Most cited papers in Ion Transport and Channel Regulation
What are the most cited papers in Ion Transport and Channel Regulation?
The most cited paper in Ion Transport and Channel Regulation is "A Paravascular Pathway Facilitates CSF Flow Through the Brain Parenchyma and the Clearance of Interstitial Solutes, Including Amyloid β" (Jeffrey J. Iliff, Minghuan Wang, Yonghong Liao et al., 2012), with 5,906 citations. Next come "Regulation of the Voltage Gated K+ Channel Kv1.3 by Recombinant Human Klotho Protein" (5,609) and "JUNCTIONAL COMPLEXES IN VARIOUS EPITHELIA" (3,654).
Showing 50 of 100 papers. Every paper with more than 859 citations is listed.
| # | Paper | ||
|---|---|---|---|
| 1 | A Paravascular Pathway Facilitates CSF Flow Through the Brain Parenchyma and the Clearance of Interstitial Solutes, Including Amyloid β Jeffrey J. Iliff, Minghuan Wang, Yonghong Liao et al. · Science Translational Medicine | 15 Aug 2012 | 5,906 |
| 2 | Regulation of the Voltage Gated K+ Channel Kv1.3 by Recombinant Human Klotho Protein Ahmad Almilaji, Sabina Honisch, Guilai Liu et al. · Kidney & Blood Pressure Research | 2014 | 5,609 |
| 3 | JUNCTIONAL COMPLEXES IN VARIOUS EPITHELIA Marilyn G. Farquhar, George E. Palade · The Journal of Cell Biology | May 1963 | 3,654 |
| 4 | Activation of nitric oxide synthase in endothelial cells by Akt-dependent phosphorylation Stefanie Dimmeler, Ingrid Fleming, Beate Fißlthaler et al. · Nature | Jun 1999 | 3,605 |
| 5 | The Blood–Brain Barrier Richard Daneman, Alexandre Prat · Cold Spring Harbor Perspectives in Biology | 2015 | 3,413 |
| 6 | Thapsigargin, a tumor promoter, discharges intracellular Ca2+ stores by specific inhibition of the endoplasmic reticulum Ca2(+)-ATPase. Ole Thastrup, Peter J. Cullen, Bjørn K. Drøbak et al. · Proceedings of the National Academy of Sciences | Apr 1990 | 3,301 |
| 7 | The Effect of Digoxin on Mortality and Morbidity in Patients with Heart Failure The Digitalis Investigation Group · New England Journal of Medicine | 20 Feb 1997 | 3,043 |
| 8 | Regulation of Renal Organic Anion Transporter 3 (SLC22A8) Expression and Function by the Integrity of Lipid Raft Domains and their Associated Cytoskeleton Chutima Srimaroeng, Jennifer Perry Cecile, Ramsey Walden et al. · Cellular Physiology and Biochemistry | 2013 | 2,992 |
| 9 | Sensors and regulators of intracellular pH Joseph R. Casey, Sergio Grinstein, John Orlowski · Nature Reviews Molecular Cell Biology | 9 Dec 2009 | 2,334 |
| 10 | Appearance of Water Channels in Xenopus Oocytes Expressing Red Cell CHIP28 Protein Gregory M. Preston, Tiziana Piazza Carroll, William B. Guggino et al. · Science | 17 Apr 1992 | 2,078 |
| 11 | Functional Significance of Cell Volume Regulatory Mechanisms Florian J.W. Lang, Gillian L. Busch, Markus Ritter et al. · Physiological Reviews | 1998 | 1,910 |
| 12 | A blood–brain barrier overview on structure, function, impairment, and biomarkers of integrity Hossam Kadry, Behnam Noorani, Luca Cucullo · Fluids and Barriers of the CNS | 18 Nov 2020 | 1,858 |
| 13 | Structural determinants of water permeation through aquaporin-1 Kazuyoshi Murata, Kaoru Mitsuoka, Teruhisa Hirai et al. · Nature | Oct 2000 | 1,832 |
| 14 | Sodium/Calcium Exchange: Its Physiological Implications Mordecai P. Blaustein, William Jonathan Lederer · Physiological Reviews | Jul 1999 | 1,749 |
| 15 | Crystal structure of a bacterial homologue of Na+/Cl--dependent neurotransmitter transporters Atsuko Yamashita, Satinder K. Singh, Toshimitsu Kawate et al. · Nature | 24 Jul 2005 | 1,709 |
