Topic · interferon and immune responses
Most cited papers in interferon and immune responses
What are the most cited papers in interferon and immune responses?
The most cited paper in interferon and immune responses is "Pathogen Recognition and Innate Immunity" (Shizuo Akira, Satoshi Uematsu, Osamu Takeuchi, 2006), with 12,064 citations. Next come "The role of pattern-recognition receptors in innate immunity: update on Toll-like receptors" (9,343) and "Pattern Recognition Receptors and Inflammation" (8,914).
Showing 50 of 100 papers. Every paper with more than 1,915 citations is listed.
| # | Paper | ||
|---|---|---|---|
| 1 | Pathogen Recognition and Innate Immunity Shizuo Akira, Satoshi Uematsu, Osamu Takeuchi · Cell | Feb 2006 | 12,064 |
| 2 | The role of pattern-recognition receptors in innate immunity: update on Toll-like receptors Taro Kawai, Shizuo Akira · Nature Immunology | 20 Apr 2010 | 9,343 |
| 3 | Pattern Recognition Receptors and Inflammation Osamu Takeuchi, Shizuo Akira · Cell | Mar 2010 | 8,914 |
| 4 | The Inflammasome Fabio Martinon, Kimberly Burns, Jürg Tschopp · Molecular Cell | Aug 2002 | 6,126 |
| 5 | The Bcl-2 Protein Family: Arbiters of Cell Survival Jerry M. Adams, Suzanne Cory · Science | 28 Aug 1998 | 5,380 |
| 6 | NF-κB AND REL PROTEINS: Evolutionarily Conserved Mediators of Immune Responses Sankar Ghosh, Michael J. May, Elizabeth B. Kopp · Annual Review of Immunology | Apr 1998 | 5,209 |
| 7 | Cyclic GMP-AMP Synthase Is a Cytosolic DNA Sensor That Activates the Type I Interferon Pathway Lijun Sun, Jiaxi Wu, Fenghe Du et al. · Science | 21 Dec 2012 | 5,027 |
| 8 | Phosphorylation Meets Ubiquitination: The Control of NF-κB Activity Michael Karin, Yinon Ben‐Neriah · Annual Review of Immunology | Apr 2000 | 4,784 |
| 9 | Imbalanced Host Response to SARS-CoV-2 Drives Development of COVID-19 Daniel Blanco-Melo, Benjamin E. Nilsson-Payant, Wen‐Chun Liu et al. · Cell | May 2020 | 4,570 |
| 10 | A clinical approach to diagnosis of autoimmune encephalitis Francesc Graus et al. · The Lancet Neurology | 20 Feb 2016 | 4,550 |
| 11 | Systematic RNA interference reveals that oncogenic KRAS-driven cancers require TBK1 David Allen Barbie et al. · Nature | 21 Oct 2009 | 4,303 |
| 12 | Interferon-γ: an overview of signals, mechanisms and functions Kate Schroder, Paul J. Hertzog, Timothy Ravasi et al. · Journal of Leukocyte Biology | 2 Oct 2003 | 4,131 |
| 13 | Molecular characterization of mitochondrial apoptosis-inducing factor Santos A. Susín, Hans Kristian Lorenzo, Naoufal Zamzami et al. · Nature | Feb 1999 | 4,082 |
| 14 | STATs and Gene Regulation James E. Darnell Jr. · Science | 12 Sep 1997 | 4,030 |
| 15 | The Fas Death Factor Shigekazu Nagata, Pierre Golstein · Science | 10 Mar 1995 | 4,028 |
| 16 | HOW CELLS RESPOND TO INTERFERONS George Robert Stark, Ian Macpherson Kerr, Bryan Williams et al. · Annual Review of Biochemistry | Jun 1998 | 3,971 |
| 17 | The RNA helicase RIG-I has an essential function in double-stranded RNA-induced innate antiviral responses Mitsutoshi Yoneyama, Mika Kikuchi, Takashi Natsukawa et al. · Nature Immunology | 20 Jun 2004 | 3,949 |
| 18 | Differential roles of MDA5 and RIG-I helicases in the recognition of RNA viruses Hiroki Kato, Osamu Takeuchi, Shintaro Sato et al. · Nature | 9 Apr 2006 | 3,913 |
| 19 | Signaling to NF-κB Matthew S. Hayden, Sankar Ghosh · Genes & Development | 15 Sep 2004 | 3,835 |
| 20 | Bcl-2 is an inner mitochondrial membrane protein that blocks programmed cell death David M. Hockenbery, Gabriel Núñez, Curt L. Milliman et al. · Nature | Nov 1990 | 3,802 |
| 21 | Chemokines — Chemotactic Cytokines That Mediate Inflammation Andrew D. Luster · New England Journal of Medicine | 12 Feb 1998 | 3,664 |
| 22 | STING is an endoplasmic reticulum adaptor that facilitates innate immune signalling Hiroki Ishikawa, Glen N. Barber · Nature | 24 Aug 2008 | 3,591 |
| 23 | Inflammasomes: mechanism of assembly, regulation and signalling Petr Brož, Vishva M. Dixit · Nature reviews. Immunology | 13 Jun 2016 | 3,561 |
| 24 | Mechanisms of type-I- and type-II-interferon-mediated signalling Leonidas C. Platanias · Nature reviews. Immunology | 29 Apr 2005 | 3,534 |
| 25 | Innate Antiviral Responses by Means of TLR7-Mediated Recognition of Single-Stranded RNA Sandra S. Diebold, Tsuneyasu Kaisho, Hiroaki Hemmi et al. · Science | 23 Feb 2004 | 3,453 |
