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Most cited papers in Inflammatory Bowel Disease

What are the most cited papers in Inflammatory Bowel Disease?

The most cited paper in Inflammatory Bowel Disease is "Worldwide incidence and prevalence of inflammatory bowel disease in the 21st century: a systematic review of population-based studies" (Siew C. Ng, Hai Yun Shi, Nima Hamidi et al., 2017), with 6,147 citations. Next come "Association of NOD2 leucine-rich repeat variants with susceptibility to Crohn's disease" (5,631) and "A frameshift mutation in NOD2 associated with susceptibility to Crohn's disease" (5,051).

Showing 50 of 99 papers. Every paper with more than 1,537 citations is listed.

Most cited papers, sortable by citations and release date
#Paper
1 Worldwide incidence and prevalence of inflammatory bowel disease in the 21st century: a systematic review of population-based studies Siew C. Ng, Hai Yun Shi, Nima Hamidi et al. · The Lancet Review 16 Oct 2017 6,147
2 Association of NOD2 leucine-rich repeat variants with susceptibility to Crohn's disease Jean‐Pierre Hugot, Mathias Chamaillard, Habib Zouali et al. · Nature May 2001 5,631
3 A frameshift mutation in NOD2 associated with susceptibility to Crohn's disease Yasunori Ogura, Denise K. Bonen, Naohiro Inohara et al. · Nature Open access May 2001 5,051
4 Host–microbe interactions have shaped the genetic architecture of inflammatory bowel disease Luke Jostins et al. · Nature Open access106 authors 31 Oct 2012 4,928
5 Increasing Incidence and Prevalence of the Inflammatory Bowel Diseases With Time, Based on Systematic Review Natalie A. Molodecky, Ing Shian Soon, Doreen M. Rabi et al. · Gastroenterology Review 17 Oct 2011 4,874
6 Nuclear Factor-κB — A Pivotal Transcription Factor in Chronic Inflammatory Diseases Peter John Barnes, Michael Karin · New England Journal of Medicine 10 Apr 1997 4,699
7 Molecular-phylogenetic characterization of microbial community imbalances in human inflammatory bowel diseases Daniel N. Frank, Allison L. St. Amand, Robert A. Feldman et al. · Proceedings of the National Academy of Sciences Open access 15 Aug 2007 4,661
8 Faecalibacterium prausnitzii is an anti-inflammatory commensal bacterium identified by gut microbiota analysis of Crohn disease patients Harry Sokol, Bénédicte Pigneur, Laurie Watterlot et al. · Proceedings of the National Academy of Sciences Open access 20 Oct 2008 4,444
9 Unravelling the pathogenesis of inflammatory bowel disease Ramnik J. Xavier, Daniel K. Podolsky · Nature Jul 2007 4,394
10 Maintenance infliximab for Crohn's disease: the ACCENT I randomised trial Stephen B. Hanauer, Brian G. Feagan, Gary R. Lichtenstein et al. · The Lancet May 2002 4,190
11 Infliximab for Induction and Maintenance Therapy for Ulcerative Colitis Paul J. Rutgeerts, William J. Sandborn, Brian G. Feagan et al. · New England Journal of Medicine Open access 7 Dec 2005 3,927
12 Ulcerative colitis Ryan C. Ungaro, Saurabh Mehandru, Patrick B. Allen et al. · The Lancet Open access 30 Nov 2016 3,581
13 Toward an Integrated Clinical, Molecular and Serological Classification of Inflammatory Bowel Disease: Report of a Working Party of the 2005 Montreal World Congress of Gastroenterology Mark S. Silverberg et al. · Canadian Journal of Gastroenterology Open access 2005 3,422
14 The Treatment-Naive Microbiome in New-Onset Crohn’s Disease Dirk Gevers et al. · Cell Host & Microbe Open access Mar 2014 3,362
