diseases Asima Bhattacharyya, Ranajoy Chattopadhyay, SANKAR P. MITRA et al. · Physiological Reviews ReviewOpen access Apr 2014 2,498
4 Physiological Implications of Hydrogen Sulfide: A Whiff Exploration That Blossomed Rui Ting Wang · Physiological Reviews Review Apr 2012 1,948
5 Defining roles of specific reactive oxygen species (ROS) in cell biology and physiology Helmut Sies, Vsevolod Vadimovich Belousov, Navdeep S. Chandel et al. · Nature Reviews Molecular Cell Biology Review 21 Feb 2022 1,727
All 100 most cited papers, with filters and sorting

Where is Hydrogen's biological and therapeutic effects research done?

The largest centres of Hydrogen's biological and therapeutic effects research in 2022-now are Beijing (China), Shanghai (China), Moscow (Russia) and Tokyo (Japan).

Largest cities, 2022-now

  1. 1 BeijingChina 81 works
  2. 2 ShanghaiChina 65 works
  3. 3 MoscowRussia 52 works
  4. 4 TokyoJapan 35 works
  5. 5 GuangzhouChina 35 works
  6. 6 NanjingChina 29 works
  7. 7 TianjinChina 24 works
  8. 8 JinanChina 24 works
  9. 9 TehranIran 23 works
  10. 10 HarbinChina 23 works
See Hydrogen's biological and therapeutic effects on the map

Where is the best place to study Hydrogen's biological and therapeutic effects?

Among universities, judged by research, Soochow University, Shanghai Jiao Tong University and Harbin Medical University score highest, combining excellence, specialisation, size, growth and international reach. Research strength is one signal when choosing where to study; it does not measure teaching.

0%20%40%60%mean 20.57%fractional works in this field (log) →share of work in the world top 10% →Soochow UniversityShanghai Jiao Tong U…Harbin Medical Unive…Fudan University
above the meannear itbelow it

One dot per university in the first ten of the table below, at the default weights. The upper left is the interesting corner: small places doing unusually strong work.

Excellenceshare of its work in the world top 10%, 2022-now and all time averaged
40%
Specialisationhow much of its work is in this field, counted up to 10× the world share
10%
Sizeits output in this field, on a log scale
30%
Growthoutput growth, counted from -20% to +20%
10%
Internationalshare of its work with a co-author abroad
10%
Each slider sets a weight; the share it gets of the score is beside it.
#UniversityScoreTop 10%SpecialisationWorksGrowth
1Soochow UniversityChina 67.653.1%5.6×10 +42.6%
2Shanghai Jiao Tong UniversityChina 63.825.0%3.6×20 +3.1%
3Harbin Medical UniversityChina 50.116.1%22.5×15 +15.0%
4Fudan UniversityChina 40.011.0%3.7×11 +27.1%
5Sichuan UniversityChina 37.117.3%2.8×12 +72.4%
6Harvard UniversityUnited States 35.111.8%1.4×9 +35.1%
7Qingdao UniversityChina 34.816.0%6.9×9 +60.2%
8Tongji UniversityChina 33.721.2%2.8×8 +33.0%
9Anhui Medical UniversityChina 32.318.0%9.5×8 +77.4%
10Tianjin Medical UniversityChina 31.816.2%16.4×11 -42.7%

Universities only. The score blends excellence (40%), size (30%), specialisation (10%), growth (10%), international reach (10%), 2022-now; growth compares 2018-21 with 2022-25 and counts up to +20%, since a jump from a small base is mostly noise.

Every institution in Hydrogen's biological and therapeutic effects, country by country

Is Hydrogen's biological and therapeutic effects research growing?

Output in 2022-2025 was 17% higher than in 2018-2021, peaking in 2024. The fastest-growing topics are Hydrogen's biological and therapeutic effects.

still counting19801990200020102020
grewheldshrank

The same series as a ribbon: one cell per year, darker for more. The line above answers how much; this answers when.

Its share of all research

Growing output can still be a shrinking share: all of science grows. This is Hydrogen's biological and therapeutic effects as a percentage of every work published that year, 0.010% in 2024.

still counting0.0050%0.010%0.015%Hydrogen's biological and therapeutic effects0.0094% in 202519801990200020102020

Fractional works of Hydrogen's biological and therapeutic effects over all fractional works that year. How the balance of science has shifted.

How much of it reaches the world top 10%

Year by year.

still counting5%10%15%Hydrogen's biological and therapeutic effects10.5% in 2025200020102020

Of each year's works in it, the share that reached the world's 10% most cited for their field and year. A field is the world for its own topics, so there is no other line to hold it against.

Which topics inside it are moving

Growth and decline on one axis around a shared zero. Two lists side by side hide the thing that matters: whether the growth dwarfs the decline, or the other way round.

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