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Topic · Molecular Biology

Ion Transport and Channel Regulation

Ion Transport and Channel Regulation is a research topic within Molecular Biology. Science Explorer counts 30k research works in it since 1950. 10.0% of them reached the world's top 10% most cited for their field and year.

This cluster of papers explores the molecular mechanisms, physiological roles, and pathophysiological implications of aquaporins, a family of water channel proteins involved in ion transport across cell membranes. The research covers various aspects such as brain edema, kidney function, regulation, and the role of aquaporins in disease.

  • Aquaporins
  • Water Channels
  • Ion Transport
  • Cell Membrane
  • Physiology
  • Pathophysiology
  • Brain Edema
  • Kidney Function
  • Regulation
  • Disease
Research works
30k
fractional, since 1950
In the world top 10%
3k
per year above
Top-10% rate
10.0%
share of its works in the world top 10%
Growth, 2018-21 → 2022-25
-12%
the tick is no change
Largest producer
United States
37% of the 10 largest, 2022-now
Ion Transport and Channel Regulation

Which countries lead Ion Transport and Channel Regulation research?

By volume, the United States and China publish the most (705 and 482 works in 2022-now).

By volume, 2022-now

  1. 1 United States 705 works
  2. 2 China 482 works
  3. 3 Japan 181 works
  4. 4 Germany 117 works
  5. 5 India 113 works
  6. 6 Italy 87 works
  7. 7 United Kingdom 78 works
  8. 8 France 61 works
  9. 9 Türkiye 49 works
  10. 10 Spain 49 works

How concentrated that is

The same countries as shares of everything the list above accounts for. A node where two countries do two thirds of the work and one spread evenly across twelve read alike as a ranking and not at all alike here.

United States: 36.7%China: 25.1%Japan: 9.4%Germany: 6.1%6 others listed: 22.7%37%largest
United States705 · 36.7%China482 · 25.1%Japan181 · 9.4%Germany117 · 6.1%6 others listed436 · 22.7%

Shares of the rows listed above, not of the whole node.

Which institutions lead Ion Transport and Channel Regulation research?

By volume in 2022-now, Aarhus University publishes the most Ion Transport and Channel Regulation research, followed by Russian Academy of Sciences and Johns Hopkins University.

By volume, 2022-now

  1. 1 Aarhus UniversityDenmark 22 works
  2. 2 Russian Academy of SciencesRussia 22 works
  3. 3 Johns Hopkins UniversityUnited States 21 works
  4. 4 Harvard UniversityUnited States 20 works
  5. 5 University of North Carolina at Chapel HillUnited States 20 works
  6. 6 University of PittsburghUnited States 20 works
  7. 7 National Institutes of HealthUnited States 17 works
  8. 8 InsermFrance 15 works
  9. 9 Vanderbilt UniversityUnited States 14 works
  10. 10 Peking UniversityChina 14 works

Who are the leading researchers in Ion Transport and Channel Regulation?

The most-cited researchers publishing on Ion Transport and Channel Regulation include Eric S. Lander, George Davey Smith and Guido Kroemer.

  1. 1 Eric S. Lander United States 524k citations
  2. 2 George Davey Smith United Kingdom 435k citations
  3. 3 Guido Kroemer France 386k citations
  4. 4 John J.V. McMurray United Kingdom 349k citations
  5. 5 Jun Wang China 340k citations
  6. 6 Giuseppe Remuzzi Italy 328k citations
  7. 7 Gordon Brent Mills United States 265k citations

Ranked by citations received across their whole record, among researchers with at least three works on this topic.

What are the most cited papers in Ion Transport and Channel Regulation?

The most cited paper in Ion Transport and Channel Regulation is "A Paravascular Pathway Facilitates CSF Flow Through the Brain Parenchyma and the Clearance of Interstitial Solutes, Including Amyloid β" (Jeffrey J. Iliff, Minghuan Wang, Yonghong Liao et al., 2012), with 5,906 citations. Next come "Regulation of the Voltage Gated K+ Channel Kv1.3 by Recombinant Human Klotho Protein" (5,609) and "JUNCTIONAL COMPLEXES IN VARIOUS EPITHELIA" (3,654).

Most cited papers
#PaperReleasedCitations
1 A Paravascular Pathway Facilitates CSF Flow Through the Brain Parenchyma and the Clearance of Interstitial Solutes, Including Amyloid β Jeffrey J. Iliff, Minghuan Wang, Yonghong Liao et al. · Science Translational Medicine Open access 15 Aug 2012 5,906
2 Regulation of the Voltage Gated K+ Channel Kv1.3 by Recombinant Human Klotho Protein Ahmad Almilaji, Sabina Honisch, Guilai Liu et al. · Kidney & Blood Pressure Research Open access 2014 5,609
3 JUNCTIONAL COMPLEXES IN VARIOUS EPITHELIA Marilyn G. Farquhar, George E. Palade · The Journal of Cell Biology Open access May 1963 3,654
4 Activation of nitric oxide synthase in endothelial cells by Akt-dependent phosphorylation Stefanie Dimmeler, Ingrid Fleming, Beate Fißlthaler et al. · Nature Jun 1999 3,605
5 The Blood–Brain Barrier Richard Daneman, Alexandre Prat · Cold Spring Harbor Perspectives in Biology Open access 2015 3,413
All 100 most cited papers, with filters and sorting

Where is Ion Transport and Channel Regulation research done?

