Most cited papers in Invertebrate Immune Response Mechanisms
What are the most cited papers in Invertebrate Immune Response Mechanisms?
The most cited paper in Invertebrate Immune Response Mechanisms is "Antimicrobial peptides of multicellular organisms" (MICHAEL A. ZASLOFF, 2002), with 8,479 citations. Next come "A human homologue of the Drosophila Toll protein signals activation of adaptive immunity" (5,620) and "Genome sequence of the human malaria parasite Plasmodium falciparum" (4,520).
Showing 50 of 100 papers. Every paper with more than 859 citations is listed.
| # | Paper | ||
|---|---|---|---|
| 1 | Antimicrobial peptides of multicellular organisms MICHAEL A. ZASLOFF · Nature | 2002 | 8,479 |
| 2 | A human homologue of the Drosophila Toll protein signals activation of adaptive immunity Ruslan M. Medzhitov, Paula Preston‐Hurlburt, Charles A. Janeway · Nature | 24 Jul 1997 | 5,620 |
| 3 | Genome sequence of the human malaria parasite Plasmodium falciparum Malcolm J. Gardner et al. · Nature | Oct 2002 | 4,520 |
| 4 | The Dorsoventral Regulatory Gene Cassette spätzle/Toll/cactus Controls the Potent Antifungal Response in Drosophila Adults Bruno Lemaître, Émmanuelle Nicolas, Lydia Michaut et al. · Cell | Sep 1996 | 4,045 |
| 5 | Antimicrobial Autophagy: A Conserved Innate Immune Response in Drosophila Ryan H. Moy, Sara R. Cherry · Journal of Innate Immunity | 2013 | 3,551 |
| 6 | Silk-based biomaterials Gregory H. Altman, Frank Diaz, Caroline M. Jakuba et al. · Biomaterials | 4 Nov 2002 | 3,463 |
| 7 | The Host Defense of Drosophila melanogaster Bruno Lemaître, Jules A. Hoffmann · Annual Review of Immunology | 13 Jan 2007 | 3,426 |
| 8 | The development of Drosophila melanogaster Philip William Ingham · Trends in Genetics | Aug 1994 | 3,165 |
| 9 | Matrix metalloproteinases and the regulation of tissue remodelling Andrea Page-McCaw, Andrew J. Ewald, Zena Werb · Nature Reviews Molecular Cell Biology | 23 Feb 2007 | 3,033 |
| 10 | A new DNA binding and dimerization motif in immunoglobulin enhancer binding, daughterless, MyoD, and myc proteins Cornelis Murre, Patrick Page-McCaw, David Baltimore · Cell | Mar 1989 | 2,742 |
| 11 | Disruption of a new forkhead/winged-helix protein, scurfin, results in the fatal lymphoproliferative disorder of the scurfy mouse Mary E. Brunkow, Eric W. Jeffery, Kathryn A. Hjerrild et al. · Nature Genetics | 2001 | 2,636 |
| 12 | Phylogenetic Perspectives in Innate Immunity Jules A. Hoffmann, Fotis C. Kafatos, Charles A. Janeway et al. · Science | 21 May 1999 | 2,510 |
| 13 | MD-2, a Molecule that Confers Lipopolysaccharide Responsiveness on Toll-like Receptor 4 Rintaro Shimazu, Sachiko Akashi, Hirotaka Ogata et al. · The Journal of Experimental Medicine | 7 Jun 1999 | 2,216 |
| 14 | Hepcidin, a Urinary Antimicrobial Peptide Synthesized in the Liver Christina H. Park, Erika V. Valore, Alan J. Waring et al. · Journal of Biological Chemistry | Mar 2001 | 2,185 |
| 15 | Innate immunity of fish (overview) Bergljót Magnadóttir · Fish & Shellfish Immunology | 28 Jun 2005 | 2,142 |
| 16 | Evolution of genes and genomes on the Drosophila phylogeny Andrew G. Clark et al. · Nature | Nov 2007 | 2,132 |
| 17 | Analysis of genetic mosaics in developing and adult Drosophila tissues Tian Xu, Gerald M. Rubin · Development | Apr 1993 | 2,061 |
| 18 | The Genome Sequence of the Malaria Mosquito Anopheles gambiae Robert A. Holt et al. · Science | 3 Oct 2002 | 2,046 |
| 19 | The Transcriptome of the Intraerythrocytic Developmental Cycle of Plasmodium falciparum Zbynek Bozdech, Manuel Llinás, Brian Pulliam et al. · PLoS Biology | 18 Aug 2003 | 1,846 |
| 20 | The prophenoloxidase‐activating system in invertebrates Lage Cerenius, Kenneth Söderhäll · Immunological Reviews | 5 Mar 2004 | 1,740 |
| 21 | Lectins: Cell-Agglutinating and Sugar-Specific Proteins Nathan Sharon, Halina Lis · Science | 15 Sep 1972 | 1,713 |
| 22 | NK CELL RECEPTORS Lewis L. Lanier · Annual Review of Immunology | Apr 1998 | 1,657 |
| 23 | Lysozyme: an important defence molecule of fish innate immune system Shailesh Saurabh, Pramoda Kumar Sahoo · Aquaculture Research | 25 Jan 2008 | 1,655 |
| 24 | Cutting Edge: 1,25-Dihydroxyvitamin D3 Is a Direct Inducer of Antimicrobial Peptide Gene Expression Tiantian Wang, Frederick P. Nestel, Véronique Bourdeau et al. · The Journal of Immunology | Sep 2004 | 1,650 |
| 25 | Insect hemocytes and their role in immunity Laura Corley Lavine, Michael R. Strand · Insect Biochemistry and Molecular Biology | Oct 2002 | 1,649 |
| 26 | Liquid crystalline spinning of spider silk Fritz W. Vollrath, David P. Knight · Nature | Mar 2001 | 1,632 |
