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Natural Compounds in Disease Treatment

Natural Compounds in Disease Treatment is a research topic within Complementary and alternative medicine. Science Explorer counts 4.9k research works in it since 1951. 10.0% of them reached the world's top 10% most cited for their field and year.

This cluster of papers explores the therapeutic potential of herbal medicines, focusing on compounds such as Celastrol and Triptolide derived from Thunder God Vine and Tripterygium wilfordii Hook F. The research covers their applications in treating inflammatory disorders, cancer, and neurodegenerative diseases, as well as their potential in targeting specific pathways like NF-?B, inducing apoptosis, and acting as antioxidants. Additionally, the cluster delves into the use of these herbal medicines in conditions like rheumatoid arthritis through drug targeting approaches.

  • Celastrol
  • Triptolide
  • Traditional Medicines
  • Inflammatory Disorders
  • Cancer Treatment
  • NF-?B Inhibition
  • Apoptosis Induction
  • Antioxidant Activity
  • Rheumatoid Arthritis
  • Drug Targeting
Research works
4.9k
fractional, since 1951
In the world top 10%
488
per year above
Top-10% rate
10.0%
share of its works in the world top 10%
Growth, 2018-21 → 2022-25
+11%
the tick is no change
Largest producer
China
74% of the 10 largest, 2022-now
Natural Compounds in Disease Treatment

This ranks research output and citation impact. It says nothing about the quality of diagnosis, treatment or care.

Which countries lead Natural Compounds in Disease Treatment research?

By volume, China and India publish the most (729 and 71 works in 2022-now).

By volume, 2022-now

  1. 1 China 729 works
  2. 2 India 71 works
  3. 3 United States 61 works
  4. 4 Brazil 24 works
  5. 5 South Korea 20 works
  6. 6 Egypt 19 works
  7. 7 Iran 19 works
  8. 8 Japan 18 works
  9. 9 Saudi Arabia 14 works
  10. 10 Italy 13 works

How concentrated that is

The same countries as shares of everything the list above accounts for. A node where two countries do two thirds of the work and one spread evenly across twelve read alike as a ranking and not at all alike here.

China: 73.7%India: 7.2%United States: 6.2%Brazil: 2.4%6 others listed: 10.5%74%largest
China729 · 73.7%India71 · 7.2%United States61 · 6.2%Brazil24 · 2.4%6 others listed104 · 10.5%

Shares of the rows listed above, not of the whole node.

Which institutions lead Natural Compounds in Disease Treatment research?

By volume in 2022-now, Chinese Academy of Medical Sciences & Peking Union Medical College publishes the most Natural Compounds in Disease Treatment research, followed by Nanjing University of Chinese Medicine and Beijing University of Chinese Medicine.

Who are the leading researchers in Natural Compounds in Disease Treatment?

The most-cited researchers publishing on Natural Compounds in Disease Treatment include Amirhossein Sahebkar, Kai You Wang and Alberto Arduan Ortiz.

  1. 1 Amirhossein Sahebkar Iran 258k citations
  2. 2 Kai You Wang China 224k citations
  3. 3 Alberto Arduan Ortiz Spain 219k citations
  4. 4 Ronald M. Evans United States 192k citations
  5. 5 Kenneth Carl Anderson United States 171k citations

Ranked by citations received across their whole record, among researchers with at least three works on this topic.

What are the most cited papers in Natural Compounds in Disease Treatment?

The most cited paper in Natural Compounds in Disease Treatment is "STRIDE-II: An Update on the Selecting Therapeutic Targets in Inflammatory Bowel Disease (STRIDE) Initiative of the International Organization for the Study of IBD (IOIBD): Determining Therapeutic Goals for Treat-to-Target strategies in IBD" (Dan Turner, Amanda Ricciuto, Ayanna E. Lewis et al., 2021), with 2,882 citations. Next come "Thalidomide is an inhibitor of angiogenesis." (2,475) and "Tofacitinib as Induction and Maintenance Therapy for Ulcerative Colitis" (1,772).

Most cited papers
#PaperReleasedCitations
1 STRIDE-II: An Update on the Selecting Therapeutic Targets in Inflammatory Bowel Disease (STRIDE) Initiative of the International Organization for the Study of IBD (IOIBD): Determining Therapeutic Goals for Treat-to-Target strategies in IBD Dan Turner, Amanda Ricciuto, Ayanna E. Lewis et al. · Gastroenterology Open access 20 Feb 2021 2,882
2 Thalidomide is an inhibitor of angiogenesis. Robert J. D’Amato, Michael Loughnan, Evelyn A. Flynn et al. · Proceedings of the National Academy of Sciences Open access 26 Apr 1994 2,475
3 Tofacitinib as Induction and Maintenance Therapy for Ulcerative Colitis William J. Sandborn, Chinyu G. Su, Bruce E. Sands et al. · New England Journal of Medicine Open access 3 May 2017 1,772
4 Phase III Trial of Cisplatin Plus Gemcitabine With Either Placebo or Bevacizumab As First-Line Therapy for Nonsquamous Non–Small-Cell Lung Cancer: AVAiL Martin Reck, Joachim von Pawel, Petr Zatloukal et al. · Journal of Clinical Oncology 2 Feb 2009 1,517
5 Subcutaneous Golimumab Induces Clinical Response and Remission in Patients With Moderate-to-Severe Ulcerative Colitis William J. Sandborn, Brian G. Feagan, Colleen W Marano et al. · Gastroenterology Open access 2 Jun 2013 939
All 100 most cited papers, with filters and sorting

Where is Natural Compounds in Disease Treatment research done?