| 16 | Molecular Mechanisms of Human Hypertension Richard P. Lifton, Ali G. Gharavi, David S. Geller · Cell | Feb 2001 | 1,705 |
| 17 | SCN5A mutations associated with an inherited cardiac arrhythmia, long QT syndrome Qing Wang, Jiaxiang Shen, Igor Splawski et al. · Cell | Mar 1995 | 1,701 |
| 18 | X-ray structure of a ClC chloride channel at 3.0 Å reveals the molecular basis of anion selectivity Raimund Dutzler, Ernest B. Campbell, Martine Cadène et al. · Nature | 2002 | 1,620 |
| 19 | Interaction of Nitric Oxide Synthase with the Postsynaptic Density Protein PSD-95 and α1-Syntrophin Mediated by PDZ Domains Jay E. Brenman, Daniel S. Chao, Stephen Gee et al. · Cell | Mar 1996 | 1,603 |
| 20 | Hyponatremia Horacio J. Adrogué, Nicolaos E. Madias · New England Journal of Medicine | 25 May 2000 | 1,597 |
| 21 | Aquaporin-4 deletion in mice reduces brain edema after acute water intoxication and ischemic stroke Geoffrey T. Manley, Miki Fujimura, Tonghui Ma et al. · Nature Medicine | Feb 2000 | 1,516 |
| 22 | Caveolins, a Family of Scaffolding Proteins for Organizing “Preassembled Signaling Complexes” at the Plasma Membrane Takashi Okamoto, Amnon Schlegel, Philipp E. Scherer et al. · Journal of Biological Chemistry | Mar 1998 | 1,511 |
| 23 | Human Hypertension Caused by Mutations in WNK Kinases Frederick Hugh Wilson, Sandra Disse-Nicodème, Keith A. Choate et al. · Science | 10 Aug 2001 | 1,499 |
| 24 | Chronic kidney disease Kamyar Kalantar‐Zadeh, Tazeen H. Jafar, Dorothea Nitsch et al. · The Lancet | 24 Jun 2021 | 1,473 |
| 25 | Specialized Membrane Domains for Water Transport in Glial Cells: High-Resolution Immunogold Cytochemistry of Aquaporin-4 in Rat Brain Søren Møller Nielsen, Erlend Arnulf Nagelhus, Mahmood Reza Amiry-Moghaddam et al. · Journal of Neuroscience | 1997 | 1,463 |
| 26 | The multiple faces of caveolae Robert G. Parton, Kai Simons · Nature Reviews Molecular Cell Biology | 23 Feb 2007 | 1,450 |
| 27 | Extracellular Calcium Sensing and Extracellular Calcium Signaling Edward Meigs Brown, John Macleod · Physiological Reviews | 2001 | 1,396 |
| 28 | A proton-gated cation channel involved in acid-sensing Rainer Waldmann, Guy Champigny, Frédéric Bassilana et al. · Nature | Mar 1997 | 1,365 |
| 29 | Genetic diagnosis by whole exome capture and massively parallel DNA sequencing Murim Choi, Ute I. Scholl, Weizhen Ji et al. · Proceedings of the National Academy of Sciences | 27 Oct 2009 | 1,364 |
| 30 | Thapsigargin inhibits the sarcoplasmic or endoplasmic reticulum Ca-ATPase family of calcium pumps. Jonathan Lytton, Marisa M. Westlin, Michael R. Hanley · Journal of Biological Chemistry | Sep 1991 | 1,349 |
| 31 | Primary structure and functional characterization of a high-affinity glutamate transporter Yoshikatsu Kanai, Matthias A. Hediger · Nature | Dec 1992 | 1,337 |
| 32 | Further studies on the properties and assay of glucose 6-phosphate dehydrogenase and 6-phosphogluconate dehydrogenase of rat liver Gertrude Evelyn Glock, Patricia McLean · Biochemical Journal | Oct 1953 | 1,333 |
| 33 | The proton-linked monocarboxylate transporter (MCT) family: structure, function and regulation Andrew P. Halestrap, Nigel T. Price · Biochemical Journal | 8 Oct 1999 | 1,328 |
| 34 | Specific Aquaporins Facilitate the Diffusion of Hydrogen Peroxide across Membranes Gerd Patrick Bienert, Anders L.B. Møller, Kim A. Kristiansen et al. · Journal of Biological Chemistry | 14 Nov 2006 | 1,315 |