| 27 | The immune response of Drosophila Jules A. Hoffmann · Nature | Nov 2003 | 1,591 |
| 28 | MyD88 Is an Adaptor Protein in the hToll/IL-1 Receptor Family Signaling Pathways Ruslan M. Medzhitov, Paula Preston‐Hurlburt, Elizabeth B. Kopp et al. · Molecular Cell | Aug 1998 | 1,580 |
| 29 | Common West African HLA antigens are associated with protection from severe malaria Adrian V. S. Hill, Catherine E. M. Allsopp, Dominic P. Kwiatkowski et al. · Nature | 15 Aug 1991 | 1,578 |
| 30 | Infection with chikungunya virus in Italy: an outbreak in a temperate region Giovanni Rezza, Loredana Nicoletti, Paola Angelini et al. · The Lancet | Dec 2007 | 1,536 |
| 31 | New Opportunities for an Ancient Material Fiorenzo G. Omenetto, David Lee Kaplan · Science | 29 Jul 2010 | 1,469 |
| 32 | Symbiotic Bacteria Direct Expression of an Intestinal Bactericidal Lectin Heather L. Cash, Cecilia V. Whitham, Cassie L. Behrendt et al. · Science | 24 Aug 2006 | 1,444 |
| 33 | Sequence and specificity of two antibacterial proteins involved in insect immunity H. Steiner, Dan Hultmark, Åke Engström et al. · Nature | Jul 1981 | 1,444 |
| 34 | The C‐type lectin‐like domain superfamily Alex N. Zelensky, Jill E. Gready · FEBS Journal | 28 Nov 2005 | 1,416 |
| 35 | The SYK tyrosine kinase: a crucial player in diverse biological functions Attila Mócsai, Jürgen Ruland, Victor L. J. Tybulewicz · Nature reviews. Immunology | 14 May 2010 | 1,401 |
| 36 | Nanoconfinement controls stiffness, strength and mechanical toughness of β-sheet crystals in silk Sinan Keten, Zhi Ping Xu, Britni Ihle et al. · Nature Materials | 14 Mar 2010 | 1,395 |
| 37 | Spatiotemporal Rescue of Memory Dysfunction in Drosophila Sean Eric McGuire, Phuong T. Le, Alexander J. Osborn et al. · Science | 4 Dec 2003 | 1,390 |
| 38 | The Toll-like receptor 2 is recruited to macrophage phagosomes and discriminates between pathogens David M. Underhill, Adrian Ozinsky, Adeline M. Hajjar et al. · Nature | Oct 1999 | 1,377 |
| 39 | BIOLOGICAL MEDIATORS OF INSECT IMMUNITY Jeremy P. Gillespie and, Michael R. Kanost, Tina E. Trenczek · Annual Review of Entomology | 1997 | 1,361 |
| 40 | Current research status of fish immunostimulants Masahiro Sakai · Aquaculture | Mar 1999 | 1,346 |
| 41 | Discovery of Gene Function by Expression Profiling of the Malaria Parasite Life Cycle Karine G. Le Roch, Yingyao Zhou, Peter L. Blair et al. · Science | 5 Aug 2003 | 1,344 |
| 42 | Role of the prophenoloxidase-activating system in invertebrate immunity Kenneth Söderhäll, Lage Cerenius · Current Opinion in Immunology | Feb 1998 | 1,339 |
| 43 | Isolation and Characterization of Human μ-Defensin-3, a Novel Human Inducible Peptide Antibiotic Jürgen Harder, Joachim Bartels, Enno Christophers et al. · Journal of Biological Chemistry | Feb 2001 | 1,316 |
| 44 | An evolutionarily conserved function of the Drosophila insulin receptor and insulin-like peptides in growth control Walter Brogiolo, Hugo Stocker, Tomoatsu Ikeya et al. · Current Biology | Feb 2001 | 1,297 |
| 45 | The Bacterial Symbiont Wolbachia Induces Resistance to RNA Viral Infections in Drosophila melanogaster Luis Antonio Fonseca Teixeira, Álvaro Ferreira, Michael Ashburner · PLoS Biology | 19 Dec 2008 | 1,283 |
| 46 | The proPO-system: pros and cons for its role in invertebrate immunity Lage Cerenius, Bok Luel Lee, Kenneth Söderhäll · Trends in Immunology | 5 May 2008 | 1,266 |
| 47 | The large diverse gene family var encodes proteins involved in cytoadherence and antigenic variation of plasmodium falciparum-infected erythrocytes Xin‐zhuan Su, Virginia M. Heatwole, Samuel P. Wertheimer et al. · Cell | Jul 1995 | 1,255 |
| 48 | Cell lines derived from late embryonic stages of Drosophila melanogaster Imogene Schneider · Development | Apr 1972 | 1,234 |
| 49 | The role of cationic antimicrobial peptides in innate host defences Robert E. W. Hancock, Gill Diamond · Trends in Microbiology | Sep 2000 | 1,228 |
| 50 | Innate host defense mechanisms of fish against viruses and bacteria Anthony E. Ellis · Developmental & Comparative Immunology | Oct 2001 | 1,221 |
Citations are OpenAlex's own counts, from its 2026-09-23 snapshot, so the ranking can differ from Google Scholar or Web of Science. A paper is listed for a field when OpenAlex files it under one of the field's topics; retracted papers and papers whose citation count cannot be traced to citing works are left out, and a preprint and the article it became are shown once. Release dates are OpenAlex's: where a source gave only a month or a year, that is what is shown. How the lists are chosen.