The largest centres of Natural Compounds in Disease Treatment research in 2022-now are Beijing (China), Nanjing (China), Guangzhou (China) and Shanghai (China). Among places with at least 20 works in it, it is an unusually large share of all research in Hangzhou.

Largest cities, 2022-now

  1. 1 BeijingChina 93 works
  2. 2 NanjingChina 46 works
  3. 3 GuangzhouChina 42 works
  4. 4 ShanghaiChina 40 works
  5. 5 HangzhouChina 33 works
  6. 6 ChengduChina 26 works
  7. 7 WuhanChina 23 works
  8. 8 ChangshaChina 20 works
  9. 9 HefeiChina 16 works
  10. 10 JinanChina 15 works

Where it is the local speciality

  1. HangzhouCN · 33.1 works4.5×
← less than its size predicts1×more →

Location quotient: how much more of its research is in Natural Compounds in Disease Treatment than the world average.

See Natural Compounds in Disease Treatment on the map

Where is the best place to study Natural Compounds in Disease Treatment?

Among universities, judged by research, Chinese Academy of Medical Sciences & Peking Union Medical College, Beijing University of Chinese Medicine and Sichuan University score highest, combining citation excellence, specialisation, size, growth and international reach. Research strength is one signal when choosing where to study; it does not measure teaching.

0%10%20%mean 12.73%fractional works in this field (log) →share of work in the world top 10% →Beijing University o…Sichuan UniversityChina Pharmaceutical…Chinese Academy of M…
above the meannear itbelow it

One dot per university in the first ten of the table below, at the default weights. The upper left is the interesting corner: small places doing unusually strong work.

Citation excellenceshare of its work in the world top 10%, 2022-now and all time averaged
40%
Specialisationhow much of its work is in this field, counted up to 10× the world share
10%
Sizeits output in this field, on a log scale
30%
Growthoutput growth, counted from -20% to +20%
10%
Internationalshare of its work with a co-author abroad
10%
Each slider sets a weight; the share it gets of the score is beside it.
#UniversityScoreTop 10%SpecialisationWorksGrowth
1Chinese Academy of Medical Sciences & Peking Union Medical CollegeChina 73.011.8%20.9×22 +4.0%
2Beijing University of Chinese MedicineChina 70.519.2%68.8×16 -3.8%
3Sichuan UniversityChina 61.217.6%4.5×10 +67.2%
4China Pharmaceutical UniversityChina 58.715.2%51.6×11 -8.2%
5Zhejiang Chinese Medical UniversityChina 44.911.9%43.3×11 +77.6%
6Nanjing University of Chinese MedicineChina 44.86.3%69.4×17 +63.4%
7Guangzhou University of Chinese MedicineChina 42.510.8%36.3×9 +28.4%
8Shanghai University of Traditional Chinese MedicineChina 42.115.0%32.5×9 -16.2%
9Nanjing Medical UniversityChina 39.613.9%10.9×10 -18.8%
10Huazhong University of Science and TechnologyChina 27.45.6%5.0×9 +70.3%

Universities only. The score blends citation excellence (40%), size (30%), specialisation (10%), growth (10%), international reach (10%), 2022-now; growth compares 2018-21 with 2022-25 and counts up to +20%, since a jump from a small base is mostly noise.

Every institution in Natural Compounds in Disease Treatment, country by country

Is Natural Compounds in Disease Treatment research growing?

Output in 2022-2025 was 11% higher than in 2018-2021, peaking in 2025. The fastest-growing topics are Natural Compounds in Disease Treatment.

still counting19801990200020102020
grewheldshrank

The same series as a ribbon: one cell per year, darker for more. The line above answers how much; this answers when.

Its share of all research

Growing output can still be a shrinking share: all of science grows. This is Natural Compounds in Disease Treatment as a percentage of every work published that year, 0.0041% in 2024.

still counting0.0025%0.0050%0.0075%Natural Compounds in Disease Treatment0.0047% in 202519801990200020102020

Fractional works of Natural Compounds in Disease Treatment over all fractional works that year. How the balance of science has shifted.

How much of it reaches the world top 10%

Year by year.

still counting5%10%15%Natural Compounds in Disease Treatment10.3% in 2025200020102020

Of each year's works in it, the share that reached the world's 10% most cited for their field and year. A field is the world for its own topics, so there is no other line to hold it against.

Which topics inside it are moving

Growth and decline on one axis around a shared zero. Two lists side by side hide the thing that matters: whether the growth dwarfs the decline, or the other way round.

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