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Topic · Immunodeficiency and Autoimmune Disorders

Most cited papers in Immunodeficiency and Autoimmune Disorders

Immunodeficiency and Autoimmune Disorders

What are the most cited papers in Immunodeficiency and Autoimmune Disorders?

The most cited paper in Immunodeficiency and Autoimmune Disorders is "Reciprocal developmental pathways for the generation of pathogenic effector TH17 and regulatory T cells" (Estelle Bettelli, Yijun Carrier, Wenda Gao et al., 2006), with 7,030 citations. Next come "A frameshift mutation in NOD2 associated with susceptibility to Crohn's disease" (5,051) and "IL-17 and Th17 Cells" (4,889).

Showing 50 of 100 papers. Every paper with more than 1,144 citations is listed.

Most cited papers, sortable by citations and release date
#Paper
1 Reciprocal developmental pathways for the generation of pathogenic effector TH17 and regulatory T cells Estelle Bettelli, Yijun Carrier, Wenda Gao et al. · Nature 30 Apr 2006 7,030
2 A frameshift mutation in NOD2 associated with susceptibility to Crohn's disease Yasunori Ogura, Denise K. Bonen, Naohiro Inohara et al. · Nature Open access May 2001 5,051
3 IL-17 and Th17 Cells Thomas Korn, Estelle Bettelli, Mohamed Oukka et al. · Annual Review of Immunology Review 8 Jan 2009 4,889
4 IL-23 drives a pathogenic T cell population that induces autoimmune inflammation Claire L. Langrish, Yi Chen, Wendy M. Blumenschein et al. · The Journal of Experimental Medicine Open access 17 Jan 2005 4,112
5 Guidelines for the diagnosis and treatment of chronic lymphocytic leukemia: a report from the International Workshop on Chronic Lymphocytic Leukemia updating the National Cancer Institute–Working Group 1996 guidelines Michael J. Hallek, Bruce D. Cheson, Daniel Catovsky et al. · Blood Open access 23 Jan 2008 3,806
6 TGFβ in the Context of an Inflammatory Cytokine Milieu Supports De Novo Differentiation of IL-17-Producing T Cells Marc Veldhoen, Richard J. Hocking, Christopher J. Atkins et al. · Immunity Open access Feb 2006 3,605
7 LMO2 -Associated Clonal T Cell Proliferation in Two Patients after Gene Therapy for SCID-X1 S. Hacein-Bey-Abina et al. · Science 16 Oct 2003 3,582
8 Treatment and prognostic factors for long-term outcome in patients with anti-NMDA receptor encephalitis: an observational cohort study Maarten J. Titulaer, Lindsey McCracken, Iñigo Gabilondo et al. · The Lancet Neurology Open access 2 Jan 2013 3,173
9 Transforming growth factor-β induces development of the TH17 lineage Paul R. Mangan, Laurie E. Harrington, Darrell B. O’Quinn et al. · Nature 30 Apr 2006 3,074
10 Bidirectional cytokine interactions in the maternal-fetal relationship: is successful pregnancy a TH2 phenomenon? Thomas G Wegmann, Hui Lin, Larry J. Guilbert et al. · Immunology Today Jul 1993 2,880
11 Follicular Helper CD4 T Cells (T FH ) Shane Crotty · Annual Review of Immunology Review Mar 2011 2,757
12 RAG-2-deficient mice lack mature lymphocytes owing to inability to initiate V(D)J rearrangement Yoichi Shinkai · Cell 6 Mar 1992 2,673
13 Gene Therapy of Human Severe Combined Immunodeficiency (SCID)-X1 Disease Marina Cavazzana, Salima Hacein‐Bey, Geneviève de Saint Basile et al. · Science 28 Apr 2000 2,641
14 A MicroRNA Signature Associated with Prognosis and Progression in Chronic Lymphocytic Leukemia George Adrian Calin et al. · New England Journal of Medicine 26 Oct 2005 2,425
15 Inborn errors of type I IFN immunity in patients with life-threatening COVID-19 Qian Zhang et al. · Science Open access746 authors 24 Sep 2020 2,421
