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Topic · Natural Compounds in Disease Treatment

Most cited papers in Natural Compounds in Disease Treatment

Natural Compounds in Disease Treatment

What are the most cited papers in Natural Compounds in Disease Treatment?

The most cited paper in Natural Compounds in Disease Treatment is "STRIDE-II: An Update on the Selecting Therapeutic Targets in Inflammatory Bowel Disease (STRIDE) Initiative of the International Organization for the Study of IBD (IOIBD): Determining Therapeutic Goals for Treat-to-Target strategies in IBD" (Dan Turner, Amanda Ricciuto, Ayanna E. Lewis et al., 2021), with 2,882 citations. Next come "Thalidomide is an inhibitor of angiogenesis." (2,475) and "Tofacitinib as Induction and Maintenance Therapy for Ulcerative Colitis" (1,772).

Showing 50 of 100 papers. Every paper with more than 233 citations is listed.

Most cited papers, sortable by citations and release date
#Paper
1 STRIDE-II: An Update on the Selecting Therapeutic Targets in Inflammatory Bowel Disease (STRIDE) Initiative of the International Organization for the Study of IBD (IOIBD): Determining Therapeutic Goals for Treat-to-Target strategies in IBD Dan Turner, Amanda Ricciuto, Ayanna E. Lewis et al. · Gastroenterology Open access 20 Feb 2021 2,882
2 Thalidomide is an inhibitor of angiogenesis. Robert J. D’Amato, Michael Loughnan, Evelyn A. Flynn et al. · Proceedings of the National Academy of Sciences Open access 26 Apr 1994 2,475
3 Tofacitinib as Induction and Maintenance Therapy for Ulcerative Colitis William J. Sandborn, Chinyu G. Su, Bruce E. Sands et al. · New England Journal of Medicine Open access 3 May 2017 1,772
4 Phase III Trial of Cisplatin Plus Gemcitabine With Either Placebo or Bevacizumab As First-Line Therapy for Nonsquamous Non–Small-Cell Lung Cancer: AVAiL Martin Reck, Joachim von Pawel, Petr Zatloukal et al. · Journal of Clinical Oncology 2 Feb 2009 1,517
5 Subcutaneous Golimumab Induces Clinical Response and Remission in Patients With Moderate-to-Severe Ulcerative Colitis William J. Sandborn, Brian G. Feagan, Colleen W Marano et al. · Gastroenterology Open access 2 Jun 2013 939
6 Treatment of Obesity with Celastrol Jun‐Li Liu, Jaemin Lee, Mario Andrés Salazar Hernández et al. · Cell Open access May 2015 741
7 BCL-2 family isoforms in apoptosis and cancer Chloe Warren, Michelle W. Wong‐Brown, Nikola A. Bowden · Cell Death and Disease Open access 21 Feb 2019 730
8 Subcutaneous Golimumab Maintains Clinical Response in Patients With Moderate-to-Severe Ulcerative Colitis William J. Sandborn, Brian G. Feagan, Colleen W Marano et al. · Gastroenterology Open access 14 Jun 2013 728
9 Apoptotic signaling induced by immunomodulatory thalidomide analogs in human multiple myeloma cells: therapeutic implications Nicholas Mitsiades, Constantine S. Mitsiades, Vassiliki Poulaki et al. · Blood Open access 15 Jun 2002 669
10 Molecular Understanding and Modern Application of Traditional Medicines: Triumphs and Trials Timothy W. Corson, Craig M. Crews · Cell Open access Sep 2007 668
11 Overall survival with cisplatin–gemcitabine and bevacizumab or placebo as first-line therapy for nonsquamous non-small-cell lung cancer: results from a randomised phase III trial (AVAiL) Martin Reck, Joachim von Pawel, Petr Zatloukal et al. · Annals of Oncology Open access 12 Feb 2010 649
12 Roles of NF-κB in Cancer and Inflammatory Diseases and Their Therapeutic Approaches Mi Park, Jin Tae Hong · Cells Open access 29 Mar 2016 641
13 Inhibiting eukaryotic transcription. Which compound to choose? How to evaluate its activity? Olivier Bensaude · Transcription Open access May 2011 619
14 Natural product and natural product derived drugs in clinical trials Mark S. Butler, Avril A. B. Robertson, Matthew A. Cooper · Natural Product Reports 2014 599
