Most cited papers in Immune Cell Function and Interaction
What are the most cited papers in Immune Cell Function and Interaction?
The most cited paper in Immune Cell Function and Interaction is "Simple Combinations of Lineage-Determining Transcription Factors Prime cis-Regulatory Elements Required for Macrophage and B Cell Identities" (Sven Heinz, Christopher W. Benner, Nathanael J. Spann et al., 2010), with 14,980 citations. Next come "Dendritic cells and the control of immunity" (14,440) and "The blockade of immune checkpoints in cancer immunotherapy" (14,033).
Showing 50 of 100 papers. Every paper with more than 2,923 citations is listed.
| # | Paper | ||
|---|---|---|---|
| 1 | Simple Combinations of Lineage-Determining Transcription Factors Prime cis-Regulatory Elements Required for Macrophage and B Cell Identities Sven Heinz, Christopher W. Benner, Nathanael J. Spann et al. · Molecular Cell | May 2010 | 14,980 |
| 2 | Dendritic cells and the control of immunity Jacques Banchereau, Ralph M. Steinman · Nature | Mar 1998 | 14,440 |
| 3 | The blockade of immune checkpoints in cancer immunotherapy Drew M. Pardoll · Nature reviews. Cancer | 22 Mar 2012 | 14,033 |
| 4 | Pathogen Recognition and Innate Immunity Shizuo Akira, Satoshi Uematsu, Osamu Takeuchi · Cell | Feb 2006 | 12,064 |
| 5 | COVID-19: consider cytokine storm syndromes and immunosuppression Puja Mehta, Daniel Francis McAuley, Michael Brown et al. · The Lancet | Mar 2020 | 10,244 |
| 6 | Innate Immune Recognition Charles A. Janeway, Ruslan M. Medzhitov · Annual Review of Immunology | Apr 2002 | 8,439 |
| 7 | Obesity is associated with macrophage accumulation in adipose tissue Stuart Phillip Weisberg, Daniel McCann, Manisha Desai et al. · Journal of Clinical Investigation | 15 Dec 2003 | 8,398 |
| 8 | Control of Regulatory T Cell Development by the Transcription Factor Foxp3 Shohei Hori, Takashi Nomura, Shimon Sakaguchi · Science | 13 Feb 2003 | 8,213 |
| 9 | Foxp3 programs the development and function of CD4+CD25+ regulatory T cells Jason D. Fontenot, Marc A. Gavin, Alexander Yu Rudensky · Nature Immunology | 3 Mar 2003 | 7,778 |
| 10 | Two types of murine helper T cell clone. I. Definition according to profiles of lymphokine activities and secreted proteins. Timothy R. Mosmann, Holly M. Cherwinski, M W Bond et al. · The Journal of Immunology | Apr 1986 | 7,553 |
| 11 | Cancer immunotherapy using checkpoint blockade Antoni Ribas, Jedd D. Wolchok · Science | 22 Mar 2018 | 6,951 |
| 12 | Immunobiology of Dendritic Cells Jacques Banchereau, Francine Brière, Christophe Caux et al. · Annual Review of Immunology | Apr 2000 | 6,652 |
| 13 | Sex differences in immune responses Sabra L. Klein, Katie L. Flanagan · Nature reviews. Immunology | 22 Aug 2016 | 6,634 |
| 14 | Type, Density, and Location of Immune Cells Within Human Colorectal Tumors Predict Clinical Outcome Jérôme Galon, Anne Costes, Fátima Sánchez‐Cabo et al. · Science | 28 Sep 2006 | 6,620 |
| 15 | Cancer Immunoediting: Integrating Immunity’s Roles in Cancer Suppression and Promotion Robert D. Schreiber, Lloyd J. Old, Mark John Smyth · Science | 24 Mar 2011 | 6,561 |
