Topic · Immune Response and Inflammation
Most cited papers in Immune Response and Inflammation
What are the most cited papers in Immune Response and Inflammation?
The most cited paper in Immune Response and Inflammation is "The Third International Consensus Definitions for Sepsis and Septic Shock (Sepsis-3)" (Mervyn Singer, Clifford Scott Deutschman, Christopher W. Seymour et al., 2016), with 29,012 citations. Next come "Pathogen Recognition and Innate Immunity" (12,064) and "Heat Shock Protein A12B Protects Vascular Endothelial Cells Against Sepsis-Induced Acute Lung Injury in Mice" (10,709).
Showing 50 of 99 papers. Every paper with more than 3,040 citations is listed.
| # | Paper | ||
|---|---|---|---|
| 1 | The Third International Consensus Definitions for Sepsis and Septic Shock (Sepsis-3) Mervyn Singer, Clifford Scott Deutschman, Christopher W. Seymour et al. · JAMA | 22 Feb 2016 | 29,012 |
| 2 | Pathogen Recognition and Innate Immunity Shizuo Akira, Satoshi Uematsu, Osamu Takeuchi · Cell | Feb 2006 | 12,064 |
| 3 | Heat Shock Protein A12B Protects Vascular Endothelial Cells Against Sepsis-Induced Acute Lung Injury in Mice Yi Chen, Lei Wang, Qiuxiang Kang et al. · Cellular Physiology and Biochemistry | 2017 | 10,709 |
| 4 | The role of pattern-recognition receptors in innate immunity: update on Toll-like receptors Taro Kawai, Shizuo Akira · Nature Immunology | 20 Apr 2010 | 9,343 |
| 5 | Pattern Recognition Receptors and Inflammation Osamu Takeuchi, Shizuo Akira · Cell | Mar 2010 | 8,914 |
| 6 | Epidemiology of severe sepsis in the United States: Analysis of incidence, outcome, and associated costs of care Derek C. Angus, Walter T. Linde‐Zwirble, Jeffrey R. Lidicker et al. · Critical Care Medicine | Jul 2001 | 8,644 |
| 7 | NF-κB signaling in inflammation Ting Liu, Lingyun Zhang, Donghyun Joo et al. · Signal Transduction and Targeted Therapy | 14 Jul 2017 | 8,517 |
| 8 | Innate Immune Recognition Charles A. Janeway, Ruslan M. Medzhitov · Annual Review of Immunology | Apr 2002 | 8,439 |
| 9 | Toll-like receptor signalling Shizuo Akira, Kiyoshi Takeda · Nature reviews. Immunology | 30 Jun 2004 | 8,340 |
| 10 | Global, regional, and national sepsis incidence and mortality, 1990–2017: analysis for the Global Burden of Disease Study Kristina E. Rudd et al. · The Lancet | 2020 | 8,189 |
| 11 | Glutamate neurotoxicity and diseases of the nervous system Dennis W. Choi · Neuron | Oct 1988 | 8,019 |
| 12 | Traffic signals for lymphocyte recirculation and leukocyte emigration: The multistep paradigm Timothy A. Springer · Cell | 1994 | 7,019 |
| 13 | Surviving Sepsis Campaign: International Guidelines for Management of Sepsis and Septic Shock: 2016 Andrew Rhodes et al. · Intensive Care Medicine | 18 Jan 2017 | 6,868 |
| 14 | Myeloid-derived suppressor cells as regulators of the immune system Dmitry I. Gabrilovich, Srinivas Nagaraj · Nature reviews. Immunology | 7 Feb 2009 | 6,796 |
| 15 | A Toll-like receptor recognizes bacterial DNA Hiroaki Hemmi, Osamu Takeuchi, Taro Kawai et al. · Nature | 7 Dec 2000 | 6,498 |
| 16 | Alternative activation of macrophages Siamon Gordon · Nature reviews. Immunology | 2003 | 6,226 |