16 FcRn: the neonatal Fc receptor comes of age Derry C. Roopenian, Shreeram Akilesh · Nature reviews. Immunology Review 17 Aug 2007 2,335
17 A severe combined immunodeficiency mutation in the mouse Gayle C. Bosma, R. Philip Custer, Melvin J. Bosma · Nature Feb 1983 2,218
18 Imiquimod-Induced Psoriasis-Like Skin Inflammation in Mice Is Mediated via the IL-23/IL-17 Axis Leslie van der Fits, Sabine Mourits, Jane S.A. Voerman et al. · The Journal of Immunology Open access 21 Apr 2009 2,199
19 Predominant Autoantibody Production by Early Human B Cell Precursors Hedda Wardemann, Sergey Yurasov, Anne W. Schaefer et al. · Science 18 Aug 2003 2,122
20 Interferon-γ and B Cell Stimulatory Factor-1 Reciprocally Regulate Ig Isotype Production Clifford M. Snapper, William E. Paul · Science 22 May 1987 1,939
21 Efficacy of BCG Vaccine in the Prevention of Tuberculosis Graham A. Colditz · JAMA 2 Mar 1994 1,936
22 Structure and function of immunoglobulins Harry W. Schroeder, Lisa A. Cavacini · Journal of Allergy and Clinical Immunology Open access Feb 2010 1,928
23 Addition of rituximab to fludarabine and cyclophosphamide in patients with chronic lymphocytic leukaemia: a randomised, open-label, phase 3 trial Michael J. Hallek et al. · The Lancet Oct 2010 1,886
24 Phenotypic and functional features of human Th17 cells Francesco Annunziato, Lorenzo Cosmi, Veronica Santarlasci et al. · The Journal of Experimental Medicine Open access 16 Jul 2007 1,874
25 TGF-β-induced Foxp3 inhibits TH17 cell differentiation by antagonizing RORγt function Liang Zhou, Jared E. Lopes, Mark M. W. Chong et al. · Nature Open access 26 Mar 2008 1,869
26 Estimating cumulative point prevalence of rare diseases: analysis of the Orphanet database Stéphanie Nguengang Wakap, Deborah M. Lambert, Annie Olry et al. · European Journal of Human Genetics Open access 16 Sep 2019 1,868
27 Ustekinumab as Induction and Maintenance Therapy for Crohn’s Disease Brian G. Feagan et al. · New England Journal of Medicine Open access 16 Nov 2016 1,860
28 Surface phenotype and antigenic specificity of human interleukin 17–producing T helper memory cells Eva V. Acosta Rodríguez, Laura Rivino, Jens Geginat et al. · Nature Immunology 7 May 2007 1,840
29 Waning Immune Humoral Response to BNT162b2 Covid-19 Vaccine over 6 Months Einav G. Levin, Yaniv Lustig, Carmit Cohen et al. · New England Journal of Medicine Open access 6 Oct 2021 1,832
30 HLA‐DR typing by PCR amplification with sequence‐specific primers (PCR‐SSP) in 2 hours: An alternative to serological DR typing in clinical practice including donor‐recipient matching in cadaveric transplantation Ole Olerup, Henrik Zetterquist · Tissue Antigens May 1992 1,822
31 Reconstitution of Cellular Immunity against Cytomegalovirus in Recipients of Allogeneic Bone Marrow by Transfer of T-Cell Clones from the Donor Elizabeth A Walter, Philip D. Greenberg, M. Jean Gilbert et al. · New England Journal of Medicine 19 Oct 1995 1,798
32 The IPD and IMGT/HLA database: allele variant databases James Theodore Robinson, Jason Alexander Halliwell, James D. Hayhurst et al. · Nucleic Acids Research Open access 20 Nov 2014 1,798
33 AC133, a Novel Marker for Human Hematopoietic Stem and Progenitor Cells Amy H. Yin, Sheri J. Miraglia, Esmail D. Zanjani et al. · Blood Open access 15 Dec 1997 1,770
34 PI3K and cancer: lessons, challenges and opportunities David A. Fruman, Christian Rommel · Nature Reviews Drug Discovery ReviewOpen access 31 Jan 2014 1,760
