Most cited papers in Multicomponent Synthesis of Heterocycles
What are the most cited papers in Multicomponent Synthesis of Heterocycles?
The most cited paper in Multicomponent Synthesis of Heterocycles is "Multicomponent Reactions with Isocyanides" (Alexander S. S. Dömling, Ivar Ugi, 2000), with 4,073 citations. Next come "Controlled Microwave Heating in Modern Organic Synthesis" (3,606) and "The Combinatorial Synthesis of Bicyclic Privileged Structures or Privileged Substructures" (3,010).
Showing 50 of 100 papers. Every paper with more than 454 citations is listed.
| # | Paper | ||
|---|---|---|---|
| 1 | Multicomponent Reactions with Isocyanides Alexander S. S. Dömling, Ivar Ugi · Angewandte Chemie International Edition | 15 Sep 2000 | 4,073 |
| 2 | Controlled Microwave Heating in Modern Organic Synthesis Christian Oliver Kappe · Angewandte Chemie International Edition | 23 Nov 2004 | 3,606 |
| 3 | The Combinatorial Synthesis of Bicyclic Privileged Structures or Privileged Substructures Douglas A. Horton, Gregory T. Bourne, Mark L. Smythe · Chemical Reviews | 22 Feb 2003 | 3,010 |
| 4 | 1,3‐Dipolar Cycloadditions. Past and Future Rolf Huisgen · Angewandte Chemie International Edition in English | Oct 1963 | 2,898 |
| 5 | Microwave assisted organic synthesis—a review Pelle Lidström, Jason P. Tierney, Bernard Wathey et al. · Tetrahedron | Nov 2001 | 2,674 |
| 6 | Amide bond formation and peptide coupling Christian Montalbetti, Virginie M. Falque · Tetrahedron | 20 Sep 2005 | 1,773 |
| 7 | Natural Product Synthesis Using Multicomponent Reaction Strategies B. Barry Touré, Dennis G. Hall · Chemical Reviews | 29 May 2009 | 1,707 |
| 8 | Asymmetric Multicomponent Reactions (AMCRs): The New Frontier Diego J. Ramón, Miguel Yus · Angewandte Chemie International Edition | 18 Feb 2005 | 1,668 |
| 9 | Privileged scaffolds for library design and drug discovery Matthew Welsch, Scott A. Snyder, Brent R. Stockwell · Current Opinion in Chemical Biology | 22 Mar 2010 | 1,506 |
| 10 | Microwave assisted organic reactions Stephen Caddick · Tetrahedron | Sep 1995 | 1,434 |
| 11 | Multicomponent reactions: advanced tools for sustainable organic synthesis Răzvan C. Cioc, Eelco Ruijter, Romano V. A. Orrù · Green Chemistry | 2014 | 1,332 |
| 12 | Biologically active dihydropyrimidones of the Biginelli-type — a literature survey Christian Oliver Kappe · European Journal of Medicinal Chemistry | Dec 2000 | 1,332 |
| 13 | Multicomponent Reaction Design in the Quest for Molecular Complexity and Diversity Eelco Ruijter, Rachel Scheffelaar, Romano V. A. Orrù · Angewandte Chemie International Edition | 27 Jun 2011 | 1,327 |
| 14 | 1.3‐Dipolare Cycloadditionen Rückschau und Ausblick Rolf Huisgen · Angewandte Chemie | 7 Jul 1963 | 1,304 |
| 15 | A tentative rationalization of microwave effects in organic synthesis according to the reaction medium, and mechanistic considerations Laurence Perreux, André Loupy · Tetrahedron | Nov 2001 | 1,278 |
| 16 | Green chemistry by nano-catalysis Vivek Polshettiwar, Rajender S. Varma · Green Chemistry | 2010 | 1,231 |
| 17 | 100 years of the biginelli dihydropyrimidine synthesis Christian Oliver Kappe · Tetrahedron | Aug 1993 | 1,226 |