| 17 | Duration of hypotension before initiation of effective antimicrobial therapy is the critical determinant of survival in human septic shock* Anand Kumar, DANIEL E. ROBERTS, Kenneth E. Wood et al. · Critical Care Medicine | 19 Apr 2006 | 6,210 |
| 18 | Toll-Like Receptors Kiyoshi Takeda, Tsuneyasu Kaisho, Shizuo Akira · Annual Review of Immunology | 3 Mar 2003 | 6,179 |
| 19 | Recognition of double-stranded RNA and activation of NF-κB by Toll-like receptor 3 Lena Alexopoulou, Agnieszka Czopik Holt, Ruslan M. Medzhitov et al. · Nature | Oct 2001 | 6,152 |
| 20 | 2001 SCCM/ESICM/ACCP/ATS/SIS International Sepsis Definitions Conference Mitchell M. Levy, Mitchell P. Fink, John C. Marshall et al. · Critical Care Medicine | Apr 2003 | 6,064 |
| 21 | Bcl-2 heterodimerizes in vivo with a conserved homolog, Bax, that accelerates programed cell death Zoltán N. Oltval, Curt L. Milliman, Stanley J. Korsmeyer · Cell | Aug 1993 | 6,042 |
| 22 | THE NF-κB AND IκB PROTEINS: New Discoveries and Insights Albert S. Baldwin · Annual Review of Immunology | Apr 1996 | 5,979 |
| 23 | What's wrong with Bonferroni adjustments Thomas Perneger · BMJ | 18 Apr 1998 | 5,951 |
| 24 | Association of NOD2 leucine-rich repeat variants with susceptibility to Crohn's disease Jean‐Pierre Hugot, Mathias Chamaillard, Habib Zouali et al. · Nature | May 2001 | 5,631 |
| 25 | Fate Mapping Analysis Reveals That Adult Microglia Derive from Primitive Macrophages Florent Ginhoux, Melanie Greter, Marylène Leboeuf et al. · Science | 21 Oct 2010 | 5,266 |
| 26 | Monocyte and macrophage heterogeneity Siamon Gordon, Philip R. Taylor · Nature reviews. Immunology | Dec 2005 | 5,210 |
| 27 | NF-κB AND REL PROTEINS: Evolutionarily Conserved Mediators of Immune Responses Sankar Ghosh, Michael J. May, Elizabeth B. Kopp · Annual Review of Immunology | Apr 1998 | 5,209 |
| 28 | Efficient presentation of soluble antigen by cultured human dendritic cells is maintained by granulocyte/macrophage colony-stimulating factor plus interleukin 4 and downregulated by tumor necrosis factor alpha. Federica Sallusto, Antonio Lanzavecchia · The Journal of Experimental Medicine | Apr 1994 | 5,185 |
| 29 | The Nuclear Factor NF- B Pathway in Inflammation Toby Lawrence · Cold Spring Harbor Perspectives in Biology | 7 Oct 2009 | 4,962 |
| 30 | Reactive Oxygen Species in Inflammation and Tissue Injury Manish Mittal, Mohammad R. Siddiqui, Khiem A. Tran et al. · Antioxidants and Redox Signaling | 2 Sep 2013 | 4,933 |
| 31 | Shared Principles in NF-κB Signaling Matthew S. Hayden, Sankar Ghosh · Cell | Feb 2008 | 4,836 |
| 32 | Toll-like receptors: critical proteins linking innate and acquired immunity Shizuo Akira, Kiyoshi Takeda, Tsuneyasu Kaisho · Nature Immunology | Aug 2001 | 4,814 |
| 33 | Phosphorylation Meets Ubiquitination: The Control of NF-κB Activity Michael Karin, Yinon Ben‐Neriah · Annual Review of Immunology | Apr 2000 | 4,784 |
| 34 | Function and Activation of NF-kappaB in the Immune System Patrick A. Baeuerle, Thomas Henkel · Annual Review of Immunology | Apr 1994 | 4,729 |