The largest centres of Ion Transport and Channel Regulation research in 2022-now are Beijing (China), Tokyo (Japan), Shanghai (China) and Paris (France). Among places with at least 20 works in it, it is an unusually large share of all research in Aarhus.

Largest cities, 2022-now

  1. 1 BeijingChina 58 works
  2. 2 TokyoJapan 49 works
  3. 3 ShanghaiChina 41 works
  4. 4 ParisFrance 32 works
  5. 5 GuangzhouChina 29 works
  6. 6 BaltimoreUnited States 28 works
  7. 7 New YorkUnited States 24 works
  8. 8 PittsburghUnited States 23 works
  9. 9 LondonUnited Kingdom 22 works
  10. 10 Mexico CityMexico 22 works

Where it is the local speciality

  1. AarhusDK · 22.2 works9.3×
← less than its size predicts1×more →

Location quotient: how much more of its research is in Ion Transport and Channel Regulation than the world average.

See Ion Transport and Channel Regulation on the map

Where is the best place to study Ion Transport and Channel Regulation?

Among universities, judged by research, Johns Hopkins University, Harvard University and Aarhus University score highest, combining citation excellence, specialisation, size, growth and international reach. Research strength is one signal when choosing where to study; it does not measure teaching.

0%10%20%30%mean 12.85%fractional works in this field (log) →share of work in the world top 10% →Harvard UniversityUniversity of Califo…Aarhus UniversityJohns Hopkins Univer…
above the meannear itbelow it

One dot per university in the first ten of the table below, at the default weights. The upper left is the interesting corner: small places doing unusually strong work.

Citation excellenceshare of its work in the world top 10%, 2022-now and all time averaged
40%
Specialisationhow much of its work is in this field, counted up to 10× the world share
10%
Sizeits output in this field, on a log scale
30%
Growthoutput growth, counted from -20% to +20%
10%
Internationalshare of its work with a co-author abroad
10%
Each slider sets a weight; the share it gets of the score is beside it.
#UniversityScoreTop 10%SpecialisationWorksGrowth
1Johns Hopkins UniversityUnited States 76.46.2%6.0×21 +53.3%
2Harvard UniversityUnited States 74.819.2%2.8×20 -22.8%
3Aarhus UniversityDenmark 70.210.1%11.4×22 -10.9%
4University of California, San FranciscoUnited States 69.014.5%6.7×11 +31.3%
5University of PittsburghUnited States 63.57.5%11.0×20 +13.3%
6Vanderbilt UniversityUnited States 61.919.1%8.6×14 -22.3%
7University of North Carolina at Chapel HillUnited States 58.36.0%4.9×20 +39.4%
8University of ZurichSwitzerland 57.226.1%5.2×8 -24.8%
9Oregon Health & Science UniversityUnited States 51.57.9%15.6×12 +11.8%
10Tulane UniversityUnited States 48.511.9%19.3×11 +116.8%

Universities only. The score blends citation excellence (40%), size (30%), specialisation (10%), growth (10%), international reach (10%), 2022-now; growth compares 2018-21 with 2022-25 and counts up to +20%, since a jump from a small base is mostly noise.

Every institution in Ion Transport and Channel Regulation, country by country

Is Ion Transport and Channel Regulation research growing?

Output in 2022-2025 was 12% lower than in 2018-2021, peaking in 2008.

still counting19801990200020102020
grewheldshrank

The same series as a ribbon: one cell per year, darker for more. The line above answers how much; this answers when.

Its share of all research

Growing output can still be a shrinking share: all of science grows. This is Ion Transport and Channel Regulation as a percentage of every work published that year, 0.0086% in 2024.

still counting0.050%0.10%Ion Transport and Channel Regulation0.0097% in 202519801990200020102020

Fractional works of Ion Transport and Channel Regulation over all fractional works that year. How the balance of science has shifted.

How much of it reaches the world top 10%

Year by year.

still counting5%10%15%Ion Transport and Channel Regulation10.1% in 2025200020102020

Of each year's works in it, the share that reached the world's 10% most cited for their field and year. A field is the world for its own topics, so there is no other line to hold it against.

Which topics inside it are moving

Growth and decline on one axis around a shared zero. Two lists side by side hide the thing that matters: whether the growth dwarfs the decline, or the other way round.

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