| 18 | Nano-magnetite (Fe3O4) as a support for recyclable catalysts in the development of sustainable methodologies Manoj B. Gawande, Paula S. Branco, Rajender S. Varma · Chemical Society Reviews | 2013 | 1,208 |
| 19 | Schiff bases: A short review of their antimicrobial activities Cleiton Moreira da Silva, Daniel L. da Silva, Luzia Valentina Modolo et al. · Journal of Advanced Research | 11 Jun 2010 | 1,197 |
| 20 | Green chemistry oriented organic synthesis in water Marc‐Olivier Simon, Chao‐Jun Li · Chemical Society Reviews | 3 Nov 2011 | 1,184 |
| 21 | Strategies for Innovation in Multicomponent Reaction Design Bruce Ganem · Accounts of Chemical Research | 28 Jan 2009 | 1,172 |
| 22 | Application of commercial microwave ovens to organic synthesis. R. J. GIGUERE, Terry L. Bray, Scott M. Duncan et al. · Tetrahedron Letters | 1986 | 1,145 |
| 23 | Multiple-Component Condensation Strategies for Combinatorial Library Synthesis Robert W. Armstrong, Andrew P. Combs, Paul A. Tempest et al. · Accounts of Chemical Research | 13 Mar 1996 | 1,113 |
| 24 | Recent Advances in the Biginelli Dihydropyrimidine Synthesis. New Tricks from an Old Dog Christian Oliver Kappe · Accounts of Chemical Research | 28 Sep 2000 | 1,101 |
| 25 | Maximizing Synthetic Efficiency: Multi-Component Transformations Lead the Way Hugues Bienaymé, Chris Hulme, Gilles Oddon et al. · Chemistry - A European Journal | 15 Sep 2000 | 1,078 |
| 26 | Multi-component syntheses of heterocycles by transition-metal catalysis D.M. D'Souza, Thomas J. J. Müller · Chemical Society Reviews | 2007 | 1,054 |
| 27 | “Multi-component Reactions : Emerging Chemistry in Drug Discovery” ‘From Xylocain to Crixivan’ Christopher Hulme, Vijay Gore · Current Medicinal Chemistry | 2003 | 1,035 |
| 28 | Synthesis and Pharmacological Activities of Pyrazole Derivatives: A Review Khalid Karrouchi, Smaail Radi, Youssef Ramli et al. · Molecules | 12 Jan 2018 | 1,008 |
| 29 | Small Heterocycles in Multicomponent Reactions Benjamin H. Rotstein, Serge Zaretsky, Vishal Rai et al. · Chemical Reviews | 17 Jul 2014 | 1,008 |
| 30 | Highly Enantioselective Conjugate Addition of Nitromethane to Chalcones Using Bifunctional Cinchona Organocatalysts Benedek Vakulya, Szilárd Varga, Antal Csámpai et al. · Organic Letters | 14 Apr 2005 | 984 |
| 31 | Recent Developments in the Isonitrile‐Based Multicomponent Synthesis of Heterocycles Jieping Zhu · European Journal of Organic Chemistry | Mar 2003 | 954 |
| 32 | Microwave assisted synthesis – a critical technology overview Matthias Nüchter, Bernd Ondruschka, Werner Bonrath et al. · Green Chemistry | 2004 | 907 |
| 33 | Brønsted-Acid-Catalyzed Asymmetric Multicomponent Reactions for the Facile Synthesis of Highly Enantioenriched Structurally Diverse Nitrogenous Heterocycles Jie Yu, Feng Shi, Liu‐Zhu Gong · Accounts of Chemical Research | 29 Jul 2011 | 904 |
| 34 | Recent developments in asymmetric multicomponent reactions Corien de Graaff, Eelco Ruijter, Romano V. A. Orrù · Chemical Society Reviews | 2012 | 880 |
| 35 | On the solid, liquid and solution structural organization of imidazolium ionic liquids Jairton Dupont · Journal of the Brazilian Chemical Society | Jun 2004 | 841 |
| 36 | Indoles in Multicomponent Processes (MCPs) Morteza Shiri · Chemical Reviews | 5 Mar 2012 | 817 |