15 Osteoarthritis chondrocytes die by apoptosis: A possible pathway for osteoarthritis pathology Francisco Javier Blanco, Ram�n Guitian, Eduardo V�zquez-Martul et al. · Arthritis & Rheumatism Feb 1998 596
16 Celastrol, a Triterpene Extracted from the Chinese “Thunder of God Vine,” Is a Potent Proteasome Inhibitor and Suppresses Human Prostate Cancer Growth in Nude Mice Huanjie Yang, Di Chen, Qiuzhi Cindy Cui et al. · Cancer Research May 2006 590
17 XPB, a subunit of TFIIH, is a target of the natural product triptolide Denis V. Titov, Benjamin W. Gilman, Qingli He et al. · Nature Chemical Biology Open access 30 Jan 2011 533
18 A randomised dose finding study of oral tacrolimus (FK506) therapy in refractory ulcerative colitis Hisao Ogata, T Matsui, M Nakamura et al. · Gut Open access 16 Feb 2006 465
19 Filgotinib as induction and maintenance therapy for ulcerative colitis (SELECTION): a phase 2b/3 double-blind, randomised, placebo-controlled trial Brian G. Feagan et al. · The Lancet Jun 2021 457
20 Coptidis Rhizoma: a comprehensive review of its traditional uses, botany, phytochemistry, pharmacology and toxicology Jin Wang, Lin Wang, Guanhua Lou et al. · Pharmaceutical Biology Open access 2019 435
21 Celastrols as Inducers of the Heat Shock Response and Cytoprotection Sandy D. Westerheide, Joshua D. Bosman, Bessie N. A. Mbadugha et al. · Journal of Biological Chemistry Open access 28 Oct 2004 435
22 Flavonoid fisetin alleviates kidney inflammation and apoptosis via inhibiting Src-mediated NF-κB p65 and MAPK signaling pathways in septic AKI mice Qian Ren, Fan Guo, Sibei Tao et al. · Biomedicine & Pharmacotherapy Open access 30 Dec 2019 429
23 Inducer-stimulated Fas targets activated endothelium for destruction by anti-angiogenic thrombospondin-1 and pigment epithelium–derived factor Olga V. Volpert, Tetiana A. Zaichuk, Wei Zhou et al. · Nature Medicine Apr 2002 424
24 Ursolic acid: An anti‐ and pro‐inflammatory triterpenoid Yasutaka Ikeda, Akira Murakami, Hajime Ohigashi · Molecular Nutrition & Food Research 2008 417
25 Medicinal chemistry and pharmacology of genus Tripterygium (Celastraceae) Anita Brinker, Jun Ma, Peter E. Lipsky et al. · Phytochemistry Open access 24 Jan 2007 416
26 Interleukin-1 receptor antagonist (anakinra) treatment in patients with systemic-onset juvenile idiopathic arthritis or adult onset Still disease: preliminary experience in France Thierry Lequerré, Pierre Quartier, David Rosellini et al. · Annals of the Rheumatic Diseases Open access 19 Oct 2007 406
27 Anti-cancer natural products isolated from chinese medicinal herbs Wen Tan, Jin‐Jian Lu, Mingqing Huang et al. · Chinese Medicine Open access 22 Jul 2011 398
28 Triptolide: Progress on research in pharmacodynamics and toxicology Xiaojiaoyang Li, Zhenzhou Jiang, Luyong Zhang · Journal of Ethnopharmacology 13 Jun 2014 396
29 NF-κB and IKK as therapeutic targets in cancer H J Kim, Noel A. Hawke, Albert S. Baldwin · Cell Death and Differentiation Open access 17 Feb 2006 395
30 Tyrosine Phosphorylation of Transmembrane Ligands for Eph Receptors Katja Brückner, Elena B. Pasquale, Rüdiger Klein · Science 14 Mar 1997 392
31 Triterpenoids as new promising anticancer drugs Alessia Petronelli, Gaetano Pannitteri, Ugo Testa · Anti-Cancer Drugs 12 Oct 2009 390
32 Withaferin A is a potent inhibitor of angiogenesis Royce Mohan, Hans J. Hammers, Paola Bargagna‐Mohan et al. · Angiogenesis 2004 383
33 Andrographolide Attenuates Inflammation by Inhibition of NF-κB Activation through Covalent Modification of Reduced Cysteine 62 of p50 Yi-Feng Xia, Bu-Qing Ye, Yi-Dan Li et al. · The Journal of Immunology Open access Sep 2004 380
34 Targeting cancer signaling pathways by natural products: Exploring promising anti-cancer agents Sheema Hashem, Tayyiba Akbar Ali, Sabah Akhtar et al. · Biomedicine & Pharmacotherapy Open access 30 Apr 2022 378