| 16 | Adhesion receptors of the immune system Timothy A. Springer · Nature | Aug 1990 | 6,541 |
| 17 | A Toll-like receptor recognizes bacterial DNA Hiroaki Hemmi, Osamu Takeuchi, Taro Kawai et al. · Nature | 7 Dec 2000 | 6,498 |
| 18 | Macrophage plasticity and polarization: in vivo veritas Antonio Sica, Alberto Mantovani · Journal of Clinical Investigation | Mar 2012 | 6,482 |
| 19 | Alternative activation of macrophages Siamon Gordon · Nature reviews. Immunology | 2003 | 6,226 |
| 20 | Recognition of double-stranded RNA and activation of NF-κB by Toll-like receptor 3 Lena Alexopoulou, Agnieszka Czopik Holt, Ruslan M. Medzhitov et al. · Nature | Oct 2001 | 6,152 |
| 21 | Jak-STAT Pathways and Transcriptional Activation in Response to IFNs and Other Extracellular Signaling Proteins James E. Darnell Jr., lan M. Kerr, George Robert Stark · Science | 3 Jun 1994 | 6,151 |
| 22 | What's wrong with Bonferroni adjustments Thomas Perneger · BMJ | 18 Apr 1998 | 5,951 |
| 23 | Two subsets of memory T lymphocytes with distinct homing potentials and effector functions Federica Sallusto, Danielle Lenig, Reinhold Förster et al. · Nature | Oct 1999 | 5,898 |
| 24 | Signaling by intrathymic cytokines, not T cell antigen receptors, specifies CD8 lineage choice and promotes the differentiation of cytotoxic-lineage T cells Jung‐Hyun Park, Stanley Adoro, Terry I. Guinter et al. · Nature Immunology | 31 Jan 2010 | 5,851 |
| 25 | Primary, Adaptive, and Acquired Resistance to Cancer Immunotherapy Padmanee Sharma, Siwen Hu‐Lieskovan, Jennifer Ann Wargo et al. · Cell | Feb 2017 | 5,686 |
| 26 | Gut microbiome influences efficacy of PD-1–based immunotherapy against epithelial tumors Bertrand Routy et al. · Science | 2 Nov 2017 | 5,679 |
| 27 | HLH‐2004: Diagnostic and therapeutic guidelines for hemophagocytic lymphohistiocytosis Jan‐Inge Henter, AnnaCarin Horne, Maurizio Aricò et al. · Pediatric Blood & Cancer | 25 Aug 2006 | 5,452 |
| 28 | PD-1 and Its Ligands in Tolerance and Immunity Mary E Keir, Manish J. Butte, Gordon James Freeman et al. · Annual Review of Immunology | 3 Jan 2008 | 5,426 |
| 29 | Regulatory T Cells and Immune Tolerance Shimon Sakaguchi, Tomoyuki Yamaguchi, Takashi Nomura et al. · Cell | May 2008 | 5,393 |
| 30 | Engagement of the Pd-1 Immunoinhibitory Receptor by a Novel B7 Family Member Leads to Negative Regulation of Lymphocyte Activation Gordon J. Freeman, Andrew J. Long, Yoshiko Iwai et al. · The Journal of Experimental Medicine | 2 Oct 2000 | 5,324 |
| 31 | Specific recruitment of regulatory T cells in ovarian carcinoma fosters immune privilege and predicts reduced survival Tyler Jay Curiel et al. · Nature Medicine | 22 Aug 2004 | 5,148 |
| 32 | Tumor-associated B7-H1 promotes T-cell apoptosis: A potential mechanism of immune evasion Haidong Dong, Scott Eric Strome, Diva R. Salomão et al. · Nature Medicine | 24 Jun 2002 | 5,107 |
| 33 | Immune-Related Adverse Events Associated with Immune Checkpoint Blockade Michael Andrew Postow, Robert Sidlow, Matthew David Hellmann · New England Journal of Medicine | 10 Jan 2018 | 4,898 |