35 iwCLL guidelines for diagnosis, indications for treatment, response assessment, and supportive management of CLL Michael J. Hallek, Bruce D. Cheson, Daniel Catovsky et al. · Blood 14 Mar 2018 1,752
36 The Biological Functions of T Helper 17 Cell Effector Cytokines in Inflammation Wenjun Ouyang, Jay K. Kolls, Yan Zheng · Immunity Open access Apr 2008 1,698
37 Chronic Lymphocytic Leukemia Nicholas Chiorazzi, Kanti R. Rai, Manlio Ferrarini · New England Journal of Medicine 23 Feb 2005 1,684
38 ADENOSINE-DEAMINASE DEFICIENCY IN TWO PATIENTS WITH SEVERELY IMPAIRED CELLULAR IMMUNITY E.R. Giblett, JeanneE. Anderson, Flossie Cohen et al. · The Lancet Nov 1972 1,655
39 Activation-Induced Cytidine Deaminase (AID) Deficiency Causes the Autosomal Recessive Form of the Hyper-IgM Syndrome (HIGM2) Patrick Revy et al. · Cell Open access Sep 2000 1,653
40 2013 IDSA Clinical Practice Guideline for Vaccination of the Immunocompromised Host Lorry G. Rubin, Myron J. Levin, Per T Ljungman et al. · Clinical Infectious Diseases 4 Dec 2013 1,620
41 Genome-wide association study implicates immune activation of multiple integrin genes in inflammatory bowel disease Katrina M. de Lange et al. · Nature Genetics Open access 9 Jan 2017 1,592
42 The IL-23–IL-17 immune axis: from mechanisms to therapeutic testing Sarah L. Gaffen, Renu K. JAIN, Abhishek V. Garg et al. · Nature reviews. Immunology ReviewOpen access 22 Aug 2014 1,585
43 Interleukin-1 and IL-23 Induce Innate IL-17 Production from γδ T Cells, Amplifying Th17 Responses and Autoimmunity Caroline E. Sutton, Stephen J. Lalor, Cheryl M. Sweeney et al. · Immunity Open access Aug 2009 1,565
44 The Bruton tyrosine kinase inhibitor PCI-32765 blocks B-cell activation and is efficacious in models of autoimmune disease and B-cell malignancy Lee A. Honigberg, Ashley M. Smith, Mint Sirisawad et al. · Proceedings of the National Academy of Sciences Open access 6 Jul 2010 1,553
45 Comparative Genomics of BCG Vaccines by Whole-Genome DNA Microarray Marcel A. Behr, Michael A. Wilson, Wendy Gill et al. · Science 28 May 1999 1,553
46 Whole-genome sequencing identifies recurrent mutations in chronic lymphocytic leukaemia Xosé S. Puente et al. · Nature Open access 3 Jun 2011 1,531
47 Common Variable Immunodeficiency: Clinical and Immunological Features of 248 Patients Charlotte Cunningham‐Rundles, Carol Bodian · Clinical Immunology Jul 1999 1,525
48 Obinutuzumab plus Chlorambucil in Patients with CLL and Coexisting Conditions Valentin Goede et al. · New England Journal of Medicine Open access 8 Jan 2014 1,521
49 Mice Transgenic for Baff Develop Lymphocytic Disorders along with Autoimmune Manifestations Fabienne Mackay, Stephen A. Woodcock, Pornsri Lawton et al. · The Journal of Experimental Medicine Open access 6 Dec 1999 1,483
50 The gene involved in X-linked agammaglobulinaemia is a member of the src family of protein-tyrosine kinases David L.P. Vetrie, Igor Vořechovský, Paschalis Sideras et al. · Nature 1993 1,473

Citations are OpenAlex's own counts, from its 2026-09-23 snapshot, so the ranking can differ from Google Scholar or Web of Science. A paper is listed for a field when OpenAlex files it under one of the field's topics; retracted papers and papers whose citation count cannot be traced to citing works are left out, and a preprint and the article it became are shown once. Release dates are OpenAlex's: where a source gave only a month or a year, that is what is shown. How the lists are chosen.