| 26 | Regulation of type I interferon responses Lionel B. Ivashkiv, Laura T. Donlin · Nature reviews. Immunology | 23 Dec 2013 | 3,394 |
| 27 | Identification and Characterization of MAVS, a Mitochondrial Antiviral Signaling Protein that Activates NF-κB and IRF3 Rashu B. Seth, Lijun Sun, Chee-Kwee Ea et al. · Cell | 26 Aug 2005 | 3,352 |
| 28 | Toll-like receptors in innate immunity Kiyoshi Takeda · International Immunology | 22 Nov 2004 | 3,326 |
| 29 | Induced expression of PD‐1, a novel member of the immunoglobulin gene superfamily, upon programmed cell death. Yasumasa Ishida, Yasutoshi Agata, Kei‐ichi Shibahara et al. · The EMBO Journal | Nov 1992 | 3,261 |
| 30 | The complexity of NF-κB signaling in inflammation and cancer Bastian Hoesel, Johannes A. Schmid · Molecular Cancer | 2013 | 3,232 |
| 31 | STATs: transcriptional control and biological impact David E. Levy, James E. Darnell Jr. · Nature Reviews Molecular Cell Biology | Sep 2002 | 3,228 |
| 32 | Impaired type I interferon activity and inflammatory responses in severe COVID-19 patients Jérôme Hadjadj et al. · Science | 13 Jul 2020 | 3,200 |
| 33 | Interferon-Stimulated Genes: A Complex Web of Host Defenses William M. Schneider, Meike Dittmann, Charles M. Rice · Annual Review of Immunology | 20 Feb 2014 | 3,196 |
| 34 | Pathogen Recognition and Inflammatory Signaling in Innate Immune Defenses Trine Hyrup Mogensen · Clinical Microbiology Reviews | Apr 2009 | 3,124 |
| 35 | The Human Papilloma Virus-16 E7 Oncoprotein Is Able to Bind to the Retinoblastoma Gene Product Nicholas J. Dyson, Peter M. Howley, Karl Münger et al. · Science | 17 Feb 1989 | 3,072 |
| 36 | Genomic responses in mouse models poorly mimic human inflammatory diseases Junhee Seok et al. · Proceedings of the National Academy of Sciences | 11 Feb 2013 | 3,062 |
| 37 | Oxidized arachidonic and adrenic PEs navigate cells to ferroptosis Valerian E. Kagan et al. · Nature Chemical Biology | 14 Nov 2016 | 2,996 |
| 38 | Restriction isotyping of human apolipoprotein E by gene amplification and cleavage with HhaI. James E. Hixson, D.T. Vernier · Journal of Lipid Research | Mar 1990 | 2,963 |
| 39 | Identification and characterization of a new member of the TNF family that induces apoptosis Steven R. Wiley, Ken Schooley, Pamela J. Smolak et al. · Immunity | Dec 1995 | 2,913 |
| 40 | A decade of molecular biology of retinoic acid receptors Pierre Chambon · The FASEB Journal | Jul 1996 | 2,899 |
| 41 | Recognition of microorganisms and activation of the immune response Ruslan M. Medzhitov · Nature | 17 Oct 2007 | 2,872 |
| 42 | Type I interferons in infectious disease Finlay W. McNab, Katrin D. Mayer-Barber, Alan Sher et al. · Nature reviews. Immunology | 23 Jan 2015 | 2,863 |
| 43 | STING regulates intracellular DNA-mediated, type I interferon-dependent innate immunity Hiroki Ishikawa, Zhe Ma, Glen N. Barber · Nature | 23 Sep 2009 | 2,791 |
| 44 | Antiviral Actions of Interferons Charles E. Samuel · Clinical Microbiology Reviews | Oct 2001 | 2,780 |
| 45 | Argonaute2 Is the Catalytic Engine of Mammalian RNAi Jidong Liu, Michelle A. Carmell, Fabiola V. Rivas et al. · Science | 29 Jul 2004 | 2,750 |
| 46 | NF-κB Antiapoptosis: Induction of TRAF1 and TRAF2 and c-IAP1 and c-IAP2 to Suppress Caspase-8 Activation Cun-Yu Wang, Marty W. Mayo, Robert G. Korneluk et al. · Science | 11 Sep 1998 | 2,728 |
| 47 | IKKε and TBK1 are essential components of the IRF3 signaling pathway Katherine A. Fitzgerald, Sarah M. McWhirter, Kerrie L. Faia et al. · Nature Immunology | 14 Apr 2003 | 2,723 |
| 48 | NF-κB at the crossroads of life and death Michael Karin, Anning Lin · Nature Immunology | Mar 2002 | 2,711 |
| 49 | AIM2 recognizes cytosolic dsDNA and forms a caspase-1-activating inflammasome with ASC Veit Hornung, Andrea Ablasser, Marie Charrel-Dennis et al. · Nature | 21 Jan 2009 | 2,632 |
| 50 | Suppression of TNF-α-Induced Apoptosis by NF-κB Daniel J. Van Antwerp, Séamus J. Martin, Tal Kafri et al. · Science | Nov 1996 | 2,619 |
Citations are OpenAlex's own counts, from its 2026-09-23 snapshot, so the ranking can differ from Google Scholar or Web of Science. A paper is listed for a field when OpenAlex files it under one of the field's topics; retracted papers and papers whose citation count cannot be traced to citing works are left out, and a preprint and the article it became are shown once. Release dates are OpenAlex's: where a source gave only a month or a year, that is what is shown. How the lists are chosen.