| 37 | Strategies for Heterocyclic Construction via Novel Multicomponent Reactions Based on Isocyanides and Nucleophilic Carbenes Vijay Nair, Cheruvallil S. Rajesh, A. Unni Vinod et al. · Accounts of Chemical Research | 4 Oct 2003 | 800 |
| 38 | Recent developments in the stereoselective synthesis of α-aminoacids Rudolf O. Duthaler · Tetrahedron | 1994 | 794 |
| 39 | Microwave-Assisted Chemistry: Synthetic Applications for Rapid Assembly of Nanomaterials and Organics Manoj B. Gawande, Sharad N. Shelke, Radek Zbořil et al. · Accounts of Chemical Research | 25 Mar 2014 | 776 |
| 40 | Microwave dielectric heating in synthetic organic chemistry Christian Oliver Kappe · Chemical Society Reviews | 2008 | 770 |
| 41 | OPC-67683, a Nitro-Dihydro-Imidazooxazole Derivative with Promising Action against Tuberculosis In Vitro and In Mice Makoto Matsumoto, Hiroyuki Hashizume, Tatsuo Tomishige et al. · PLoS Medicine | 22 Nov 2006 | 754 |
| 42 | Delamanid for Multidrug-Resistant Pulmonary Tuberculosis Maria Tarcela Gler et al. · New England Journal of Medicine | 7 Jun 2012 | 748 |
| 43 | In situhydrothermal synthesis of tetrazole coordination polymers with interesting physical properties Hong Lin Zhao, Zhi‐Rong Qu, Heng‐Yun Ye et al. · Chemical Society Reviews | Oct 2007 | 745 |
| 44 | Multicomponent reactions for the synthesis of pyrroles Verónica Estévez, Mercedes Villacampa, José Carlos Menéndez · Chemical Society Reviews | 2010 | 744 |
| 45 | Applications of Multicomponent Reactions to the Synthesis of Diverse Heterocyclic Scaffolds James D. Sunderhaus, Stephen F. Martin · Chemistry - A European Journal | 8 Jan 2009 | 743 |
| 46 | Recent advances in the synthesis of pyrroles by multicomponent reactions Verónica Estévez, Mercedes Villacampa, José Carlos Menéndez · Chemical Society Reviews | 2014 | 722 |
| 47 | Ionic Liquids in Heterocyclic Synthesis Marcos A. P. Martins, Clarissa P. Frizzo, Dayse N. Moreira et al. · Chemical Reviews | Jun 2008 | 722 |
| 48 | Synthesis and pharmacological activity of 2-oxo-(2H) 1-benzopyran-3-carboxamide derivatives Leonardo Bonsignore, Gianni Loy, Daniela Secci et al. · European Journal of Medicinal Chemistry | 1993 | 695 |
| 49 | Multi-step organic synthesis using solid-supported reagents and scavengers: a new paradigm in chemical library generation Steven V. Ley, Ian R. Baxendale, Robert N. Bream et al. · Journal of the Chemical Society Perkin Transactions 1 | 2000 | 691 |
| 50 | Expanding Applications of Metal−Organic Frameworks: Zeolite Imidazolate Framework ZIF-8 as an Efficient Heterogeneous Catalyst for the Knoevenagel Reaction Uyen P. N. Tran, Ky Khac Anh Le, Nam T. S. Phan · ACS Catalysis | 18 Jan 2011 | 691 |
Citations are OpenAlex's own counts, from its 2026-09-23 snapshot, so the ranking can differ from Google Scholar or Web of Science. A paper is listed for a field when OpenAlex files it under one of the field's topics; retracted papers and papers whose citation count cannot be traced to citing works are left out, and a preprint and the article it became are shown once. Release dates are OpenAlex's: where a source gave only a month or a year, that is what is shown. How the lists are chosen.