| 35 | Acidic extracellular microenvironment and cancer Yukio Kato, Shigeyuki Ozawa, Chihiro Miyamoto et al. · Cancer Cell International | 2013 | 1,308 |
| 36 | De Novo Mutations in the Sodium-Channel Gene SCN1A Cause Severe Myoclonic Epilepsy of Infancy Lieve R. F. Claes, Jurgen Del‐Favero, Berten Ceulemans et al. · The American Journal of Human Genetics | Jun 2001 | 1,303 |
| 37 | Liddle's syndrome: Heritable human hypertension caused by mutations in the β subunit of the epithelial sodium channel Richard A. Shimkets, David G. Warnock, Christopher M. Bositis et al. · Cell | Nov 1994 | 1,265 |
| 38 | Aquaporins in the Kidney: From Molecules to Medicine Søren Møller Nielsen, Jørgen Frøkiær, David D.R. Marples et al. · Physiological Reviews | 2002 | 1,262 |
| 39 | Isozymes of the Na-K-ATPase: heterogeneity in structure, diversity in function Gustavo V. Blanco, Robert W. Mercer · American Journal of Physiology-Renal Physiology | Nov 1998 | 1,255 |
| 40 | Gitelman's variant of Barter's syndrome, inherited hypokalaemic alkalosis, is caused by mutations in the thiazide-sensitive Na–Cl cotransporter David B. Simon, Carol J. Nelson-Williams, MARGARET JOHNSON BIA et al. · Nature Genetics | 1996 | 1,225 |
| 41 | Tolvaptan, a Selective Oral Vasopressin V 2 -Receptor Antagonist, for Hyponatremia Robert W. Schrier, Peter A. Gross, Mihai Gheorghiade et al. · New England Journal of Medicine | 14 Nov 2006 | 1,221 |
| 42 | A novel potassium channel gene, KCNQ2, is mutated in an inherited epilepsy of newborns Nanda A. Singh, Carole Charlier, Dora Stauffer et al. · Nature Genetics | 1998 | 1,215 |
| 43 | Diagnosis, Evaluation, and Treatment of Hyponatremia: Expert Panel Recommendations Joseph George Verbalis, Steven R. Goldsmith, Arthur Greenberg et al. · The American Journal of Medicine | 25 Sep 2013 | 1,210 |
| 44 | The Reduction of Cytochrome c by Milk Xanthine Oxidase Joe M. McCord, Irwin Fridovich · Journal of Biological Chemistry | Nov 1968 | 1,203 |
| 45 | Biochemistry of Na,K-ATPase Jack H. Kaplan · Annual Review of Biochemistry | Jun 2002 | 1,198 |
| 46 | Structural basis of water-specific transport through the AQP1 water channel Haixin Sui, Bong-Gyoon Han, John K. Lee et al. · Nature | Dec 2001 | 1,173 |
| 47 | A syndrome of renal sodium loss and hyponatremia probably resulting from inappropriate secretion of antidiuretic hormone William B. Schwartz, Warren A. Bennett, Sidney Curelop et al. · The American Journal of Medicine | Oct 1957 | 1,162 |
| 48 | Edg-1, the G protein–coupled receptor for sphingosine-1-phosphate, is essential for vascular maturation Yujing Liu, Ryuichi Wada, Tadashi Yamashita et al. · Journal of Clinical Investigation | 15 Oct 2000 | 1,156 |
| 49 | Epithelial sodium channels: function, structure, and regulation Haim Garty, Lawrence G. Palmer · Physiological Reviews | Apr 1997 | 1,155 |
| 50 | Aquaporin water channels – from atomic structure to clinical medicine Peter C. Agre, Landon Stuart King, Masato Yasui et al. · The Journal of Physiology | Jul 2002 | 1,151 |
Citations are OpenAlex's own counts, from its 2026-09-23 snapshot, so the ranking can differ from Google Scholar or Web of Science. A paper is listed for a field when OpenAlex files it under one of the field's topics; retracted papers and papers whose citation count cannot be traced to citing works are left out, and a preprint and the article it became are shown once. Release dates are OpenAlex's: where a source gave only a month or a year, that is what is shown. How the lists are chosen.