15 Multi-omics of the gut microbial ecosystem in inflammatory bowel diseases Jason Lloyd‐Price et al. · Nature Open access 29 May 2019 3,328
16 The Montreal classification of inflammatory bowel disease: controversies, consensus, and implications Jack Satsangi, M S Silverberg, S Vermeire et al. · Gut Open access 11 May 2006 3,215
17 Development of a Crohn's Disease Activity Index William R. Best, Jack M. Becktel, John W. Singleton et al. · Gastroenterology Mar 1976 3,183
18 Development of a Crohn's disease activity index. National Cooperative Crohn's Disease Study. William R. Best, Jack M. Becktel, John W. Singleton et al. · PubMed Mar 1976 3,182
19 Inflammatory Bowel Disease Daniel K. Podolsky · New England Journal of Medicine 8 Aug 2002 3,178
20 A Short-Term Study of Chimeric Monoclonal Antibody cA2 to Tumor Necrosis Factor α for Crohn's Disease Stephan R. Targan, Stephen B. Hanauer, Sander J. H. van Deventer et al. · New England Journal of Medicine Open access 9 Oct 1997 3,171
21 Clinical epidemiology of inflammatory bowel disease: incidence, prevalence, and environmental influences Edward V. Loftus · Gastroenterology May 2004 3,144
22 Infliximab, Azathioprine, or Combination Therapy for Crohn's Disease Jean‐Frédéric Colombel, William J. Sandborn, Walter Reinisch et al. · New England Journal of Medicine Open access 14 Apr 2010 3,137
23 Coated Oral 5-Aminosalicylic Acid Therapy for Mildly to Moderately Active Ulcerative Colitis Kenneth W. Schroeder, William J. Tremaine, Duane M. Ilstrup · New England Journal of Medicine 24 Dec 1987 3,069
24 A Genome-Wide Association Study Identifies IL23R as an Inflammatory Bowel Disease Gene Richard H. Duerr et al. · Science Open access 26 Oct 2006 3,019
25 A SIMPLE INDEX OF CROHN'S-DISEASE ACTIVITY Richard F. Harvey, J.M. Bradshaw · The Lancet Mar 1980 2,993
26 The risk of colorectal cancer in ulcerative colitis: a meta-analysis Jayne Eaden, K R Abrams, J F Mayberry · Gut ReviewOpen access Apr 2001 2,979
27 Vedolizumab as Induction and Maintenance Therapy for Ulcerative Colitis Brian G. Feagan, Paul J. Rutgeerts, Bruce E. Sands et al. · New England Journal of Medicine Open access 21 Aug 2013 2,910
28 STRIDE-II: An Update on the Selecting Therapeutic Targets in Inflammatory Bowel Disease (STRIDE) Initiative of the International Organization for the Study of IBD (IOIBD): Determining Therapeutic Goals for Treat-to-Target strategies in IBD Dan Turner, Amanda Ricciuto, Ayanna E. Lewis et al. · Gastroenterology Open access 20 Feb 2021 2,882
29 Dysfunction of the intestinal microbiome in inflammatory bowel disease and treatment Xochitl C. Morgan, Timothy L. Tickle, Harry Sokol et al. · Genome biology Open access 26 Sep 2012 2,818
30 Association analyses identify 38 susceptibility loci for inflammatory bowel disease and highlight shared genetic risk across populations Jimmy Z. Liu et al. · Nature Genetics Open access 20 Jul 2015 2,805
31 Infliximab for the Treatment of Fistulas in Patients with Crohn's Disease Daniel H. Present, Paul Rutgeerts, Stephan Targan et al. · New England Journal of Medicine Open access 6 May 1999 2,765
32 Vedolizumab as Induction and Maintenance Therapy for Crohn's Disease William J. Sandborn, Brian G. Feagan, Paul J. Rutgeerts et al. · New England Journal of Medicine Open access 21 Aug 2013 2,734
33 Crohn's disease Joana Torres, Saurabh Mehandru, Jean‐Frédéric Colombel et al. · The Lancet 30 Nov 2016 2,720