| 35 | Lipopolysaccharide Endotoxins Christian R.H. Raetz, Chris Whitfield · Annual Review of Biochemistry | Jun 2002 | 4,420 |
| 36 | Biologic basis for interleukin-1 in disease CA Dinarello · Blood | 15 Mar 1996 | 4,380 |
| 37 | Getting to the site of inflammation: the leukocyte adhesion cascade updated Klaus F. Ley, Carlo Laudanna, Myron I. Cybulsky et al. · Nature reviews. Immunology | 24 Aug 2007 | 4,348 |
| 38 | NF-κB-dependent induction of microRNA miR-146, an inhibitor targeted to signaling proteins of innate immune responses Konstantin D. Taganov, Mark Boldin, Kuang‐Jung Chang et al. · Proceedings of the National Academy of Sciences | 2 Aug 2006 | 4,341 |
| 39 | Toll-like receptors and innate immunity Ruslan M. Medzhitov · Nature reviews. Immunology | Nov 2001 | 4,298 |
| 40 | Osteoclast differentiation factor is a ligand for osteoprotegerin/osteoclastogenesis-inhibitory factor and is identical to TRANCE/RANKL Hisataka Yasuda, Nobuyuki Shima, Nobuaki NAKAGAWA et al. · Proceedings of the National Academy of Sciences | 31 Mar 1998 | 4,281 |
| 41 | Recognition of Commensal Microflora by Toll-Like Receptors Is Required for Intestinal Homeostasis Seth Rakoff-Nahoum, Justin C. Paglino, Fatima Eslami-Varzaneh et al. · Cell | Jul 2004 | 4,278 |
| 42 | Release of chromatin protein HMGB1 by necrotic cells triggers inflammation Paola Scaffidi, Tom Misteli, Marco Emilio Bianchi · Nature | 11 Jul 2002 | 4,239 |
| 43 | Toll-like receptor control of the adaptive immune responses Akiko Iwasaki, Ruslan M. Medzhitov · Nature Immunology | 28 Sep 2004 | 4,186 |
| 44 | Microglia-mediated neurotoxicity: uncovering the molecular mechanisms Michelle L. Block, Luigi Zecca, Jau‐Shyong Hong · Nature reviews. Neuroscience | 20 Dec 2006 | 4,164 |
| 45 | The Pathophysiology and Treatment of Sepsis Richard S. Hotchkiss, Irene E. Karl · New England Journal of Medicine | 8 Jan 2003 | 4,137 |
| 46 | Interferon-γ: an overview of signals, mechanisms and functions Kate Schroder, Paul J. Hertzog, Timothy Ravasi et al. · Journal of Leukocyte Biology | 2 Oct 2003 | 4,131 |
| 47 | CD14, a Receptor for Complexes of Lipopolysaccharide (LPS) and LPS Binding Protein Samuel D. Wright, Robert Ramos, Peter S. Tobias et al. · Science | 21 Sep 1990 | 4,038 |
| 48 | NF-κB regulation in the immune system Qiutang Li, Inder M. Verma · Nature reviews. Immunology | Oct 2002 | 4,031 |
| 49 | The Fas Death Factor Shigekazu Nagata, Pierre Golstein · Science | 10 Mar 1995 | 4,028 |
| 50 | Species-Specific Recognition of Single-Stranded RNA via Toll-like Receptor 7 and 8 Florian Heil, Hiroaki Hemmi, Hubertus Hochrein et al. · Science | 23 Feb 2004 | 3,973 |
Citations are OpenAlex's own counts, from its 2026-09-23 snapshot, so the ranking can differ from Google Scholar or Web of Science. A paper is listed for a field when OpenAlex files it under one of the field's topics; retracted papers and papers whose citation count cannot be traced to citing works are left out, and a preprint and the article it became are shown once. Release dates are OpenAlex's: where a source gave only a month or a year, that is what is shown. How the lists are chosen.