35 Anticancer Plants: A Review of the Active Phytochemicals, Applications in Animal Models, and Regulatory Aspects Tariq Khan, Muhammad Ali, Ajmal Khan et al. · Biomolecules Open access 27 Dec 2019 375
36 Celastrol, a potent antioxidant and anti-inflammatory drug, as a possible treatment for Alzheimer's disease ANTHONY C. ALLISON, Ramón Cacabelos, Valter Lombardi et al. · Progress in Neuro-Psychopharmacology and Biological Psychiatry Oct 2001 375
37 Green synthesis of copper nanoparticles using Celastrus paniculatus Willd. leaf extract and their photocatalytic and antifungal properties Suresh Chand Mali, Anita Dhaka, Chanda Kumari Githala et al. · Biotechnology Reports Open access 10 Aug 2020 362
38 Andrographolide prevents oxygen radical production by human neutrophils: possible mechanism(s) involved in its anti‐inflammatory effect Yuh‐Chiang Shen, Chieh‐Fu Chen, Wen‐Fei Chiou · British Journal of Pharmacology Open access 2002 359
39 Revisiting the ancient concept of botanical therapeutics Barbara M. Schmidt, David Ribnicky, Peter E. Lipsky et al. · Nature Chemical Biology 19 Jun 2007 358
40 Thymoquinone inhibits tumor angiogenesis and tumor growth through suppressing AKT and extracellular signal-regulated kinase signaling pathways Tingfang Yi, Sung‐Gook Cho, Zhengfang Yi et al. · Molecular Cancer Therapeutics Open access Jul 2008 354
41 Antitumor, antioxidant and anti-inflammatory activities of kaempferol and its corresponding glycosides and the enzymatic preparation of kaempferol Jingqiu Wang, Xianying Fang, Lin Ge et al. · PLoS ONE Open access 17 May 2018 351
42 Molecular targets of celastrol derived from Thunder of God Vine: Potential role in the treatment of inflammatory disorders and cancer Radhamani Kannaiyan, Muthu Kumaraswamy Shanmugam, Gautam Sethi · Cancer Letters 18 Dec 2010 351
43 Triptolide and its expanding multiple pharmacological functions Qiuyan Liu · International Immunopharmacology 20 Jan 2011 350
44 A Mechanistic Overview of Triptolide and Celastrol, Natural Products from Tripterygium wilfordii Hook F Shaoru Chen, Yan Dai, J. Y. Zhao et al. · Frontiers in Pharmacology Open access 14 Feb 2018 341
45 Celastrol, a novel triterpene, potentiates TNF-induced apoptosis and suppresses invasion of tumor cells by inhibiting NF-κB–regulated gene products and TAK1-mediated NF-κB activation Gautam Sethi, Kwang Seok Ahn, Manoj Kumar Pandey et al. · Blood Open access 16 Nov 2006 341
46 Efficacy and safety of certolizumab pegol monotherapy every 4 weeks in patients with rheumatoid arthritis failing previous disease-modifying antirheumatic therapy: the FAST4WARD study Roy Fleischmann, Jiří Vencovský, Ronald van Vollenhoven et al. · Annals of the Rheumatic Diseases Open access 18 Nov 2008 339
47 Cell death in intervertebral disc degeneration Fan Ding, Zengwu Shao, Liming Xiong · APOPTOSIS 19 Mar 2013 337
48 Terpenoids: natural products for cancer therapy Min Huang, Jin‐Jian Lu, Mingqing Huang et al. · Expert Opinion on Investigational Drugs 23 Oct 2012 336
49 Triptolide: structural modifications, structure–activity relationships, bioactivities, clinical development and mechanisms Zhaoli Zhou, Ya-Xi Yang, Jian Ding et al. · Natural Product Reports 2012 335
50 Celastrol-Induced Nur77 Interaction with TRAF2 Alleviates Inflammation by Promoting Mitochondrial Ubiquitination and Autophagy Mengjie Hu et al. · Molecular Cell Open access Apr 2017 326

Citations are OpenAlex's own counts, from its 2026-09-23 snapshot, so the ranking can differ from Google Scholar or Web of Science. A paper is listed for a field when OpenAlex files it under one of the field's topics; retracted papers and papers whose citation count cannot be traced to citing works are left out, and a preprint and the article it became are shown once. Release dates are OpenAlex's: where a source gave only a month or a year, that is what is shown. How the lists are chosen.