34 Cytokines in inflammatory bowel disease Markus Friedrich Neurath · Nature reviews. Immunology Review 22 Apr 2014 2,704
35 The global burden of IBD: from 2015 to 2025 Gilaad G. Kaplan · Nature Reviews Gastroenterology & Hepatology Review Sep 2015 2,701
36 Inflammatory Bowel Disease Clara Abraham, Judy H. Cho · New England Journal of Medicine Open access 18 Nov 2009 2,691
37 Genetics and pathogenesis of inflammatory bowel disease Bernard Khor, Agnès Gardet, Ramnik J. Xavier · Nature Open access Jun 2011 2,645
38 Genome-wide association defines more than 30 distinct susceptibility loci for Crohn's disease Jeffrey C. Barrett et al. · Nature Genetics Open access 29 Jun 2008 2,644
39 Genome-wide meta-analysis increases to 71 the number of confirmed Crohn's disease susceptibility loci André Franke et al. · Nature Genetics Open access 21 Nov 2010 2,592
40 A novel method in the induction of reliable experimental acute and chronic ulcerative colitis in mice Isao Okayasu, Shigeru Hatakeyama, Masahiro Yamada et al. · Gastroenterology Mar 1990 2,433
41 British Society of Gastroenterology consensus guidelines on the management of inflammatory bowel disease in adults Christopher Andrew Lamb et al. · Gut Open access 27 Sep 2019 2,370
42 The global, regional, and national burden of inflammatory bowel disease in 195 countries and territories, 1990–2017: a systematic analysis for the Global Burden of Disease Study 2017 Sudabeh Alatab et al. · ˜The œLancet. Gastroenterology & hepatology Open access 21 Oct 2019 2,339
43 Reduced diversity of faecal microbiota in Crohn’s disease revealed by a metagenomic approach Chaysavanh Manichanh, L Rigottier-Gois, E Bonnaud et al. · Gut Open access 27 Sep 2005 2,298
44 Intestinal Inflammation Targets Cancer-Inducing Activity of the Microbiota Janelle C. Arthur, Ernesto Peréz-Chanona, Marcus Mühlbauer et al. · Science Open access 17 Aug 2012 2,284
45 Worldwide Prevalence and Burden of Functional Gastrointestinal Disorders, Results of Rome Foundation Global Study Ami D. Sperber et al. · Gastroenterology Open access 12 Apr 2020 2,280
46 Adalimumab for Maintenance of Clinical Response and Remission in Patients With Crohn’s Disease: The CHARM Trial Jean–Frédéric Colombel, William J. Sandborn, Paul J. Rutgeerts et al. · Gastroenterology Open access 30 Nov 2006 2,263
47 Infliximab Maintenance Therapy for Fistulizing Crohn's Disease Bruce E. Sands, Frank Anderson, Charles Noah Bernstein et al. · New England Journal of Medicine Open access 25 Feb 2004 2,234
48 Epidemiology and Natural History of Inflammatory Bowel Diseases Jacques Cosnes, Corinne Gower‐Rousseau, Philippe Seksik et al. · Gastroenterology Open access May 2011 2,226
49 Inflammatory bowel disease: cause and immunobiology Daniel C. Baumgart, Simon R. Carding · The Lancet May 2007 2,171
50 IL-6 and Stat3 Are Required for Survival of Intestinal Epithelial Cells and Development of Colitis-Associated Cancer Sergei I. Grivennikov, Eliad Karin, Janoš Terzić et al. · Cancer Cell Open access Feb 2009 2,161

Citations are OpenAlex's own counts, from its 2026-09-23 snapshot, so the ranking can differ from Google Scholar or Web of Science. A paper is listed for a field when OpenAlex files it under one of the field's topics; retracted papers and papers whose citation count cannot be traced to citing works are left out, and a preprint and the article it became are shown once. Release dates are OpenAlex's: where a source gave only a month or a year, that is what is shown. How the lists are chosen.