| 34 | The M1 and M2 paradigm of macrophage activation: time for reassessment Fernando O. Martínez, Siamon Gordon · F1000Prime Reports | 28 Feb 2014 | 4,795 |
| 35 | Interleukin 17–producing CD4+ effector T cells develop via a lineage distinct from the T helper type 1 and 2 lineages Laurie E. Harrington, Robin D. Hatton, Paul R. Mangan et al. · Nature Immunology | 2 Oct 2005 | 4,759 |
| 36 | Molecular and cellular insights into T cell exhaustion E. John Wherry, Makoto Kurachi · Nature reviews. Immunology | 24 Jul 2015 | 4,739 |
| 37 | Conversion of Peripheral CD4+CD25− Naive T Cells to CD4+CD25+ Regulatory T Cells by TGF-β Induction of Transcription Factor Foxp3 WanJun Chen, Wenwen Jin, Neil J. Hardegen et al. · The Journal of Experimental Medicine | 15 Dec 2003 | 4,695 |
| 38 | Obesity induces a phenotypic switch in adipose tissue macrophage polarization Carey Nien-Kai Lumeng, Jennifer L. Bodzin, Alan R. Saltiel · Journal of Clinical Investigation | 2 Jan 2007 | 4,656 |
| 39 | Gain-of-Function Mutations of c- kit in Human Gastrointestinal Stromal Tumors Seiichi Hirota, Koji Isozaki, Yasuhiro Moriyama et al. · Science | 23 Jan 1998 | 4,517 |
| 40 | Functional diversity of helper T lymphocytes Abul K. Abbas, KENNETH M. M. MURPHY, Alan Sher · Nature | 31 Oct 1996 | 4,488 |
| 41 | Biologic basis for interleukin-1 in disease CA Dinarello · Blood | 15 Mar 1996 | 4,380 |
| 42 | Immune Checkpoint Blockade: A Common Denominator Approach to Cancer Therapy Suzanne Louise Topalian, Charles G. Drake, Drew M. Pardoll · Cancer Cell | Apr 2015 | 4,339 |
| 43 | Interleukin-10-deficient mice develop chronic enterocolitis Ralf Kühn, Jürgen Löhler, Donna M. Rennick et al. · Cell | Oct 1993 | 4,325 |
| 44 | Innate and adaptive immune cells in the tumor microenvironment Thomas F. Gajewski, Hans Wilhelm Schreiber, Yang‐Xin Fu · Nature Immunology | 18 Sep 2013 | 4,299 |
| 45 | Toll-like receptors and innate immunity Ruslan M. Medzhitov · Nature reviews. Immunology | Nov 2001 | 4,298 |
| 46 | Alternative Activation of Macrophages: Mechanism and Functions Siamon Gordon, Fernando O. Martínez · Immunity | May 2010 | 4,251 |
| 47 | Toll-like receptor control of the adaptive immune responses Akiko Iwasaki, Ruslan M. Medzhitov · Nature Immunology | 28 Sep 2004 | 4,186 |
| 48 | T cell exhaustion E. John Wherry · Nature Immunology | 18 May 2011 | 4,131 |
| 49 | CD14, a Receptor for Complexes of Lipopolysaccharide (LPS) and LPS Binding Protein Samuel D. Wright, Robert Ramos, Peter S. Tobias et al. · Science | 21 Sep 1990 | 4,038 |
| 50 | Restoring function in exhausted CD8 T cells during chronic viral infection Daniel L. Barber, E. John Wherry, David Masopust et al. · Nature | 28 Dec 2005 | 4,031 |
Citations are OpenAlex's own counts, from its 2026-09-23 snapshot, so the ranking can differ from Google Scholar or Web of Science. A paper is listed for a field when OpenAlex files it under one of the field's topics; retracted papers and papers whose citation count cannot be traced to citing works are left out, and a preprint and the article it became are shown once. Release dates are OpenAlex's: where a source gave only a month or a year, that is what is shown. How the lists are chosen.